| 1 | Prognostic significance of preoperative fibrinogen in patients with colon cancer显示文摘AIM:To investigate the prognostic significance of preoperative fibrinogen levels in colon cancer patients.METHODS:A total of 255 colon cancer patients treated at the Affiliated Tumor Hospital of Xinjiang Medical University from June 1st 2005 to June 1st 2008 were enrolled in the study.All patients received radical surgery as their primary treatment method.Preoperative fibrinogen was detected by the Clauss method,and all patients were followed up after surgery.Preoperative fibrinogen measurements were correlated with a number of clinicopathological parameters using the Student t test and analysis of variance.Survival analyses were performed by the Kaplan-Meier method and Cox regression modeling to measure 5-year disease-free survival(DFS)and overall survival(OS).RESULTS:The mean preoperative fibrinogen concentration of all colon cancer patients was 3.17±0.88 g/L.Statistically significant differences were found between preoperative fibrinogen levels and the clinicopathological parameters of age,smoking status,tumor size,tumor location,tumor-node-metastasis(TNM)stage,modified Glasgow prognostic scores(mGPS),white blood cell(WBC)count,neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),and carcinoembryonic antigen(CEA)levels.Univariate survival analysis showed that TNM stage,tumor cell differentiation grade,vascular invasion,mGPS score,preoperative fibrinogen,WBC,NLR,PLR and CEA all correlated with both OS and DFS.Alpha-fetoprotein(AFP)and body mass index correlated only with OS.Kaplan-Meier analysis revealed that both OS and DFS of the total cohort,as well as of the stageⅡandⅢpatients,were higher in the hypofibrinogen group compared to the hyperfibrinogen group(all P<0.05).In contrast,there was no significant difference between OS and DFS in stageⅠpatients with low or high fibrinogen levels.Cox regression analysis indicated preoperative fibrinogen levels,TNM stage,mGPS score,CEA,and AFP levels correlated with both OS and DFS.CONCLUSION:Preoperative fibrinogen levels can serve as an independent prognostic marker to evaluate patient response to colon cancer treatment. | Zhen-Qiang Sun Xiao-Na Han Hai-Jiang Wang Yong Tang Ze-Liang Zhao Yan-Li Qu Rui-Wei Xu Yan-Yan Liu Xian-Bo Yu | 2014 | World Journal of Gastroenterology2014，20，26： | 16 |
| 2 | 纤维蛋白原在预测接受新辅助治疗的非小细胞肺癌术后复发的临床意义显示文摘目的探讨接受新辅助治疗的非小细胞肺癌(NSCLC)患者血浆纤维蛋白原与术后复发的关系。方法 2006~2011年该院接受新辅助治疗后行肺癌切除术患者80例,检测新辅助治疗前后血浆纤维蛋白原水平,探讨其与临床病理特点、新辅助治疗效果及术后复发的关系。并根据术前纤维蛋白原的水平和新辅助治疗期间纤维蛋白原的变化进行分类,探讨其与预后的关系。结果纤维蛋白原在新辅助治疗前后水平变化和年龄、性别、肿瘤大小、淋巴结转移、治疗前分期、术前治疗方案无统计学差异(P>0.05),纤维蛋白原降低者,新辅助治疗疗效好(P=0.004),有较低的复发率(P=0.026)。术前高纤维蛋白原血症和新辅助化疗后纤维蛋白原升高者术后无病生存期(DFS)显著缩短,而纤维蛋白原术前正常和治疗后水平下降者DFS明显延长(P<0.005),这种分类(χ2=2.165,P=0.002)和新辅助治疗的疗效(危险比=0.280,P=0.001)是术后DFS的重要决定因素。结论术前纤维蛋白原水平和新辅助治疗期间纤维蛋白原的变化是影响肺癌术后复发的独立因素,纤维蛋白原分类可能是一种简单有效的预测术后复发的指标。 | 田文 高敬华 李永生 张菁华 李际君 | 2015 | 中国老年学杂志2015，35，2： | 1 |
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