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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Multiple haploids, triploids, and tetraploids found in modern-day “living fossil” Ginkgo biloba显示文摘Ginkgo biloba,the last extant representative of a lineage of Mesozoic gymnosperms,is one of the few seed plants with an exceptionally long(~300 Myr)evolutionary history free of genome-wide duplications(polyploidy).Despite this genome conservatism,we have recently found a viable spontaneous tetraploid Ginkgo sapling during routine screening of several plants,demonstrating that natural polyploidy is possible in Ginkgo.Here we provide a much wider flow cytometry survey of ploidy in some European Ginkgo collections,and own seedlings(>2200 individuals and~200 cultivars).We found a surprisingly high level of ploidy variation in modern-day Ginkgo and documented altogether 13 haploid,3 triploid,and 10 tetraploid Ginkgo plants or cultivars,most of them being morphologically distinct from common diploids.Haploids frequently produced polyploid(dihaploid)buds or branches.Tetraploids showed some genome size variation.The surveyed plants provide a unique resource for future Ginkgo research and breeding,and they might be used to accelerate the modern diversification of this nearly extinct plant lineage. | PetrŠmarda Lucie Horová Ondřej Knápek Heidi Dieck Martin Dieck Katarína Ražná Pavel Hrubík Laszlo Orlóci Laszlo Papp Kristýna Veselá Pavel Veselý Petr Bureš | 2018 | Horticulture Research2018，5，1： | 4 |
| 3 | Identification of the DNA Binding specificity and potential target genes for the farnesold X-activated receptor显示文摘 | Bryan A L Heidi R K Catherine M N | 2000 | J Biol Chem2000，275，10： | 1 |
| 4 | Cardiospheres reverse adverse remodeling in chronic rat myocardial infarction: roles of soluble endoglin and Tgf-β signaling显示文摘 | Eleni Tseliou Heidi Reich Geoffrey Couto John Terrovitis Baiming Sun Weixin Liu Eduardo Marbán | 2014 | Basic Research in Cardiology2014，，6： | 1 |
| 5 | Development of language and speech perception in congenitally,profoundly deaf children as a function of age at cochlear implantation显示文摘 | MARIO A S SU-WOOI T HEIDI N | 2004 | Audiol Neurotol2004，9，： | 1 |
| 6 | Increasing lake water and sediment oxygen levels using slow release peroxide 显示文摘 | Anne N yknen Heidi Kontio Oskari Klutas | 2012 | Science of the Total Environment2012，，429： | 1 |
| 7 | Postmenopausal hormone replacement therapy: scientific review显示文摘 | Heidi DN Linda LH Peggy N | 2002 | JAMA2002，288，： | 1 |
| 8 | Prognostic impact of immuno histochemieally defined germinal center phenotype in dffuse large B-cell lymphoma patients treated with inununochemotherapy显示文摘 | Heidi N Magdalena A Marja L | 2007 | Blood2007，10，11： | 1 |
| 9 | The true Cramer-Rao bound for carrier frequency estimation from a PSK signal显示文摘 | NELE N HEIDI S MOENECLAEY M | 2004 | IEEE Transactions on Communications2004，52，5： | 1 |
| 10 | Combined Modality Therapy Including Intraoperative Electron Irradiation for Locally Recurrent Colorectal Cancer 显示文摘 | Michael GH Robert CM Heidi N | 2011 | Int J Radiat Oncol Biol Phys2011，79，1： | 1 |
| 11 | Deoxygenation of dodecanoic acid under inert atmosphere显示文摘 | Heidi Bernas Kari Er?nen Irina Simakova Anne-Riikka Leino Krisztián Kordás Jukka Myllyoja P?ivi M?ki-Arvela Tapio Salmi Dmitry Yu. Murzin | 2009 | Fuel2009，，8： | 1 |
| 12 | Melting glaciers: a probable source of DDT to the Antarctic marine ecosystem显示文摘 | Heidi N Geisz Rebecca M Dickhut Michele A Cochran | 2008 | Environ Sci Technol2008，42，11： | 1 |
| 13 | Postmenopausal hormone replacement therapy显示文摘 | Heidi D Linda L Peggy N | 2002 | JAMA2002，288，7： | 1 |
| 14 | Drought effects on fine-root and ectomycorrhizal-root biomass in managed Pinus oaxacana Mirov stands in Oaxaca, Mexico显示文摘 | María Valdés Heidi Asbjornsen Martín Gómez-Cárdenas Margarita Juárez Kristiina A. Vogt | 2006 | Mycorrhiza2006，，2： | 1 |
| 15 | Induced defenses of Veronica spicata : Variability in herbivore-induced volatile organic compounds显示文摘 | Delia M. Pinto-Zevallos Heidi Hellén Hannele Hakola Saskya van Nouhuys Jarmo K. Holopainen | 2013 | Phytochemistry Letters2013，，4： | 1 |
| 16 | Combined Modality Therapy Including Intraoperative Electron Irradiation for Locally Recurrent Colorectal Cancer 显示文摘 | Michael GH Robert CM Heidi N e| al | 2011 | Int J Radiat Oncol Biol Phys2011，79，1： | 1 |
| 17 | Markedly increased urinary preprohaptoglobin and haptoglobin in passive heymann nephritis:a dif- ferential proteomics approach显示文摘 | Heidi H N Sit W H Jiang P P | 2007 | J Proteome Res2007，6，8： | 1 |
| 18 | Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas:hypoxia-induced transcription profile signifies metastatic potential 显示文摘 | Francis P Heidi N Christoph M | 2007 | BMC Genomics2007，8，1： | 1 |
| 19 | Exploring QSAR of antiamoebic agents of isolated natural products by MLR,ANN,and RTO显示文摘 | Guillermo Ram'rez-Galicia Heidy Marfnez-Pacheco Ramo'n Gardun-o-Jua'rez | 2011 | Med Chem Res2011，，9： | 1 |
| 20 | Carrier phase tracking from Turbo and LDPC coded signals affected by a frequency offset显示文摘 | Sig Nele N Heidi S Moeneclaey M | 2005 | IEEE Communications Letters2005，9，10： | 1 |
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