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| 1 | Advances and Trends on Tube Bending Forming Technologies显示文摘作为有庞大的数量和差异的一个种关键部件,弄弯的试管部分从材料和结构方面为无足轻重的人和高张力产品满足增加的需要。弄弯的试管广泛地在象航空,太空,造船,汽车,精力和护理那样的许多高端工业被使用了。弯曲的试管成为了为小产品形成生产技术的钥匙之一。经由把特征和多重缺点弄弯的分析,在试管弯曲探索普通问题上的进展在穹隆之内面关于起皱的不稳定性被总结,墙变瘦(裂开) 在拱背, springback 现象,剖面图变丑,形成的限制和过程 / 工具设计 / 优化。一些当前发达的弯曲技术以他们的优点和限制被考察。最后,鉴于高效的建筑群的迫切要求,在航空与 difficult-to-deform 和小材料把试管部件弄弯,太空域,发展趋势和相应挑战为认识到把变丑弄弯的精确、高效率的试管被介绍。 | YANG He LI Heng ZHANG Zhiyong ZHAN Mei LIU Jing LI Guanjun | 2012 | Chinese Journal of Aeronautics2012,25,1: | 86 |
| 2 | Artemisinin analogue SM934 ameliorates DSS- induced mouse ulcerative colitis via suppressing neutrophils and macrophages显示文摘 | Yu-xi YAN Mei-juan SHAO Qing QI Yan-sheng XU Xiao-qian YANG Feng-hua ZHU Shi-jun HE Pei-lan HE Chun-lan FENG Yan-wei WU Heng LI Wei TANG Jian-ping ZUO | 2018 | Acta Pharmacologica Sinica2018,39,10: | 32 |
| 3 | A Study on Multi-defect Constrained Bendability of Thin-walled Tube NC Bending Under Different Clearance显示文摘Thin-walled tube numerical control (NC) bending is a tri-nonlinear physical process with multi-defect and multi-die constraints. The clearance on each contact interface is the major factor to indicate the contact conditions. A three-dimensional-finite element (3D-FE) model is established to consider the realistic dynamic boundary conditions of multiple dies under ABAQUS/Explicit platform. Combined with experiment, numerical study on bending behavior and bendability under different clearance between tube and various dies is conducted in terms of wrinkling, wall thinning and cross section deformation. The results show that (1)with smaller clearance of tube-wiper die and tube-mandrel, the wrinkling can be restrained while the wall thinning It and cross-section deformation Id increase; while excessive small clearance blocks tube materials to flow past tangent point and causes piles up, the onset of wrinkling enhances It and Id. (2)Both It and Id decrease with smaller clearance of tube-pressure die; the wrinkling possibility rises with larger clearance on this interface if the mandrel’s freedom along Y-axis is opened; smaller clearance of tube-bend die prevents wrinkling while increases It, and the clearance on this interface has little effect on Id. (3)A modified Yoshida buckling test (YBT) is used to address the wrinkling mechanisms under normal constraints in tube bending: the smaller clearance may restrain wrinkling efficiently; the smaller wall thickness, the less critical clearance needed; the critical clearance for tube bending 38 mm×1 mm×57 mm (tube outer diameter×wall thickness×centerline bending radius) equals about 20% of initial wall thickness. | LI Heng YANG He | 2011 | Chinese Journal of Aeronautics2011,24,1: | 23 |
| 4 | Forming limits under multi-index constraints in NC bending of aluminum alloy thin-walled tubes with large diameters显示文摘With increasing diameters of aluminum alloy thin-walled tubes (AATTs), the tube forming limits, i.e. the minimum bending factors, and their predictions under multi-index constraints including wrinkling, thinning and flattening have been being a key problem to be urgently solved for improving tube forming potential in numerical control (NC) bending processes of AATTs with large diameters. Thus in this paper, a search algorithm of the forming limits is put forward based on a 3D elastic-plastic finite element (FE) model and a wrinkling energy prediction model for the bending processes under axial compression loading (ACL) or not. This algorithm enables to be considered the effects of process parameter combinations including die, friction parameters on the multi-indices. Based on this algorithm, the forming limits of the different size tubes are obtained, and the roles of the process parameter combinations in enabling the limit bending processes are also revealed. The followings are found: the first, within the appropriate ranges of friction and clearances between the different dies and the tubes enabling the bending processes with smaller bending factors, the ACL enables the tube limit bending processes after a decrease of the mandrel ball thickness and diameters; then, without considering the effects of the tube geometry sizes on the tube constitutive equations, the forming limits will be decided by the limit thinning values for the tubes with diameters smaller than 80 mm, while the wrinkling for the tubes with diameters no less than 80 mm. The forming limits obtained from this algorithm are smaller than the analytical results, and reduced by 57.39%; the last, the roles of the process parameter combinations in enabling the limit bending processes are verified by experimental results. | YAN Jing, YANG He, ZHAN Mei & LI Heng College of Materials Science and Engineering, State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China | 2010 | Science China(Technological Sciences)2010,53,2: | 21 |
| 5 | Enhanced control of DFIG-used back-to-back PWM VSC under unbalanced grid voltage conditions显示文摘This paper presents a unified positive-and negative-sequence dual-dq dynamic model of wind-turbine driven doubly-fed induction generator(DFIG) under unbalanced grid voltage conditions. Strategies for enhanced control and operation of a DFIG-used back-to-back(BTB) PWM voltage source converter(VSC) are proposed. The modified control design for the grid-side converter in the stationary αβ frames diminishes the amplitude of DC-link voltage ripples of twice the grid frequency,and the two proposed control targets for the rotor-side converter are alternatively achieved,which,as a result,improve the fault-ride through(FRT) capability of the DFIG based wind power generation systems during unbalanced network supply. A complete unbalanced control scheme with both grid-and rotor-side converters included is designed. Finally,simulation was carried out on a 1.5 MW wind-turbine driven DFIG system and the validity of the developed unified model and the feasibility of the proposed control strategies are all confirmed by the simulated results. | HU Jia-bing HE Yi-kang NIAN Heng | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007,8,8: | 20 |
| 6 | ‘Size effect’ related bending formability of thin-walled aluminum alloy tube显示文摘Aluminum alloy (Al-alloy) thin-walled (D/t > 20, diameter D, wall thickness t) bent tubes have attracted increasing applications in many industries with mass quantities and diverse specifications due to satisfying high strength to weigh ratio requirements of product manufacturing. However, due to nonlinear nature of bending with coupling effects of multiple factors, the similarity theory seems not applicable and there occurs a challenge for efficient and reliable evaluation of the bending formability of thin-walled tube with various bending specifications. Considering the unequal deformation and three major instabilities, the bending formability of thin-walled Al-alloy tube in changing tube sizes such as D and t are clarified via both the analytical and FE modeling/ simulations. The experiments of rotary draw bending are conducted to validate the theoretical models and further confirm 'size effect' related bending formability. The major results show that (1) The anti-wrinkling capability of tube decreases with the larger D and smaller t, and the effect significance of t is larger than that of D even under rigid supports; (2) The wall thinning increases with the larger D and smaller t, and this tendency becomes much more obvious under rigid supports; (3) The cross-section deformation increases with the larger D and smaller t according to the analytical model obtained intrinsic relationship, while this tendency becomes opposite due to the nonlinear role of mandrel die; (4) The size factor D/t can be used as a nondimensional index to evaluate both the bending formability regarding the wall thinning and cross-section deformation. | Li Heng Yang He Zhang Zhiyong Wang Zekang | 2013 | Chinese Journal of Aeronautics2013,26,1: | 16 |
| 7 | Springback prediction of thick-walled high-strength titanium tube bending显示文摘Signifcant springback occurs after tube rotary-draw-bending(RDB),especially for a high-strength Ti–3Al–2.5V tube(HSTT) due to its high ratio of yield strength to Young's modulus.The combination scheme of explicit and implicit is preferred to predict the springback.This simulation strategy includes several numerical parameters,such as element type,number of elements through thickness(NEL),element size,etc.However,the influences of these parameters on springback prediction accuracy are not fully understood.Thus,taking the geometrical specifcation9.525 mm · 0.508 mm of a HSTT as the objective,the effects of numerical parameters on prediction accuracy and computation effciency of springback simulation of HSTT RDB are investigated.The simulated springback results are compared with experimental ones.The main results are:(1) solid and continuum-shell elements predict the experimental results well;(2) for C3D8R elements,NEL of at least 3 is required to obtain reliable results and a relative error of 29% can occur as NEL is varied in the range of 1–3;(3) specifying damping factor typically works well in Abaqus/Emplicit simulation of springback and the springback results are sensitive to the magnitude of damping factor.In addition,the explanations of the effect rules are given and a guideline is added. | Song Feifei Yang He Li Heng Zhan Mei Li Guangjun | 2013 | Chinese Journal of Aeronautics2013,26,5: | 15 |
| 8 | Secure Sensitive Data Sharing on a Big Data Platform显示文摘Users store vast amounts of sensitive data on a big data platform. Sharing sensitive data will help enterprises reduce the cost of providing users with personalized services and provide value-added data services.However, secure data sharing is problematic. This paper proposes a framework for secure sensitive data sharing on a big data platform, including secure data delivery, storage, usage, and destruction on a semi-trusted big data sharing platform. We present a proxy re-encryption algorithm based on heterogeneous ciphertext transformation and a user process protection method based on a virtual machine monitor, which provides support for the realization of system functions. The framework protects the security of users' sensitive data effectively and shares these data safely. At the same time, data owners retain complete control of their own data in a sound environment for modern Internet information security. | Xinhua Dong Ruixuan Li Heng He Wanwan Zhou Zhengyuan Xue Hao Wu | 2015 | Tsinghua Science and Technology2015,20,1: | 12 |
| 9 | Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota显示文摘Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. | Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong | 2022 | Acta Pharmaceutica Sinica B2022,12,8: | 12 |
| 10 | Cultivated land information extraction in UAV imagery based on deep convolutional neural network and transfer learning显示文摘The development of precision agriculture demands high accuracy and efficiency of cultivated land information extraction. As a new means of monitoring the ground in recent years, unmanned aerial vehicle(UAV) low-height remote sensing technique, which is flexible, efficient with low cost and with high resolution, is widely applied to investing various resources. Based on this, a novel extraction method for cultivated land information based on Deep Convolutional Neural Network and Transfer Learning(DTCLE) was proposed. First, linear features(roads and ridges etc.) were excluded based on Deep Convolutional Neural Network(DCNN). Next, feature extraction method learned from DCNN was used to cultivated land information extraction by introducing transfer learning mechanism. Last, cultivated land information extraction results were completed by the DTCLE and e Cognition for cultivated land information extraction(ECLE). The location of the Pengzhou County and Guanghan County, Sichuan Province were selected for the experimental purpose. The experimental results showed that the overall precision for the experimental image 1, 2 and 3(of extracting cultivated land) with the DTCLE method was 91.7%, 88.1% and 88.2% respectively, and the overall precision of ECLE is 90.7%, 90.5% and 87.0%, respectively. Accuracy of DTCLE was equivalent to that of ECLE, and also outperformed ECLE in terms of integrity and continuity. | LU Heng FU Xiao LIU Chao LI Long-guo HE Yu-xin LI Nai-wen | 2017 | Journal of Mountain Science2017,14,4: | 11 |
| 11 | Sinomenine induces apoptosis in RAW 264.7 cell- derived osteoclasts in vitro via caspase-3 activation显示文摘 | Long-gang HE Xiang-lian LI Xiang-zhou ZENG Heng DUAN Song WANG Lin-sheng LEI Xiao-juan LI Shu-wen LIU | 2014 | Acta Pharmacologica Sinica2014,35,2: | 10 |
| 12 | Effects of Pinus massoniana bark extract on cell proliferation and apoptosis of human hepatoma BEL-7402 cells显示文摘AIM: To study the effects of Pinus massoniana bark extract (PMBE) on cell proliferation and apoptosis of human hepatoma BEL-7402 cells and to elucidate its molecular mechanism.METHODS: BEL-7402 cells were incubated with various concentrations (20-200 μg/mL) of PMBE for different periods of time. After 48 h, cell proliferation was determined by 3-(4,5-dimethyl-thiazolyl-2)-2,5-diphenyl tetrazolium bromide (MTT) assay. Apoptosis was evaluated by morphological observation, agarose gel electrophoresis,and flow cytometry analysis. Possible molecular mechanisms were primarily explored through immunohistochemical staining.RESULTS: PMBE (20-200 μg/mL) significantly suppressed BEL-7402 cell proliferation in a time- and dose-dependent manner. After treatment of BEL-7402 cells with 160 μg/mL PMBE for 24, 48, or 72 h, a typical apoptotic 'DNA ladder'was observed using agarose gel electrophoresis. Nuclear condensation and boundary aggregation or split, apoptotic bodies were seen by fluorescence and electron microscopy.Sub-G1 curves were displayed by flow cytometry analysis.PMBE decreased the expression levels of Bcl-2 protein in a time-dependent manner after treatment of cells with 160 μg/mL PMBE.CONCLUSION: PMBE suppresses proliferation of BEL-7402 cells in a time- and dose-dependent manner and induces cell apoptosis by possibly downregulating the expression of the bcl-2 gene. | Ying-Yu Cui Heng Xie Kang-Biao Qi Yan-Ming He Jin-Fa Wang | 2005 | World Journal of Gastroenterology2005,11,34: | 10 |
| 13 | Geometry-dependent springback behaviors of thin-walled tube upon cold bending显示文摘As one kind of key lightweight components with enormous quantities and diversities, the bent tubular parts have attracted in- creasing applications in aerospace, automobile, etc. Thus, how the inevitable springback behaves under different bending specifications should be fully addressed to efficiently achieve the precision forming of various bent tubes. Taking the medium strength thin-walled 6061-T4 Al-alloy tube as the objective, via the deformation theory of plasticity, explicit/implicit FE method and experimental approaches, we explored and clarified the nonlinear springback rules of the tubes and corresponding mechanisms in universal rotary draw bending regarding angular springback and radius growth by deliberately changing the tube diameter D and wall thickness t. The geometry dependent springback behaviors of thin-walled tube upon cold bending are thus revealed: 1) With the increasing of D, the tangent tensile strain increases and the proportional coefficient decreases, which causes the angular springback to decrease, while the radius springback increases due to the larger bending radius. 2) With the increasing of t, the tangent tensile strain decreases and the proportional coefficient increases, resulting in the increase of both angular springback and radius springback. 3) Under the same D/t, the angular springback varies little, while the radius springback increases with the larger diameter D. 4) The D/t can be used as a reasonable nondimensional index to evaluate the springback angle; as to the radius growth, the individual effects of the D and t should be considered. 5) The verification of the above results was conducted by experiments and analytical analysis. | LI Heng YANG He TIAN YuLi LI GuangJun WANG ZhengHua | 2012 | Science China(Technological Sciences)2012,55,12: | 10 |
| 14 | Tribological evaluation of surface modified H13 tool steel in warm forming of Ti–6Al–4V titanium alloy sheet显示文摘The H13 hot-working tool steel is widely used as die material in the warm forming of Ti–6Al–4V titanium alloy sheet. However, under the heating condition, severe friction and lubricating conditions between the H13 tools and Ti–6Al–4V titanium alloy sheet would cause difficulty in guaranteeing forming quality. Surface modification may be used to control the level of friction force, reduce the friction wear and extend the service life of dies. In this paper, four surface modification methods(chromium plating, TiAlN coating, surface polishing and nitriding treatment)were applied to the H13 surfaces. Taking the coefficient of friction(CoF) and the wear degree as evaluation indicators, the high-temperature tribological behavior of the surface modified H13 steel was experimentally investigated under different tribological conditions. The results of this study indicate that the tribological properties of the TiAlN coating under dry friction condition are better than the others for a wide range of temperature(from room temperature to 500 C), while there is little difference of tribological properties between different surface modifications under graphite lubricated condition, and the variation law of CoF with temperature under graphite lubricated is opposite to that under the dry friction. | Wang Dan Li Heng Yang He Ma Jun Li Guangjun | 2014 | Chinese Journal of Aeronautics2014,27,4: | 9 |
| 15 | Bending behaviors of large diameter thin-walled CP-Ti tube in rotary draw bending | Zhi-yong ZHANG He YANG Heng LI Ning REN Yu-li TIAN | 2011 | Progress in Natural Science:Materials International2011,21,5: | 8 |
| 16 | mRNA cancer vaccines:Advances,trends and challenges显示文摘Patients exhibit good tolerance to messenger ribonucleic acid(m RNA)vaccines,and the choice of encoded molecules is flexible and diverse.These vaccines can be engineered to express full-length antigens containing multiple epitopes without major histocompatibility complex(MHC)restriction,are relatively easy to control and can be rapidly mass produced.In 2021,the U.S.Food and Drug Administration(FDA)approved the first m RNA-based coronavirus disease 2019(COVID-19)vaccine produced by Pfizer and Bio NTech,which has generated enthusiasm for m RNA vaccine research and development.Based on the above characteristics and the development of m RNA vaccines,m RNA cancer vaccines have become a research hotspot and have undergone rapid development,especially in the last five years.This review analyzes the advances in m RNA cancer vaccines from various perspectives,including the selection and expression of antigens/targets,the application of vectors and adjuvants,different administration routes,and preclinical evaluation,to reflect the trends and challenges associated with these vaccines. | Qing He Hua Gao Dejiang Tan Heng Zhang Jun-zhi Wang | 2022 | Acta Pharmaceutica Sinica B2022,12,7: | 7 |
| 17 | Quasi-static tensile behavior of large-diameter thin-walled Ti–6Al–4V tubes at elevated temperature显示文摘As promising light-weight and high-performance structure components, large-diameter thin-walled(LDTW) Ti–6Al–4V titanium alloy(TC4) bent tubes are needed most urgently in many industries such as aviation and aerospace. Warm bending may be a feasible way for manufacturing these components. Understanding their temperature and strain rate dependent tensile behavior is the foundation for formability improvement and warm bending design. In this paper, uniaxial tensile tests were conducted at elevated temperatures ranging from 298 K to 873 K at tensile velocities of 2, 10, 15 mm/min. The main results show that the tensile behavior of LDTW TC4 tubes is different from that of TC4 sheets. The typical elongation of TC4 tubes at room temperature is 10%lower than that of TC4 sheets. The flow stress of TC4 tubes decreases greatly by about 50% with the temperature rising to 873 K. At temperatures of 573–673 K, the hardening exponent is at its highest value, which means the deformation mechanism changes from twining to more dislocation movement by slipping. The fracture elongation of TC4 tubes fluctuates with increasing temperature,which is associated with changes in the deformation mechanism and with the blue brittleness. The fractography of TC4 tubes at various temperatures, especially at 673 K, shows that second phases and impurities significantly influence fracture elongation. By considering the characteristics of the tensile behavior and by properly choosing the die material, the warm bending for TC4 tubes can be achieved at temperatures of 723–823 K. | Tao Zhijun Yang He Li Heng Fan Xiaoguang | 2016 | Chinese Journal of Aeronautics2016,29,2: | 7 |
| 18 | A cohort autopsy study defines COVID-19 systemic pathogenesis显示文摘Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs.However,the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown.We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan,China,and determined the systemic distribution of SARS-CoV-2. | Xiao-Hong Yao Tao Luo Yu Shi Zhi-Cheng He Rui Tang Pei-Pei Zhang Jun Cai Xiang-Dong Zhou Dong-Po Jiang Xiao-Chun Fei Xue-Quan Huang Lei Zhao Heng Zhang Hai-Bo Wu Yong Ren Zhen-Hua Liu Hua-Rong Zhang Cong Chen Wen-Juan Fu Heng Li Xin-Yi Xia Rong Chen Yan Wang Xin-Dong Liu Chang-Lin Yin Ze-Xuan Yan Juan Wang Rui Jing Tai-Sheng Li Wei-Qin Li Chao-Fu Wang Yan-Qing Ding Qing Mao Ding-Yu Zhang Shu-Yang Zhang Yi-Fang Ping Xiu-Wu Bian | 2021 | Cell Research2021,31,8: | 7 |
| 19 | Identification and characterization of rice blast resistance gene Pid4 by a combination of transcriptomic profiling and genome analysis显示文摘Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast. Amino acid sequence comparison and blast resistance spectrum tests showed that Pid4 is a novel R gene, different from the previously reported R genes located in the same gene cluster. A Pid4 Indel marker was developed to facilitate the identification of Pid4 in different rice varieties. We demonstrated that a plant R gene can be quickly isolated using transcriptomic profiling coupled with genome-wide sequence analysis. | Zhixiong Chen Wen Zhao Xiaobo Zhu Chengdong Zou Junjie Yin Mawsheng Chern Xiaogang Zhou Heng Ying Xin Jiang Yongzhen Li Haicheng Liao Mengping Cheng Weitao Li Min He Jing Wang Jichun Wang Bingtian Ma Jirui Wang Shigui Li Lihuang Zhu Xuewei Chen | 2018 | Journal of Genetics and Genomics2018,45,12: | 7 |
| 20 | Specific CYP450 Genotypes in the Chinese Population Affect Sorafenib Toxicity in HBV/HCV-associated Hepatocellular Carcinoma Patients显示文摘Objective The purpose of this study was to screen for frequencies of different CYP450 genotypes in the Chinese population and explore the relationship between sorafenib toxicity and CYP450 polymorphism. Methods A total of 600 peripheral blood samples were obtained from two groups for this study. The first group of 300 samples were from Chinese patients with HBV/HCV-associated HCC, while the remaining 300 samples were from a healthy population of recruited subjects. Allele-specific PCR and long-fragment gene sequencing was used to identify the frequencies of CYP450 polymorphism. Aflatoxin-induced HCC rat models expressing CYP3A4*1, CYP3A5*3, CYP2C19*2, and CYP2D6*10 were established and treated with sorafenib at certain time points. Hepatic and renal function, along with plasma concentration of sorafenib, were monitored regularly. Results The most common forms of CYP mutations in the Chinese population were identified. The levels of sorafenib plasma concentration, as well as damage to hepatic and renal function in aflatoxin-induced HCC rat models varied significantly across the different CYP genotypes. Conclusion The mutational frequencies of CYP3A5, CYP3A4, CYP2C19, and CYP2D6 genotypes varied among different ethnic groups and populations. Individuals with CYP3A5*3 demonstrated minimal sorafenib metabolism, which led to severe hepatic and renal damage. Inter-individual variability in sorafenib-toxicity may be interpreted by CYP450 genetic polymorphisms, suggesting that identification of CYP polymorphism within a certain population should be considered in sorafenib therapy. | GUO Xing Gang WANG Zhi Heng DONG Wei HE Xu Dong LIU Fu Chen LIU Hui | 2018 | Biomedical and Environmental Sciences2018,31,8: | 7 |