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| 1 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 2 | Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios. | Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，5： | 32 |
| 3 | Application of Hot Forming High Strength Steel Parts on Car Body in Side Impact显示文摘Lightweight structure is an important method to increase vehicle fuel efficiency.High strength steel is applied for replacing mild steel in automotive structures to decrease thickness of parts for lightweight.However,the lightweight structures must show the improved capability for structural rigidity and crash energy absorption.Advanced high strength steels are attractive materials to achieve higher strength for energy absorption and reduce weight of vehicles.Currently,many research works focus on component level axial crash testing and simulation of high strength steels.However,the effects of high strength steel parts to the impact of auto body are not considered.The goal of this research is to study the application of hot forming high strength steel(HFHSS) in order to evaluate the potential using in vehicle design for lightweight and passive safety.The performance of HFHSS is investigated by using both experimental and analytical techniques.In particular,the focus is on HFHSS which may have potential to enhance the passive safety for lightweight auto body.Automotive components made of HFHSS and general high strength steel(GHSS) are considered in this study.The material characterization of HFHSS is carried out through material experiments.The finite element method,in conjunction with the validated model is used to simulate the side impact of a car with GHSS and HFHSS parts according to China New Car Assessment Programme(C-NCAP) crash test.The deformation and acceleration characteristics of car body are analyzed and the injuries of an occupant are calculated.The results from the simulation analyses of HFHSS are compared with those of GHSS.The comparison indicates that the HFHSS parts on car body enhance the passive safety for the lightweight car body in side impact.Parts of HFHSS reduce weight of vehicle through thinner thickness offering higher strength of parts.Passive safety of lightweight car body is improved through reduction of crash deformation on car body by the application of HFHSS parts.The experiments and simulation are conducted to the HFHSS parts on auto body.The results demonstrate the feasibility of the application of HFHSS materials on automotive components for improved capability of passive safety and lightweight. | SUN Hongtu HU Ping MA Ning SHEN Guozhe LIU Bo ZHOU Dinglu | 2010 | Chinese Journal of Mechanical Engineering2010，23，2： | 19 |
| 4 | CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phase Ⅱ trial显示文摘Objective: The aim of this prospective, single-arm phase II trial was to confirm the safety and efficacy of neoadjuvant chemotherapy(NAC) using oxaliplatin plus capecitabine(Cap OX) for patients with operable locally advanced colon cancer(CC).Methods: Patients with computed tomography-defined T4 or lymph node-positive CCs were enrolled. After radiological staging, patients were treated with at least 2 cycles of NAC consisting of 130 mg/m2 oxaliplatin on d 1,plus 1,000 mg/m2 capecitabine twice daily for 14 d every 3 weeks, followed by surgery, and then with the rest cycles of adjuvant chemotherapy. Radiological response was evaluated after 2 cycles of NAC. Tumor response, treatment toxicity, and surgical complications were recorded. The pathological response to therapy was evaluated according to the tumor regression grade(TRG) score. The primary endpoint was pathologic tumor response. This trial is registered in Clinical Trials.gov(No: NCT02415829).Results: Forty-seven patients were enrolled in the study. Forty-two patients completed the planned treatments.The total radiological response rate was 68%(32/47), including complete and partial response rates of 2%(1/47)and 66%(31/47), respectively. Stable disease was observed in 32%(15/47) and progressive disease was observed in none. Complete pathologic response, major regression, and at least moderate regression were achieved in 1(2%), 2(4%), and 29(62%) patients, respectively. Four patients developed grade 3 treatment toxicities. One patient with wound infection occurred after operation(1/47, 2%). There was no treatment-related death.Conclusions: Our results suggest that NAC with Cap OX is an effective and safe treatment option for patients with locally advanced CCs. | Fangqi Liu Li Yang Yuchen Wu Cong Li Jiang Zhao Adili Keranmu Hongtu Zheng Dan Huang Lei Wang Tong Tong Junyan Xu Ji Zhu Sanjun Cai Ye Xu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 14 |
| 5 | Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘 | Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 14 |
| 6 | SF_(6)decomposition and insulation condition monitoring of GIE:A review显示文摘The statistics of the Conference International des Grands Reseaux Electriques(CIGRE)indicate that the operational reliability of SF6 gas‐insulated equipment(GIE)is very high;however,the failure rate of the GIE in operation is much higher than that of the IEC standard,and the fault occurs frequently in the GIE at a high voltage level.The reason is due to the complex and strong on‐site electromagnetic interference environment and fully enclosed structure of GIE.The key method and technology for effective on‐line monitoring and fault diagnosis of GIE are still lacking.Given the partial strong electromagnetic energy and high temperature induced by early latent insulation faults in the equipment,SF6 gas insulation presents different degrees of decomposition.The decomposition products mainly include SO_(2)F_(2),SOF_(2),SO_(2),HF,and H2S.The decomposition characteristics of SF6 are closely related to the property of insulation faults.At present,this area is attracting attention from the power industry and research institutes.This study summarises the current research on SF_(6)decomposition component analysis(DCA).The content mainly includes the latest progress of SF_(6)decomposition characteristics and mechanism under fault conditions,and fault diagnosis methods based on decomposition components. | Fuping Zeng Haotian Li Hongtu Cheng Ju Tang Yilu Liu | 2021 | High Voltage2021，6，6： | 3 |
| 7 | Plasmacytoid Transitional Cell Carcinoma of Bladder: A Clinico-pathological Study and Review of Literatures显示文摘客观:学习血浆的病理学的特征,并且分析诊断特征,为鉴别诊断的标准和肿瘤的临床的意义膀胱的似细胞的过渡房间癌。方法:膀胱 plasmacytoidtransitional 房间癌的二个盒子被学习。平淡的石蜡节与他染色,由 S-P 方法的奶头油迹 andimmunohistochemistry 在一台轻显微镜下面被观察。病理学、临床的数据被比较在文学与早报导的案例分析。结果:这个肿瘤的 Acharacteristic 特征具有在薄板 propria 或 muscularispropria 的深侵略,除了在粘膜的原位癌的部件,当肿瘤被诊断时。组织学的模式和 cytological 特征显示出类似到 plasmacytoidtumor。肿瘤房间为 AE1/AE3, CEA 和 CK18 是强烈积极的。预后看起来比平常的过渡房间癌更坏。结论:血浆膀胱的似细胞的过渡房间癌是稀罕的,但是有典型病理学,免疫组织学、临床的特征。病理学家们应该知道膀胱的这种原发性瘤。 | FENG Xiaoli ZHANG Hongtu SUN Yuntian LIU Xiuyun | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 3 |
| 8 | Carbon and nitrogen pools in different aggregates of a Chinese Mollisol as influenced by long-term fertilization显示文摘 | Ying Chen Xudong Zhang Hongbo He Hongtu Xie Ying Yan Ping Zhu Jun Ren Lichun Wang | 2010 | Journal of Soils and Sediments2010，，6： | 3 |
| 9 | Crystallographic orientation dependence on nanoscale friction behavior of energetic β-HMX crystal显示文摘Tribology behaviors of energetic crystals play critical roles in the friction-induced hotspot in highenergy explosive,however,the binder and energetic crystals are not distinguished properly in previous investigations.In this study,for the first time,the nanoscale friction ofβ-octahydro-1,3,5,7-tetranitro1,3,5,7-tetrazocine(β-HMX)crystal is studied with nanoscratch tests under the ramping load mode.The results show that the nanoscale friction and wear ofβ-HMX crystal,as a typical energetic material,is highly depended on the applied load.The friction coefficient ofβ-HMX crystal is initially high when no discernible wear is observed,and then it decreases to a stable value which varies from~0.2 to~0.7,depending on the applied load,scratch direction,and crystal planes.Theβ-HMX(011)surfaces show weakly friction and wear anisotropy behavior;in contrast,theβ-HMX(110)surfaces show strongly friction and wear anisotropy behavior where the friction coefficient,critical load for the elastic–plastic deformation transition and plastic–cracking deformation transition,and deformation index at higher normal load are highly depended on the scratch directions.Further analyses indicate the slip system and direction ofβ-HMX surfaces play key roles in determining the nanoscale friction and wear ofβ-HMX surfaces.The obtained results can provide deeper insight into the friction and wear of energetic crystal materials. | Ying YIN Hongtao LI Zhihong CAO Binghong LI Qingshan LI Hongtu HE Jiaxin YU | 2023 | Friction2023，11，12： | 2 |
| 10 | Synthesis of thermoresponsive polystyrene-based comb-type grafted poly(N-isopropylacrylamide)显示文摘Narrowly distributed polystyrene-g-p(N-isopropylacrylamide) (PSt-g-PNIPAM) was prepared by atom transfer radical polymerization (ATRP) of N-isopropylacrylamide using the brominated polystyrene as macroinitiator and CuCl combined with hexamethyltriethylenetetramine as catalyst. Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy confirmed the structure of PSt-g-PNIPAM. The gel permeation chromatography (GPC) showed that the graft copoly- mer had a single distribution peak with molecular weight, Mn (g/mol) of 19815 g/mol (using polystyrene as the standard). Differential scanning calorimetry (DSC) revealed that due to both effects of hydro- phobic isopropyl groups and hydrogen bonds in the amide group, the glass transition temperature (Tg) of PSt-g-PNIPAM enhanced 16.0 ℃ compared to the Tg of the polystyrene. | XU YaXin LI HongTu ZHANG Kai ZHANG Bao AI Peng WANG JingYuan | 2007 | Science China Chemistry2007，50，5： | 2 |
| 11 | Synchronous primary cancers of the endometrium and ovary: review of 43 cases显示文摘目的将调查子宫内膜和卵巢的同步原发癌的临床、病理学的特征,治疗方法,和预后。有子宫内膜和卵巢的同步原发癌的 43 个病人的临床的数据回顾地被考察的方法。幸存被 Kaplan-Meier 方法计算并且比较了使用木头等级测试。结果在诊断的病人的中部的年龄是 49 年(范围, 28 73 年) 。最普通的症状是反常阴道流血(69.8%) 并且腹或骨盆的疼痛(44.2%) 。骨盆的群众在 39.5% 病人被发现并且在药品检查在 27.9% 扩大了宫体,当骨盆的群众在 43 个病人(29 个案例) 中的 67.4% 个被发现并且变厚时或在 23.3% 的反常子宫内膜(10 个案例) 在超声检查期间。CT/MRI 检查的 25 个病人,骨盆的群众在 13 种情况中被发现并且在 11 种情况中扩大了子宫。经历了子宫内膜的活体检视的所有 15 个病人被证明有子宫内膜样癌。浆液 CA125 水平被发现与中部的价值在 34 个检验盒子(64.7%) 中的 22 个中被提高 500 U/mL (范围, 39 3439 U/mL ) 。子宫内膜的癌的 FIGO 阶段:IA 18 盒子, IB 20 盒子, IC 2 盒子,和 IIA 3 盒子;卵巢的癌的阶段:IA 19 大小写, IB 4 盒子, IC 7 盒子, II 4 盒子,和 IIIC 9 盒子。24 个病人(55.8%) 在舞台我子宫内膜、卵巢的癌。同时, 31 个病人与网膜切除术和阑尾切除术加双边的输卵管卵巢切除术经历了全部的子宫切除 12 个病人有骨盆的淋巴节点解剖。43 个病人(88.4%) 中的 38 个有一病理地证明的子宫内膜的腺癌。占优势的卵巢的组织学与子宫内膜样部件是子宫内膜样或混合瘤(30/43, 69.8%) 。手术后地, 26 个病人(60.5%) 独自收到了辅助化疗,加放射疗法的 12 有的化疗,仅仅一个病人有独自一个的放射并且留下 4 个盒子没收到辅佐疗法。这个组的 3 年、 5 年的幸存率分别地是 87.4% 和 71.1% 。有子宫内膜样癌在的病人的 3 年、 5 年的幸存率子宫内膜、卵巢比有 non-endometrioid 的那些的高或混合了 histologic 子类型(93.8% , 82% 对 79.7% , 69%) 。有早阶段疾病的病人的 3 年、 5 年的幸存率比另外的病人的那些好(93.3% , 93.3% 对 69.7% , 36.7%) 。复发在 15 个病人(34.9%) 发展了。它被降低加放射疗法的化疗显著地并且断然影响了的 CA125 水平,早 FIGO 阶段,和助手的 univariate 分析显示出 5 年的幸存评价,当加放射疗法的仅仅早的 FIGO 舞台和化疗被揭示由时多变量分析同样独立的预示的因素。子宫内膜和卵巢的结论同步原发癌与也不同主要子宫内膜或卵巢的癌症,当通常它能与好预后在早舞台被检测时。进一步的预后需要上的 CA125 水平的影响学习了。外科治疗可能独自为早阶段病人是足够的。化疗正放射疗法可能为先进病人是必要的。 | Shaokang Ma Hongtu Zhang Yangchun Sun Lingying Wu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 2 |
| 12 | Cervical clear cell adenoearcino- ma infected with human papillomavirus type 18 in an adolescent显示文摘 | Guo Yifan Song Lei Liu Hongtu | 2014 | J PediatrAdolescGynecol2014，27，1： | 1 |
| 13 | Using a biocell to measure effect of compressive settlement on free air space and microbial activity in windrow composting显示文摘 | Daryl McCartney and Hongtu Chen | 2001 | Compost Science & Utilization2001，9，4： | 1 |
| 14 | Quantitative analysis of the tribological properties of phosphate glass at the nano- and macro-scales显示文摘Processing(grinding,polishing)of phosphate laser(PL)glass involves material removal at two vastly different(spatial)scales.In this study,the nano‐and macro‐tribological properties of PL glass are investigated by rubbing the glass against a SiO_(2) counter‐surface in both dry and humid conditions.The results indicate that the friction of the PL glass/SiO_(2) pair has opposing trends at the nano‐and macroscales.At the nanoscale,the friction coefficient(COF)in humid air is much higher than in dry air,which is attributed to the capillary effect of the absorbed water‐film at the interface.At the macroscale,on the other hand,the COF in humid air is lower than in dry air,because the water‐related mechanochemical wear makes the worn surface less susceptible to cracking.Material removal for PL glass is better facilitated by humid air than by dry air at both scales,because the stress‐enhanced hydrolysis accelerates the material‐removal process in glass.Moreover,the material‐removal is more sensitive to contact pressure at the macroscale,because stronger mechanical‐interaction occurs during material removal at the macroscale with the multi asperity contact mode.At the macroscale,the material removal is more sensitive to contact pressure in humid air compared to dry air.Because almost all mechanical energy is used to remove material in humid air,and most of the mechanical energy is used to produce cracks in PL glass in dry air.The results of this study can help optimize the multi‐scale surface processing of optical glasses. | Huimin QI Wen HU Hongtu HE Yafeng ZHANG Chenfei SONG Jiaxin YU | 2021 | Friction2021，9，5： | 1 |
| 15 | The emotional distress in a community after the terrorist attack on the world trade center 显示文摘 | Hongtu Chen Henry Chung Teddy Chen | 2003 | Community Mental Health Journal2003，39，2： | 1 |
| 16 | Jingyuan Wang Synthesis and characterization of nanocomposites of silicon dioxide and polyurethane and epoxy resin interpenetrating network显示文摘 | Hongwen Zhang Bing Wang Hongtu Li | 2003 | Polymer International2003，52，9： | 1 |
| 17 | Using a biocell to measure effect of compressive settlement on free air space and mi- crobial activity in window composting 显示文摘 | McCartney D Chen Hongtu | 2001 | Compost Sci- ence & Utilization2001，9，4： | 1 |
| 18 | TIMER: Tensor Image Morphing for Elastic Registration显示文摘 | Pew-Thian Yap Guorong Wu Hongtu Zhu Weili Lin Dinggang Shen | 2009 | Neuroimage2009，，2： | 1 |
| 19 | The emotional distress in a community after the terrorist attack on the world trade center显示文摘 | Hongtu Chen Henry Chung Teddy Chen | 2003 | Community Mental Health Journal2003，139，： | 1 |
| 20 | An efficient three-party authentication key exchange protocol for wireless sensor networks显示文摘 | Li Hongtu Hu Liang Chu Jianfeng | 2013 | Sensor Letters2013，11，5： | 1 |
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