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| 1 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 2 | High-resolution multimodal flexible coherent Raman endoscope显示文摘Coherent Raman scattering microscopy is a fast,label-free,and chemically specific imaging technique that shows high potential for future in vivo optical histology.However,the imaging depth in tissues is limited to the sub-millimeter range because of absorption and scattering.Realization of coherent Raman imaging using a fiber endoscope system is a crucial step towards imaging deep inside living tissues and providing information that is inaccessible with current microscopy tools.Until now,the development of coherent Raman endoscopy has been hampered by several issues,mainly related to the fiber delivery of the excitation pulses and signal collection.Here,we present a flexible,compact,coherent Raman,and multimodal nonlinear endoscope(4.2mm outer diameter,71mm rigid length)based on a resonantly scanned hollow-core Kagomé-lattice double-clad fiber.The fiber design enables distortion-less,background-free delivery of femtosecond excitation pulses and back-collection of nonlinear signals through the same fiber.Sub-micrometer spatial resolution over a large field of view is obtained by combination of a miniature objective lens with a silica microsphere lens inserted into the fiber core.We demonstrate high-resolution,high-contrast coherent anti-Stokes Raman scattering,and second harmonic generation endoscopic imaging of biological tissues over a field of view of 320μm at a rate of 0.8 frames per second.These results pave the way for intraoperative label-free imaging applied to real-time histopathology diagnosis and surgery guidance. | Alberto Lombardini Vasyl Mytskaniuk Siddharth Sivankutty Esben Ravn Andresen Xueqin Chen Jérôme Wenger Marc Fabert Nicolas Joly Frédéric Louradour Alexandre Kudlinski Hervé Rigneault | 2018 | Light(Science & Applications)2018，7，1： | 6 |
| 3 | Upper digestive intolerance during enteral nutrition in critically ill patients: Frequency, risk factors, and complications显示文摘 | Hervé Mentec Hervé Dupont Maria Bocchetti Pascale Cani Frédérique Ponche Gérard Bleichner | 2001 | Critical Care Medicine2001，，10： | 2 |
| 4 | Biliary obstruction caused by portal cavernoma: a study of 8 cases显示文摘 | Gabriel Perlemuter Hervé Béjanin Jacques Fritsch Frédéric Prat Marianne Gaudric Stanislas Chaussade Catherine Buffet | 1996 | Journal of Hepatology1996，，1： | 2 |
| 5 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 6 | Waste management solution显示文摘 | Herve de Ladebat Lemarchand D | 2000 | World cement2000，，3： | 1 |
| 7 | Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment显示文摘 | Ariane Vienne Ehlam Hobeika Hervé Gouya Nathanael Lapidus Jacques Fritsch André Daniel Choury Ariane Chryssostalis Marianne Gaudric Gilles Pelletier Catherine Buffet Stanislas Chaussade Frédéric Prat | 2010 | Gastrointestinal Endoscopy2010，，4： | 1 |
| 8 | Finding drug targets in microbial genomes 显示文摘 | Timothy D R Steven R G Herve T | 2001 | Res Focus2001，6，17： | 1 |
| 9 | Gap junctional complexes: From partners to functions显示文摘 | Herve JC Bourmeyster N Sarrouilhe D | 2007 | Prog Biophys Mol Biol2007，94，12： | 1 |
| 10 | Longitudinal thalamic diffusion changes after middle cerebral ar tery infarcts显示文摘 | Herve D Molko N Pappata S | 2005 | J Neurol Neurosurg Psychiatry2005，76，2： | 1 |
| 11 | MpaA is a murein-tripeptide-specific zinc carboxypeptidase thatfunctions as part of a catabolic pathway for peptidoglycan-derived peptides in gamma- proteobacteria 显示文摘 | MAQBOOL A HERVE M LECREULX D M | 2012 | Biochem J2012，448，： | 1 |
| 12 | Haemodynamic evaluation of pulmonary hypertension显示文摘 | Castelain V Herve P | 2002 | Eur Respir J2002，20，5： | 1 |
| 13 | Regulated expression of Arabidopsis Shaker K+ channel genes involved in K+ uptake and distribution in the plant显示文摘 | Guillaume Pilot Frédéric Gaymard Karine Mouline Isabelle Chérel Hervé Sentenac | 2003 | Plant Molecular Biology2003，，5： | 1 |
| 14 | 肺动脉高压启动治疗后血流动力学指标的预后价值显示文摘血流动力学指标,如心脏指数和右心房压力(right atrial pressure,RAP)与患者确诊肺动脉高压时的生存率持续相关。近期研究表明,肺动脉顺应性(pulmon aryarterial compliance,Pea)也可能预测肺动脉高压的预后。而在治疗开始之后测定的血流动力学指标对预后的价值还未确定。 | 黄洁 叶鹏 Weatherald J Boucly A Chemla D Savale L Peng M Jevnikar M Ja?s X Taniguchi Y O'Connell C Parent F Sattler C Hervé P Simonneau G Montani D Humbert M Adir Y Sitbon O | 2017 | 中华高血压杂志2017，25，11： | 1 |
| 15 | Protein phosphatase modulation of the intercellular junctional communication: importance in cardiac myocytes 显示文摘 | Herve JC Sarrouilhe D | 2006 | Prog Biophys Mol Biol2006，90，13： | 1 |
| 16 | The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection显示文摘 | Zaidman-Rémy A Hervé M Poidevin M Pili-Floury S Kim MS Blanot D Oh BH Ueda R Mengin-Lecreulx D Lemaitre B | | 0，，04： | 1 |
| 17 | Cadasil 显示文摘 | Herve D Chabriat H | 2010 | J Geriatr Psychiatry Neurol2010，23，4： | 1 |
| 18 | Molecular analysis of transgenie rapeseed plants obtained by direct transfer of two separate plasmids containing, respectively, the caullflower mosaic virus coat protein gene and a selectable marker gene显示文摘 | Hervé C Rouan D Guerde P | 1993 | Plant Sci1993，91，： | 1 |
| 19 | Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation显示文摘 | Pascoli V Besnard A Herv D | 2011 | Biol Psychiatry2011，69，3： | 1 |
| 20 | Exploration de rinnervation des glandes sudoripares chezle diabetique显示文摘 | Philppe B Herve M Olivier D | 2007 | Diabete Metab2007，33，1： | 1 |
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