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| 1 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 2 | 膳食因素对高血压发生的影响:NutriNet-Santé队列前瞻性分析显示文摘膳食是高血压发展的主要影响因素之一。这方面的数据主要来源于横断面研究。该研究旨在通过大型队列研究调查营养因素及坚持高血压防治膳食与高血压发生之间的关系。在80 426名参加NutriNet-Santé队列研究的法国成年人中前瞻性调查高血压发生率。基线及之后的每年都进行社会人口学问卷、生活健康方式问卷和3份24h记录评定膳食消费的调查。 | 陈嘉睿 叶鹏 Lelong H Blacher J Baudry J Adriouch S Galan P Fezeu L Hercberg S Kesse-Guyot E | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 3 | 以英国FSA营养素度量体系为基础的个体膳食指数在法国的开发和验证显示文摘背景:以食品正面包装的营养标签、广告规范或粮食税为基础的营养素度量体系对于公共健康是一个很有用的工具。然而,它的能耐远超于对产品描述并能够充分地塑造个体膳食有必要更进一步的调查目的:本研究旨在(1)计算个体层面的分值基于英国FSA食物级别的每个食物消耗的营养素度量体系,(2)依据食物组消耗量、营养摄入量以及社会人口和生活方式的改变评估膳食状况评分的正确性。方法:从Nu1riNet-Sante研究(n=4225)中选定法国人群作为代表性样本。采用24小时膳食回顾记录收集膳食数据。社会人口和生活方式的数据采用自我报告形式记录。所有食物消耗量采用FSA营养素度量法描述,并且来自于每个食物消耗的能量摄入量用于计算个体层面的FSA导出的累积分值。遵循法国营养素推荐规范(PNNS-GS)的分数以膳食质量评分作为比较而计算。在食物消耗、营养指标、生活方式和社会人口的变化与累积分的四分位之间的关联性通过ANOVAs和线性回归模型调查。结果:得到有利分值的受试者消耗大量的水果(差异△=156g/d,P<0.001),蔬菜(△=85g/d,P<0.001),以及鱼和少量的零食(△=-72g/d,P<0.001);同时他们也有大量维生素和矿物质的摄入以及少量的饱和脂肪酸的摄入。得到有利分值的受试者很好的遵循了依据PNNS-GS衡量的营养素推荐标准(△=2.13 points,P<0.001)。女性年长的受试者以及高收入的群体更可能得到较高的分值。结论:研究结果表明FSA营养素度量体系对法国人群中个体膳食的概述更加全面可行。NutriNet-Sante研究已被登录于2013-000929-31欧洲临床试验数据库(EudraCT)。 | Chantal Julia Mathilde Touvier Caroline Mejean Pauline Ducrot Sandrine Peneau Serge Hercberg Emmanuelle Kesse-Guyot 刘轶群 | 2014 | 营养健康新观察2014，0，1： | 2 |
| 4 | A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians显示文摘 | Siddiq A Lepretre F Hercberg S | 2005 | Diabetes2005，54，8： | 1 |
| 5 | The activity of tissue enzymes in iron-deficient rat and man: an overview 显示文摘 | Galan P Hercberg S Touitou Y | 1984 | Comp Biochem Physiol B1984，77，4： | 1 |
| 6 | Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies显示文摘 | Dauchet L Amouye IP Hercberg S | 2006 | J Nutr2006，136，10： | 1 |
| 7 | A synonymous coding polymorphism in the 2-Heremans-Schmid glycoprotein gene is associated with type 2 diabetes in french caucasians显示文摘 | Siddiq A Lepretre F Hercberg S | 2005 | Diabetes2005，54，8： | 1 |
| 8 | Yearly incidence of rhinitis,nasal bleeding,and other nasal symptoms in mature women 显示文摘 | Lund V J Preziosi P Hercberg S | 2006 | Rhinology2006，44，1： | 1 |
| 9 | Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03) 显示文摘 | Le Clerc S Limou S Coulonges C Carpentier W Dina C Taing L Delaneau O Labib T Sladek R ANRS Genomic Group Deveau C Guillemain H Ratsimandresy R Montes M Spadoni JL Therwath A Schichter F Matsuda F Gut I Leli6vre JD L6vy Y Froguel P Delfraissy JF Hercberg S Zagury JF | 2009 | Infect Dis2009，200，8： | 1 |
| 10 | Modulation of angiogenesis by thyroid hormone and hormone analogues: implications for cancer management显示文摘 | Shaker A. Mousa Hung-Yun Lin Heng Yuan Tang Aleck Hercbergs Mary K. Luidens Paul J. Davis | 2014 | Angiogenesis2014，，： | 1 |
| 11 | Recurrence of Differentiated Thyroid Carcinoma During Full TSH Suppression: Is the Tumor Now Thyroid Hormone Dependent?显示文摘 | Paul J. Davis Aleck Hercbergs Mary K. Luidens Hung-Yun Lin | 2015 | Hormones and Cancer2015，，： | 1 |
| 12 | Fruit and vegetableconsumption and risk of coronary heart disease:A meta-analysis ofcohort studies显示文摘 | Dauchet L Amouyel P Hercberg S | 2006 | J Nutr2006，136，： | 1 |
| 13 | A synonymous cod-ing polymorphism in the 2-Heremans-Schmid glycoprotein gene is associated with type 2 diabetes in French caucasians显示文摘 | Siddiq A Lepretre F Hercberg S | 2005 | Diabetes2005，54，8： | 1 |
| 14 | Thioridazine: a radiation enhancer in advanced cervical cancer? 显示文摘 | Hercbergs A | 1988 | Lancet1988，2，8613： | 1 |
| 15 | Antioxidant supplemen-tation increases the risk of skin cancers in women but not in men显示文摘 | Hercberg S Ezzedine K Guinot C | 2007 | J Nutr2007，137，9： | 1 |
| 16 | A synonymous coding polymorphlsm in the alpha2-Herernans schmid glycoprotein gene is assodated with type 2 diabetes in French Caucasians显示文摘 | Siddiq A Lepretre F Hercberg S | 2005 | Diabetes2005，54，8： | 1 |
| 17 | Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity显示文摘 | Clement K Durand E Hercberg S Guy-Grand B Froguel P | 2000 | J Clin Invest2000，106，2： | 1 |
| 18 | Spontaneous remission of metastatic lung cancer following myxedema coma-an apoptosis-related phenom- enon 显示文摘 | Hercbergs A Leith JT | 1993 | J Natl Cancer Inst1993，85，16： | 1 |
| 19 | Folate status and the immune system显示文摘 | Dhur A Galan P Hercberg S | | 0，，： | 1 |
| 20 | A synonnymous coding polymorphism in the alpha 2-Heremans-Schmid glycoprotein gene is associated with Type 2 diabetes in Frrench Caucasians显示文摘 | Siddiq A Lepretre F Hercberg S | 2005 | Diabetes2005，54，： | 1 |
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