|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Predictors of premature delivery in patients with intrahepatic cholestasis of pregnancy显示文摘瞄准:在怀孕(ICP ) 的肝内胆汁郁积为早熟评估临床的症状和生物化学的参数的预兆的价值。方法:有 ICP 的六十个征兆的病人在这回顾的分析被包括。Preterm 交货在 37 wk 怀孕期前被定义为交货。preterm 交货的预言者被二进制代码多揭示变量逻辑回归分析。结果:交货的吝啬的时间是 38.1 +/- 1.7 wk。没有死胎发生了。早产在八被观察(13.3%) 病人。全部的禁食浆液胆汁酸更高(47.8 +/- 15.2 对 41.0 +/- 10.0 mumol/L, P <
0.05 ) ,并且瘙痒趋于更早开始(29.0 +/- 3.9 对 31.6 +/- 3.3 wk, P = 0.057 ) 在有早产的病人什么时候与那些相比与术语交货。二进制多逻辑回归分析揭示了的变量瘙痒的那早发作(或 1.70, 95% CI 1.23-2.95, P = 0.038 ) 并且浆液胆汁酸(或 2.13, 95% CI 1.13-3.25, P = 0.013 ) 是 preterm 的独立预言者交货。结论:瘙痒的早发作和浆液胆汁酸的高水平在 ICP 预言 preterm 交货,并且为穷人在风险定义病人的亚群新生的结果。 | Jurate Kondrackiene Ulrich Beuers Rimantas Zalinkevicius Horst-Dietmar Tauschel Vladas Gintautas Limas Kupcinskas | 2007 | World Journal of Gastroenterology2007，13，46： | 39 |
| 2 | 催化吲哚生成靛蓝的细胞色素P450BM-3定向进化研究显示文摘以催化吲哚产生的靛蓝在630nm处具有特殊的吸收峰为高通量筛选指标,将来源于Bacillusmegaterium的细胞色素P450BM-3单加氧酶的基因序列用易错聚合酶链式反应进行定向进化,通过多轮突变,在原有的能产靛蓝的高活力突变酶的基础上成功获得了三个高于亲本酶的突变酶,突变酶的酶活分别是亲本酶的6.6倍(hml001),9.6倍(hml002)和5.3倍(hml003),并对突变酶的动力学参数进行了分析.突变酶DNA测序的结果表明,hml001含有一个有义氨基酸置换I39V,hml002含有三个有义氨基酸置换D168N,A225V,K440N,hml003含有一个有义氨基酸置换E435D,这些突变位点有些远离底物结合部位,有些位于底物结合部位. | 李红梅 梅乐和 URLACHER VLADA SCHMID ROLF D | 2005 | 生物化学与生物物理进展2005，32，7： | 14 |
| 3 | Role of autophagy in differential sensitivity of hepatocarcinoma cells to sorafenib显示文摘AIM: To investigate the role of sorafenib(SFN) in autophagy of hepatocellular carcinoma(HCC). We evaluated how SFN affects autophagy signaling pathway in human HCC cell lines. METHODS: Two different human HCC cell lines, Hep3 B and Huh7, were subjected to different concentrations of SFN. Cell viability and onset of apoptosis were determined with colorimetric assay and immunoblotting analysis, respectively. The changes in autophagy-related proteins, including LC3, ULK1, AMPK, and LKB, were determined with immunoblotting analysis in the presence or absence of SFN. To assess autophagic dynamics, autophagic flux was measured with chloroquine, a lysosomal inhibitor. The autophagic responsiveness between different HCC cell lines was compared under the autophagy enhancing conditions.RESULTS: Hep3 B cells were significantly more resistant to SFN than Huh7 cells. Immunoblotting analysis revealed a marked increase in SFN-mediated autophagy flux in Huh7 cells, which was, however, absent in Hep3 B cells. While both starvation and rapamycin enhanced autophagy in Huh7 cells, only rapamycin increased autophagy in Hep3 B cells. Immunoblotting analysis of autophagy initiation proteins showed that SFN substantially increased phosphorylation of AMPK and consequently autophagy in Huh7, but not in Hep3 B cells.CONCLUSION: The autophagic responsiveness to SFN is distinct between Hep3 B and Huh7 cells. Resistance of Hep3 B cells to SFN may be associated with altered autophagy signaling pathways. | Trevan D Fischer Jin-Hee Wang Adrian Vlada Jae-Sung Kim Kevin E Behrns | 2014 | World Journal of Hepatology2014，6，10： | 5 |
| 4 | A further study of the kinetics and optimization of the essential oil hydrodistillation from lavender flowers显示文摘Hydrodistillation has commonly been used to recover essential oil from various plant materials,including lavender(Lavandula officinalis) flowers.The main objectives of the present study were to model the kinetics of the lavender essential oil(LEO) hydrodistillation using a phenomenological model,to evaluate the statistical significance of the hydromodule and hydrodistillation time on LEO yield combining a 4~2 full factorial design with the response surface methodology,to model statistically LEO yield by multiple non-linear regression and to determine the optimal process conditions that provided the maximum LEO yield.The fast-essential oil distillation(washing stage) in the initial period and the slow diffusion stage until the saturation occurring simultaneously were observed,justifying the use of the phenomenological model.With increasing the hydromodule,the saturation LEO yield and the washable fraction of the LEO decreased while the washing and diffusion rate constants increased.Knowledge of the LEO oil yield and the hydrodistillation kinetics is important from the techno-economical point of view. | Aleksandra Perovic Mihajlo Z.Stankovic Vlada B.Veljkovic Milan D.Kostic Olivera S.Stamenkovic | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 3 |
| 5 | 用传统和超声提取的松果菊(紫锥菊属)的抗氧化和抗菌活性(英文)显示文摘Antioxidant and antimicrobial activities of Echinacea purpurea L. (Asteraceae) extracts obtained by classical and ultrasound solvent extraction were compared. The dry aerial part of plant was extracted by 70% etha-nol at a solid-to-liquid ratio of 1︰10 (m/v) and 25°C. The extract obtained by classical solvent extraction contained 29% larger amounts of phenolic compounds and 20% higher content of flavonoids. 2,2-diphenyl-1-picril hydrazyl radical (DPPH) scavenging reached 93.6% and the values of EC50 were (34.16±0.65) μg·ml-1 and (65.48±1.12) μg·ml-1 for the extracts obtained by the classical and ultrasound extractions, respectively. The extracts, independent of the extraction technique applied, showed a considerable growth inhibition on Candida albicans and Saccharo-myces cerevisiae, while no growth inhibition zones were observed for Aspergillus niger. The diameters of inhibition zone observed for all the microorganisms were larger for extracts obtained by classical extraction than those by ul-trasound extraction. | Ivana Stanisavljevi Sаa Stojievi Dragan Velikovi Vlada Veljkovi Miodrag Lazi | 2009 | Chinese Journal of Chemical Engineering2009，17，3： | 2 |
| 6 | A new kinetic model for the common juniper essenstial oil extraction by microwave hydrodistillation显示文摘The main objective of the present study was to model the kinetics of essential oil extraction from swelled ground juniper berries by classic hydrodistillation(HD) and microwave-assisted hydrodistillation(MAHD). A new phenomenological kinetic model was developed on the basis of the juniper essential oil extraction mechanism that assumed three mass transfer processes occurring simultaneously: washing, unhindered diffusion and hindered diffusion. The new model was compared to the existing kinetic models. Among the tested models,the new model had the smallest mean relative percentage deviation and the highest corrected Akaike information criterion value. In addition, that, the new model was verified for HD and MAHD of essential oils from some other plant materials. On the basis of the above-mentioned facts, the new model can be recommended for modeling the kinetics of essential oil extraction by both HD and MAHD. | Miljana S. Markovi? Svetomir ?. Milojevi? Nevenka M. Bo?kovi?-Vragolovi? Vladimir P. Pavi?evi? Ljiljana М. Babincev Vlada B. Veljkovi? | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 2 |
| 7 | Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell显示文摘 | Katarína Kyselá Anatoly A. Philimonenko Vlada V. Philimonenko Ji?í Janá?ek Michal Kahle Pavel Hozák | 2005 | Histochemistry and Cell Biology2005，，5： | 1 |
| 8 | 不同萃取技术获得的Artemisia sp的甲醇提取物其抗氧化和抗菌活性的比较(英文)显示文摘The polyphenol content,antioxidant and antimicrobial activities of the extracts obtained by classical, ultrasonic and Soxhlet extractions from dry aerial parts of two Artemisia species(Artemisia vulgaris and Artemisia campestris)were compared.Ultrasound positively affected the yield of extractive substance and the kinetics of extraction,but the extract obtained by the classical extraction showed the highest antioxidant activities and contained higher total contents of phenolic compounds and flavonoids than the extracts obtained by two other extraction techniques.Both flavonoid aglycones(apigenin,quercetin,quercetin 3,3′-dimethyl ether)and flavonoid glycosides(rutin,hyperoside and kaempferol 3-rhamnoside)were identified by thin layer chromatograph(TLC)analysis in the extracts from both species.A.campestris extracts were richer in quercetin than A.vulgaris and its antimicrobial activity was also better than A.vulgaris.Extracts obtained from both species were found to be more effective on the tested yeasts than bacteria.The kinetics of the total extractive substances,such as phenolic,flavonoids and quercetin extraction,was successfully described by the model of unsteady-state diffusion. | Ivana Karabegovi Milena Nikolova Dragan Velikovi Sаa Stojievi Vlada Veljkovi Miodrag Lazi | 2011 | Chinese Journal of Chemical Engineering2011，19，3： | 1 |
| 9 | Microbes,Mating,and Morality:Individual Differences in Three Functional Domains of Disgust显示文摘 | Joshua M Tybur Debra Lieberman Vladas Griskevicius | 2009 | Journal of Personality and Social Psycholo-gy2009，97，1： | 1 |
| 10 | The Influence of Mortality and Socioe- conomic Status on Risk and Delayed Rewards:A Life History Theory Approach 显示文摘 | Vladas Griskevicius | 2011 | Journal of Personality and Social Psychology2011，100，6： | 1 |
| 11 | Influence of various phosphopeptides of caseins on iron absorption显示文摘 | SAID B VLADAS C NABIL A O | 2002 | J Agric Food Chem2002，50，： | 1 |
| 12 | Room with a Viewpoint: Using Social Norms to Motivate Environmental Conservation in Hotels 显示文摘 | Noah J Robert B Vladas A | 2008 | Journal of Consumer Research2008，35，3： | 1 |
| 13 | Going green to be seen: status, reputation, and conspicuous conservation 显示文摘 | Vladas Griskevicius Bram Van den Bergh Joshua M T | 2010 | Journal of Personality and Social Psychology2010，98，3： | 1 |
| 14 | Integration of INS, GPS, Magnetometer and Barometer for Improving Accuracy Navigation of the Vehicle 显示文摘 | Vlada S Goran D Rade D | 2013 | Defenee Science Journal2013，63，5： | 1 |
| 15 | Gender and school-related experience differences in students'perception of teacher interpersonal behavior in the classroom显示文摘 | Negovana V Raciua A Vlada M | 2010 | Procedia-Soc Behav Sci2010，5，： | 1 |
| 16 | Failure Analysis of the Tower Crane Counterjib显示文摘 | Nenad D Zrnic Srcdan M Bosnjak Vlada M Gasic | 2011 | Proce- dia Engineering2011，，10： | 1 |
| 17 | Cytochrome P450 monooxygenases:perspectives for synthetic application显示文摘 | Vlada B U Sabine E | | 0，，07： | 1 |
| 18 | 定向进化细胞色素P450BM-3的研究显示文摘以来自于巨大芽孢杆菌的细胞色素P450BM-3为研究对象,采用随机突变和饱和定点突变定向进化技术对P450BM-3进行改造,通过突变体催化靛蓝显色的特性采用活性琼脂平板分析和96微孔板相结合的高通量筛选成功获得了几个具有更高催化性能的突变体。 | 李红梅 yh 梅乐和 Vlada Urlacher Rolf D.Schmid | 2006 | 生物加工过程2006，4，1： | 1 |
| 19 | Autophagy : self-preservationthrough cannibalism of proteins and organelles 显示文摘 | Vlada C A Kim J S Behrns K E | 2015 | Surgery2015，157，1： | 1 |
| 20 | Microbes,Mating,and Morality:Individual Differences in Three Functional Domains of Disgust显示文摘 | Joshua M Tybur Debra Lieberman Vladas Griskevicius | 2009 | Journal of Personality and Social Psychology2009，97，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员