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| 1 | Assessment of lymph node involvement in colorectal cancer显示文摘Lymph node metastasis informs prognosis and is a key factor in deciding further management, particularly adjuvant chemotherapy. It is core to all contemporary staging systems, including the widely used tumor node metastasis staging system. Patients with nodenegative disease have 5-year survival rates of 70%-80%, implying a significant minority of patients with occult lymph node metastases will succumb to disease recurrence. Enhanced staging techniques may help to identify this subset of patients, who might benefit from further treatment. Obtaining adequate numbers of lymph nodes is essential for accurate staging. Lymph node yields are affected by numerous factors, many inherent to the patient and the tumour, but others related to surgical and histopathological practice. Good lymph node recovery relies on close collaboration between surgeon and pathologist. The optimal extent of surgical resection remains a subject of debate. Extended lymphadenectomy, extra-mesenteric lymph node dissection, high arterial ligation and complete mesocolic excision are amongst the surgical techniques with plausible oncological bases, but which are not supported by the highest levels of evidence. With further development and refinement, intra-operative lymphatic mapping and sentinel lymph node biopsy may provide a guide to the optimum extent of lymphadenectomy, but in its present form, it is beset by false negatives, skip lesions and failures to identify a sentinel node. Once resected, histopathological assessment of the surgical specimen can be improved by thorough dissection techniques, step-sectioning of tissue blocks and immunohistochemistry. More recently, molecular methods have been employed. In this review, we consider the numerous factors that affect lymph node yields, including the impact of the surgical and histopathological techniques. Potential future strategies, including the use of evolving technologies, are also discussed. | Mark L H Ong John B Schofield | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 8 |
| 2 | Proteolytic pattern and organic acid profiles of probiotic Cheeddar cheese as influenced by probiotic strains of Lactobacillus acidophilus, LactobaciUus paracasei, Lactobacillus casei or Bifidobacterium sp 显示文摘 | ONG L HENRIKSSON A SHAH N P | 2007 | International Dairy Journal2007，17，1： | 1 |
| 3 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Water Research2003，37，： | 1 |
| 4 | Criteria for the occurrence of projective synchronization in chaotic systems of arbitrary dimension显示文摘 | Xu D Ong L W Li Z | 2002 | Phys Lett A2002，305，： | 1 |
| 5 | Magnetic properties of BaFe12-2xZnxZrxO19 particles显示文摘 | WEI F L FANG H C ONG C K | 2000 | J Appl Phys2000，87，： | 1 |
| 6 | Magnetic order in Co-doped and (Mn,Co) codoped ZnO thin films by pulsed laser eposition显示文摘 | YAN L ONG C K RAO X S | 2004 | Appl Phys2004，96，： | 1 |
| 7 | Optimal planar evasive aircraft maneuvers against proportional navigation missiles 显示文摘 | Ong S Y Pierson B L | 1996 | Journal of Guidance Control and Dynamics1996，19，6： | 1 |
| 8 | Is estrogen receptorαkey to controlling bones'resistance to fracture显示文摘 | Lanyon L Armstrong V Ong D | 2004 | Endocrinol2004，182，2： | 1 |
| 9 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors 显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Water Res2003，37，3： | 1 |
| 10 | Wastewater treatment with bacterial augmentation显示文摘 | Chin K K Ong S L Poh L H | 1998 | Water Sci Technol1998，33，8： | 1 |
| 11 | Automated high-performance liquid chromatographic method with pre-column reduction for the determination of ubiquinol and ubiquinone plasma 显示文摘 | WANG Q LEE B L ONG C N | 1999 | J Chromatogr B1999，726，： | 1 |
| 12 | Investigation of thermal benefits of rooftop garden in the tropical environment显示文摘 | Wong N H Chen Y Ong G L | 2003 | Build Environ2003，38，： | 1 |
| 13 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Wat Ros2003，37，14： | 1 |
| 14 | Traffic noise survey and analysis in Singapore显示文摘 | Sy H K Ong P P Tang S H Tan K L | 1985 | Applied Acoustics1985，，18： | 1 |
| 15 | Pancreas development and diabetes显示文摘 | St Onge L Wehr R Grass P | | 0，，： | 1 |
| 16 | Local Ca2 en- try via Orail regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca2 signals required for specific cell functions 显示文摘 | CHENG K T LIU X ONG H L | 2011 | PLoS Biol2011，9，10： | 1 |
| 17 | Analysis of step-lifetest data:a new approach 显示文摘 | Sun YS Goh T N Ong H L | 1996 | IEEE Transactions on Reliability1996，45，1： | 1 |
| 18 | Microclimatic interactions in agroforestry systems显示文摘 | Monteith J L Ong C K Corlett J E | 1991 | Forest Ecology and Management1991，45，： | 1 |
| 19 | Osteoblast precursor cell activity on HA surfaces of different treatments显示文摘 | ONG J L HOPPE C A CARDENAS H L | 1998 | J Biomed Mater Res1998，39，： | 1 |
| 20 | Bone response to plasma-sprayed hydroxyapatite and radiofrequency-sputtered calcium phosphate implants in vivo 显示文摘 | ONG J L BESSHO K CARNES D L | 2002 | Int J Oral Maxillofac Implants2002，17，4： | 1 |
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