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| 1 | Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis显示文摘BACKGROUND To date, the histopathological parameters predicting the risk of lymph node (LN) metastases and local recurrence, associated mortality and appropriateness of endoscopic or surgical resection in patients with gastric neuroendocrine neoplasms type 1 (GNENs1) have not been fully elucidated. AIM To determine the rate of LN metastases and its impact in survival in patients with GNEN1 in relation to certain clinico-pathological parameters. METHODS The PubMed, EMBASE, Cochrane Library, Web of Science and Scopus databases were searched through January 2019. The quality of the included studies and risk of bias were assessed using the Newcastle-Ottawa Scale (NOS) in accordance with the Cochrane guidelines. A random effects model and pooled odds ratios (OR) with 95%CI were applied for the quantitative meta-analysis. RESULTS We screened 2933 articles. Thirteen studies with 769 unique patients with GNEN1 were included. Overall, the rate of metastasis to locoregional LNs was 3.3%(25/769). The rate of LN metastases with a cut-off size of 10 mm was 15.3% for lesions > 10 mm (vs 0.8% for lesions < 10 mm) with a random-effects OR of 10.5 (95%CI: 1.4 -80.8;heterogeneity: P = 0.126;I2 = 47.5%). Invasion of the muscularis propria was identified as a predictor for LN metastases (OR: 17.2;95%CI: 1.8-161.1;heterogeneity: P = 0.165;I2 = 44.5%), whereas grade was not clearly associated with LN metastases (OR: 2;95%CI: 0.3-11.6;heterogeneity: P = 0.304;I2 = 17.4%). With regard to GNEN1 local recurrence, scarce data were available. The 5-year disease-specific survival for patients with and without LN metastases was 100% in most available studies irrespective of the type of intervention. Surgical resection was linked to a lower risk of recurrence (OR: 0.3;95%CI: 0.1-1.1;heterogeneity: P = 0.173;I2 = 31.9%). The reported complication rates of endoscopic and surgical intervention were 0.6 and 3.8%, respectively. CONCLUSION This meta-analysis confirms that tumor size ≥ 10 mm and invasion of the muscularis propria are linked to a higher risk of LN metastases in patients with GNEN1. Overall, the metastatic propensity of GNEN1 is low with favorable 5- year disease-specific survival rates reported;hence, no clear evidence of the prognostic value of LN positivity is available. Additionally, there is a lack of evidence supporting the prediction of local recurrence in GNEN1, even if surgery was more often a definitive treatment. | Apostolos V Tsolakis Athanasia Ragkousi Miroslav Vujasinovic Gregory Kaltsas Kosmas Daskalakis | 2019 | World Journal of Gastroenterology2019，25，35： | 6 |
| 2 | Pancreatic fistula: definition and current problems显示文摘 | Giovanni Butturini Despoina Daskalaki Enrico Molinari Filippo Scopelliti Andrea Casarotto Claudio Bassi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，3： | 3 |
| 3 | Pregnancy outcome after multifetal pregnancy reduction显示文摘 | Antsaklis A Souka AP Daskalakis G | 2004 | J Matern Fetal Neonatal Med2004，16，： | 1 |
| 4 | GM1 ganglioside in Parkinson' s disease: Results of a five year open study显示文摘 | Schneider JS Sendek S Daskalakis C | 2010 | J Neu- rol Sci2010，292，12： | 1 |
| 5 | Pancreatic fistula:definition and current problems显示文摘 | Butturini G Daskalaki D Molinari E | 2008 | J Hepatobiliary Pancreat Surg2008，15，： | 1 |
| 6 | New targets for rTMS in depression:areview of convergent evidence显示文摘 | Downar J Daskalakis ZJ | 2013 | Brain Stimulat2013，6，3： | 1 |
| 7 | Assesgment of the effect of surgery on the kinetics of circulating tumour cells in patients with operable breast cancer based on cytokeratin-19 mENA detectien显示文摘 | Daskalakis M Mavroudis D | 2011 | Eur J Surg Oncol2011，37，5： | 1 |
| 8 | Management of cervical insufficiency and bulging fetal membranes 显示文摘 | Daskalakis G Papantoniou N Mesogitis S | 2006 | Obstet Gynecol2006，107，2： | 1 |
| 9 | Pancreatic fistula: definition and current problems显示文摘 | Giovanni Butturini Despoina Daskalaki Enrico Molinari Filippo Scopelliti Andrea Casarotto Claudio Bassi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008，，3： | 1 |
| 10 | High flow insuftlation for the maintenance of the pneumoperitoneum during bariatric sm'gery 显示文摘 | Daskalakis M Scheffel O Weiner RA | 2009 | Obes Facts2009，21，： | 1 |
| 11 | The treatment of re- curring auditory hallucinations in schizophrenia with rTMS 显示文摘 | Fitzgerald PB Benitez J Daskalakis JZ | 2006 | World J Biological Psychiatry2006，7，2： | 1 |
| 12 | Decitabine显示文摘 | Hackanson B Daskalakis M | 2014 | Recent Re- sults Cancer Res2014，201，： | 1 |
| 13 | The application of transcranial magnetic stimulation in psychiatry and neurosciences research显示文摘 | Fitzgerald PB Brown TL Daskalakis ZJ | 2002 | Acta Psychiatr Scand2002，105，： | 1 |
| 14 | Risk factors predisposing to fetal loss following a second trimester amniocentesis显示文摘 | Papantoniou NE Daskalakis GJ Tziotis JG | 2001 | Br J Obstet Gynaecol2001，108，10： | 1 |
| 15 | Anemia follow- ing renal transplantation erythropoietin response and iron de- ficiency显示文摘 | Miles AM Markell MS Daskalakis P | 1997 | Clin Transplant1997，11，4： | 1 |
| 16 | Clini- cally meaningful efficacy and acceptability of low-fre- quency repetitive transcranial magnetic stimulation(rTMS) for treating primary major depression:a meta-analysis of randomized,double-blind and sham-controlled trials 显示文摘 | Berlim MT Van den Eynde F Jeff Daskalakis Z | 2013 | Neuropsychopharmacology2013，38，4： | 1 |
| 17 | Rupture of noneommnicating rudimentary uterine horn pregnancy显示文摘 | Daskalakis G Pilalis A Lykeridou K | 2002 | Obstet Gynecol2002，100，5： | 1 |
| 18 | Comparisons of sediment toxicity with predictions based on chemical guidelines 显示文摘 | Connor T P O Daskalakis K D Hyland J L | 1998 | Environmental Toxicology and Chemistry1998，17，3： | 1 |
| 19 | Neuroplasticity-based brain stimulation intervention in the study and treatment of schizophrenia: a review显示文摘 | Rajji T K Rogasch N C Daskalakis Z J | 2013 | Can J Psychiatry2013，58，2： | 1 |
| 20 | Emergency obstet- ric hysterectomy显示文摘 | Daskalakis G Papantoniou N Papantoniou N | 2007 | Aeta Obstet Gynecol Stand2007，86，2： | 1 |
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