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| 1 | Emissions of polycyclic aromatic hydrocarbons from coking industries in China显示文摘这研究开始估计多不的芳香的烃的特征(哼) 从 coking 工业的排放,与在四典型焦炭植物进行的领域采样。为每选择植物,栈烟道气体样品在包括的进程期间是镇定的控告煤进炉(CC ) ,推焦炭(PC ) 和焦炭炉气体(CG ) 的燃烧。十六个个人在 US EPA 优先级表上哼被煤气的层析 / 团 spectrometry (GC/MS ) 分析。结果证明总数哼在烟道气体的集中从 45.776 ~ 414.874 g/m3 ,与为 CC (359.545 g/m3 ) 的最高的排放水平。集中哼在 CP1 (收费的邮票) 从 CC 过程射出从 CP3 和 CP4 (收费的顶) 是比那低的。Low-molecular-weight 哼(即,二 -- 到三戒指哼) 到总数的占优势的贡献者哼内容,和小睡, AcPy,流感, PhA,和蚂蚁被发现是最丰富的。为 CC (2.248 g/m3 ) 的全部的 BaPeq 集中比为 PC (1.838 g/m3 ) 的那些高, CG (1.082 g/m3 ) ,和 DbA 作为在从 coking 过程的排出物的 BaP 是到 carcinogenic 风险的一个重要贡献者。微粒哼比对总数的相应贡献哼的占了超过 20% 全部的 BaPeq 集中,它显著地高集体集中(5%) 。微粒并且气体哼当时,应该被考虑潜在的毒性风险哼污染在 coking 期间,过程被估计。吝啬的总数 -- 哼排放因素分别地是为 CC 和 PC 的 346.132 和 93.173 g/kg。 | Ling Mu Lin Peng Junji Cao Qiusheng He Fan Li Jianqiang Zhang Xiaofeng Liu Huiling Bai | 2013 | Particuology2013，11，1： | 17 |
| 2 | Effect of Calcium Oxide Additive on the Performance of Iron Oxide Sorbent for High-Temperature Coal Gas Desulfurization显示文摘The effect of calcium oxide additive in iron oxide sorbent for hot gas desulfurization was investigated by XRD and TPR techniques.XRD characterization showed that CaO was highly dispersed after the calcination of sorbents.Calcium sulfate formed in the desulfurization was decomposed and regenerated to CaO by reacting with CO before the next sulfidation process.Calcium participated in every sulfidation/regeneration cycle and contributed to the enhancement of sulfur capacity.The TPR results showed that the reduction temperature of the sorbent increased with the increase of the content of calcium.Calcium played a role of retarding reduction.Therefore,the addition of calcium oxide additive will benefit the utilization of iron oxide sorbent in strongly reducing atmospheres. | Huiling Fan Kechang Xie Ju Shangguan Fang Shen Chunhu Li | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 7 |
| 3 | Tandem catalysis in electrochemical CO_(2) reduction reaction显示文摘Electrochemical CO_(2) reduction reaction(CO_(2)RR)is an attractive pathway for closing the anthropogenic carbon cycle and storing intermittent renewable energy by converting CO_(2) to valuable chemicals and fuels.The production of highly reduced carbon compounds beyond CO and formate,such as hydrocarbon and oxygenate products with higher energy density,is particularly desirable for practical applications.However,the productivity towards highly reduced chemicals is typically limited by high overpotential and poor selectivity due to the multiple electron-proton transfer steps.Tandem catalysis,which is extensively utilized by nature for producing biological macromolecules with multiple enzymes via coupled reaction steps,represents a promising strategy for enhancing the CO_(2)RR performance.Improving the efficiency of CO_(2)RR via tandem catalysis has recently emerged as an exciting research frontier and achieved significant advances.Here we describe the general principles and also considerations for designing tandem catalysis for CO_(2)RR.Recent advances in constructing tandem catalysts,mainly including bimetallic alloy nanostructures,bimetallic heterostructures,bimetallic core-shell nanostructures,bimetallic mixture catalysts,metal-metal organic framework(MOF)and metal-metallic complexes,metal-nonmetal hybrid nanomaterials and copper-free hybrid nanomaterials for boosting the CO_(2)RR performance are systematically summarized.The study of tandem catalysis for CO_(2)RR is still at the early stage,and future research challenges and opportunities are also discussed. | Yating Zhu Xiaoya Cui Huiling Liu Zhenguo Guo Yanfeng Dang Zhanxi Fan Zhicheng Zhang Wenping Hu | 2021 | Nano Research2021，14，12： | 5 |
| 4 | A nanocleaner specifically penetrates the blood-brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer's disease显示文摘Insurmountable blood-brain barrier(BBB) and complex pathological features are the key factors affecting the treatment of Alzheimer's disease(AD).Poor accumulation of drugs in lesion sites and undesired effectiveness of simply reducing Aβ deposition or TAU protein need to be resolved urgently.Herein,a nanocleaner is designed with a rapamycin-loaded ROS-responsive PLGA core and surface modification with KLVFF peptide and acid-cleavable DAG peptide [R@(ox-PLGA)-KcD].DAG can enhance the targeting and internalization effect of nanocleaner towards neurovascular unit endothelial cells in AD lesions,and subsequently detach from nanocleaner in response to acidic microenvironment of endosomes to promote the transcytosis of nanocleaner from endothelial cells into brain parenchyma.Then exposed KLVFF can capture and carry Aβ to microglia,attenuating Aβ-induced neurotoxicity.Strikingly,rapamycin,an autophagy promoter,is rapidly liberated from nanocleaner in the high ROS level of lesions to improve Aβ degradation and normalize inflammatory condition.This design altogether accelerates Aβ degradation and alleviates oxidative stress and excessive inflammatory response.Collectively,our finding offers a strategy to target the AD lesions precisely and multi-pronged therapies for clearing the toxic proteins and modulating lesion microenvironment,to achieve efficient AD therapy. | Ting Lei Zhihang Yang Xue Xia Yuxiu Chen Xiaotong Yang Rou Xie Fan Tong Xiaolin Wang Huile Gao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 4 |
| 5 | Efficient quantum arithmetic operation circuits for quantum image processing显示文摘Efficient quantum circuits for arithmetic operations are vital for quantum algorithms.A fault-tolerant circuit is required for a robust quantum computing in the presence of noise.Quantum circuits based on Clifford+T gates are easily rendered faulttolerant.Therefore,reducing the T-depth and T-Count without increasing the qubit number represents vital optimization goals for quantum circuits.In this study,we propose the fault-tolerant implementations for TR and Peres gates with optimized T-depth and T-Count.Next,we design fault-tolerant circuits for quantum arithmetic operations using the TR and Peres gates.Then,we implement cyclic and complete translations of quantum images using quantum arithmetic operations,and the scalar matrix multiplication.Comparative analysis and simulation results reveal that the proposed arithmetic and image operations are efficient.For instance,cyclic translations of a quantum image produce 50%T-depth reduction relative to the previous best-known cyclic translation. | Hai-Sheng Li Ping Fan Haiying Xia Huiling Peng Gui-Lu Long | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，8： | 3 |
| 6 | Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors显示文摘Considering that photodynamic therapy(PDT)-induced oxygen consumption and microvascular damage could exacerbate hypoxia to drive more glycolysis and angiogenesis, a novel approach to potentiate PDT and overcome the resistances of hypoxia is avidly needed. Herein, morpholine-modified PEGylated bilirubin was proposed to co-deliver chlorin e6, a photosensitizer, and diclofenac(Dc). In acidic milieu, the presence of morpholine could enable the nanocarriers to selectively accumulate in tumor cells, while PDT-generated reactive oxidative species(ROS) resulted in the collapse of bilirubin nanoparticles and rapid release of Dc. Combining with Dc showed a higher rate of apoptosis over PDT alone and simultaneously triggered a domino effect, including blocking the activity and expression of lactate dehydrogenase A(LDHA), interfering with lactate secretion, suppressing the activation of various angiogenic factors and thus obviating hypoxia-induced resistance-glycolysis and angiogenesis. In addition, inhibition of hypoxia-inducible factor-1a(HIF-1a) by Dc alleviated hypoxia-induced resistance. This study offered a sequentially responsive platform to achieve sufficient tumor enrichment, on-demand drug release and superior anti-tumor outcomes in vitro and in vivo. | Yang Zhou Fan Tong Weilong Gu Siqin He Xiaotong Yang Jiamei Li Yue-Dong Gao Huile Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 7 | Poly(ADP-ribose) mediates asymmetric division of mouse oocyte显示文摘在授精前,哺乳动物的卵母细胞经历取决于形成极的身体和一个鸡蛋的在卵母细胞外皮的锭子的怪癖的放的一个不对称的部门。因为中吣粒是不在的,作为结果,极的数组微导管充分没在卵母细胞被开发,微导管是为锭子的怪癖的放要求了很少被考虑了,当肌动朊相关的力量相反被建议了为这进程主要负责时。然而,存在模型大部分正在冲突,不对称的分割的内在的机制仍然是逃犯的。这里,我们证明(自动数据处理核糖)( 同等) 那 poly 在老鼠卵母细胞被充实在整个成熟分裂的外皮的区域。在一支宫外的锭子和不对称的分割的失败的外皮的同等结果的特定的移动。在锭子移植期间,当锭子由细胞质的肌动朊的推的力量从卵母细胞的中心背离时,从 juxtacortical 锭子杆发出的短极的数组微导管延长到外皮并且渗透进外皮的同等,停靠并且稳定在便于不对称的部门的外皮的锭子。这个过程取决于与同等和联系微导管的蛋白质例如的亲密关系细长纤弱,它为外皮的同等和锭子贡献一个物理连接。尤其是,熔化同等绑定域到结束绑定蛋白质 3,在极的数组微导管的正结束的追踪蛋白质,恢复卵母细胞的不对称的部门与细长纤弱击倒。因此,我们的工作为卵母细胞锭子放和不对称的分割表明全面机制。 | Bingteng Xie Lu Zhang Huiling Zhao Qingyun Bai Yong Fan Xiaohui Zhu Yang Yu Rong Li Xin Liang Qing-Yuan Sun Mo Li Jie Qiao | 2018 | Cell Research2018，28，4： | 2 |
| 8 | A review on nitrogen transformation and conversion during coal pyrolysis and combustion based on quantum chemical calculation and experimental study显示文摘The emission of NOx during coal combustion contributes to the formation of acid rain and photochemical smog,which would seriously affect the quality of atmospheric environment.Therefore,the decrease of NOx is of great importance for improving the efficient utilization of coal.The present review comprehensively summarized the influence factors and mechanisms of migration and transformation of nitrogen during the coal pyrolysis and combustion based on experimental study and quantum chemical calculation.Firstly,in the process of pyrolysis:the occurrence state and transformation of nitrogen were concluded.The influence of temperature,atmosphere,heating rate and catalyst on formation of NOx precursor and nitrogen migration path at the molecular level were summarized;Secondly,during the process of combustion:the influence of temperature,ambient oxygen concentration,physical structure of coal char,catalyst on heterogeneous oxidation of char(N)were summarized;The effects of char surface properties,catalyst and ambient atmosphere on heterogeneous reduction of NOx were also concluded.Based on the quantum chemical calculation,the reaction path of heterogeneous oxidation of char-N and heterogeneous reduction of NOx were described in detail.Current studies focus more on the generation of HCN and NH3,but in order to reduce the pollution of NOx from the source,it is necessary to further improve the process conditions and the optimal formula of producing more N2 during pyrolysis,as well as clarify the path of the generation of N2.Experiments study and quantum chemistry calculation should be combined to complete the research of directional nitrogen reduction during pyrolysis and denitration during combustion. | Tingting Jiao Huiling Fan Shoujun Liu Song Yang Wenguang Du Pengzheng Shi Chao Yang Yeshuang Wang Ju Shangguan | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 2 |
| 9 | Hierarchical porous carbon heterojunction flake arrays derived from metal organic frameworks and ionic liquid for H2O2 electrochemical detection in cancer tissue显示文摘The development of hierarchical nanostructure is demonstrated as an effective strategy to improve catalytic activity and stability of electrocatalysts.Herein,a novel leaf-like hierarchically porous heterojunction flake arrays(FAs),integrated graphitic N-doped carbon(NC)with amorphous B,N-doped carbon(BNC),has been designed and grown on flexible carbon fiber(CF)using metal-organic framework(MOF)FAs and green ionic liquids as precursors.The hierarchical heterojunction structure possesses micro-and nano-scaled pores,large surface areas,and exposed high-density catalytic active sites,which enhances electronic conductivity and offers accessible transport channels for effectively decreasing mass transport resistance.The results of discrete Fourier transform(DFT)calculations and experiments also suggest that the catalytic activity has been promoted by the heterojunction structure through narrowing the banding gap.Consequently,the resultant nanohybrid microelectrode exhibits remarkable electrochemical sensing performance towards H2O2 with a low detection limit of 50 nM,and a high sensitivity of 213μA×mM-1×cm-2,as well as good anti-interference capability.The practical application of nanohybrid fiber microelectrode has been explored by real-time monitoring H2O2 released from live colon cells and surgically-resected fresh colon cancer tissue,which can provide important information for the identification of different types of cells as well as distinguish cancer cells from normal ones.We believe this research will pave the way towards the development of advanced carbon nanomaterials for application in the fields of electrochemistry,biosensing,and cancer diagnosis. | Yan Zhang Qiying Lv Kai Chi Qilin Li Huiling Fan Bo Cai Fei Xiao Shuai Wang Zheng Wang Lin Wang | 2021 | Nano Research2021，14，5： | 2 |
| 10 | Combined organic-inorganic fertilization builds higher stability of soil and root microbial networks than exclusive mineral or organic fertilization显示文摘Plant health and performance are highly dependent on the root microbiome.The impact of agricultural management on the soil microbiome has been studied extensively.However,a comprehensive understanding of how soil types and fertilization regimes affect both soil and root microbiome is still lacking,such as how fertilization regimes affect the root microbiome's stability,and whether it follows the same patterns as the soil microbiome.In this study,we carried out a longterm experiment to see how different soil types,plant varieties,and fertilizer regimens affected the soil and root bacterial communities.Our results revealed higher stability of microbial networks under combined organic-inorganic fertilization than those relied solely on inorganic or organic fertilization.The root microbiome variation was predominantly caused by total nitrogen,while the soil microbiome variation was primarily caused by pH and soil organic matter.Bacteroidetes and Firmicutes were major drivers when the soil was amended with organic fertilizer,but Actinobacteria was found to be enriched in the soil when the soil was treated with inorganic fertilizer.Our findings demonstrate how the soil and root microbiome respond to diverse fertilizing regimes,and hence contribute to a better understanding of smart fertilizer as a strategy for sustainable agriculture. | Luhua Yang Renhua Sun Jungai Li Limei Zhai Huiling Cui Bingqian Fan Hongyuan Wang Hongbin Liu | 2023 | Soil Ecology Letters2023，5，2： | 1 |
| 11 | Nimodipine alleviates apoptosis-mediated impairments through the mitochondrial pathway after spinal cord injury显示文摘 | Yafei CAI Rui FAN Tianmiao HUA Huiling LIU Jing LI | 2011 | Current Zoology2011，57，3： | 1 |
| 12 | Recombinant protein production in the filamentous fungus Trichoderma显示文摘Trichoderma is an ascomycete fungal genus widely distributed in the soils.Several species were selected,engineered and utilized for protein production for decades.The high extracellular secretion capability and eukaryotic post-translational modification machinery make Trichoderma spp.particularly interesting hosts.In this review,we summarized the recombinant proteins produced in Trichoderma since 2014,concerning their origins,hosts,promoters,terminators,signal peptides,yields and commonly used media.Meanwhile,strategies and merging trends in protein production and strain engineering are classified and summarized regarding codon optimization,promoter utilization,transcription factor regulation,post-translational modification and proteolytic degradation inhibition.With state-of-art biotechnologies and more available expression platforms,Trichoderma spp.could be more successful hosts to produce recombinant proteins as desired,i.e.better enzyme formula for efficient cellulose degradation or functional protein with high purity and yield. | Huiling Wei Mengyue Wu Aili Fan Haijia Su | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 1 |
| 13 | A comparative study of the effect of clay binders on iron oxide sorbent in the high-temperature re- moval of hydrogen sulfide显示文摘 | Fan Huiling | 2013 | Process Safety and Envir- onmental Protection2013，91，3： | 1 |
| 14 | A Study on Removal of Organic Sulfur Compound with Modified Activated Carbon显示文摘 | Fan Huiling Li Chunhu | 1999 | Journal of Natural Gas Chemistry1999，8，2： | 1 |
| 15 | Treatment outcomes of transcatheter arterial chemoembolization combined with local ablative therapy versus monotherapy in hepatocellular carcinoma: a meta-analysis显示文摘 | Lili Gu Huiling Liu Linlin Fan Yuanjun Lv Zhuang Cui Yan Luo Yuanyuan Liu Guang Li Changping Li Jun Ma | 2014 | Journal of Cancer Research and Clinical Oncology2014，，2： | 1 |
| 16 | Research progress of the role of HGF/c-Met in the proliferation, invasion, angiogenesis and metastasis of cancer显示文摘The HGF/c-Met pathway plays an important role in the proliferation, invasion, angiogenesis, and metastasis of tumors. With the successful development of small molecule c-Met kinase inhibitors, this signal pathway has become the focus of oncology research. In this review, we discuss the basic mechanism, targeted therapy, and early results of clinical trials of the HGF/c-Met pathway. | Honghui Su Hongjun Fan Huiling Su | 2015 | Oncology and Translational Medicine2015，1，4： | 1 |
| 17 | A study on removal of organic sulfur compound with modified activaled carbon 显示文摘 | Fan Huiling Li Chunhu Guo Hanxian | 1999 | Jounal of Natural Gas Chemistry1999，8，2： | 1 |
| 18 | Removal of sulfur compounds by a copper-based metal organic framework under ambient conditions显示文摘 | Li Ye Wang Longjiang Fan Huiling | 2015 | Energ Fuels2015，29，5： | 1 |
| 19 | Emissions of polycyclic aromatic hydrocarbons from coking industries in China显示文摘 | Ling Mu Lin Peng Junji Cao Qiusheng He Fan Li Jianqiang Zhang Xiaofeng Liu Huiling Bai | 2012 | Particuology2012，，： | 1 |
| 20 | Three-dimensionally ordered macroporous iron oxide for removal of H 2 S at medium temperatures显示文摘 | Fan Huiling Sun Ting Zhao Yanpeng | 2013 | Environ Sci Technol2013，47，： | 1 |
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