3篇
您的检索式：作者名="Heqin Zhan"
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| 1 | The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression显示文摘 | Yanwei Ye Yingqiang Shi Ye Zhou Chunyan Du Chunmeng Wang Heqin Zhan Biqiang Zheng Xi Cao Meng-hong Sun Hong Fu | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 2 | The Fibroblast Growth Factor Receptor-4 Arg388 Allele is Associated with Gastric Cancer Progression显示文摘 | Yanwei Ye MD Yingqiang Shi MD Ye Zhou MD Chunyan Du MD Chunmeng Wang MD Heqin Zhan PhD Biqiang Zheng PhD Xi Cao MD Meng-hong Sun MD Hong Fu MD | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 3 | Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats显示文摘Previous studies have shown that puerarin plays a key role in protecting humans and animals from cardiovascular diseases.The exact mechanism of the therapeutic effect of puerarin on various cardiovascular diseases(protective effect on cardiomyocytes)is still unclear.In the present study,we identify the role of puerarin in an animal model of experimental heart failure(HF)and explore its underlying mechanisms.The HF rat model is induced by in-traperitoneal injection of adriamycin(ADR),and puerarin is administered intragastrically at low,medium,and high concentrations.We demonstrate that puerarin significantly improves myocardial fibrosis and inflammatory in-filtration and,as a result,improves cardiac function in ADR-induced HF rats.Mechanistically,we find for the first time that puerarin inhibits overactivated Na+/H+exchange isoform 1(NHE1)in HF,which may improve HF by decreasing Na+and Ca2+ion concentrations and attenuating mitochondrial damage caused by calcium overload;on the other hand,puerarin inhibits the activation of the p38 pathway in HF,reduces the expressions of TGF-βand proinflammatory cytokines,and suppresses myocardial fibrosis.In conclusion,our results suggest that Puerarin is an effective drug against HF and may play a protective role in the myocardium by inhibiting the activation of p38 and its downstream NHE1. | Guopin Pan Baoyue Cui Mingming Han Laibiao Lin Yinlan Li Ling Wang Shuang Guo Yaling Yin Heqin Zhan Peng Li | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
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