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| 1 | Human RELM beta is a mitogenic factor in lung cells and induced in hypoxia显示文摘 | Renigunta A Hild C Rose F | 2006 | FEBS Lett2006，580，3： | 1 |
| 2 | Treatment of ovarian cancer using intraperitoneal chemotherapy with taxanes: From laboratory bench to bedside显示文摘 | Eelco de Bree Panayiotis A. Theodoropoulos Hilde Rosing John Michalakis John Romanos Jos H. Beijnen Dimitris D. Tsiftsis | 2006 | Cancer Treatment Reviews2006，，6： | 1 |
| 3 | Determination of 9-nitro-camptothecin and its metabolite 9-amino-camptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection显示文摘 | Nadja E Schoemaker Hilde Rosing | 2002 | Journal of Chromatography B2002，775，： | 1 |
| 4 | The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry 显示文摘 | Elisabeth J Rook Michel J X Hillebrand Hilde Rosing et al | 2005 | Journal of Chromatography B2005，824，： | 1 |
| 5 | Human RELMbeta is a mitogenie aetor in lung cells and induced in hypoxia显示文摘 | Renigunta A Hild C Rose F | 2006 | FEBS Lett2006，580，： | 1 |
| 6 | Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia 显示文摘 | Renigunta A Hild C Rose F | 2006 | FEBS Lett2006，580，3： | 1 |
| 7 | Human RELMβ is a mitogenic factor in lung cells and induced in hypoxia显示文摘 | Renigunta A Hild C Rose F | 2006 | FEBS Lett2006，580，3： | 1 |
| 8 | Human RELM beta is a mitogenic factor in lung cells and induced in hypoxia 显示文摘 | RENIGUNTA A HILD C ROSE F | 2006 | FEBSLett2006，580，3： | 1 |
| 9 | Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia显示文摘 | Renigunta A Hild C Rose F | 2006 | FEBS Lett2006，580，3： | 1 |
| 10 | Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D显示文摘 | Carola W. N. Damen Hilde Rosing Jan H. M. Schellens Jos H. Beijnen | 2009 | Analytical and Bioanalytical Chemistry2009，，4： | 1 |
| 11 | Cytoreductive Surgery and Intraoperative Hyperthermic Intraperitoneal Chemotherapy with Paclitaxel: A Clinical and Pharmacokinetic Study显示文摘 | Eelco Bree MD Hilde Rosing PhD Dimitris Filis MD John Romanos MD Maria Melisssourgaki Markos Daskalakis MD Maria Pilatou Elias Sanidas MD Panagiotis Taflampas MD Konstantinos Kalbakis MD Jos H. Beijnen PhD Dimitris D. Tsiftsis MD | 2008 | Annals of Surgical Oncology2008，，4： | 1 |
| 12 | A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry显示文摘 | Carola W.N. Damen Hilde Rosing Matthijs M. Tibben Maria J. van Maanen Jurjen S. Lagas Alfred H. Schinkel Jan H.M. Schellens Jos H. Beijnen | 2008 | Journal of Chromatography B2008，，1： | 1 |
| 13 | Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection 显示文摘 | Nadja E Schoemaker Hilde Rosing | 2002 | J chromatography B Analyt Technol Biomed Life Sci2002，775，2： | 1 |
| 14 | Human RELMbeta is a mitogenic factor in lung cells and induced in hypoxia显示文摘 | Renigunta A Hild C Rose F | 2006 | FEBS Lett2006，580，3： | 1 |
| 15 | The quantitative analysis of heroin, methadone and their metabo- lites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry显示文摘 | Elisabeth J Rooka Michel J X Hillebrand Hilde Rosing | 2005 | Journal of Chromatography B2005，824，21： | 1 |
| 16 | Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism显示文摘The mammalian carboxylesterase 1(Ces1/CES1)family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids.To investigate the pharmacological and physiological roles of Ces1/CES1,we generated Ces1 cluster knockout(Ces1^(-/-))mice,and a hepatic human CES1 transgenic model in the Ces1^(-/-)background(TgCES1).Ces1^(-/-)mice displayed profoundly decreased conversion of the anticancer prodrug irinotecan to SN-38 in plasma and tissues.TgCES1 mice exhibited enhanced metabolism of irinotecan to SN-38 in liver and kidney.Ces1 and hCES1 activity increased irinotecan toxicity,likely by enhancing the formation of pharmacodynamically active SN-38.Ces1^(-/-)mice also showed markedly increased capecitabine plasma exposure,which was moderately decreased in TgCES1 mice.Ces1^(-/-)mice were overweight with increased adipose tissue,white adipose tissue inflammation(in males),a higher lipid load in brown adipose tissue,and impaired blood glucose tolerance(in males).These phenotypes were mostly reversed in TgCES1 mice.TgCES1 mice displayed increased triglyceride secretion from liver to plasma,together with higher triglyceride levels in the male liver.These results indicate that the carboxylesterase 1 family plays essential roles in drug and lipid metabolism and detoxification.Ces1^(-/-)and TgCES1 mice will provide excellent tools for further study of the in vivo functions of Ces1/CES1 enzymes. | Changpei Gan Jing Wang Alejandra Martínez-Chávez Michel Hillebrand Niels de Vries Joke Beukers Els Wagenaar Yaogeng Wang Maria C.Lebre Hilde Rosing Sjoerd Klarenbeek Rahmen Bin Ali Colin Pritchard Ivo Huijbers Jos H.Beijnen Alfred H.Schinkel | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 17 | Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar显示文摘Many anticancer drugs have an impaired bioavailability and poor brain penetration because they are substrates to drug efflux pumps such as P-glycoprotein and Breast Cancer Resistance Protein.Elacridar is a strong inhibitor of these two drug efflux pumps and therefore has great potential to improve oral absorption and brain penetration of many anticancer drugs.Currently,a clinical formulation of elacridar is unavailable and therefore the pharmaceutical development of a drug product is highly warranted.This also necessitates the availability of an analytical method for its quality control.A reverse-phase high-performance liquid chromatographic method with ultraviolet detection was developed for the pharmaceutical quality control of products containing elacridar as the active pharmaceutical ingredient.The analytical method was validated for linearity,accuracy,precision,selectivity,carry-over,stability of stock and reference solutions,stability of the final extract,stability-indicating capability and impurity testing.We found that elacridar is unstable in aqueous solutions that are exposed to light because a hydroxylation product of elacridar is formed.Therefore,sample solutions with elacridar must be protected from light. | Emilia Sawicki Michel J.Hillebrand Hilde Rosing Jan H.M.Schellens Bastiaan Nuijen Jos H.Beijnen | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 0 |
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