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| 1 | Solvothermal-Assisted Exfoliation Process to Produce Graphene with High Yield and High Quality显示文摘Monolayer and bilayer graphene sheets have been produced by a solvothermal-assisted exfoliation process in a highly polar organic solvent,acetonitrile,using expanded graphite(EG)as the starting material.It is proposed that the dipole-induced dipole interactions between graphene and acetonitrile facilitate the exfoliation and dispersion of graphene.The facile and effective solvothermal-assisted exfoliation process raises the low yield of graphene reported in previous syntheses to 10 wt%12 wt%.By means of centrifugation at 2000 rpm for 90 min,monolayer and bilayer graphene were separated effectively without the need to add a stabilizer or modifi er.Electron diffraction and Raman spectroscopy indicate that the resulting graphene sheets are high quality products without any signifi cant structural defects. | Wen Qian Rui Hao Yanglong Hou Yuan Tian Chengmin Shen Hongjun Gao Xuelei Liang | 2009 | Nano Research2009，2，9： | 28 |
| 2 | Review and prospect of active distribution system planning显示文摘The approach to planning,design and operation of distribution networks have significantly changed due to the proliferation of distributed energy resources(DERs)together with load growth,energy storage technology advancements and increased consumer expectations.Planning of active distribution systems(ADS)has been a very hot topic in the 21st Century.A large number of studies have been done on ADS planning.This paper reviews the state of the art of current ADS planning.Firstly,the influences of DERs on the ADS planning are addressed.Secondly,the characteristics and objectives of ADS planning are summarized.Then,up to date planning model and some related research are highlighted in different areas such as forecasting load and distributed generation,mathematical model of ADS planning and solution algorithms.Finally,the paper explores some directions of future research on ADS planning including planning collaboratively with all elements combined in ADS,taking into account of joint planning in secondary system,coordinating goals among different layers,integrating detailed operation simulations and regular performance based reviews into planning,and developing advanced planning tools. | Junyong LIU Hongjun GAO Zhao MA Yuanxi LI | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，4： | 23 |
| 3 | Synthesis of Fe_3O_4@SiO_2@polymer nanoparticles for controlled drug release显示文摘Novel multifunctional nanoparticles containing a magnetic Fe3O4@SiO2 sphere and a biocompatible block copolymer poly(ethylene glycol)-b-poly(aspartate)(PEG-b-PAsp) were prepared.The silica coated on the superparamagnetic core was able to achieve a magnetic dispersivity,as well as to protect Fe3O4 against oxidation and acid corrosion.The PAsp block was grafted to the surface of Fe3O4@SiO2 nanoparticles by amido bonds,and the PEG block formed the outermost shell.The anticancer agent doxorubicin(DOX) was loaded into the hybrid nanoparticles via an electrostatic interaction between DOX and PAsp.The release rate of DOX could be adjusted by the pH value. | WU ChengLin,HE Huan,GAO HongJun,LIU Gan,MA RuJiang,AN YingLi & SHI LinQi Key Laboratory of Functional Polymer Materials,Ministry of Education Institute of Polymer Chemistry,Nankai University,Tianjin 300071,China | 2010 | Science China Chemistry2010，53，3： | 9 |
| 4 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 5 | Organic amendments increase corn yield by enhancing soil resilience to climate change显示文摘A 22-year field experiment was conducted in Gongzhuling, Jilin province, China to investigate corn yield response to fertilization practice. Compared to an unfertilized control(CK), all fertilization treatments, including inorganic nitrogen fertilizer only(N), balanced inorganic fertilizers(NPK), NPK plus corn straw(SNPK), and NPK plus farmyard manure(MNPK), resulted in significant increases in corn yield. However, only organic matter amendments sustained increasing yield trends, with annual rates of 0.137 and 0.194 t ha-1for the SPNK and MNPK treatments, respectively(P < 0.05). During the 22 years, the daily mean, maximum and minimum temperatures increased by 0.50, 0.53, and 0.46 °C per decade, whereas precipitation displayed no significant change but showed large seasonal variation. According to a regression analysis, increased air temperature exerted positive effects on corn yields under the SNPK and the MNPK treatments. Under both treatments,soil organic carbon contents and soil nutrient availabilities increased significantly compared to their initial levels in 1990, whereas soil bulk density and total porosity changed slightly under the two treatments, which showed higher soil water storage than other treatments. In contrast, significant increases in soil bulk density and decreases in soil total porosity and soil nutrient availability were observed under the CK, N and NPK treatments. The contributions of soil fertility to corn yield were 28.4%, 37.9%, 38.4%, 39.0%,and 42.9% under CK, N, NPK, SNPK, and MNPK treatments, respectively, whereas climate changes accounted for 27.0%, 14.6%, 12.4%, 11.8%, and 10.8%. These results indicate that, in Northeast China, organic matter amendments can mitigate negative and exploit positive effects of climate change on crop production by enhancing soil quality. | Zhenwei Song Hongjun Gao Ping Zhu Chang Peng Aixing Deng Chengyan Zheng Md Abdul Mannaf Md Nurul Islam Weijian Zhang | 2015 | The Crop Journal2015，3，2： | 8 |
| 6 | A Two-stage Robust Optimal Allocation Model of Distributed Generation Considering Capacity Curve and Real-time Price Based Demand Response显示文摘Demand response, the reactive power output of distributed generation(DG), and network reconfiguration have significant impacts on a DG allocation strategy. In this context, a novel real-time price-based demand response formulation is integrated into the allocation model of DG. The tariff is regulated by the difference between the load and active power of renewable energy. Meanwhile, network reconfiguration and the capacity curve describing the active and reactive power limits of DG are included in the optimization model for promoting the allocation of DG.With these measures, the optimal allocation model of DG is established with the goal of maximizing the net annual profit while guaranteeing the efficient utilization of renewable energy. In addition, the uncertainties of renewable energy are considered on the basis of a two-stage robust optimization method. Finally, the entire optimization model is solved by the column and constraint generation algorithm in the IEEE 33-bus distribution system and a practical 99-bus distribution system. Numerical simulations show that the proposed model is effective in terms of improving both the usage of renewable energy and net annual profit. | Shuaijia He Hongjun Gao Hao Tian Lingfeng Wang Youbo Liu Junyong Liu | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，1： | 5 |
| 7 | Two-dimensional self-organization of 1-nonanethiol-capped gold nanoparticles显示文摘A two-dimensional (2D) ordered hexagonal close-packed structure, formed by 1-nonanethiol-capped gold nanoparticles, is reported. The structure was constructed only by dipping the gold nanoparticle colloidal solution on flat substrate. The gold nanoparticles were synthesized as follows: First, AuCl4-1 was transferred from aqueous solution to toluene by the phase-transfer reagent of tetraoc-tylanunonium bromide. Then it was reduced with aqueous sodium borohydride in the presence of a given amount of 1-nonanethiol molecules which was used to control the nu-cleation and growth of the gold nanoparticles for the desired size. The experimental techniques, such as UV-Vis, FT-IR, and X-ray photoelectron spectroscopy (XPS), were employed to characterize the obtained product. Transmission electron microscopy (TEM) measurement demonstrated the size of the gold nanoparticle and the formation of two-dimensional ordered hexagonal close-packed gold nanoparticle structure. | JIANG Peng XIE Sishen YAO Jiannian HE Shengtai ZHANG Haoxu SHI Dongxia PANG Shijin GAO Hongjun | 2001 | Chinese Science Bulletin2001，46，12： | 5 |
| 8 | Based on the Theory of Five Yun Six Qi to Study the Clinical Effect of Chaigui Decoction on Jueyin Type Hypertension显示文摘[Objectives]To study the clinical effect of Chaigui decoction(CGD)on Jueyin type hypertension based on the theory of Five Yun Six Qi.[Methods]52 patients with Jueyin type hypertension in Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine from January,2020 to March,2021 were randomly divided into Western medicine control group(18 cases)and CGD group(34 cases).CGD group was treated with CGD,while the control group was treated with irbesartan or amlodipine.[Results]After treatment,the systolic blood pressure(SBP)of the two groups decreased significantly,the difference was statistically significant(P<0.05).After treatment,the diastolic blood pressure(DBP)of CGD group was significantly lower than that of the control group(P<0.05).[Conclusions]Based on the theory of Five Yun Six Qi,CGD has significant effect on Jueyin type hypertension,and the effect of reducing DBP is better than that of Western medicine control group. | Jingru GAO Hongjun ZHU Han YAN Xiaohai HU Yuanchun YAO | 2021 | Medicinal Plant2021，12，3： | 4 |
| 9 | Intrastriatal glial cell line-derived neurotrophic factors for protecting dopaminergic neurons in the substantia nigra of mice with Parkinson disease显示文摘BACKGROUND:Substantia nigra is deep in position and limited in range,the glial cell line-derived neurotrophic factor(GDNF)injection directly into substantia nigra has relatively greater damages with higher difficulty.GDNF injection into striatum,the target area of dopaminergic neuron,may protect the dopaminergic neurons in the compact part of substantia nigra through retrograde transport.OBJECTIVE:To investigate the protective effect of intrastriatal GDNF on dopaminergic neurons in the substantia nigra of mice with Parkinson disease(PD),and analyze the action pathway.DESIGN:A controlled observation.SETTING:Neurobiological Laboratory of Xuzhou Medical College.MATERIALS:Twenty-four male Kunming mice of 7-8 weeks old were used.GDNF,1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)were purchased from Sigma Company(USA);LEICAQWin image processing and analytical system.METHODS:The experiments were carried out in the Neurobiological Laboratory of Xuzhou Medical College from September 2005 to October 2006.The PD models were established in adult KunMing mice by intraperitoneal injection of MPTP.The model mice were were randomly divided into four groups with 6 mice in each group:GDNF 4-day group,phosphate buffer solution(PSB)4-day group,GDNF 6-day group and PSB 6-day group.Mice in the GDNF 4 and 6-day groups were administrated with 1 μL GDNF solution(20 μg/L,dispensed with 0.01 mol/L PBS)injected into right striatum at 4 and 6 days after model establishment.Mice in the PSB 4 and 6-day groups were administrated with 0.01 mol/L PBS of the same volume to the same injection at corresponding time points.② On the 12th day after model establishment,the midbrain tissue section of each mice was divided into 3 areas from rostral to caudal sides.The positive neurons of tyroxine hydroxylase(TH)and calcium binding protein(CB)with obvious nucleolus and clear outline were randomly selected for the measurement,and the number of positive neurons in unit area was counted.MAIN OUTCOME MEASURES:Number of positive neurons of TH and CB in midbrain substantia nigra of mice in each group.RESULTS:All the 24 mice were involved in the analysis of results.The numbers of TH+ and CB+ neurons in the GDNF 4-day group(54.33±6.92,46.33±5.54)were obviously more than those in the PBS 4-day group(27.67±5.01,21.50±5.96,P < 0.01).The numbers of TH+ and CB+ neurons in the GDNF 6-day group(75.67±5.39,69.67±8.69)were obviously more than those in the PBS 6-day group(27.17±4.50,21.33±5.72,P < 0.01)and those in the GDNF 4-day group(P < 0.01).CONCLUSION:Intrastriatal GDNF can protect dopaminergic neurons in substantia nigra of PD mice,and it may be related to the increase of CB expression. | Chenghua Xiao Yanqiang Wang Hongmei Liu Hongjun Wang Junping Cao Dianshuai Gao | 2007 | Neural Regeneration Research2007，2，4： | 4 |
| 10 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 11 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://gffzz3ff3e9d9e9f64aa3hcwkocx6wqbn9650b.ffgz.tsg.suse.edu.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
| 12 | Dissection of heterosis for yield and related traits using populations derived from introgression lines in rice显示文摘Despite the great success achieved by the exploitation of heterosis in rice,the genetic basis of heterosis is still not well understood.We adopted an advanced-backcross breeding strategy to dissect the genetic basis of heterosis for yield and eight related traits.Four testcross(TC) populations with 228 testcross F1 combinations were developed by crossing57 introgression lines with four types of widely used male sterile lines using a North Carolina II mating design.Analysis of variance indicated that the effects of testcross F1 combinations and their parents were significant or highly significant for most of the traits in both years,and all interaction effects with year were significant for most of the traits.Positive midparent heterosis(HMP) was observed for most traits in the four TC populations in the two years.The relative HMPlevels for most traits varied from highly negative to highly positive.Sixty-two dominant-effect QTL were identified for HMPof the nine traits in the four TC populations in the two years.Of these,22 QTL were also identified for the performance of testcross F1.Most dominant-effect QTL could individually explain more than 10% of the phenotypic variation.Four QTL clusters were observed including the region surrounding the RM9–RM297 region on chromosome 1,the RM110–RM279–RM8–RM5699–RM452 region on chromosome 2,the RM5463 locus on chromosome 6 and the RM1146–RM147 region on chromosome 10.The identified QTL for heterosis provide valuable information for dissecting the genetic basis of heterosis. | Chao Xiang Hongjun Zhang Hui Wang Shaobo Wei Binying Fu Jiafa Xia Zefu Li Yongming Gao Guoyou Ye | 2016 | The Crop Journal2016，4，6： | 3 |
| 13 | Generation and characterization of monoclonal antibodies against the NS1 protein of H17N10 bat influenza virus显示文摘 | Junna Gao Kaidi Xu Haiwei Sun Qinfang Liu Jianmei Yang Qiaoyang Teng Xuesong Li Zhaoguo Chen Zejun Li Hongjun Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 2 |
| 14 | 洛铂联合依托泊苷与顺铂联合依托泊苷一线治疗广泛期小细胞肺癌随机对照临床研究(英文)显示文摘Objective: To compare the efficacy and safety of Lobaplatin plus Etoposide (EL) and Cisplatin plus Etoposide (EP) regimens in chemonaive with extensive-stage small-cell lung cancer (SCLC). Methods: Between July 2010 and July 2011, a total of 62 patients with extensive-stage small-cell lung cancer who received initial treatment in our hospital and 309 hospital of PLA. 31 patients were randomly assigned to the EL Group: Lobaplatin was given intravenously at a dose of 30 mg/m2 on day 1 and Etoposide 100 mg/m2 on days 1 to 3 of 21-day cycles for a maximum of six cycles. Another 31 patients were assigned to the EP Group: Cisplatin was given intravenously at a dose of 75 mg/m2 on day 1 and Etoposide 100 mg/m2 on days 1 to 3 of 21-day cycles for a maximum of six cycles. We evaluated the efficacy, overall response rate (ORR), disease control rate (DCR), the progression-free survival (PFS) and toxicity between the patients of the two groups. Results: All 62 patients were eligible. In the EL group, 2 (6.5%) patients had complete response, 20 (64.5%) patients had partial response, 5 (16.1%) patients had stable disease and 4 (12.9%) patients had progress disease. In the EP group, 2 (6.5%) patients had complete response, 22 (70.9%) patients had partial response, 4 (12.9%) patients had stable disease and 3 (9.7%) patients had progress disease. The ORR of EL and EP group were 70.9% and 77.4%, respectively, showing no significant difference (P = 0.562). The DCR of both groups were 87% and 90%, respectively, showing no significant difference (P = 0.688). Median PFS of patients with EL and EP regimens were 5.5 months and 5 months, respectively, showing no significant difference (P = 0.637). Adverse events were observed in all 62 patients. Grade 1 to 4 anemia was higher in the EP group than in EL group, showing significant difference (P = 0.02). Grade 3 and 4 thrombocytopenia was seen in 4 patients (12.9%) in EL group and 1 patient (3.2%) in EP group. Although one patient had platelet transfusion owing to Grade 4 thrombocytopenia in EL group, no significant difference (P = 0.637) were shown. The incidence of nausea/vomiting was higher in the EP group than in the EL group (96.7% vs 51.6%, P = 0.00). Conclusion: The EL regimen is an effective and low-toxicity chemotherapy and no inferior to EP regimen in treatment response, therefore, EL regimen maybe is a good choice for patients with extensive-stage SCLC. | Wanfeng Guo Guoqing Liao Hongjun Gao Hongmei Wang Chuanhao Tang Haifeng Qin Jianjie Li Xiaoyan Li Xiaoqing Liu | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，8： | 2 |
| 15 | Multi-objective Dynamic Reconfiguration for Urban Distribution Network Considering Multi-level Switching Modes显示文摘The increasing integration of photovoltaic generators(PVGs) and the uneven economic development in different regions may cause the unbalanced spatial-temporal distribution of load demands in an urban distribution network(UDN). This may lead to undesired consequences, including PVG curtailment, load shedding, and equipment inefficiency, etc. Global dynamic reconfiguration provides a promising method to solve those challenges. However, the power flow transfer capabilities for different kinds of switches are diverse, and the willingness of distribution system operators(DSOs) to select them is also different. In this paper, we formulate a multi-objective dynamic reconfiguration optimization model suitable for multi-level switching modes to minimize the operation cost, load imbalance, and the PVG curtailment. The multi-level switching includes feeder-level switching, transformer-level switching, and substation-level switching. A novel load balancing index is devised to quantify the global load balancing degree at different levels. Then, a stochastic programming model based on selected scenarios is established to address the uncertainties of PVGs and loads. Afterward, the fuzzy c-means(FCMs) clustering is applied to divide the time periods of reconfiguration. Furthermore, the modified binary particle swarm optimization(BPSO)and Cplex solver are combined to solve the proposed mixed-integer second-order cone programming(MISOCP) model. Numerical results based on the 148-node and 297-node systems are obtained to validate the effectiveness of the proposed method. | Hongjun Gao Wang Ma Yingmeng Xiang Zao Tang Xiandong Xu Hongjin Pan Fan Zhang Junyong Liu | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 2 |
| 16 | Expression of calbindin D28K in substantia nigra of model rats with Parkinson disease显示文摘BACKGROUND: Previous researches suggested that expression level of calbindin D28K mRNA decreased in substantia nigra (SN) of model rats with Parkinson disease (PD), and this might be related to the decrease of anti-degeneration potentials of dopaminergic neurons. OBJECTIVE: To observe expression changes of calbindin D28K in SN dopaminergic neurons during their degeneration and death in midbrain of PD model rats. DESIGN: Completely randomized grouping design. SETTING: Department of Neurobiology, Xuzhou Medical College. MATERIALS: A total of 92 healthy male SD rats, with the age of 3 months, weighing 200-250 g, were selected from Experimental Animal Center of Xuzhou Medical College [certification: SCXK (su) 2003-0003]. Calbindin D28K(CB), tyroxine hydroxylase (TH), ABC kit, 6-hydroxydopamine (6-OHDA) and Nissl dyes were provided by Sigma Company, and sheep serum was provided by Beijing Zhongshan Company. METHODS: The experiment was carried out in the Neurobiological Center of Xuzhou Medical College from October 2003 to October 2004. ① With lot method, rats were divided into blank control group (n=28), experimental control group (n=28) and experimental group (n=36). Rats in experimental group were injected with 6-OHDA at right corpus striatum for PD modeling; rats in experimental control group were injected with saline at the same site; rats in blank control group did not give any injections. ② On the 7th, 14th, 21st and 28th days, SN segments on right midbrain from every 5 rats in experimental group were fixed, embedded with paraffin and cut into successively coronary pieces. Rats in other two groups were treated with the same methods and then stained with Nissl to show neuronal form. Meanwhile, CB and TH antibodies staining with immunohistochemistry were used to show CB containing dopaminergic neurons and dopaminergic neurons, and cells were calculated and observed under optic microscope. ③ On the 14th and 28th days, every 4 rats in experimental group and every 4 rats in control group were selected to obtain their brains and separate SN on the injured side. Western blot was used to detect expression of calbindin D28K, protein band was scanned with imaging equipment, and data were analyzed with LabWorks software. MAIN OUTCOME MEASURES: ① On the 7th, 14th, 21st and 28th days, Nissl staining results of SN neurons and immunohistochemical staining results of CB and TH antibodies; ② On the 14th and 28th days, Western blot results of calbindin D28K in SN neurons. RESULTS: Among 92 rats, 2 rats in experimental group died after 1 day due to 6-OHDA injection and other 90 rats were involved in the final analysis. ① Nissl staining results: On the 7th day of 6-OHDA injection, most neuronal somas on right SN pars compacta were shown as deep pycnosis or lysis breakage; on the 14th and 21st days, amount of neurons was decreased remarkably; on the 28th day, most neurons in SN pars compacta disappeared. ② Results of immunohistochemical staining: Amount of positive neurons of calbindin D28K in right SN pars compacta was not changed on the 7th day after 6-OHDA injection; on the 14th day, the amount was higher in experimental group than that in both control groups (P < 0.01) and was decreased till the 21st day, but it was still higher than that in the two control groups (P < 0.05); on the 28th day, positive neurons of calbindin D28K nearly disappeared, and the amount was lower than that in the two control groups (P < 0.01). In addition, on the 7th day after 6-OHDA injection into corpus striatum, positive TH neurons decreased 24% in right SN, and there was significant difference from that in control groups; on the 14th, 21st and 28th days, positive TH neurons decreased 37%, 46% and 64%, respectively. ③ Western blot results: On the 14th day after 6-OHDA injection into corpus striatum, expression of calbindin D28K in right SN was higher in experimental group than that in both control groups (P < 0.05); however, on the 28th day, the expression was lower than that in the two control groups (P < 0.01). CONCLUSION: During degeneration and death of dopaminergic neurons, CB expression in SN pars compacta increases firstly and decreased gradually. | Dianshuai Gao Hongmei Liu Yanxia Ding Hongjun Wang Yanqiang Wang | 2006 | Neural Regeneration Research2006，1，2： | 2 |
| 17 | Electronic structure of exfoliated millimeter-sized monolayer WSe2 on silicon wafer显示文摘The mono layer WSe2 is in teresting and important for future application in nanoelectronics,spintronics and valleytronics devices,because it has the largest spin splitting and Ion gest valley coherence time among all the known monolayer transition-metal dichalcogenides(TMDs).Toobtain the large-area monolayer TMDs'crystal is the first step to manu facture scalable and high-performance electronic devices.In this letter,we have successfully fabricated millimeter-sized mono layer WSe2 single crystals with very high quality,based on our improved mecha nicalexfoliation method.With such superior samples,using standard high resolution angle-resolved photoemission spectroscopy,we didcomprehe nsive electronic band structure measurements on our mono layer WSe2.The overall band features point it to be a 1.2 eV direct bandgap semico nductor.Its spin splitting of the valence band at K point is found as 460 meV,which is 30 meV less than the corresponding band splitting in its bulk counterpart.The effective hole masses of valence bands are determined as 2.344 me atГ,and 0.529 me as well as 0.532 meat K for the upper and lower branch of splitting ban ds,respectively.And screening effect from substrate is shown to substa ntially impact onthe electronic properties.Our results provide importa nt insights into band structure engineering in mono layer TMDs.Our mono layer WSe2 crystals may constitute a valuable device platform. | Wenjuan Zhao Yuan Huang Cheng Shen Cong Li Yongqing Cai Yu Xu Hongtao Rong Qiang Gao Yang Wang Lin Zhao Lihong Bao Qingyan Wang Guangyu Zhang Hongjun Gao Zuyan Xu Xingjiang Zhou Guodong Liu | 2019 | Nano Research2019，12，12： | 2 |
| 18 | Simultaneous improvement and genetic dissection of grain yield and its related traits in a backbone parent of hybrid rice ( Oryza sativa L.) using selective introgression显示文摘 | Hongjun Zhang Hui Wang Yiliang Qian Jiafa Xia Zefu Li Yingyao Shi Linghua Zhu Jauhar Ali Yongming Gao Zhikang Li | 2013 | Molecular Breeding2013，，1： | 1 |
| 19 | Compact tunable high power picosecond source based on Yb -doped fiber amplification of gain switch laser diode 显示文摘 | Liu Hongjun Gao Cunxiao Tao Jintao | 2008 | Opt Express2008，16，11： | 1 |
| 20 | Biopelymer and carbona notubes interface prepared by self-assembly for studying the electrochemistry of mieroperoxidase-11显示文摘 | Xu Zhiai Gao Na Chen Hongjun | 2005 | Langmuir2005，21，10： | 1 |
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