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| 1 | Outbreak of human astrovirus 1 lineage 1d in a childcare center in China显示文摘Dear Editor,Astrovirus is an enteric virus associated with sporadic diarrhea or large outbreaks of gastroenteritis(Mendez et al.,2013).Until 2008,human astroviruses(HAst Vs)were classified into eight serotypes—HAstV-1 to HAstV-8—based on the reactivity of their capsid protein with type-specific antibodies.Among these serotypes,HAstV-1is the most prevalent globally.However,some divergent new astroviruses(MLB1/MLB2,VA1/VA2/VA3,and HMO A/B/C)have been discovered recently in | Meiling Hou Xuexue Liang Liqian Tan Pengfei Liu Wei Zhao | 2016 | Virologica Sinica2016，31，3： | 9 |
| 2 | Pt/WO_3/C nanocomposite with parallel WO_3 nanorods as cathode catalyst for proton exchange membrane fuel cells显示文摘Pt/WO3/C nanocomposites with parallel WO3 nanorods were synthesized and applied as the cathode catalyst for proton exchange membrane fuel cells(PEMFCs). Electrochemical results and single cell tests show that an enhanced activity for the oxygen reduction reaction(ORR) is obtained for the Pt/WO3/C catalyst compared with Pt/C. The higher catalytic activity might be ascribed to the improved Pt dispersion with smaller particle sizes. The Pt/WO3/C catalyst also exhibits a good electrochemical stability under potential cycling. Thus, the Pt/WO3/C catalyst can be used as a potential PEMFC cathode catalyst. | Meiling Dou Ming Hou Zhilin Li Feng Wang Dong Liang Zhigang Shao Baolian Yi | 2015 | Journal of Energy Chemistry2015，24，1： | 4 |
| 3 | In vitro expansion of human sperm through nuclear transfer显示文摘Dear Editor,Mammalian haploid embryonic stem cells(haESCs)represent an ideal tool for genetic analysis due to the presence of only one set of genetic materials.HaESCs fall into two readily distinguishable groups based on their genome origins:parthenogenetic haESCs(PG-haESCs)that are derived from oocyte-originated parthenogenetic embryos and androgenetic haESCs(AG-haESCs)that are produced through sperm nuclear transfer.Both PG-and AGhaESCs are feasible for delineating genome function at cellular level in vitro.Importantly,AG-haESCs can be used as a sperm replacement and applied to deciphering gene function at organismal level when combined with CRISPR-Cas9 technology.1 However,while PG-haESCs have been generated from both rodent and primates,2-5 AG-haESCs can only be obtained in rodent to date. | Xiaoyu Merlin Zhang Keliang Wu Yuxuan Zheng Han Zhao Junpeng Gao Zhenzhen Hou Meiling Zhang Jiaoyang Liao Jingye Zhang Yuan Gao Yuanyuan Li Lin Li Fuchou Tang Zi-Jiang Chen Jinsong Li | 2020 | Cell Research2020，30，4： | 3 |
| 4 | Configuration optimization of regularly spaced short-length twisted tape in a circular tube to enhance turbulent heat transfer using CFD modeling 显示文摘 | Wang Yangjun Hou Meiling Deng Xianhe | 2011 | Applied Thermal Engineering2011，31，67： | 1 |
| 5 | Behavior of a unit proton exchange membrane fuel cell in a stack under fuel starvation显示文摘 | Dong Liang Meiling Dou Ming Hou Qiang Shen Zhigang Shao Baolian Yi | 2011 | Journal of Power Sources2011，，13： | 1 |
| 6 | Behaviors of proton exchange membrane fuel cells under oxidant starvation显示文摘 | Meiling Dou Ming Hou Dong Liang Qiang Shen Huabing Zhang Wangting Lu Zhigang Shao Baolian Yi | 2010 | Journal of Power Sources2010，，5： | 1 |
| 7 | Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration显示文摘Skin tissue engineering with considerable skin regeneration capability is an urgent need for the wound site.The current challenge for researchers is to develop a bionic scaffold that imitates the extracellular matrix for the regeneration of the damaged regions.In our study,poly(L-lactide-co-caprolactone)(PLCL)was blended with polyurethane(PU)to obtain nanofibrous scaffolds via electrospinning.The electrospun fibers with 50%PLCL content had a certain number of intersections and jointing points,and exhibited significantly enhanced mechani-cal properties combined with suitable porosity.Moreover,cell activities demonstrated that PU/PLCL membranes had significantly biological advantages in enhanced growth of human skin fibroblasts with spreading morphology compared with PU membranes,indicating good cytocompatibility of composite scaffolds.These findings proved that PU/PLCL electrospun membranes have great potential in applications of skin tissue engineering. | Xiang Gao Meiling Wen Yang Liu Tian Hou Meiwen An | 2022 | Engineered Regeneration2022，3，1： | 1 |
| 8 | Erratum to Mechanical performance and cyocompatibility of PU/PLCL nanofibrous electrospun scaffolds for skin regeneration显示文摘The publisher regrets that ethical approval was not included in the published version.Upon request,the authors have provided the appropriate ethical approval statement,which states that the human skin fibroblasts used in this study were derived from normal skin tissues of patients after scar resection at Shanxi Bethune Hospital,and were obtained under ethical requirements.The experimental process strictly adhered to relevant ethical requirements and guidelines,and was granted approval by the ethics committee with protocol number SBQLL-2021-065 from Shanxi Bethune Hospital. | Xiang Gao Meiling Wen Yang Liu Tian Hou Meiwen An | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 9 | Differences in olfactory functional connectivity in early-onset depression and late-onset depression显示文摘Background:Late-onset depression(LOD)and early-onset depression(EOD)exhibit different pathological mechanisms and clinical phenotypes,including different extents of olfactory dysfunction.However,the brain abnormalities underlying the differences in ol-factory dysfunction between EOD and LOD remain unclear.Objective:The aim of this study was to compare the functional connectivity(FC)patterns of olfactory regions between EOD patients and LOD patients and examine their relationship with cognitive function.Methods:One hundred and five patients with EOD,101 patients with LOD and 160 normal controls(NCs)were recruited for the present study.Participants underwent clinical assessment,olfactory testing,cognitive assessments,and magnetic resonance imaging.Eight regions of the primary and secondary olfactory regions were selected to investigate olfactory FC.Results:Patients with LOD exhibited decreased odor identification(OI)compared with patients with EOD and NCs.The LOD group exhibited decreased FC compared with the EOD and NC groups when primary and secondary olfactory regions were selected as the regions of interest(the piriform cortex,lateral entorhinal cortex,and orbital-frontal cortex).Additionally,these abnormal olfactory FCs were associated with decreased cognitive function scores and OI,and the FC between the left orbital-frontal cortex and left amygdala was a partial mediator of the relationship between global cognitive scores and OI.Conclusion:Overall,patients with LOD exhibited decreased FC in both the primary and secondary olfactory cortices compared with patients with EOD,and abnormal olfactory FC was associated with OI dysfunction and cognitive impairment.The FC between the orbital-frontal cortex and amygdala mediated the relationship between global cognitive function and OI. | Ben Chen Mingfeng Yang Meiling Liu Qiang Wang Huarong Zhou Min Zhang Le Hou Zhangying Wu Si Zhang Gaohong Lin Xiaomei Zhong Yuping Ning | 2023 | Psychoradiology2023，3，1： | 0 |
| 10 | Biomimetic microchannel network with functional endothelium formed by sacrificial electrospun fibers inside 3D gelatin methacryloyl(GelMA)hydrogel models显示文摘Three-dimensional(3D)hydrogel models play a crucial role in tissue engineering for promoting tissue regeneration.A biomimetic microchannel network system in the 3D hydrogel model is necessary for optimal cellular function.This report describes the preparation of a biomimetic hydrogel scaffold with an internal microchannel network,using electrospinning techniques and the sacrificial template method for 3D cell culture.Microchannels and cavities were created within the gelatin methacryloyl(GelMA)hydrogel by sacrificing polyvinyl alcohol(PVA)electrospun fibers(>10µm),resulting in the creation of microvessel-like channels.Mechanical characterizations,swelling properties,and biodegradation analysis were conducted to investigate the feasibility of a biomimetic microchannel network hydrogel scaffold for 3D cell culture applications.Compared to pure GelMA hydrogel,the hydrogel with microchannels promoted cell proliferation,adhesion,and endothelial tube formation.Moreover,the results confirmed that the biomimetic microchannel network scaffold had a major impact on the distribution and arrangement of human umbilical vein endothelial cells(HUVECs)and can enable the formation of artificial microvasculature by the culture of HUVECs and cell media perfusion. | Haoyu SUN Haiyang MA Li WANG Yang LIU Tian HOU Wenjie TANG Qing YU Meiwen AN Meiling WEN | 2024 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2024，25，1： | 0 |
| 11 | Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma显示文摘Application of differentiation therapy targeting cellular plasticity for the treatment of solid malignancies has been lagging.Nasopharyngeal carci noma(NPC)is a distinctive cancer with poor differe ntiatio n and high prevalenee of Epstein-Barr virus(EBV)infection.Here,we show that the expressi on of EBV latent protein LMP1 in duces dediffere ntiated and stem-like status with high plasticity through the transcriptional inhibition of CEBPA.Mechanistically,LMP1 upregulates STAT5A and recruits HDAC 1/2 to the CEBPA locus to reduce its histone acetylation.HDAC inhibition restored CEBPA expression,reversing cellular dedifferentiation and stem-like status in mouse xeno graft models.These fin dings provide a novel mecha nistic epigenetic-based in sight into virus-induced cellular plasticity and propose a promising concept of differentiation therapy in solid tumor by using HDAC inhibitors to target cellular plasticity. | Jiajun Xie Zifeng Wang Wenjun Fan Youping Liu Fang Liu Xiangbo Wan Meiling Liu Xuan Wang Deshun Zeng Van Wang Bin He Min Yan Zijian Zhang Mengjuan Zhang Zhijie Hou Chunli Wang Zhijie Kang Wenfeng Fang Li Zhang Eric W-F Lam Xiang Guo Jinsong Yan Yixin Zeng Mingyuan Chen Quentin Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 12 | Stabilizing high-efficiency iridium single atoms via lattice confinement for acidic oxygen evolution显示文摘Stable and efficient single atom catalysts(SACs)are highly desirable yet challenging in catalyzing acidic oxygen evolution reaction(OER).Herein,we report a novel iridium single atom catalyst structure,with atomic Ir doped in tetragonal PdO matrix(IrSAs-PdO)via a lattice-confined strategy.The optimized IrSAs-PdO-0.10 exhibited remarkable OER activity with an overpotential of 277 mV at 10 mA·cm^(-2) and long-term stability of 1000 h in 0.5 M H_(2)SO_(4).Furthermore,the turnover frequency attains 1.6 s^(-1) at an overpotential of 300 mV with a 24-fold increase in the intrinsic activity.The high activity originates from isolated iridium sites with low valence states and decreased Ir–O bonding covalency,and the excellent stability is a result of the effective confinement of iridium sites by Ir–O–Pd motifs.Moreover,we demonstrated for the first time that SACs have great potential in realizing ultralow loading of iridium(as low as microgram per square center meter level)in a practical water electrolyzer. | Yibo Wang Jiadong Jiang Zhaoping Shi Hongxiang Wu Jiahao Yang Pengbo Wang Shuai Hou Meiling Xiao Junjie Ge Changpeng Liu Wei Xing | 2024 | Nano Research2024，17，4： | 0 |
| 13 | What Influences The Family Migration Decision of China’s New Generation Rural-urban Migrants? A Multilevel Logistic Regression Analysis显示文摘The massive scale of new-generation rural-urban migrants in China has attracted extensive scholarly attention in recent years.While previous studies on China’s rural migrant workers focus on migrants’settlement intentions,migrants’family migration decision-making and the intergenerational differences between the old-generation migrants and new-generation migrants are underexplored.Based on the data of the 2017 China Migrants Dynamic Survey,this paper adopts a multilevel logistic regression approach to explore family and destination factors influencing the family migration decisions of China’s new generation of rural migrant workers.The empirical results reveal that both the migrants’family and destination attributes significantly influence their family migration decision.The demographic and socioeconomic characteristics of the family have been pivotal factors underlying the family migration decision of China’s new generation rural-urban migrants,while 16.9%of the chances are explained by between-destination differences.Self-employed migrants with housing properties in host cities,long migration duration and high-income levels are more likely to migrate with their family members.Yet,the possibility of family migration is found to be significantly and negatively correlated with the age,education level,number of children and inter-provincial mobility of the new generation of migrant workers.In addition,new-generation rural-urban migrants’family migration is more likely to be found in cities with service-oriented industry structures,better environmental quality,and higher hukou barriers which is possibly related to more job opportunities.These research findings not only complement the existing literature on China’s new generation of rural urban migrants,but also have important policy implications for reforming the hukou system and enhancing social integration of the rural-to-urban migrant population. | Meiling Hou Xiaoyan Zhou Ronghao Jiang | 2022 | Journal of Geographical Research2022，5，4： | 0 |
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