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| 1 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 2 | A multiplex RT-PCR Assay for the Rapid and Differential Diagnosis of Classical Swine Fever and Other Pestivirus infections显示文摘 | Heidy D Lester J Perez M | 2009 | Veterinary Microbiology2009，139，34： | 1 |
| 3 | the PPAR /ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in dia- betic mice 显示文摘 | Hwang J Kleinhenz D J Heidi L | 2007 | Vase Pharmacol2007，46，： | 1 |
| 4 | How Can SMEs in a Cluster Respond to Global Demands for Cor- porate Responsibility 显示文摘 | Heidi von Weltzien Haeivik Shankar D | 2011 | Journal of Business Ethics2011，101，2： | 1 |
| 5 | Assessing benefits and harms of hormone replacement therapy显示文摘 | Heidi D Nelson MD MPH | 2002 | JAMA2002，288，7： | 1 |
| 6 | Menopause显示文摘 | Heidi D Nelson | 2008 | 2008 (9614)2008，，9614： | 1 |
| 7 | Screening for breast cancer: an update for the US preventive services task iorce 显示文摘 | Heidi D Nelson MD MPH etc | 2009 | Ann Intern Med2009，151，： | 1 |
| 8 | Roles of salicylicacid,jasmonic acid,and ethylene in cpr-induced resistance inArabidopsis显示文摘 | Joseph D C Sigrid M V Heidi L | 2000 | Plant Cell2000，12，： | 1 |
| 9 | Enterpreneurs in romance tourism in Indonesia显示文摘 | Heidi D Bras K | 1999 | Annals of Tourism Research1999，，26： | 1 |
| 10 | The effects of burial by sand on survival and growth of Pitcher’s thistle (Cirsium pitcheri) along lake huron显示文摘 | M. Anwar Maun Heidi Elberling Angelo D’Ulisse | 1996 | Journal of Coastal Conservation1996，，1： | 1 |
| 11 | Mammalian Telomeres End in a Large Duplex Loop显示文摘 | Jack D Griffith Laurey Comeau Soraya Rosenfield Rachel M Stansel Alessandro Bianchi Heidi Moss Titia de Lange | 1999 | Cell1999，，4： | 1 |
| 12 | A multiplex RT-PCR assay for the rapid and differential diagnosis of classical swine fever and other pestivirus infections 显示文摘 | Heidy D A Lester J Maria T | 2009 | Veterinary Microbiology2009，139，： | 1 |
| 13 | Fabrication and characterization of contact lenses bearing surfaceimmobilized layers of intact liposomes显示文摘 | Anne D Heidi B Yves M | 2007 | J Biomed-Mater Res A2007，80，： | 1 |
| 14 | Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo 显示文摘 | Jesse J Smith Renee Deehan Kenney David J Gagne Brian P Frushour William Ladd Heidi L Galonek Kristine Israelian Jeffrey Song Giedre Razvadauskaite Amy V Lynch David P Carney Robin J Johnson Siva Lavu Andre Iffland Peter J Elliott Philip D Lambert Keith O Elliston Michael R Jirousek Jill C Milne and Olivier Boss | 2009 | BMC Systems Biology2009，284，27： | 1 |
| 15 | Postmenopausal hormone replacement therapy显示文摘 | Heidi D Linda L Peggy N | 2002 | JAMA2002，288，7： | 1 |
| 16 | Analysis of integral membrance protein contributions to the deformability and stability of the human erythrocyte membrance显示文摘 | DAVID W K JOEL A C | 2001 | Biological Chemistry2001，276，46： | 1 |
| 17 | Ex vivo isolation and characterization of CD4^+ CD25^+ T cells with regulatory properties from human blood 显示文摘 | Detlef D Heidi P Susanne B | 2001 | J Exp Med2001，193，： | 1 |
| 18 | Postmenopausal hormone replacement therapy 显示文摘 | Heidi D | 2014 | JAMA2014，288，2： | 1 |
| 19 | The space of flows, the rules of play, and sustainable urban design: The sustainability game as a tool of critical pedagogy in higher education显示文摘 | Ernest J Richard S Heidi D | 2013 | International Journal of Sustainability in Higher Education2013，0，01： | 1 |
| 20 | Adaptive Model - driven Bit Allocation for MPEGVideo Coding 显示文摘 | Bo T Bradley W D Heidi A P | 2000 | IEEE Tram on Circuits and Systems for Video Technology2000，10，1： | 1 |
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