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| 1 | Emerging transporter-targeted nanoparticulate drug delivery systems显示文摘Transporter-targeted nanoparticulate drug delivery systems(nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments in nanotherapeutics. In this review, we outline the recent advances in transporter-targeted nano-DDS. First, the emerging transporter-targeted nano-DDS developed to facilitate oral drug delivery are reviewed. These include improvements in the oral absorption of protein and peptide drugs, facilitating the intravenous-to-oral switch in cancer chemotherapy. Secondly, the recent advances in transporter-assisted brain-targeting nano-DDS are discussed,focusing on the specific transporter-based targeting strategies. Recent developments in transportermediated tumor-targeting drug delivery are also discussed. Finally, the possible transport mechanisms involved in transporter-mediated endocytosis are highlighted, with special attention to the latest findings of the interactions between membrane transporters and nano-DDS. | Hongyan Su Yan Wang Shuo Liu Yue Wang Qian Liu Guangxuan Liu Qin Chen | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 9 |
| 2 | Vaterite or aragonite observed in the prismatic layer of freshwater-cultured pearls from South China显示文摘A prismatic layer is present in both freshwater-cultured pearls and seawater-cultured pearls. The phase structure of the prismatic layer of freshwater-cultured pearls is investigated for the first time and novel findings are reported in this paper. X-ray diffraction (XRD), optical microscopy (OM) and micro-infrared (IR) spectroscopy were used to characterize the crystallized layers of high and low-quality freshwater-cultured pearls. Results show that there is no calcite in the prismatic layer of freshwater-cultured pearls, which is different from what was found for seawater-cultured pearls. We found that an aragonite phase was present in the prismatic layer of high-quality freshwater-cultured pearls and that a vaterite or aragonite phase was present in low-quality pearls. Based on this study an internal factor that influences the quality of freshwater-cultured pearls is discussed. | Hongyan Ma Anan Su Beili Zhang Ru-Kang Li Longchang Zhou Baoli Wang | 2009 | Progress in Natural Science:Materials International2009，19，7： | 7 |
| 3 | Velocity compensation methods for LPRF modulated frequency stepped-frequency(MFSF) radar显示文摘In the high speed target environment,there exists serious Doppler effect in the low pulse repetition frequency(LPRF) modulated frequency stepped frequency(MFSF) radar signal.The velocity range of the target is large and the velocity is high ambiguous,so the single method is difficult to satisfy the velocity measurement requirement.For this problem,a novel method is presented,it is a combination of cross-correlation inner frame velocity measurement and range-Doppler coupling velocity measurement.The cross-correlation inner frame method,overcoming the low Doppler tolerance of the cross-correlation between frames,can obtain the coarse velocity of the high speed target,and then the precision velocity can be obtained with the range-Doppler coupling method.The simulation results confirm the method is effective,and also it is well real-time and easy to the project application. | Guifen Xia Hongyan Su Peikang Huang | 2010 | Journal of Systems Engineering and Electronics2010，21，5： | 5 |
| 4 | Weaving 3D highly conductive hierarchically interconnected nanoporous web by threading MOF crystals onto multi walled carbon nanotubes for high performance Li-Se battery显示文摘Lithium-selenium(Li-Se)battery has attracted growing attention.Nevertheless,its practical application is still impeded by the shuttle effect of the formed polyselenides.Herein,we report in-situ hydrothermal weaving the three-dimensional(3 D)highly conductive hierarchically interconnected nanoporous web by threading microporous metal organic framework MIL-68(Al)crystals onto multi-walled carbon nanotubes(MWCNTs).Such 3 D hierarchically nanoporous web(3 D MIL-68(Al)@MWCNTs web)with a very high surface area,a large amount of micropores,electrical conductivity and elasticity strongly traps the soluble polyselenides during the electrochemical reaction and significantly facilitates lithium ion diffusion and electron transportation.Molecular dynamic calculation confirmed the strong affinity of MIL-68(Al)for the adsorption of polyselenides,quite suitable for Li-Se battery.Their hexahedral channels(1.56 nm)are more efficient for the confinement of polyselenides and for the diffusion of electrolytes compared to their smaller triangular channels(0.63 nm).All these excellent characteristics of 3 D MIL-68(Al)@MWCNTs web with suitable confinement of a large amount of selenium and the conductive linkage between MIL-68(Al)host by MWCNTs result in a high capacity of 453 m Ah/g at 0.2 C with 99.5%coulombic efficiency after 200 cycles with significantly improved cycle stability and rate performance.The 3 D MIL-68(Al)@MWCNTs web presents a good performance in Li-Se battery in term of the specific capacity and cycling stability and also in terms of rate performance compared with all the metal-organic framework(MOF)based or MOF derived porous carbons used in Li-Se battery. | Chao Li Yingying Wang Hongyan Li Jing Liu Jianping Song Luca Fusaro Zhi-Yi Hu Yanxin Chen Yu Li Bao-Lian Su | 2021 | Journal of Energy Chemistry2021，30，8： | 4 |
| 5 | Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma显示文摘Glioblastoma(GBM),one of the most common primary intracranial malignant tumours,is very difficult to be completely excised by surgery due to its irregular shape.Here,we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles(SPIONs)modified with indocyanine(Cy7)molecules and peptides(ANG orDANG)to locate malignant gliomas and guide accurate excision.Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro. | Ruoxi Xie Zijun Wu Fanxin Zeng Huawei Cai Dan Wang Lei Gu Hongyan Zhu Su Lui Gang Guo Bin Song Jinxing Li Min Wu Qiyong Gong | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 3 |
| 6 | The families Distoseptisporaceae fam.nov.,Kirschsteiniotheliaceae,Sporormiaceae and Torulaceae,with new species from freshwater in Yunnan Province,China显示文摘During a north–south latitudinal survey of aquatic fungi on submerged wood and herbaceous material in streams in the Asian region,we collected several hyphomycetous taxa.This paper is part of a series where we provide illustrated accounts of these taxa and place them in a natural classification in the fungi.DNA sequence based phylogenies in recent literature have shown that Dendryphion,Sporidesmium and Torula-like species are polyphyletic in the phylum Ascomycota and their taxonomyhas been problematic due to a lack of understanding of the importance of morphological characters used to delimit taxa,as well as the lack of ex-type or reference strains.Based on multi-locus phylogenies together with morphology,we propose the novel family Distoseptisporaceae(Sordariomycetes)and three novel genera Neotorula(Pleosporales,Dothideomycetes),Distoseptispora(Sordariomycetes)and Pseudosporidesmium(Sordariomycetes).In addition,Dendryphion aquaticum,D.submersum,Distoseptispora fluminicola,D.aquatica,Kirschsteiniothelia submersa,Neotorula aquatica,Sporidesmium aquaticum,S.submersum and S.fluminicola are introduced as new species.Pseudosporidesmium knawiae comb.nov.is proposed to accommodate Sporidesmium knawiae in Sordariomycetes.The polyphyletic nature of Dendryphion,Sporidesmium and Torula-like species are partially resolved,but further sampling with fresh collections and molecular data of species are needed to obtain a natural classification. | HongYan Su Kevin D.Hyde Sajeewa S.N.Maharachchikumbura Hiran A.Ariyawansa ZongLong Luo Itthayakorn Promputtha Qing Tian ChuanGen Lin QiuJu Shang YongChang Zhao HongMei Chai XiaoYing Liu Ali H.Bahkali Jayarama D.Bhat Eric H.C.McKenzie DeQun Zhou | 2016 | Fungal Diversity2016，，5： | 2 |
| 7 | Association between gene polymorphisms of vitamin D receptor and pulmonary tuberculosis susceptibility:a meta-analysis显示文摘Background:The vitamin D receptor(VDR) gene is a primary candidate gene for tuberculosis susceptibility,but results of previous studies are somewhat contradictory and underpowered.Thus,it is essential to further explore the association between VDR gene polymorphisms and risk of pulmonary tuberculosis(PTB).Methods:A systematic review and meta-analysis about the association between FokI,TaqI,ApaI and BsmI polymorphisms and PTB susceptibility was conducted.Statistical Package for Social Science(Version 13.0) and Review Manager(Version 4.2,The Cochrane Collaboration) were used to analyze the data reported in studies.Results:A total of 13 studies with 2 262 cases and 2 833 controls were involved in the FokI polymorphism,and the results showed FokI polymorphism was associated with PTB susceptibility(allele f vs F:OR=1.12,95% CI=[1.02,1.23];the additive effect model ff vs FF:OR=1.40,95%CI=[1.10,1.77];the recessive genetic model ff vs Ff+FF:OR=1.39,95%CI=[1.12,1.71]).No significant associations were observed between TaqI(15 studies with 3 031 cases and 3 132 controls),ApaI(7 studies with 1 495 cases and 1 922 controls),BsmI(6 studies with 919 cases and 1 250 controls) variants and PTB susceptibility.Conclusion:We found variant FokI polymorphism of VDR gene may play a risky role in PTB development,and the genetic model was presumed to be recessive. | Su Qian Ma Xiangyu Lin Hui Li Ying Hu Daiyu Xiong Hongyan Xu Rufu Li Yafei | 2011 | Journal of Medical Colleges of PLA(China)2011，26，2： | 2 |
| 8 | Three-dimensional ordered hierarchically porous carbon materials for high performance Li-Se battery显示文摘Developing host materials with high specific surface area, good electron conductivity, and fast ion transportation channel is critical for high performance lithium-selenium(Li-Se) batteries. Herein, a series of three dimensional ordered hierarchically porous carbon(3D OHPC) materials with micro/meso/macropores are designed and synthesized for Li-Se battery. The porous structure is tuned by following the concept of the generalized Murray’s law to facilitate the mass diffusion and reduce ion transport resistance.The optimized 3D Se/OHPC cathode exhibits a very high 2 nd discharge capacity of 651 m Ah/g and retains 361 m Ah/g after 200 cycles at 0.2 C. Even at a high current rate of 5 C, the battery still shows a discharge capacity as high as 155 m Ah/g. The improved electrochemical performance is attributed to the synergy effect of the interconnected and well-designed micro, meso and macroporosity while shortened ions diffusion pathways of such Murray materials accelerate its ionic and electronic conductivities leading to the enhanced electrochemical reaction. The diffusivity coefficient in Se/OHPC can reach a very high value of 1.3 × 10^(-11)cm^(2)/s, much higher than those in single pore size carbon hosts. Their effective volume expansion accommodation capability and reduced dissolution of polyselenides ensure the high stability of the battery. This work, for the first time, established the clear relationship between textural properties of cathode materials and their performance and demonstrates that the concept of the generalized Murray’s law can be used as efficient guidance for the rational design and synthesis of advanced hierarchically porous materials and the great potential of 3D OHPC materials as a practical high performance cathode material for Li-Se batteries. | Hongyan Li Wenda Dong Chao Li Tarek Barakat Minghui Sun Yingying Wang Liang Wu Lang Wang Lei Xia Zhi-Yi Hu Yu Li Bao-Lian Su | 2022 | Journal of Energy Chemistry2022，31，5： | 1 |
| 9 | Adsorption of Ag^+ by a surface molecular-imprinted biosorbent显示文摘 | HUO Hongyan SU Haijia TAN Tianwei | 2009 | Chemical Engineering Journal2009，150，1： | 1 |
| 10 | The ecology of nematode-trapping hyphomycetes in cattle dung from three plateau pastures显示文摘 | Hongyan Su Yu'e Hao Minghe Mo | 2007 | Veterinary Parasitol2007，144，： | 1 |
| 11 | In vitro acute cytotoxicity of the neonicotinoid insecticide acetamiprid to FG cells, the gill cell line of flounder Paralichthy olivaceus显示文摘The in vitro acute cytotoxicity of the neonicotinoid insecticide acetamiprid to FG cell line, derived from the gill of flounder Paralichthys olivaceus, was tested by the three widely used endpoint bioassays-neutral red (NR) assay, tetrazolium (MTT) assay and cell protein assay. It was found that acetamiprid was increasingly toxic to FG cells at concentrations of 1 μg/cm^3 or above, and the inhibitory concentration 50% values for NR, MTT, and cell protein assays were 38.38, 36.27 and 32.03 μg/cm^3, respectively. This appeared to be the first report on the in vitro cytotoxicity of acetamiprid to non-mammalian vertebrate cells. Ultrastructural examination revealed that for the cells exposed to 60 μg/cm^3 acetamiprid for 48 h, their mitochondria were severely damaged with the cristae swelled up or disrupted, while their nuclei and rough endoplasmic reticlum (RER) appeared to be still normal. This suggests that mitochondria are possibly the primary target of acetamiprid. | SU Feng ZHANG Shicui YANG Ming LI Hongyan | 2006 | Acta Oceanologica Sinica2006，25，5： | 1 |
| 12 | Tea Polyphenols Reducing Lipopolysaccharide-induced Inflammatory Responses in RAW264.7 Macrophages via NF-κB Pathway显示文摘The anti-inflammatory activity of tea polyphenols(TPs)in RAW264.7 macrophages stimulated by lipopolysaccharide(LPS)was investigated in this paper.RAW264.7 macrophages were treated with different concentrations of TP(0,12.5,25,50,100,and 200μg/mL)and then stimulated by LPS.Another blank control group was set up.The expression of pro-inflammatory cytokines associated with the nuclear factor-kappa B(NF-κB)signaling pathway was investigated before and after TP treatment.Pretreatment of RAW264.7 cells with TP decreased the expression of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin 1 beta(IL-1β)pro-inflammatory cytokines.In addition,TP inhibited the phosphorylation of p65 and IκB by blocking the phosphorylation and the degradation of NF-κB inhibitor protein.In conclusion,TP exerts anti-inflammatory effects by regulating the release of inflammatory mediators via the NF-κB signaling pathway. | SU Siyi LI Xiaoyu GUO Xu ZHOU Ruiming LI Manman MING Pengfei HUANG Yingying Sajid Ur RAHMAN DING Hongyan FENG Shibin LI Jinchun WANG Xichun LI Yu WU linjie | 2019 | Chemical Research in Chinese Universities2019，35，6： | 1 |
| 13 | Adsorption of Ag^+ by a surface molecular-imprinted biosorbent显示文摘 | Huo Hongyan Su Hanjia Tan Tianwei | 2009 | Chemical Engineering Journal2009，150，1： | 1 |
| 14 | Ligase-based ultrasensitive detection of DNAzyme cleavage product using molecular beacon显示文摘为劈开通常需要的 deoxyribozyme (DNAzyme ) 的察觉建筑群并且费时间的光线的标记,胶化电气泳动和 autoradiography。一条新途径基于分子的烽火(MB ) 为察觉 DNAzyme 劈开产品被报导。MB 的环的部分被设计到对 DNAzyme 补足劈开产品。MB 被采用监视复杂的 RNA/DNA 的结扎过程并且直接把劈开产品信息变换成荧光信号。试金的察觉限制是 0.02 nmol/L。对 HCV-RNA 的 817 DNAzyme 的劈开产品基于这试金完美地被检测。方法是快的,简单并且 ultrasensitive,它在 DNAzyme 反应的力量抓住伟人诺言和 DNAzyme 基因治疗。 | Hong Peng Xie Xiang Xian Meng Hongyan Su Qing Yun Cai Yong Jun Tan Xiao Qin Huang | 2012 | Chinese Chemical Letters2012，23，10： | 1 |
| 15 | Development of strain-specific SCAR markers for authentication of Ganoderma lucidum显示文摘 | Su Hongyan Wang Lei Ge Yihe | 2008 | World Journal of Microbiology and Biotechnology2008，24，7： | 1 |
| 16 | Heavy metal tolerance of nematode-trapping fungi in lead- polluted soils显示文摘 | MO Minghe CHEN Weimin SU Hongyan | 2006 | Applied Soil Ecology2006，31，： | 1 |
| 17 | Genome-wide analysis and identification of stress-responsive genes of the NAM–ATAF1,2–CUC2 transcription factor family in apple显示文摘 | Hongyan Su Shizhong Zhang Xiaowei Yuan Changtian Chen Xiao-Fei Wang Yu-Jin Hao | 2013 | Plant Physiology and Biochemistry2013，，： | 1 |
| 18 | Ecology of aquatic nematode-trapping hyphomycete in southwestern china显示文摘 | HAO Yu' e SU Hongyan MO Minghe | 2005 | Aquat Mycrob Ecol2005，40，2： | 1 |
| 19 | Heterogeneous hydroxylation catalyzed by multi-walled carbon nanotubes at low temperature 显示文摘 | Kang Zhenhui Wang Enbo Mao Baodong Su Zhongmin Gao Lei Niu Li Shan Hongyan Xu Lin | 2006 | Applied Catalysis A: General2006，299，： | 1 |
| 20 | Declaring Tess’s Tragedy显示文摘 | hongyan Su | 2014 | 卷宗2014，4，2： | 0 |
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