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| 1 | Effect of subsoil tillage depth on nutrient accumulation, root distribution, and grain yield in spring maize显示文摘A four-year field experiment was conducted to investigate the effect of subsoiling depth on root morphology, nitrogen(N), phosphorus(P), and potassium(K) uptake, and grain yield of spring maize. The results indicated that subsoil tillage promoted root development,increased nutrient accumulation, and increased yield. Compared with conventional soil management(CK), root length, root surface area, and root dry weight at 0–80 cm soil depth under subsoil tillage to 30 cm(T1) and subsoil tillage to 50 cm(T2) were significantly increased, especially the proportions of roots in deeper soil. Root length, surface area, and dry weight differed significantly among three treatments in the order of T2 > T1 > CK at the12-leaf and early filling stages. The range of variation of root diameter in different soil layers in T2 treatment was the smallest, suggesting that roots were more likely to grow downwards with deeper subsoil tillage in soil. The accumulation of N, P, and K in subsoil tillage treatment was significantly increased, but the proportions of kernel and straw were different. In a comparison of T1 with T2, the grain accumulated more N and P, while K accumulation in kernel and straw varied in different years. Grain yield and biomass were increased by 12.8% and 14.6% on average in subsoil tillage treatments compared to conventional soil treatment. Although no significant differences between different subsoil tillage depths were observed for nutrient accumulation and grain yield, lodging resistance of plants was significantly improved in subsoil tillage to 50 cm, a characteristic that favors a high and stable yield under extreme environments. | Hongguang Cai Wei Ma Xiuzhi Zhang Jieqing Ping Xiaogong Yan Jianzhao Liu Jingchao Yuan Lichun Wang Jun Ren | 2014 | The Crop Journal2014，2，5： | 42 |
| 2 | Late Quaternary surface deformation and rupture behavior of strong earthquake on the segment north of Mianning of the Anninghe fault显示文摘The Anninghe fault is an important active fault along the eastern boundary of Sichuan-Yunnan active tectonic block, and the study of its surface deformation and rupture behavior during strong earthquake in the late Quaternary is of fundamental importance for understanding the future seismic risk of the fault zone or even the entire western Sichuan region. Using the methods of detailed geomorphic and geological survey, digital image analysis, total station instrument survey, excavation of combined trench and dating, we analyze the geomorphologic sequences of the offset strata at several sites where the late Quaternary deformation remnants are fairly well preserved and obtain some new results as follows: Strong earthquake events with left-lateral displacements of about 3 m occurred at the two sites of Zimakua and Yejitong at 1634-1811, 1030-1050 and 280-550 a BP, respectively, and the recurrence interval is 520-660 a; The youngest event in the area of Dahaizi-Ganhaizi should be the earthquake of 1536, other events are at 1768-1826, 2755-4108 and 4108-6593 a BP, respectively, with a recurrence interval of 1300-1900 a. The strong earthquake activity shows a clustering character. The possibility of occurrence of a strong earthquake exists on the north segment of the Anninghe fault sometime in the future. | RAN YongKang CHEN LiChun CHENG JianWu GONG HuiLing | 2008 | Science China Earth Sciences2008，51，9： | 25 |
| 3 | The Lushan M_S7.0 earthquake and activity of the southern segment of the Longmenshan fault zone显示文摘Following the Lushan MS7.0 earthquake on 20 April 2013,a topic of much concern is whether events of MS7 or greater could occur again on the southern segment of the Longmenshan fault zone.In providing evidence to answer this question,this work analyzes the tectonic relationship between the Lushan event and the 2008 Wenchuan earthquake and the rupture history of the southern segment of the Longmenshan fault zone,through field investigations of active tectonics and paleoearthquake research,and our preliminary conclusions are as follows.The activity of the southern segment of the Longmenshan fault zone is much different to that of its central section,and the late Quaternary activity has propagated forward to the basin in the east.The seismogenic structure of the 2008 Wenchuan earthquake is the central-fore-range fault system,whereas that of the 2013 Lushan event is attributed to the fore-range-range-front fault system,rather than the central fault.The southern segment of the Longmenshan fault zone becomes wider towards the south with an increasing number of secondary faults,of which the individual faults exhibit much weaker surface activity.Therefore,this section is not as capable of generating a major earthquake as is the central segment.It is most likely that the 2013 earthquake fills the seismic gap around Lushan on the southern segment of the Longmenshan fault zone. | CHEN LiChun RAN YongKang WANG Hu LI YanBao MA XinQuan | 2013 | Chinese Science Bulletin2013，58，28： | 24 |
| 4 | The M_S7.1 Yushu earthquake surface rupture and large historical earthquakes on the Garzê-Yushu Fault显示文摘As revealed by field investigations,the co-seismic surface rupture zone of the 2010 MS7.1 Yushu earthquake,Qinghai is a characteristic sinistral strike-slip feature consisting of three distinct sinistral primary ruptures,with an overall strike of 310°-320° and a total length of 31 km.In addition,an approximately 2-km-long en-echelon tensile fissure zone was found east of Longbao Town;if this site is taken as the north end of the rupture zone,then the rupture had a total length of ~51 km.The surface rupture zone is composed of a series of fissures arranged in an en-echelon or alternating relationship between compressive bulges and tensile fissures,with a measured maximum horizontal displacement of 1.8 m.The surface rupture zone extends along the mapped Garzê-Yushu Fault,which implicates it as the seismogenic fault for this earthquake.Historically,a few earthquakes with a magnitude of about 7 have occurred along the fault,and additionally traces of paleoearthquakes are evident that characterize the short-period recurrence interval of large earthquakes here.Similar to the seismogenic process of the 2008 Wenchuan earthquake,the Yushu earthquake is also due to the stress accumulation and release on the block boundaries resulting from the eastward expansion of Qinghai-Tibet Plateau.However,in contrast with the Wenchuan earthquake,the Yushu earthquake had a sinistral strike-slip mechanism resulting from the uneven eastward extrusion of the Baryan Har and Sichuan-Yunnan fault blocks. | CHEN LiChun WANG Hu RAN YongKang SUN XinZhe SU GuiWu WANG Ji TAN XiBin LI ZhiMin ZHANG XiaoQing | 2010 | Chinese Science Bulletin2010，55，31： | 17 |
| 5 | High precision landing site mapping and rover localization for Chang'e-3 mission显示文摘This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 mission.High-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 DOM.Local DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover traverse.The lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM matching.In order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching localization.The latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly identifiable.During CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning. | LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun YU TianYi WANG BaoFeng ZHOU JianLiang CHEN HongMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 15 |
| 6 | Stability analysis of the temperature cracks in Xiaowan arch dam显示文摘In the Xiaowan arch dam there are massive temperature cracks nearly parallel to the dam axis. Obviously, whether the cracks may spread or not during the water storage process is one of the crucial factors for the safety of a dam. In this paper, a new type of crack element, in which the contact component is implicitly included into the concrete component, is proposed to simulate the effects of the existing cracks. The crack element is proved by numerical example to share the merits of both conventional contact elements and joint elements. With a finite element model of the cracked arch dam together with its rock foundation established, the transient displacement and stress fields of the dam are obtained. The complicated rock foundation, the construction process of the arch dam, the massive cracks, the transient temperature field, as well as the water storage process have been taken into consideration in the simulation. In addition to the global model, several sub-models for typical crack tips are also generated with finer elements placed around the tips. Thus, more accurate displacement and stress distribution are obtained by simultaneous sub-model simulation. Based on the calculation of stress intensity factor for crack tips by extension method, the temperature cracks in the Xiaowan arch dam are finally proved to be stable. | WANG WeiMing DING JianXin WANG GuoJin ZOU LiChun CHEN ShengHong | 2011 | Science China(Technological Sciences)2011，54，3： | 12 |
| 7 | High precision topographic data on Lop Nor basin's Lake 'Great Ear' ? and the timing of its becoming a dry salt lake显示文摘High precision elevation measurements using DGPS were carried out along three representative tran- sects for the 'Great Ear' area, a dry salt lake within the Lop Nor basin. Results indicate that the Lop Nor basin is only 5.2 m deep and its lowest point occurs at the center of the 'Great Ear'. In addition, the basin is asymmetric - steeper in the southwest (0.19‰) and gentler in the northeast (0.09‰). Points along the same 'Great Ear' ring were found to have an identical elevation value, but different when from different ones (lower towards the center). The spacing of the 'Great Ear' rings was found to be closely related with the surface steepness. The closer the 'Great Ear' rings are spaced, the steeper the ground surface, and vice versa. These findings support the argument that the 'Great Ear' rings are the former shoreline trails left behind by Lop Nor water during the last few episodes of recession towards its total dry up. A comprehensive analysis of the high precision elevation data, historical accounts, aerial and satellite photographs and imagery, and official topographic maps of the study area suggests that the 'Great Ear' area in the Lop Nor basin was incorrectly mapped as being covered by a great body of water on the 1963 topographic maps. A re-interpretation of the 1958 aerial photographs and newer remote sensing imagery indicated that the 'Great Ear' ring structure was already in place in 1958 and it continued to appear on the subsequent remote sensing data without any major changes. It is estimated that lake water in the 'Great Ear' area of the Lop Nor basin disappeared between the late 1930s and early 1940s. | LI BaoGuo MA LiChun JIANG PingAn DUAN ZengQiang SUN DanFeng QIU HongLie ZHONG JunPing WU HongQi | 2008 | Chinese Science Bulletin2008，53，6： | 11 |
| 8 | Monocular trajectory intersection method for 3D motion measurement of a point target显示文摘This article proposes a monocular trajectory intersection method,a videometrics measurement with a mature theoretical system to solve the 3D motion parameters of a point target.It determines the target’s motion parameters including its 3D trajectory and velocity by intersecting the parametric trajectory of a motion target and series of sight-rays by which a motion camera observes the target,in contrast with the regular intersection method for 3D measurement by which the sight-rays intersect at one point.The method offers an approach to overcome the technical failure of traditional monocular measurements for the 3D motion of a point target and thus extends the application fields of photogrammetry and computer vision.Wide application is expected in passive observations of motion targets on various mobile beds. | YU QiFeng SHANG Yang ZHOU Jian ZHANG XiaoHu LI LiChun | 2009 | Science China(Technological Sciences)2009，52，12： | 10 |
| 9 | Geological analysis and FT dating of the large-scale right-lateral strike-slip movement of the Red River fault zone显示文摘Tectonically, the large-scale right-lateral strike-slip movement along the Red River fault zone is char-acterized at its late phase with the southeastward extension and deformation of the Northwestern Yunnan normal fault depression on its northern segment, and the dextral shear displacement on its central-southern segment. Research of the relations between stratum deformation and fault movement on the typical fault segments, such as Jianchuan, southeast Midu, Yuanjiang River, Yuanyang, etc. since the Miocene Epoch shows that there are two times dextral faulting dominated by normal shearing occurring along the Red River fault zone since the Miocene Epoch. The fission track dating (abbrevi-ated to FT dating, the same below) is conducted on apatite samples collected from the above fault segments and relating to these movements. Based on the measured single grain’s age and the con-fined track length, we choose the Laslet annealing model to retrieve the thermal history of the samples, and the results show that the fault zone experienced two times obvious shear displacement, one in 5.5 ± 1.5 MaBP and the other in 2.1± 0.8 MaBP. The central-southern segment sees two intensive uplifts of mountain mass in the Yuanjiang River-Yuanyang region at 3.6―3.8 MaBP and 1.6―2.3 MaBP, which correspond to the above-mentioned two dextral normal displacement events since the late Miocene Epoch. | XIANG HongFa WAN JingLin HAN ZhuJun GUO ShunMin ZHANG WanXia CHEN LiChun DONG XingQuan | 2007 | Science China Earth Sciences2007，50，3： | 10 |
| 10 | Evaluation of cracking potential for concrete arch dam based on simulation feedback analysis显示文摘It is still very difficult for researchers and engineers to implement the simulation analysis including a complete process and a full model with the complicated arch dam and the foundation, and to evaluate the cracking potential in the construction and service periods. To take Xiaowan project of China for an example, a practical system of simulation feedback analysis, a specific cracking criterion, and a resolution for the conflicting requirements of temperature and stress/strain simulation are presented, which are put into a successful practice. The simulation results of temperature, stress, and cracking are identical well with the monitor data. A modified temperature control measure is propounded, and the significant effect is gained by adopting the new scheme. | FU ShaoJun HE Ting WANG GuoJin ZHANG ShiHu ZOU LiChun CHEN ShengHong | 2011 | Science China(Technological Sciences)2011，54，3： | 10 |
| 11 | The maximum coseismic vertical surface displacement and surface deformation pattern accompanying the Ms 8.0 Wenchuan earthquake显示文摘The amount of coseismic deformation and its distribution of the Wenchuan earthquake provide important scientific bases for revealing the mechanisms of earthquake preparation and characterizing the rupture propagation of the Wenchuan earthquake. The previous studies have indicated that the earthquake ruptured the middle-to-north segment of the Longmenshan central fault and the middle segment of the Longmenshan range-front fault, which are characterized by two surface rupture zones of 240 km and 90 km in length, respectively. Based on the pre-earthquake information and photos of landforms and buildings obtained through ge-ologic and geomorphic survey of the area around Shaba Village of Beichuan County, Sichuan Province and the extensive interview with local villagers, we measured the displacements of the major terrain features and the dislocated buildings by total station instruments and differential GPS and obtained the maximum vertical displacement of 9±0.5 m and right-lateral displacement of 2±0.5 m around the Zou’s house in Shaba Village. Though the near-surface deformation exhibits a normal faulting around Shaba Village, the dynamic environment has not changed on the whole. The NW wall of the fault uplifted but without gravity gliding as normally occurring on the hanging wall of a normal fault, which proves that the 9±0.5 m displacement should be the maximum coseismic vertical displacement of the May 12, 2008 Ms 8.0 Wenchuan earthquake. | Ran YongKang Shi Xiang Wang Hu Chen LiChun Chen Jie Liu RuiChun Gong Huiling | 2010 | Chinese Science Bulletin2010，55，9： | 9 |
| 12 | Ultimately exposed roof area prediction of bauxite deposit goaf based on macro joint damage显示文摘The ultimately exposed roof area(UERA)of goaf is crucial to the safety and economics of underground mining.The prediction models do not consider the mechanical weakness of rock mass and ignore the influence of the joint damage factor,causing a large predicted exposure area with a high roof falling risk.This work adopted joint damage factor to derive a new UERA prediction model.The relationships between the UERA(S)and the span ratio(m),the density(k)and the diameter of fracture(d)were analysed by the new prediction model.The results showed that the exposed area S and the span ratio m have a U-shaped curve relationship.The S decreases with the increase of m and then increases when m is beyond 2.The exposed roof area S is in an inversely proportional power-law relationship with the fracture surface density k,and the curvature of the S-k relationship curve decreases when d=0.5 and k>7,and S is close to 0.There is a negative correlation between S and the fracture surface diameter d,the curvature of the S-d curve decreases with the increase of d and k,and the variation rate increases first and then decreases with the increase of d;when k=0.5 and d>9,S is close to 0.The predicted values of the UERA prediction model are 119.3,112.8,and 114.6 m2 with different joint damage parameters,which are slightly smaller than the actual critical exposure area of a roof(S=120 m2).The case study shows that the alternative prediction model is reasonable and acceptable and provides new theoretical support for the underground mining safety of sedimentary bauxite ore. | Lichun Jiang Chao Yang Huazhe Jiao | 2020 | International Journal of Mining Science and Technology2020，30，5： | 9 |
| 13 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 14 | Reservoir differences and formation mechanisms in the Ke-Bai overthrust belt,northwestern margin of the Junggar Basin,China显示文摘There are some differences in reservoir quality of clastic rock between the hanging wall and the foot wall of the Ke-Bai overthrust belt,northwestern margin of the Junggar Basin,western China,which affect the effi cient petroleum exploration in this highly mature exploration area. Based on a large number of thin-sections,cast thin-sections,and physical property analysis of cores,we systematically discuss the Permian-Jurassic reservoir differences between the hanging wall and the foot wall of the Ke-Bai overthrust fault from the aspects of structural evolution,time-space distribution of the depositional system,diagenesis characteristics,and reservoir quality and analyzed the reasons for the differences in reservoir properties. The overthrusting of the Ke-Bai fault directly results in different burial histories,diagenesis evolution,and porosity evolution between the hanging wall and the foot wall. The differences of reservoir characteristics are mainly embodied in buried depth,grain size,sedimentary facies,diagenetic stage,and reservoir quality. The analysis results showed that burial history and depositional characteristics controlled by overthrusting are direct influencing factors of reservoir differences. Because of shallow burial depth of the hanging wall,the reservoir compaction is weak and primary pores are preserved well. The porosity of reservoir on the hanging wall is generally 10%-25%. The strata on the foot wall are deeply buried,and there are mainly mixed pores with the average porosity of 5%-20%. The favorable reservoir on the foot wall is generally developed near faults or in the channel sand bodies,which are usually dissolution development areas. | Zhu Xiaomin Zhu Shifa Xian Benzhong Chen Shuping Kuang Lichun Xue Xinke Xue Jingjing You Xincai | 2010 | Petroleum Science2010，7，1： | 7 |
| 15 | Measurement of terrace deformation and crustal shortening of some renascent fold zones within Kalpin nappe structure显示文摘The Kalpin nappe structure is a strongest thrust and fold deformation belt in front of the Tianshan Mountains since the Cenozoic time. The tectonic deformation occurred in 5―6 striking Meso-zoic-Cenozoic fold zones, and some renascent folds formed on the recent alluvial-proluvial fans in front of the folded mountains. We used the total station to measure gully terraces along the longitudinal to-pographic profile in the renascent fold zones and collected samples from terrace deposits for age de-termination. Using the obtained formation time and shortening amount of the deformed terraces, we calculated the shortening rate of 4 renascent folds to be 0.1±0.03 mm/a, 0.12±0.04 mm/a, 0.59±0.18 mm/a, and 0.26±0.08 mm/a, respectively. The formation time of the renascent folds is some later than the major tectonic uplift event of the Qinghai-Tibet Plateau 0.14 Ma ago. It may be the long-distance effect of this tectonic event on the Tianshan piedmont fold belt. | YANG XiaoPing RAN YongKang CHENG JianWu CHEN LiChun XU XiWei | 2007 | Science China Earth Sciences2007，50，1： | 7 |
| 16 | Late Quaternary Large Earthquakes on the Western Branch of the Xiaojiang Fault and Their Tectonic Implications显示文摘Xiaojiang 差错是沿着西藏的高原的东南的边缘的一个主要活跃左侧面的差错。在云南省的最大的历史的地震,与大小 8 并且吝啬的 coseismic ∼ 的左侧面的排水量 6.9 m,发生在学习这个差错的 Xiaojiang 差错的西方的分支上在理解当前的变丑和西藏的高原的运动学的特征是重要的。活动和段很好在 Xiaojiang 差错上被承担了,当 paleoseismic 研究工作总是是这个差错上的弱连接时。为了调查 paleoseismic 历史和 Xiaojiang 的大地震活动,指责,我们在 Caohaizi 的北边打开了一条大沟下垂 Xiaojiang 差错的西方的分支上的池溏。六个 paleoseismic 事件通过 E6 被鉴别了,并且称为 E1 从对最年轻的炭和森林最旧是丰富的 20 件样品被标明日期在 40 000-36 抑制 paleoseismic 事件的年龄 300 BC , 35 400-24 800 BC , 9 500 BC广告 500 ,广告 390-720 ,广告 1120-1620 和广告1750礼品我们把最年轻的事件 E6 与 1833 M8 地震联系。事件 E4, E5 和 E6 在迟了的 Holocene 显示出 Xiaojiang 差错的西方的海滨的一个连续记录,与 370-480 年的平均复发间隔。在迟了的 Holocene 的大地震复发是远的不到 2000-4000 年的复发在以前的研究摆姿势。因此, Xiaojiang 差错上的地震危险应该被重新估计。而且, Xiaojiang 差错和其它上的大地震的不规则的复发在 Xianshuihe-Xiaojiang 系统指责,沿着西藏的高原的东南的边缘显示四川云南块的不平的向东南的挤出。 | LI Xi RAN Yongkang CHEN Lichun WU Fuyao MA Xinquan CAO Jun | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 7 |
| 17 | Contemplation on China’s Energy-Development Strategies and Initiatives in the Context of Its Carbon Neutrality Goal显示文摘1.Introduction Climate change has become a global nontraditional security challenge,and achieving carbon neutrality is the global trend of the era that will determine the future of humanity[1-5].So far,more than 137 countries have set goals or pledged to achieve carbon neutrality.In September 2020,China committed itself to peak carbon emissions by 2030 and to achieve carbon neutrality by 2060,in what are known as China’s“dual carbon goals”[6]. | Houliang Dai Yinao Su Lichun Kuang Jizhen Liu Dazhao Gu Caineng Zou | 2021 | Engineering2021，7，12： | 6 |
| 18 | Active blocks and strong seismic activity in North China region显示文摘The active North China block consists of three second-order blocks: Ordos, North China Plain, and East Shandong-Huanghai Sea blocks. Two active tectonic zones, the Anyang-Heze- Linyi and Tangshan-Cixian zones, exist in the active North China Plain block and have separated the active block into 3 third-order active blocks, Taihangshan, Hebei-Shandong, and Henan-Huai blocks. The 3 third-order active blocks are characterized by their entire motion and are clearly different in their Cenozoic structures and deep structures. The active boundary tectonic zones between the third-order active blocks are less than those between the first- and second-order active blocks in their movement strength, extent, and seismic activity. The density of M ≥ 6 earthquakes in the boundary zones between active blocks is higher than that within the blocks by 9-22 times in the North China region, up to one order of magnitude on average. M ≥ 7 earthquakes occurred basically in the boundary zones between active blocks. The difference is not occasional, but reflects the nature of intraplate movement and the characteristics of strong seismic activity and is the powerful evidence for hypothesis of active blocks. | HAN Zhujun (韩竹军) XU Jie (徐 杰) RAN Yongkang (冉勇康) CHEN Lichun (陈立春) YANG Xiaoping (杨晓平) | 2003 | Science China Earth Sciences2003，46，z2： | 6 |
| 19 | Knockdown of S-phase Kinase-associated Protein-2 Expression in MCF-7 Inhibits Cell Growth and Enhances the Cytotoxic Effects of Epirubicin显示文摘S 阶段联系 kinase 的 protein-2 (Skp2 ) 在调停 ubiquitin 的解朊作用起一个关键作用,导致房间从的前进一对一个 proliferative 状态静止。Skp2 完了在许多肿瘤表示了并且相反地与 p27 表示相关,包括乳癌。在这研究,我们使用了小介入的 RNA (siRNAs ) 在人的乳癌 MCF-7 细胞禁止 Skp2 表示并且如果击倒,从而由 RNA 干扰(RNAi ) Skp2 调查将禁止乳癌细胞生长并且在 MCF-7 细胞上影响 epirubicin 的效果。三 Skp2 siRNA 构造被重新结合并且短暂地 transfected 人乳癌 MCF-7 房间。Skp2 的下面规定被反向的抄写聚合酶链反应和蛋白质印迹分析证实。我们证明 Skp2 siRNA 转染减少了 Skp2 蛋白质并且在 MCF-7 房间导致了 p27 蛋白质的累积。Skp2 siRNA 在 vitro 并且在 vivo 禁止了房间增长。由 RNAi 的 Skp2 击倒在 vitro 的增加的细胞的 apoptosis。有治疗进一步与 epirubicin 跟随的 Skp2 siRNA 的治疗禁止了癌症房间线的增长,与 epirubicin 跟随的控制 siRNA 相比。因此, Skp2 击倒由 RNAi 的表示禁止乳癌细胞生长并且提高 epirubicin 的效果。Skp2 的调停 siRNA 的基因 silencing 能是为在规定下面的 p27 的抑制的新奇癌症基因治疗。 | Lichun SUN Li CAI Yan YU Qingwei MENG Xuesong CHENG Yanbin ZHAO Guangjie SUI Fengmin ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 6 |
| 20 | A microRNA encoded by HSV-1 inhibits a cellular transcriptional repressor of viral immediate early and early genes显示文摘Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. In addition, prior work has suggested that Kaposi's sarcoma-associated herpesvirus (KSHV) is capable of regulating cellular gene transcription by miRNA. We demonstrate that a miRNA, hsv1-mir-H27, encoded within the genome of herpes simplex virus 1 (HSV-1), targets the mRNA of the cellular transcriptional repressor Kelch-like 24 (KLHL24) that inhibits transcriptional efficiency of viral immediate-early and early genes. The viral miRNA is able to block the expression of KLHL24 in cells infected by HSV-1. Our discovery reveals an effective viral strategy for evading host cell defenses and supporting the efficient replication and proliferation of HSV-1. | WU WenJuan GUO ZhongPing ZHANG XueMei GUO Lei LIU LongDing LIAO Yun WANG JingJing WANG LiChun LI QiHan | 2013 | Science China(Life Sciences)2013，56，4： | 6 |
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