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| 1 | A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine显示文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very. | Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 18 |
| 2 | Intra-continental back-arc basin inversion and Late Carboniferous magmatism in Eastern Tianshan,NW China:Constraints from the Shaquanzi magmatic suite显示文摘The Yamansu belt,an important tectonic component of Eastern Tianshan Mountains,of the Central Asian Orogenic Belt,NW China hosts many Fe-(Cu)deposit.In this study,we present new zircon U-Pb geochronology and geochemical data of the volcanic rocks of Shaquanzi Formation and diorite intrusions in the Yamansu belt.The Shaquanzi Formation comprises mainly basalt,andesite/andesitic tuff,rhyolite and sub-volcanic diabase with local diorite intrusions.The volcanic rocks and diorites contain ca.315-305 Ma and ca.298 Ma zircons respectively.These rocks show calc-alkaline affinity with enrichment in large-ion lithophile elements(LILEs),light rare-earth elements(LREEs),and depletion in high field strength elements(HFSEs)in primitive mantle normalized multi-element diagrams,which resemble typical back-arc basin rocks.They show depleted mantle signature with ε_(Nd)(t)ranging from+3.1 to +5.6 for basalt;+2.1 to+4.7 for andesite;-0.2 to+1.5 for rhyolite and the ε_(Hf)(t)ranges from-0.1 to +13.0 for andesites;+5.8 to +10.7 for andesitic tuffs.We suggest that the Shaquanzi Formation basalt might have originated from a depleted,metasomatized lithospheric mantle source mixed with minor(3-5%)subduction-derived materials,whereas the andesite and rhyolite could be fractional crystallization products of the basaltic magma.The Shaquanzi Formation volcanic rocks could have formed in an intracontinental back-arc basin setting,probably via the southward subduction of the Kangguer Ocean beneath the Middle Tianshan Massif.The Yamansu mineralization belt might have undergone a continental arc to back-arc basin transition during the Late Carboniferous and the intra-continental back-arc basin might have closed in the Early Permian,marked by the emplacement of dioritic magma in the Shaquanzi belt. | Hongjun Jiang Jinsheng Han Huayong Chen Yi Zheng Wanjian Lu Gang Deng Zhixiong Tan | 2017 | Geoscience Frontiers2017，8，6： | 11 |
| 3 | Heterogeneous reaction of NO_2 on the surface of NaCl particles显示文摘The heterogeneous reaction of NO2 on NaCl particles has been investigated with the new sample preparation and the mode of gas-solid free diffusion. Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) is used to characterize the adsorbed products in situ, combined with Ion Chromatographic (IC), X-ray Photoelectron Spectroscopy (XPS) and Scan Electron Micros- copy (SEM). Our results indicate that the reaction is not limited to the surface of the NaCl particles, but penetrated into the upper layers. Surface reactive sites determine the reaction. Kinetic measurements show that nitrate formation on sodium chloride is second order in NO2 concentration and reactive uptake coefficient is (1.54 ± 0.70) × 10?5. | LI Hongjun ZHU Tong DING Jie CHEN Qi XU Bingye | 2006 | Science China Chemistry2006，49，4： | 9 |
| 4 | How technological proximity affect collaborative innovation?An empirical study of China’s Beijing-Tianjin-Hebei region显示文摘Based on joint-innovation patent data from 2000 to 2016 in the Beijing-Tianjin-Hebei region of China,the purpose of this paper is to analyze how technological proximity affects university-industry collaborative innovation in the Beijing-Tianjin-Hebei region.We adopt a 1:1 matching design to conduct an empirical study.The results show that the effect of technological proximity on the formation of collaborative innovation displays an inverted U-shape,and geographical proximity and institutional proximity play a positive role of forming a tie.Geographical proximity and institutional proximity as a coordination mechanism,have negatively influenced the relationship between technological proximity and the formation of university-industry collaborative innovation.Furthermore,university strength improves the possibility of collaborative innovation.These findings contributed to the understanding of the relationship between technological proximity and collaborative innovation. | Hongjun Chen Fuji Xie | 2018 | Journal of Management Analytics2018，5，4： | 9 |
| 5 | Analysis of volatile flavor compounds in top fermented wheat beer by headspace sampling-gas chromatography显示文摘Headspace sampling-gas chromatography(HS-GC)coupled with an internal standard method(ISM)was developed to analyze the volatile flavor compounds in top fermented wheat beer in the laboratory.Eight compounds,i.e.acetaldehyde,N-propanol,ethyl acetate,isobutyl alcohol,isoamyl alcohol,isoamyl acetate,ethyl hexanoate and ethyl octanoate were separated and quantified.This method was validated to ensure the quality of the results:the precision was satisfactory with relative standard deviation(RSD)in the range of 1.51%-4.22%,recoveries for all the analytes ranged from 95.15%to 99.85%,and the limits of detection were in the range of 0.0002-0.024 mg/L.Results of real wheat beer samples analyzed using this method showed that the volatile compound concentrations were in the range of 0.08-99.91 mg/L.Results suggested that this method exhibited good reproducibility,selectivity and high precision,and it can be useful for the analysis of routine beer samples. | Li Huimin Li Hongjun Liu Xiuhua Chen Bing | 2012 | International Journal of Agricultural and Biological Engineering2012，5，2： | 8 |
| 6 | A more consistent intraluminal rhesus monkey model of ischemic stroke显示文摘Endovascular surgery is advantageous in experimentally induced ischemic stroke because it causes fewer cranial traumatic lesions than invasive surgery and can closely mimic the pathophysiology in stroke patients. However, the outcomes are highly variable, which limits the accuracy of evaluations of ischemic stroke studies. In this study, eight healthy adult rhesus monkeys were randomized into two groups with four monkeys in each group: middle cerebral artery occlusion at origin segment(M1) and middle cerebral artery occlusion at M2 segment. The blood flow in the middle cerebral artery was blocked completely for 2 hours using the endovascular microcoil placement technique(1 mm × 10 cm)(undetachable), to establish a model of cerebral ischemia. The microcoil was withdrawn and the middle cerebral artery blood flow was restored. A reversible middle cerebral artery occlusion model was identified by hematoxylin-eosin staining, digital subtraction angiography, magnetic resonance angiography, magnetic resonance imaging, and neurological evaluation. The results showed that the middle cerebral artery occlusion model was successfully established in eight adult healthy rhesus monkeys, and ischemic lesions were apparent in the brain tissue of rhesus monkeys at 24 hours after occlusion. The rhesus monkeys had symptoms of neurological deficits. Compared with the M1 occlusion group, the M2 occlusion group had lower infarction volume and higher neurological scores. These experimental findings indicate that reversible middle cerebral artery occlusion can be produced with the endovascular microcoil technique in rhesus monkeys. The M2 occluded model had less infarction and less neurological impairment, which offers the potential for application in the field of brain injury research. | Bo Zhao Guowei Shang Jian Chen Xiaokun Geng Xin Ye Guoxun Xu Ju Wang Jiasheng Zheng Hongjun Li Fauzia Akbary Shengli Li Jing Lu Feng Ling Xunming Ji | 2014 | Neural Regeneration Research2014，9，23： | 6 |
| 7 | Expression and intercellular trafficking of the VP22 protein of CVI988/Rispens vaccine strain of Marek’s disease virus显示文摘The viral protein 22 (VP22) in the tegument of Marek’s disease virus serotype 1 (MDV-1) plays an im-portant role in cell-to-cell spread and viral propagation. Antiserum against the carboxyl terminus of VP22 was prepared by immunizing mice with recombinant VP22 expressed in E. coli, and used to in-vestigate its expression in chicken embryo fibroblast (CEF) cells infected with different MDV-1 strains. At an infection dose of PFU=50, intercellular trafficking of the VP22 into the nuclei of the surrounding receipt cells was detected as early as 3 hours post infection. By 6 hours after infection (before viral plague formation), the protein was detected in the whole nuclei of the recipient cells with no difference among MDV-1 strains CVI988/Rispens, GA and RB1B. Intra-nuclear accumulation of the VP22 protein was further increased when the viral plagues started to form. These results indicate that, albeit the ex-istence of the 201TKSERT206 deletion, the VP22 of the CVI988/Rispens vaccine strain has also intercel-lular-trafficking function, which might serve as a potential alternative delivering protein instead of virulent strains VP22. | CHEN HongJun, SONG CuiPing, QIN AiJian & ZHANG ChenFei Key Lab of Jiangsu Preventive Veterinary Medicine, Yangzhou University, Yangzhou 225009, China | 2007 | Science China(Life Sciences)2007，50，1： | 6 |
| 8 | Paleoenvironmental changes during the late Quaternary as inferred from foraminifera assemblages in the Laizhou Bay显示文摘Controlled by climate changes, there were three large-scale transgressions and regressions around the Bohai Sea during the late Quaternary, which were accepted by most geologists. However, a big controversy still exists about the time when the transgressions occurred separately. In order to find out the process of the paleoenvironmental changes around the Bohai Sea in the late Quaternary, the foraminifera assemblages from a new borehole Lz908 in the southern coast of the Laizhou Bay were studied, and then the transgressive strata were indentified. Combined with accelerator mass spectrometry radiocarbon 14C(AMS14C) and optically stimulated luminescence(OSL) ages, the occurrence time of these transgressions were re-determined. The result showed that three major large-scale transgressions occurred separately at the beginning of marine isotopic stage 7(MIS7), the last interglacial period(MIS5) and the Holocene. In addition, a small-scale transgression occurred in the mid-MIS6, and the corresponding transgressive stratum was deposited. The transgressive deposition of MIS3 was also discovered in this study. However, the characteristics of the foraminifera indicated the environment during this period was colder than that in the MIS5. By comparison with the global sea-level changes, the paleoenvironmental changes around the Bohai Sea in the late Quaternary can be consistent with the global climate changes. | YAO Jing YU Hongjun XU Xingyong YI Liang CHEN Guangquan SU Qiao | 2014 | Acta Oceanologica Sinica2014，33，10： | 6 |
| 9 | Numerical simulation for erosion effects of three-phase flow containing sulfur particles on elbows in high sour gas fields显示文摘Sulfur particles carried by high-speed flow impact pipelines,which may cause equipment malfunctions and even failure.This paper investigates the scouring effect of mist gas containing sulfur particles on elbows in highly sour gas fields.The multiphase-flow hydrodynamic model of the 90elbow was established by using the computational fluid dynamics(CFD)method.The scouring effects of the gasliquid mist fluid with the water-liquid fraction of 20%and particles with the diameter of 0.01 e0.05mm on elbows were explored within the flow velocity range of 0e20 m/s.In addition,the influences of secondary collision,mean curvature radius to diameter(R/D)ratio,inertial force,drag force,and Stokes number on trajectories of sulfur particles were studied.Moreover,the influences of hydrodynamic parameters of multiphase flow on corrosion inhibitor film were analyzed with the wall shear stress as the reference value.Serious erosion mainly occurred in the extrados of elbow as well as the junction between downstream pipeline and the intrados of elbow,the maximum erosion area occurs at 61.9.When the incident position of the particle was far away from the top of the inlet plane,the probability of secondary collision became smaller.Furthermore,the erosion rate decreased with the rise in the R/D radio.The maximum erosion rate of elbow increased with the increase in the Stoke number.The maximum erosion rate reached 0.428 mm/a at 0.05mm particle diameter and 20 m/s fluid velocity.The wall shear stress increased with the increase in fluid velocity and mass flow rate of particle,the fitting function of the wall shear stress curve was the Fourier type.The results indicated that highvelocity particles had a serious erosion effect on elbows and affected the stability of the corrosion inhibitor film.The erosion effect could be retarded by controlling the velocity and diameter of particles.The results provided technical supports for the safe production in highly sour gas fields. | Enbo Zhang Dezhi Zeng Hongjun Zhu Shuanggui Li Dongbo Chen Jie Li Yanyan Ding Gang Tian | 2018 | Petroleum2018，4，2： | 5 |
| 10 | KEY TECHNOLOGY OF D-INSAR AT X-BAND FOR MONITORING LAND SUBSIDENCE IN MINING AREA AND ITS APPLICATION显示文摘In theory, land subsidence measurement results with high accuracy can be obtained by using the Differential Interferometry Synthetic Aperture Radar(D-InSAR) at X-band. In practice, however, the measuring accuracy of D-InSAR at X-band has been seriously affected by some factors, e.g., decorrelation and high deformation gradient. In this work, the monitoring capability of D-InSAR for coal-mining subsidence is evaluated by using SAR data acquired by TerrraSAR-X system. The SAR image registration method for low coherence image pairs, the denoising phase filter for high noise level interferogram and atmospheric effects mitigation method are the key technical aspects which directly influence the measurement results of D-InSAR at X-band. Thus, a robust image registration method, an improved phase filter method and an atmospheric effects mitigation method are proposed in this paper. The proposed image registration method successfully achieves InSAR coregistration, while the amplitude cross-correlation cannot properly coregister low coherence SAR image pairs. Moreover, the time complexity of the proposed image registration method is obviously slighter than that of the Singular Value Decomposition(SVD) method. The comparing experiment results and the unwrapping phase results show that the improved Goldstein filter is more effective than the original Goldstein filter in noise elimination. The atmospheric influence correction experiment results show that the land subsidence areas with atmospheric influence correction are more clarified than that of without atmospheric influence correction. In summary, the presented methods directly improved the measurement results of D-InSAR at X-band. | Li Xinglin Liu Donglie Song Hongjun Chen Runpu Li Hongyu | 2014 | Journal of Electronics(China)2014，31，5： | 5 |
| 11 | Non-coding Transcripts from Enhancers:New Insights into Enhancer Activity and Gene Expression Regulation显示文摘Long non-coding RNAs(lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes.Some lncRNAs exert function as enhancers,i.e.,activating gene transcription by serving as the cis-regulatory molecules.Furthermore,recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules,which are termed as enhancer RNAs(eRNAs).The e RNAs are not merely the by-product of the enhancer transcription.In fact,many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms.Here,we provide an overview of enhancer activity,transcription of enhancer itself,characteristics of e RNAs,as well as their roles in regulating enhancer activity and gene expression. | Hongjun Chen Guangshi Du Xu Song Ling Li | 2017 | Genomics, Proteomics & Bioinformatics2017，15，3： | 5 |
| 12 | Wetland Definitions:Creation,Evolution and Application显示文摘In this paper,we review the creation,evolution and application of wetland definitions.Varying wetlands are found from the tundra to the tropics and on every continent except Antarctica in the planet.Wetlands have many distinguishing features,the most notable of which are water presence,unique soil conditions,and biota that are adapted to or tolerant of saturated soils.Many wetland definitions have been developed by scientists,U.S.federal agencies,and the Ramsar Convention for both scientific and regulatory purposes.Wetlands are not easily defined but a well-conceived,science-based definition of wetlands is important for scientists and resource managers to understand the nature of wetlands and/or to use and protect wetlands.A scientific definition is the basis for wetland classification.Developing an effective wetland classification system requires a well-conceived,science-based definition and clearly explicit guidance on the appropriate use of various wetland indicators to verify the presence of wetlands on the ground.Based on a well-accepted wetland definition,both wetland classification and inventory further provide needed information and a working frame for wise use and management of wetlands. | CHEN Hongjun WANG Guoping LU Xianguo | 2010 | 湿地科学2010，8，3： | 4 |
| 13 | Marek's disease virus VP22 enhances potentially the immune response of E SAT-6/CFP-10 against Mycobacterium bovis infection显示文摘对 Mycobacterium bovis 的当前可得到的疫苗,肺结核的原因的代理人,别提供可靠功效,因此对有改进功效的一支新奇疫苗有需要。这里,我们使用蛋白质 transduction 技术交付直接表示 mycobacterial 抗原指向房间的 DNA 疫苗。我们使用了包括 VP22 的领域(PTD ) 蛋白质从 Marek 的疾病病毒 serotype 结合的各种各样的蛋白质 transduction 1 (MDV-1 ) ,作为为编码抗原的 DNA 构造的交货系统,早能分泌的 antigenic target-6 kDa (ESAT-6 ) 蛋白质和文化过滤蛋白质 10 (CFP-10 ) M。bovis。真核细胞的表示 plasmid pZ106,编码抗原 ESAT-6 和 CFP-10,结合了到各种各样的 PTD,被用来构造试验性的准备。我们的调查结果与 CFP-10 独自或在联合表明了那 VP22 : ESAT-6 熔化蛋白质能传播进包围 transfected 房间的房间单层的所有原子核。而激活 trans transcriptional PTD 出现了,熔化蛋白质和 8R 肽的有限交货是不能的交付熔化蛋白质进任何 untransfected 房间。我们证明了有熔化到 VP22 的准备的那免疫导致更高的抗体和干扰素 -- titer (P < 0.05 ) 。一起拿,我们的结果证明 MDV-1 VP22 用 DNA 疫苗在基因治疗和免疫用作潜在的有免疫力的 enhancer,为 M 的预防提供一条新奇途径。bovis 感染。 | Hongjun Chen Wei Wang Cuiping Song Shengqing Yu Chan Ding | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 4 |
| 14 | Global localization of in-pipe robot based on ultra-long wave antenna array and global position system显示文摘A global localization system of in-pipe robot is introduced in this paper.Global position system(GPS)is applied to monitor the motion of robot along the whole pipeline which is equally divided intomany segments by tracking stations.The definite segment in which robot existing can be detected and thisis long-range localization.Ultra-long wave(ULW)is adopted to solve the problem of metallic shieldingand realize effective communication between inside and outside of pipeline.ULW emitter is carried byrobot.When the plant is broken or defects on pipe-wall are inspected,the robot will stop moving.Anten-na array is presented and disposed upon the definite segment to search the accurate location of robot,andthis is short-range localization.In this paper,five-antenna array is adopted and an effective linear signalfusion algorithm is presented.The localization precision reaches R < 25cm.By tests in Shengli oil field,the whole system is verified with robust solutions. | 齐海铭 Zhang Xiaohua Chen Hongjun Sun Dongchang Sun Yongtai | 2009 | High Technology Letters2009，15，2： | 4 |
| 15 | Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout显示文摘 | Dong, Zheng Li, Yuan Zhou, Jingru Jiang, Shuai Wang, Yi Chen, Yulin Zhao, Dongbao Yang, Chengde Qian, Qiaoxia Ma, Yanyun He, Hongjun Ji, Hengdong Yang, Yajun Wang, Xiaofeng Xu, Xia Pang, Yafei Zou, Hejian Jin, Li Zhang, Feng Wang, Jiucun | 2017 | Protein & Cell2017，8，6： | 3 |
| 16 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://gffzz3ff3e9d9e9f64aa3h9c095xu5kb596p0c.ffgz.tsg.suse.edu.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
| 17 | Isolation of fucoxanthin from Sargassum thunbergii and preparation of microcapsules based on palm stearin solid lipid core显示文摘 | Xuanxuan WANG Hongyan LI Fangqin WANG Guixue XIA Hongjun LIU Xiaojie CHENG Ming KONG Ya LIU Chao FENG Xiguang CHEN Ying WANG | 2017 | Frontiers of Materials Science2017，11，1： | 3 |
| 18 | Agricultural Risk Factors Influence Microbial Ecology in Honghu Lake显示文摘Agricultural activities, including stock-farming, planting industry, and fish aquaculture,can affect the physicochemical and biological characters of freshwater lakes. However, the effects of pollution producing by agricultural activities on microbial ecosystem of lakes remain unclear.Hence, in this work, we selected Honghu Lake as a typical lake that is influenced by agriculture activities. We collected water and sediment samples from 18 sites, which span a wide range of areas from impacted and less-impacted areas. We performed a geospatial analysis on the composition of microbial communities associated with physicochemical properties and antibiotic pollution of samples. The co-occurrence networks of water and sediment were also built and analyzed. Our results showed that the microbial communities of impacted and less-impacted samples of water were largely driven by the concentrations of TN, TP, NO_3^--N, and NO_2^--N, while those of sediment were affected by the concentrations of Sed-OM and Sed-TN. Antibiotics have also played important roles in shaping these microbial communities: the concentrations of oxytetracycline and tetracycline clearly reflected the variance in taxonomic diversity and predicted functional diversity between impacted and less-impacted sites in water and sediment samples, respectively. Furthermore, for samples from both water and sediment, large differences of network topology structures between impacted and less-impacted were also observed. Our results provide compelling evidence that the microbial community can be used as a sentinel of eutrophication and antibiotics pollution risk associated with agricultural activity; and that proper monitoring of this environment is vital to maintain a sustainable environment in Honghu Lake. | Maozhen Han Melissa Dsouza Chunyu Zhou Hongjun Li Junqian Zhang Chaoyun Chen Qi Yao Chaofang Zhong Hao Zhou Jack A Gilbert Zhi Wang Kang Ning | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 3 |
| 19 | Controlling Effects of Tight Reservoir Micropore Structures on Seepage Ability: A Case Study of the Upper Paleozoic of the Eastern Ordos Basin, China显示文摘In this study, the types of micropores in a reservoir are analyzed using casting thin section(CTS) observation and scanning electron microscopy(SEM) experiments. The high-pressure mercury injection(HPMI) and constant-rate mercury injection(CRMI) experiments are performed to study the micropore structure of the reservoir. Nuclear magnetic resonance(NMR), gas-water relative seepage, and gas-water two-phase displacement studies are performed to examine the seepage ability and parameters of the reservoir, and further analyses are done to confirm the controlling effects of reservoir micropore structures on seepage ability. The experimental results show that Benxi, Taiyuan, Shanxi, and Shihezi formations in the study area are typical ultra-low porosity and ultra-low permeability reservoirs. Owing to compaction and later diagenetic transformation, they contain few primary pores. Secondary pores are the main pore types of reservoirs in the study area. Six main types of secondary pores are: intergranular dissolved pores, intragranular dissolved pores, lithic dissolved pores, intercrystalline dissolved pores, micropores, and microfracture. The results show that reservoirs with small pore-throat radius, medium displacement pressure, and large differences in pore-throat structures are present in the study area. The four types of micropore structures observed are: lower displacement pressure and fine pores with medium-fine throats, low displacement pressure and fine micropores with fine throats, medium displacement pressure and micropores with micro-fine throats, and high displacement pressure and micropores with micro throats. The micropore structure is complex, and the reservoir seepage ability is poor in the study areas. The movable fluid saturation, range of the gas-water two-phase seepage zone, and displacement types are the three parameters that well represent the reservoir seepage ability. According to the characteristic parameters of microscopic pore structure and seepage characteristics, the reservoirs in the study area are classified into four types(Ⅰ–Ⅳ), and types Ⅰ, Ⅱ, and Ⅲ are the main types observed. From type Ⅰ to type Ⅳ, the displacement pressure increases, and the movable fluid saturation and gas-water two-phase seepage zone decrease, and the displacement type changes from the reticulation-uniform displacement to dendritic and snake like. | YANG Bo QU Hongjun PU Renhai TIAN Xiahe YANG Huan DONG Wenwu CHEN Yahui | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 3 |
| 20 | Information environment,market-wide sentiment and IPO initial returns:Evidence from analyst forecasts before listing显示文摘Measuring the information environment of firms using analyst(price)forecast bias and forecast dispersion before listing,we empirically examine the interactive influence of the information environment and market-wide sentiment on the initial returns of initial public offerings(IPOs).We find the smaller the analyst forecast bias/dispersion,the lower the effect market-wide sentiment has on IPO initial returns.This finding indicates that information asymmetry is a basic reason for noise trading occurs and demonstrates the positive effect of financial analysts during IPOs.In addition,the effect of analyst forecasts is more pronounced during periods of rising markets and when IPO prices are not regulated. | Hongjun Zhu Cheng Zhang He Li Shimin Chen | 2015 | China Journal of Accounting Research2015，，3： | 2 |
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