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| 1 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 2 | An ORF2 protein-based ELISA for porcine circovirus type 2 antibodies in post-weaning multisystemic wasting syndrome显示文摘 | Ph Blanchard D Mahé R Cariolet C Truong M Le Dimna C Arnauld N Rose E Eveno E Albina F Madec A Jestin | 2003 | Veterinary Microbiology2003，，3： | 2 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Technical efficiency in the use of health care resources: a comparison of OECD countries显示文摘 | Donna Retzlaff-Roberts Cyril F Chang Rose M Rubin | 2003 | Health policy2003，，1： | 2 |
| 5 | Technical efficiency in the use of health care resources: a comparison of OECD countries显示文摘 | Donna Retzlaff-Roberts Cyril F Chang Rose M Rubin | 2003 | Health policy2003，，1： | 2 |
| 6 | Wave reflection and transmission in beams containing delamination and inhomogeneity 显示文摘 | Wang C H Rose L R F | 2003 | Journal of Sound and Vibration2003，264，： | 1 |
| 7 | Effect of ethanol on activity of the plasma-membrane ATPase in and accumulation of glycine by Saccharomyces cerevisiae 显示文摘 | CARTWRIGHT C P VEAZEY F J ROSE A H | 1987 | J Gen Microbiol1987，133，： | 1 |
| 8 | Nursery and field fertilization of 2 + 0 ponderosa pine seedlings: the effect on morphology, physiology, and field performance 显示文摘 | Gleason J F Duryea M L Rose R | 1990 | Can J For Res1990，20，： | 1 |
| 9 | Individual differences in nicotine dependence,withdrawal symptoms,and sex predict transient fMRI-BOLD responses to smoking cues显示文摘 | McClernon F J Kozink R V Rose J E | 2008 | Neuropsychopharmacology2008，33，9： | 1 |
| 10 | Universal Features of the Equation of State of Metals显示文摘 | Rose J H Smith J R Guinea F | 1984 | Phys Rev B1984，29，： | 1 |
| 11 | Preparation of amino-functionalized silica in aqueous conditions显示文摘 | Cuoq F Masion A Labille J Rose J Ziarelli F Prelot B Bottero J Y | 2013 | Applied Surface Science2013，266，： | 1 |
| 12 | A synthetic time- reversal imaging method for structural health monito- ring显示文摘 | Wang C H Rose J T Chang F K | 2004 | Smart Materials and Structures2004，13，2： | 1 |
| 13 | Loss of connectivity in Alzheimer's disease:an evaluation of white matter tract integrity with color coded MR diffusion tensor imaging显示文摘 | Rose SE Chen F Chalk JB | 2000 | J Neurol Neurosurg Psychiat2000，69，4： | 1 |
| 14 | Loss of connectivity in Alzheimer's disease:an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging显示文摘 | Rose SE Chen F Chalk JB | 2000 | J Neurol Neurosurg Psychiatry2000，69，4： | 1 |
| 15 | High-performance liquid chromatographic procedures for the quantitative determination of paelitaxel (Taxol) in human urine显示文摘 | Huizing MT Rosing H Koopman F | 1995 | J Chromatogr A1995，664，4： | 1 |
| 16 | Dry drainage: a sustainable solution to waterlogging and salinity problems in irrigation areas?显示文摘 | Konukcu F Gowing J W Rose D A | 2006 | Agricultural water management2006，，83： | 1 |
| 17 | A novel VNTR enhancer within the SIRT3 gene,a human homologue of SIR2,is associated with survival at oldest ages显示文摘 | Bellizzi D Rose G Cavalcante P Covello G Dato S De Rango F | | 0，，： | 1 |
| 18 | Validation of an instrument for the documentation of clinical pharmacists' interven- tions 显示文摘 | ALLENET B BEDOUCH P ROSE F X | 2006 | Pharm World Sci2006，28，4： | 1 |
| 19 | Sensorineural hearing loss from quinolinic acid:a neurotoxin in middle ear effusions显示文摘 | Yellon R F Rose E Kenna M A | 1994 | Laryngoscope1994，104，2： | 1 |
| 20 | Biologic and clinical considerations for autografts and allografts in periodontal regeneration therapy显示文摘 | Rose L F | 1998 | Dent Clin North Am1998，42，3： | 1 |
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