| 1 | Regulatory mechanisms of retinal ganglion cell death in normal tension glaucoma and potential therapies显示文摘Normal tension glaucoma(NTG)is a multifactorial optic neuropathy characterized by normal intraocular pressure,progressive retinal ganglion cell(RGC)death,and glaucomatous visual field loss.Recent studies have described the mechanisms underlying the pathogenesis of NTG.In addition to controlling intraocular pressure,neuroprotection and reduction of RGC degeneration may be beneficial therapies for NTG.In this review,we summarized the main regulatory mechanisms of RGC death in NTG,including autophagy,glutamate neurotoxicity,oxidative stress,neuroinflammation,immunity,and vasoconstriction.Autophagy can be induced by retinal hypoxia and axonal damage.In this process,ischemia can cause mutations of optineurin and activate the nuclear factor-kappa B pathway.Glutamate neurotoxicity is induced by the over-stimulation of N-methyl-D-aspartate membrane receptors by glutamate,which occurs in RGCs and induces progressive glaucomatous optic neuropathy.Oxidative stress also participates in NTG-related glaucomatous optic neuropathy.It impairs the mitochondrial and DNA function of RGCs through the apoptosis signal-regulating kinase-JUN N-terminal kinase pathway.Moreover,it increases inflammation and the immune response of RGCs.Endothelin 1 causes endothelial dysfunction and impairment of ocular blood flow,promoting vasospasm and glaucomatous optic neuropathy,as a result of NTG.In conclusion,we discussed research progress on potential options for the protection of RGCs,including TANK binding kinase 1 inhibitors regulating autophagy,N-methyl-D-aspartate receptor antagonists inhibiting glutamate toxicity,ASK1 inhibitors regulating mitochondrial function,and antioxidants inhibiting oxidative stress.In NTG,RGC death is regulated by a network of mechanisms,while various potential targets protect RGCs.Collectively,these findings provide insight into the pathogenesis of NTG and potential therapeutic strategies. | Wen-Cui Shen Bing-Qing Huang Jin Yang | 2023 | Neural Regeneration Research2023，18，1： | 2 |
| 2 | 针刺干预青光眼动物实验研究报告质量评价显示文摘目的通过SYRCLE动物实验风险评估工具、ARRIVE 2.0指南和GSPC清单评价针刺干预青光眼的动物实验报告质量。方法计算机检索CNKI、VIP、Wanfang、Sinomed、PubMed、Web of Science、Embase、Cochrane Library等数据库,寻找针刺干预青光眼的动物研究文章。使用SYRCLE工具对纳入研究进行偏倚风险评估,使用ARRIVE 2.0指南和GSPC清单对研究报告质量进行评价,通过Excel和SPSS软件进行统计分析。结果共30篇文章符合纳入/排除标准被纳入最终的分析,其中SYRCLE工具的10项条目中有6项条目低风险率<50%,非低风险条目主要集中在选择性偏倚、实施偏倚和测量偏倚方面。ARRIVE 2.0指南的22项必备子条目中有12项低风险率<50%;16项推荐子条目中有9项低风险率低于50%。GSPC清单19项子条目中有12项子条目低风险率<50%,随机化、盲法、伦理声明、饲养场所和饲养、动物护理和监测以及方案注册是ARRIVE 2.0指南和GSPC清单的非低风险条目。结论当前公开发表的针刺干预青光眼动物研究方法学质量和实验报告质量普遍不高,对多个条目的描述尚不完善,可能影响读者对实验结果能否进一步转化为临床研究的判断。建议未来的研究严格按照动物实验偏倚风险工具以及报告指南进行,以提高动物实验的设计、实施和报告,保证实验步骤的可重复性及实验结果的再现性,为结果转化到临床提供可靠的证据。 | 李佳贤 梁丽娜 许凯 李亚敏 黄子杨 李晓宇 周维 金昱 | 2024 | 中国比较医学杂志2024，34，1： | 0 |
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