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| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | A genome-wide association study identifies novel risk loci for type 2 diabetes显示文摘 | Sladek R Rocheleau G Rung J | | 0，，7130： | 1 |
| 3 | Elastic Constants and the Electrical Transition in Ti2O3显示文摘 | CHI T C SLADEK R J | 1973 | Physical Review B1973，7，： | 1 |
| 4 | A genome-wide association study identifies novel risk loci for type 2 diabetes 显示文摘 | Sladek R Rocheleau G Rung J | 2007 | Nature2007，445，7130： | 1 |
| 5 | A model for diffusion in a glassy polymer显示文摘 | Vieth W R Sladek K J | 1965 | Journal of Colloid Sci1965，20，： | 1 |
| 6 | Microarray analysis of uerine gene expression in mouse and human pregnancy显示文摘 | Bethin K E Nagai Y Sladek R | 2003 | Mol Endocrinnol2003，17，8： | 1 |
| 7 | A genome-wide association study identifies novel risk loci for type 2 diabetes 显示文摘 | SLADEK R ROCHELEAU G RUNG J | 2007 | Nature2007，445，7130： | 1 |
| 8 | 显示文摘 | Vohl MC Sladek R Robitaille J | 2004 | Obes Res2004，12，8： | 1 |
| 9 | Diffusion on surface Ⅱ, correlation of diffusivities of physically and chemically adsorbed specie显示文摘 | Sladek K J Gilliland E R Buddour R F | 1974 | Industr Chem fundam1974，13，2： | 1 |
| 10 | A genome-wide association study identifies novel risk loci for type 2 diabetes显示文摘 | SLADEK R ROCI-IELEAU G RUNG J | 2007 | Nature2007，445，2： | 1 |
| 11 | A genome-wide association study identifies novel risk loci for type 2 diabetes显示文摘 | Sladek R Rocheleau G Rung J | 2007 | Nature2007，445，7130： | 1 |
| 12 | Nitric oxide and pregnancy显示文摘 | Sladek SM Magness R R Conrad K P | 1997 | Am J physiology1997，272，： | 1 |
| 13 | A genome-wide association study identifies novel risk loci for type 2 diabetes显示文摘 | Sladek R Rocheleau G Rung J | 2007 | Nature2007，224，7130： | 1 |
| 14 | Deactivation of escherichia coli by the plasma needle显示文摘 | Sladek R E J Stoffels E | | 0，，： | 1 |
| 15 | Functional classes of bronchial mucosa genes that are differentially expressed in asthma显示文摘 | Laprise C Sladek R Ponton A | 2004 | J Histochem Cytochem2004，52，： | 1 |
| 16 | Elastic anharmonicity of InP:its relationship to the high pressure transition显示文摘 | Nichols D N Rimai D S Sladek R J | 1980 | Solid State Commun1980，36，： | 1 |
| 17 | Functional classes of bronchial mucosa genes that are differentially expressed in asthma显示文摘 | Laprise C Sladek R Ponton A | 2004 | BMC Genomics2004，5，1： | 1 |
| 18 | A genome wide association study identifies novel risk loci for type 2 diabetes显示文摘 | Sladek R Rocheleau G Rung J | | 0，，： | 1 |
| 19 | Characterization of variability in large-scale gene expression data: Implications for study design显示文摘 | Novak J P Sladek R Hudson T J | 2002 | Genomics2002，79，： | 1 |
| 20 | The role of steroid hormones in the regulation of vasopressin and oxytocin release and mRNA expression in hypothalamo-neurohypophysial explants from the rat显示文摘 | Sladek CD Swenson KL Kapoor R | 2000 | Exp Physiol2000，85，9： | 1 |
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