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| 1 | Open globe injury in Hospital Universiti Sains Malaysia- a 10-year review显示文摘AIM:To identify the aetiology of open globe injuries at Hospital Universiti Sains Malaysia over a period of 10y and the prognostic factors for visual outcome.METHODS:Retrospective review of medical records of open globe injury cases that presented from January2000 to December 2009.Classification of open globe injury was based on the Birmingham Eye Trauma Terminology(BETT).Records were obtained with hospital permission via the in-house electronic patient management system,and the case notes of all patients with a diagnosis of open globe injury were scrutinised.Patients with prior ocular trauma,pre-existing ocular conditions affecting the visual acuity,contrast sensitivity,central vision or corneal thickness,as well as those with a history of previous intraocular or refractive surgery were excluded.Analysis of data was with SPSS version20.0.Ordinal logistic regression analysis was used to examine the association between prognostic factors and visual outcome.RESULTS:This study involved 220 patients(n=222eyes).The most common place of injury was the home(51.8%),followed by the workplace(23.4%).Among children aged less than 16y of age,domestic-related injury was the predominant cause(54.6%),while in those aged 16y and above,occupational injuries were the most common cause(40.0%).Most eyes(76.5%)had an initial visual acuity worse than 3/60,and in half of these,the visual acuity improved.The visual outcome was found to be significantly associated with the initial visual acuity(P<0.005),posterior extent of wound(P<0.001),length of wound(P<0.001),presence of hyphaema(P<0.001)and presence of vitreous prolapse(P<0.005).CONCLUSION:The most common causes of open globe injury are domestic accidents and occupational injuries.Significant prognostic factors for final visual outcome in patients with open globe injury are initial visual acuity,posterior extent and length of wound,presence of hyphaema and presence of vitreous prolapse.Awareness of the factors predicting a poor visual outcome may be helpful during counselling of patients with open globe injuries. | Madhusudhan A/L Paramananda Evelyn-Tai Li Min Zamri Noordin Adil Hussein Wan-Hazabbah Wan Hitam | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 9 |
| 2 | 眼部鞭炮损伤的系列病例显示文摘小儿获得性单眼盲值得急切的关注。这类盲通常是由于眼球机械性损伤所致,说明机械性损伤是其首要的致盲原因。绝大多数眼外伤是意外的,而且是机械性的损伤。鞭炮是一个潜在的单眼盲的原因。其损伤类型多样,有的比较轻微,有的则比较严重,有穿通伤、钝挫伤、化学烧伤或热烧伤。常导致不可逆的视力损害。而这是可以预防的。增强公众对此的防范意识是预防鞭炮导致眼损伤的一个主要措施。 | Rohana Abdul Rashid Azlyn Azwa Jasman Mohtar Ibrahim Shatriah Ismail Wan Hazabbah Wan Hitam | 2008 | 国际眼科杂志2008，8，3： | 5 |
| 3 | 急性视神经炎后视神经功能与视觉诱发电位的研究(英文)显示文摘目的:比较视神经炎患者和正常人的视神经功能与视觉诱发电位。方法:本研究为2011年9月至2013年2月在马来西亚大学眼科医院进行的横断面研究。研究包含在检查前3mo至2y间发生特发性神经炎一次的视神经炎患者20例和10例正常人。眼科检查包括视力、色觉、视觉灵敏度、视野和视觉诱发电位。独立t检验用于比较视神经炎组与对照组视神经功能和VEP参数的差异。在参数非正态分布时,Mann-Whitney试验用于比较两组间的中位数。结果:视神经炎组的平均年龄为30.8岁。在视神经炎发作至评估期间的平均持续时间为6.6个月。视神经炎组视力较差,平均LogM AR值(0.52)明显高于对照组(P=0.001)。色觉下降,视神经炎组的平均值为63%(P=0.001)。视神经炎患者的对比敏感度在四个空间频率上均有所下降[3CPD(P=0.029),6CPD(P=0.026),12CPD(P=0.002)、18CPD(P=0.006)]。视神经炎组的视野下降有统计学意义(P<0.001)。与对照组相比,视神经炎组的VEP P100潜伏期有轻微延长。但使用棋盘格模式1或2时,VEP潜伏期的差异不显著。视神经炎患者的VEP振幅较高,但两组差异无统计学意义。结论:视神经炎急性发作,平均6mo后视神经功能(即视力、色觉、对比敏感度和视野)显著下降。视神经炎组和对照组的VEP振幅和潜伏期无显著差异。VEP可能不是理想的诊断视神经炎既往发作史的试验,尽管VEP参数在浮动后趋于正常。 | Evelyn Tai Li Min Ng Seok Hui Jakiyah Daud Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam | 2017 | 国际眼科杂志2017，17，5： | 5 |
| 4 | 影响增殖性糖尿病视网膜病变玻璃体切除术后视力改善的因素(英文)显示文摘目的:分析影响增殖性糖尿病视网膜病变(PDR)玻璃体切除术后视力改善的因素。方法:回顾性分析。收集2014-01/2014-12在马来西亚吉打州,亚罗士打Sultanah Bahiyah医院收治的PDR行玻璃体切除术病例资料,包括1y内患者统计,基线视力(VA)和LogMAR术后最佳矫正视力。使用IBM SPSS Statistics Version 22.0进行数据分析。结果:共103例患者。平均年龄51.2y。在多变量分析中,每个0 logMAR基线VA的1 logMAR术前正偏差与0.859logMAR的术后改善相关(P<0.001)。同样,术前附着的黄斑与玻璃体切除术后的logMAR视力改善相关(b=0.374,P=0.003)。无虹膜新血管和无术后并发症与玻璃体切除术后改善的logMAR视力相关,分别为1.126(P=0.001)和0.377(P=0.005)。无长效眼内填充与玻璃体切除术后logMAR视力改善相关,为0.302(P=0.010)。结论:玻璃体切除术后与视力改善的相关因素是:术前视力较差,黄斑附着,无虹膜新生血管,无术后并发症和未使用长效眼内填充物。了解视力改善的因素将有助于玻璃体视网膜手术的决策。 | Evelyn Tai Li Min Goh Yihu Wan-Hazabbah Wan Hitam Haslina Mohd Ali | 2017 | 国际眼科杂志2017，17，8： | 4 |
| 5 | Bilateral atypical optic neuritis associated with tuberculosis in an immunocompromised patient显示文摘A 27 year-old lady,presented with sudden loss of vision in the right eve tor a week.It was followed In poor vision in the left eye alter 3 days.It involved the whole entire visual field and was associated with pain on eye movement.She was diagnosed to have miliary tuberculosis and retroviral disease 4 months ago.She was started on anti-TB since then but defaulted highly active anti-retroviral therapy(HAART).On examination.her visual acuity was no perception of light in the right eye and 6/120(pinhole 3/60) in the lelt eye.Anterior segment in both eyes was unremarkable.Funduscopy showed bilateral optic disc swelling with presence ot multiple foci of choroiditis in the peripheral retina.The vitreous and relinal vessels were normal.Chest radiography was normal.CT scan of orbit and brain revealed bilateral enhancement of the optic nerve sheath that suggest the diagnosis of bilateral atypical optic neuritis.This patient was managed with infectious disease team.She was started on HAART and anti-TB treatment was continued.She completed anti-TB treatment alter 9 months without any serious side effects.During follow up the visual acuity in both eyes was not improved.However.funduscopy showed resolving ol disc swelling and choroiditis following treatment. | Juanarita Jaafar Wan Hazabbah Wan Hitam Raja Azmi Mohd Noor | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，7： | 3 |
| 6 | 马来西亚视神经萎缩的临床特点及病因(英文)显示文摘目的:研究在马来西亚非青光眼视神经萎缩的病因及临床特点。方法:一系列回顾性的研究分析马来西亚理科大学校医院眼诊所在2007/2011年间被诊断为非青光眼视神经萎缩的患者。至少随访1a。评估这些患者的医疗记录及汇编调查结果。结果:100例患者符合选择标准,56%的患者双眼都参与研究。主要症状为视力模糊(61%),除了视力模糊外还出现神经方面病症(18%),视野狭窄(9%)。大多数患者(63%)患眼视力下降到3/60以下。主要的病因是颅内占位性病变(26%),先天性疾病(13%),脑积水(12%),创伤(12%)及血管因素(12%)。对大多数患者(67%)采用保守治疗。不管其病因,视神经萎缩都伴有不同程度的视功能障碍。随访1a后,50%的患者出现不同程度的视觉障碍。结论:视神经萎缩主要的病因是颅内占位性病变,其次分别是先天性疾病,创伤和血管疾病。在诊断之前常常就出现视觉和神经上的症状,而疾病显著地影响着视力的变化。为了早期诊断视神经萎缩,当视力模糊的主诉为非特异性时,应该高度怀疑本病。 | Evelyn Tai Li Min Jessica Mani Penny Tevara Zunaina Embong Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam | 2014 | 国际眼科杂志2014，14，2： | 2 |
| 7 | 在结核病患者中通过评估解剖结构和视功能变化早期发现乙胺丁醇毒性(英文)显示文摘目的:通过评估比较治疗前后解剖结构和视功能的变化,包括视网膜神经纤维厚度、图形视觉诱发电位、传统视神经功能检查,早期检测乙胺丁醇毒性。方法:前瞻性研究,包括参加马来西亚理科大学医院的短期治疗观察项目的36例72眼结核病患者。视力和视神经功能检查由同一位研究者进行。同样,Humphrey自动视野检查、光学相干断层扫描(OCT)检查视网膜神经纤维厚度(RNFL)和图形视觉诱发电位(PVEP)均由同一位技术人员进行。在开始乙胺丁醇治疗前和治疗3mo后各进行检查一次。结果:乙胺丁醇治疗前后视力、彩色视觉、光亮度、红光反射和眼底检查无明显改变。然而,平均视野缺损在治疗后较前变差(P=0.010)。OCT和PVEP有显著变化,P100潜伏期延长、幅度降低,RNFL在各个象限均增厚(P<0.05)。结论:通过OCT检测RNFL厚度以及使用PVEP检测P100波峰潜伏期和幅度,可以在传统视神经功能检查异常之前,发现乙胺丁醇治疗后早期解剖结构和视功能的亚临床改变。 | Jessica Mani Penny Tevaraj Tan Chai Keong Evelyn Tai Li Min Muhammed Julieana Raja Azmi Mohd Noor Wan-Hazabbah Wan Hitam | 2017 | 国际眼科杂志2017，17，11： | 2 |
| 8 | 急性突眼发作继发于皮下脂膜炎样T细胞淋巴瘤1例(英文)显示文摘目的:报告罕见突眼急性发作病例继发于皮下脂膜炎样T细胞淋巴瘤(SPTCL)1例。方法:病例报告。结果:患者,男,27岁,马来人,左眼眼球突出急性发病2wk。伴随长期高烧病史。在此期间他的身体和双大腿还多发肿胀红斑。双眼视力为6/6。左眼眼球突出和球结膜水肿。各个方向眼外运动受限。角膜和眼前段正常。眼底检查显示正常视盘和视网膜。右眼检查为正常。体温40.0℃,全身多发皮下红斑病灶主要分布在左腋下、右季肋部、双大腿和耻骨上区。腹股沟淋巴结也是可触及的。脑磁共振成像显示左冠外和眶后广泛软组织肿胀,暗示着炎症反应。海绵窦和大脑正常。红斑病灶处皮肤切片揭示为SPTCL。其被提交给血液病医师,并开始CHOP方案化疗。患者化疗反应良好,眼球突出复位。结论:眼球突出继发于SPTCL是非常罕见的。这是一个外周T细胞淋巴瘤的变异,特点是多发皮下结节表现为眼球突出和发烧。 | Hayati Abdul Aziz Loh Swee Seng Choon Slew Eng Wan Hazabbah Wan Hitam | 2010 | 国际眼科杂志2010，10，7： | 2 |
| 9 | 梅毒性葡萄膜炎3例(英文)显示文摘目的:评估梅毒性葡萄膜炎患者的临床表现和视力。方法:梅毒性葡萄膜炎患者3例在USM医院接受治疗。结果:患者3例被诊断为继发性梅毒性葡萄膜炎,这3例患者患病之前均不知道患有梅毒,但他们有明确的乱交史。并且每个月都伴有逐步的视力下降。其中两人伴有发热、眼痛、眼前悬浮物。视力从6/12到手动。所有患者均出现前葡萄膜炎,玻璃体炎和视神经炎。第一例患者出现了多灶性脉络膜视网膜炎,并伴有渗出性视网膜脱离。第二例患者出现渗出性视网膜脱离,而第三例患者仅出现了脉络膜视网膜炎。所有患者每周注射苄青霉素2.4MU,共4wk,其中2例患者口服多西霉素200mg2次/d,共3mo。治疗效果良好,其中2例患者有显著的视力上升,分别从6/120到6/21和6/12到6/6。其中较严重的1例患者出现逆转录酶为阳性。结论:眼梅毒作为非肉芽肿性的炎症与渗出性视网膜脱离有关。治疗后虽然视力恢复比较缓慢,但普遍有良好的效果。 | Shin Wei Pan Nor Sharina Yusof Wan Hazabbah Wan Hitam Raja Azmi Mohd Noor Zunaina Embong | 2010 | 国际眼科杂志2010，10，12： | 1 |
| 10 | Traumatic optic neuropathy:a review of 24 patients显示文摘AIM:To evaluate the clinical presentations of traumatic optic neuropathy and to assess the visual outcome of three groups of patients managed differently(conservative, intravenous corticosteroids only and combination of intravenous and oral corticosteroids)at an academic tertiary care referral centre. METHODS:A retrospective study was conducted involving 24 consecutive patients(27 eyes)with traumatic optic neuropathy attending Hospital Universiti Sains Malaysia from January 2007 till December 2009. RESULTS:Twenty-four patients(27 eyes)were included. All cases involved were males.Mean age was 33 years old. Motor vehicle accident was the major cause(83.3%).Both eyes were equally involved.Most of the eyes had poor vision on presentation(HM-NPL,81.5%)with associated periorbital haematoma(22 eyes)and subconjunctival haemorrhage(20 eyes).Majority of patients(19 patients,79.2%)presented with more than one bony fracture of skull or orbit and 5 patients(20.8%)had no fractures.None of the patients had evidence of optic nerve compression on CT scans or MRI done.Eleven patients(45.8%)had been treated with intravenous and oral corticosteroids.The other 7 patients (29.2%)were treated conservatively and the third group(6 patients,25.0%)was on intravenous corticosteroids only. Eleven of 12 eyes(91.7%)treated with intravenous and oral corticosteroids had shown 1 line improvement of visual acuity. Those eyes treated conservatively(77.8%)had shown 1 line improvement of visual acuity.As for patients treated with intravenous corticosteroids only,four patients remained NPL, one patient had mild visual improvement and the other one’s vision remained the same.The visual improvement in patients treated with conservative management was not significant (P=0.386).Patients treated with intravenous corticosteroids alone have shown no visual improvement statistically(P<0.05).Patients treated with intravenous followed by oral corticosteroids had significant visual improvement(P<0.05). There was no statistically significant difference in visual outcome between patients treated with corticosteroids and patients treated conservatively(P=0.368).No patient underwent surgical decompression of the optic nerve.In this series,the follow up ranges from 6 months to 3 years. CONCLUSION:Most of the traumatic optic neuropathy patients presented with periorbital haematoma,subconjunctival haemorrhage and orbital wall fractures.Patients treated with intravenous followed by oral corticosteroids have better visual outcome compared to conservative management. | Kok Foo Lee Nor Idahriani Muhd Nor Azhany Yaakub Wan Hazabbah Wan Hitam | 2010 | International Journal of Ophthalmology(English edition)2010，3，2： | 1 |
| 11 | 罕见梅毒性视神经周围炎1例(英文)显示文摘目的:报告1例罕见的由梅毒感染引起的视神经周围炎,经皮质类固醇治疗后严重视力缺损得到显著改善。方法:病例报告。结果:一名66岁马来裔女性患者来我院就诊,一眼突然出现视力缺损,动眼时有疼痛感。视力无光感,右眼出现相对性瞳孔传入缺陷(relative afferent pupillary defect,RAPD)。血清学和放射学检查证明为梅毒性视神经周围炎。肌肉注射苄星青霉素,静脉注射甲基醋酸泼尼松龙,然后长期口服类固醇,剂量逐渐降低。经过治疗,患者视力明显提高,恢复到6/18。随访4mo,未出现复发和类固醇相关的副作用。结论:本病诊断正确、治疗及时,能使患者视力得到显著改善。 | Azlyn Azwa Jasman Azreen Redzal Anuar Rohana Abdul Rashid Wan Hazabbah Wan Hitam | 2008 | 国际眼科杂志2008，8，6： | 1 |
| 12 | Ocular burns and related injuries due to fireworks during the Aidil Fitri celebration on the East Coast of the Peninsular Malaysia显示文摘 | Rasdi Abd Rashid Fatemeh Heidary Adil Hussein Wan Hazabbah Wan Hitam Rohana Abd Rashid Zulkifli Abd Ghani Nor Anita Che Omar Zuraidah Mustari Ismail Shatriah | 2010 | Burns2010，，1： | 1 |
| 13 | 外伤性视神经病变24例回顾研究(英文)显示文摘目的:探讨的外伤性视神经病变的临床表现,评估在眼科第三病区住院的经过三组不同处理(保守估计,单独静脉注射皮质类固醇,静脉注射和口服皮质类固醇联合治疗)的外伤性视神经病变患者的治疗效果。方法:对2007-01/2009-12在马来西亚医科大学眼科连续住院的24例27眼外伤性视神经患者进行了回顾性研究。结果:本次研究对象为24例27眼男性外伤性视神经患者(平均年龄为33岁)。车祸是导致发病的主要原因(83%)。大部分患者的视力低下(手动/眼前~无光感约占82%),其中有22眼并发眶周血肿,20眼并发有结膜下出血。并发多于一骨(颅骨或眶骨)骨折有19例(79%),5例(21%)没有出现骨折。CT扫描或核磁共振检查显示患者均没有视神经压迫的证据。第一组: 11例(46%)患者进行静脉注射联合口服类固醇的治疗;第二组:7例患者(29%)进行保守治疗;第三组:6例(25%)患者给予静脉注射皮质类固醇治疗。92%(11/12眼)给予静脉注射和口服类固醇治疗的患者和78%保守治疗患者视力能提高1行。单独静脉注射皮质类固醇治疗的患者4例呈现无光感,1例有轻度视力改善,而其他患者视力保持不变。保守治疗患者和单独静脉注射皮质类固醇患者视力改善不显著,且两组间相比在统计学上无显著性差异(P=0.368)。静脉注射联合口服类固醇治疗的患者有明显的视觉改善(P<0.05)。没有患者接受视神经减压手术。在本研究中,随访时间为6mo~3a。结论:大部分外伤性视神经病变患者都存在有眶周血肿,结膜下出血,眶壁骨折的症状。对比保守治疗,经过静脉注射和口服皮质类固醇联合治疗的患者有更好的治疗效果。 | Kok Foo Lee Nor Idahriani Muhd Nor Azhany Yaakub Wan Hazabbah Wan Hitam | 2010 | 国际眼科杂志2010，10，6： | 1 |
| 14 | Specific detection of fungal pathogens by 18S rRNA gene PCR in microbial keratitis显示文摘 | Embong Z Wan Hitam WH Yean CY | 2008 | BMC Ophthalmol2008，8，： | 1 |
| 15 | FDI, Growth and The Environment: Im- pact on Quality of Life in Malaysia显示文摘 | Hitam M B Borhanb H B | 2012 | Procedia--Social and Behavior- al Sciences2012，，50： | 1 |
| 16 | Current statut of Elaeidobius kamerunicus Faust and its effects on the oil palm industry in Malaysia 显示文摘 | Basil MW Halim AH Hitam AH | 1983 | Palm Oil Research Institute of Malaysia1983，6，： | 1 |
| 17 | Multi-wave- length fiber laser with enhanced reverse-S-shaped feedback coupling assisted by out-of-cavity optical amplifier显示文摘 | Abd Abd Rahman Z Hitam AI-Mansoori | 2011 | Op- tics Express2011，19，21： | 1 |
| 18 | Muhi-wavelength fiber laser with enhanced re- verse-S-shaped feedback coupling assisted by out-of-cavity optical amplifier 显示文摘 | Rahman Z Abd Hitam S A1-Mansoori M H | 2011 | Optics Express2011，19，21： | 1 |
| 19 | Hybrid fiber-to-the-x and free space optics for high bandwidth access networks显示文摘 | Anas S.B Ahmad Hamat F.H Hitam S | | 0，，01： | 1 |
| 20 | Multiwavelength brillou in fiber laser with enhanced reverse-S-shaped feedback coupling assisted by out-of-cavity optical amplifier显示文摘 | Abd Rahman Z A Hitam S Al-Mansoori M H | 2011 | Optics Express2011，19，21： | 1 |
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