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| 1 | Spinal Circuits Transmitting Mechanical Pain and Itch显示文摘In 1905, Henry Head first suggested that transmission of pain-related protopathic information can be negatively modulated by inputs from afferents sensing innocuous touch and temperature. In 1965, Melzak and Wall proposed a more concrete gate control theory of pain that highlights the interaction between unmyelinated C fibers and myelinated A fibers in pain transmission. Here we review the current understanding of the spinal microcircuits transmitting and gating mechanical pain or itch.We also discuss how disruption of the gate control could cause pain or itch evoked by innocuous mechanical stimuli,a hallmark symptom for many chronic pain or itch patients. | Bo Duan Longzhen Cheng Qiufu Ma | 2018 | Neuroscience Bulletin2018，34，1： | 8 |
| 2 | Activation of extrasynaptic GABA_A receptors inhibits cyclothiazideinduced epileptiform activity in hippocampal CA1 neurons显示文摘Extrasynaptic GABA_A receptors(GABA_ARs)-mediated tonic inhibition is reported to involve in the pathogenesis of epilepsy.In this study,we used cyclothiazide(CTZ)-induced in vitro brain slice seizure model to explore the effect of selective activation of extrasynaptic GABA_ARs by 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol(THIP)on the CTZ-induced epileptiform activity in hippocampal neurons.Perfusion with CTZ dose-dependently induced multiple epileptiform peaks of evoked population spikes(PSs)in CA1 pyramidal neurons,and treatment with THIP(5 umol/L)significantly reduced the multiple PS peaks induced by CTZ stimulation.Western blot showed that the 5-subunit of the GABA_AR,an extrasynaptic specific GABA_AR subunit,was also significantly down-regulated in the cell membrane 2h after CTZ treatment.Our results suggest that the CTZ-induced epileptiform activity in hippocampal CA1neurons is suppressed by the activation of extrasynaptic GABA_ARs,and further support the hypothesis that tonic inhibition mediated by extrasynaptic GABA_ARs plays a prominent role in seizure generation. | Li Wan Xu Liu Zheng Wu Wanting Ren Shuzhen Kong Raya Abou Dargham Longzhen Cheng Yun Wang | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 3 | Band-gap-tailored random laser显示文摘A band-gap-tailored random laser with a wide tunable range and low threshold through infrared radiation is demonstrated. When fluorescent dyes are doped into the liquid crystal and heavily doped chiral agent system,we demonstrate a wavelength tuning random laser instead of a side-band laser, which is caused by the combined effect of multi-scattering of liquid crystal(LC) and band-gap control. Through rotating the infrared absorbing material on the side of the LC cell, an adjustable range for random lasing of 80 nm by infrared light irradiation was observed. | HONGBO Lu JIAN XING CHENG WEI JIANGYING XIA JUNQING SHA YUNSHENG DING GUOBING ZHANG KANG XIE LONGZHEN QIU ZHIJIA Hu | 2018 | Photonics Research2018，6，5： | 1 |
| 4 | Wide tunable laser based on electrically regulated bandwidth broadening in polymer-stabilized cholesteric liquid crystal显示文摘Electrically responsive photonic crystals represent one of the most promising intelligent material candidates for technological applications in optoelectronics. In this research, dye-doped polymer-stabilized cholesteric liquid crystals(PSCLCs) with negative dielectric anisotropy were fabricated, and mirrorless lasing with an electrically tunable wavelength was successfully achieved. Unlike conventional liquid-crystal lasers, the proposed laser aided in tuning the emission wavelength through controlling the reflection bandwidth based on gradient pitch distribution. The principal advantage of the electrically controlled dye-doped PSCLC laser is that the electric field is applied parallel to the helical axis, which changes the pitch gradient instead of rotating the helix axis, thus keeping the heliconical structure intact during lasing. The broad tuning range(~110 nm) of PSCLC lasers,coupled with their stable emission performance, continuous tunability, and easy fabrication, leads to its numerous potential applications in intelligent optoelectronic devices, such as sensing, medicine, and display. | HONGBO LU CHENG WEI QIANG ZHANG MIAO XU YUNSHENG DING GUOBING ZHANG JUN ZHU KANG XIE XIAOJUAN ZHANG ZHIJIA HU LONGZHEN QIU | 2019 | Photonics Research2019，7，2： | 1 |
| 5 | Targeting Peripheral μ-opioid Receptors or μ-opioid Receptor-Expressing Neurons Does not Prevent Morphine-induced Mechanical Allodynia and Anti-allodynic Tolerance显示文摘The chronic use of morphine and other opioids is associated with opioid-induced hypersensitivity(OIH)and analgesic tolerance.Among the different forms of OIH and tolerance,the opioid receptors and cell types mediating opioid-induced mechanical allodynia and anti-allodynic tolerance remain unresolved.Here we demonstrated that the loss of peripheralμ-opioid receptors(MORs)or MOR-expressing neurons attenuated thermal tolerance,but did not affect the expression and maintenance of morphine-induced mechanical allodynia and anti-allodynic tolerance.To confirm this result,we made dorsal root ganglia-dorsal roots-sagittal spinal cord slice preparations and recorded low-threshold Aβ-fiber stimulation-evoked inputs and outputs in superficial dorsal horn neurons.Consistent with the behavioral results,peripheral MOR loss did not prevent the opening of Aβmechanical allodynia pathways in the spinal dorsal horn.Therefore,the peripheral MOR signaling pathway may not be an optimal target for preventing mechanical OIH and analgesic tolerance.Future studies should focus more on central mechanisms. | Feng Du Guangjuan Yin Lei Han Xi Liu Dong Dong Kaifang Duan Jiantao Huo Yanyan Sun Longzhen Cheng | 2023 | Neuroscience Bulletin2023，39，8： | 0 |
| 6 | Microglial Depletion does not Afect the Laterality of Mechanical Allodynia in Mice显示文摘Mechanical allodynia(MA),including punctate and dynamic forms,is a common and debilitating symptom suffered by millions of chronic pain patients.Some peripheral injuries result in the development of bilateral MA,while most injuries usually led to unilateral MA.To date,the control of such laterality remains poorly understood.Here,to study the role of microglia in the control of MA laterality,we used genetic strategies to deplete microglia and tested both dynamic and punctate forms of MA in mice.Surprisingly,the depletion of central microglia did not prevent the induction of bilateral dynamic and punctate MA.Moreover,in dorsal root ganglion-dorsal root-sagittal spinal cord slice preparations we recorded the low-threshold Aβ-fiber stimulation-evoked inputs and outputs of superficial dorsal horn neurons.Consistent with behavioral results,microglial depletion did not prevent the opening of bilateral gates for Aβpathways in the superficial dorsal horn.This study challenges the role of microglia in the control of MA laterality in mice.Future studies are needed to further understand whether the role of microglia in the control of MA laterality is etiology-or species-specific. | Quan Ma Dongmei Su Jiantao Huo Guangjuan Yin Dong Dong Kaifang Duan Hong Cheng Huiling Xu Jiao Ma Dong Liu Bin Mou Jiyun Peng Longzhen Cheng | 2023 | Neuroscience Bulletin2023，39，8： | 0 |
| 7 | Correction:Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice显示文摘The original version of this article unfortunately contained one error.The authors found that in the middle panel of Fig.2A,the example traces recorded from a contralateral dorsal horn neuron of the capsaicin-treated mouse were wrong,and the corrected Fig.2 was as follows. | Quan Ma Dongmei Su Jiantao Huo Guangjuan Yin Dong Dong Kaifang Duan Hong Cheng Huiling Xu Jiao Ma Dong Liu Bin Mou Jiyun Peng Longzhen Cheng | 2023 | Neuroscience Bulletin2023，39，11： | 0 |
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