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| 1 | 急性缺血性卒中的血管内治疗:神经介入外科学学会实践标准委员会的报告显示文摘目的总结采用血管内技术治疗急性缺血性卒中的有关证据并等级分类。方法对美国心脏协会(American Heart Association,AHA)以前发表的推荐意见进行审查并作为当前流程的基础。在此这基础上,进行系统的文献回顾以评估支持急性缺血性卒中血管内治疗的证据。根据AHA卒中委员会和牛津大学循证医学中心提出的循证医学证据分级指南进行评估。对操作安全性、技术效果以及对临床转归的影响进行特别审核。 | K A Blackham P M Meyers T A Abruzzo F C Alberquerque D Fiorella J Fraser D Frei C D Gandhi D V Heck J A Hirsch D P Hsu M Jayaraman S Narayanan C Prestigiacomo J L Sunshine 包元飞(译) 李永坤(译) 刘新峰(译) | 2012 | 国际脑血管病杂志2012，20，12： | 28 |
| 2 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 3 | 一般人群的神经病理性疼痛:流行病学研究系统回顾显示文摘1.前言神经病理性疼痛是公认的最难治疗的疼痛综合征之一,而且转归往往不尽人意。原因部分是由于神经病变产生的疼痛可能在初级医疗中未被发现,并且药物的使用未达标准。在这一领域的流行病学研究是存在疑问的,例如缺乏一致性,缺乏能真实反映病例状态和应用于人群研究的有效病例定义;再如变量的多样性研究,病例确诊的方法不同;此外,疼痛不是主诉表现,病例如何纳入或排除等。现有的一般人群患病率的评估可能变得更高,可能有更多的患者正经历着神经病理性疼痛的折磨。 | van Hecke O 冯刚 | 2015 | 中国疼痛医学杂志2015，21，5： | 6 |
| 4 | 物系管理与可持续发展显示文摘该文回顾德国自60年代以来,从“末端治理型”环保政策到现在提出“物系管理”的发展变化,介绍了德国环境保护工作的成功与不足。从物系管理的产生背景出发,探讨了物系管理的概念、意义、应用实践、面临的困难。此外,该文还阐明物系管理可以成为促进中国可持续发展的一个及时、有效的工具。 | Peter Heck | 2003 | 福建环境2003，20，3： | 6 |
| 5 | Synthesis, Crystal Structure and Catalytic Properties of a 2D Cobalt(II) Coordination Polymer Based on Mixed Ligands显示文摘A new Co(II) metal-organic coordination polymer based on flexible bis(imidazole) and aromatic dicarboxylate co-ligands, namely [Co(bix)(nph)]n(H2nph = 3-nitrophthalic acid, bix = 1,4-bis(imidazole-1-ylmethyl)benzene), has been hydrothermally synthesized and characterized by elemental analyses, TG, IR spectroscopy and single-crystal X-ray diffraction. It crystallizes in the triclinic space group P1 with a = 9.3767(14), b = 10.1451(15), c = 12.1488(17), α = 102.6450(10), β = 108.856(2), γ = 98.807(2)°, V = 1035.3(3)3, Z = 2, C22H17 Co N5O6, Mr = 506.34, Dc = 1.624 g/cm3, μ = 0.882 mm-1 and F(000) = 518. In the complex, the nph2- ligands connect neighbouring cobalt atoms to form binuclear [Co(nph)]2 subunits, which are linked by pairs of bix ligands to form a 2D honeycomb-like(6,3) network. In addition, the compound is further extended into a 3D supramolecular architecture by π···π stacking interactions. Moreover, the luminescence and catalytic properties of the complex are investigated. | 张旭 葛明 HECKE Kristof Van 崔广华 | 2015 | Chinese Journal of Structural Chemistry2015，34，4： | 3 |
| 6 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 7 | Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites显示文摘 | Carlos Guarner Bruce A. Runyon Sharon Young Mary Heck M.Yasin Sheikh | 1997 | Journal of Hepatology1997，，6： | 2 |
| 8 | Mass Spectrometry–Based Proteomics and Network Biology显示文摘 | Ariel Bensimon Albert J.R. Heck Ruedi Aebersold | 2012 | Annual Review of Biochemistry2012，，： | 2 |
| 9 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 10 | Microbial responses to combined oxidation and catalysis treatment of 1,4-dioxane and co-contaminants in groundwater and soil显示文摘Post-treatment impacts of a novel combined hydrogen peroxide(H2O_(2))oxidation and WOx/ZrO_(2) catalysis used for the removal of 1,4-dioxane and chlorinated volatile organic compound(CVOC)contaminants were investigated in soil and groundwater microbial community.This treatment train removed~90%1,4-dioxane regardless of initial concentrations of 1,4-dioxane and CVOCs.The Illumina Miseq platform and bioinformatics were used to study the changes to microbial community structure.This approach determined that dynamic shifts of microbiomes were associated with conditions specific to treatments as well as 1,4-dioxane and CVOCs mixtures.The biodiversity was observed to decrease only after oxidation under conditions that included high levels of 1,4-dioxane and CVOCs,but increased when 1,4-dioxane was present without CVOCs.WO_(x)/ZrO_(2) catalysis reduced biodiversity across all conditions.Taxonomic classification demonstrated oxidative tolerance for members of the genera Massilia and Rhodococcus,while catalyst tolerance was observed for members of the genera Sphingomonas and Devosia.Linear discriminant analysis effect size was a useful statistical tool to highlight representative microbes,while the multidimensional analysis elucidated the separation of microbiomes under the low 1,4-dioxane-only condition from all other conditions containing CVOCs,as well as the differences of microbial population among original,post-oxidation,and post-catalysis states.The results of this study enhance our understanding of microbial community responses to a promising chemical treatment train,and the metagenomic analysis will help practitioners predict the microbial community status during the post-treatment period,which may have consequences for long-term management strategies that include additional biodegradation treatment or natural attenuation. | Yu Miao Nicholas W.Johnson Kimberly Heck Sujin Guo Camilah D.Powell Thien Phan Phillip B.Gedalanga David T.Adamson Charles J.Newell Michael S.Wong Shaily Mahendra | 2018 | Frontiers of Environmental Science & Engineering2018，12，5： | 2 |
| 11 | 12q24 locus association with type 1 diabetes:SH2B3 or ATXN2?显示文摘Genetic linkage analyses, genome-wide association studies of single nucleotide polymorphisms, copy number variation surveys, and mutation screenings found the human chromosomal 12q24 locus, with the genes SH2B3 and ATXN2 in its core, to be associated with an exceptionally wide spectrum of disease susceptibilities. Hematopoietic traits of red and white blood cells(like erythrocytosis and myeloproliferative disease), autoimmune disorders(like type 1 diabetes, coeliac disease, juvenile idiopathic arthritis, rheumatoid arthritis, thrombotic antiphospholipid syndrome, lupus erythematosus, multiple sclerosis, hypothyroidism and vitiligo), also vascular pathology(like kidney glomerular filtration rate deficits, serum urate levels, plasma beta-2-microglobulin levels, retinal microcirculation problems, diastolic and systolic blood pressure and hypertension, cardiovascular infarction), furthermore obesity, neurodegenerative conditions(like the polyglutamine-expansion disorder spinocerebellar ataxia type 2, Parkinson's disease, the motor-neuron disease amyotrophic lateral sclerosis, and progressive supranuclear palsy), andfinally longevity were reported. Now it is important to clarify, in which ways the loss or gain of function of the locally encoded proteins SH2B3/LNK and ataxin-2, respectively, contribute to these polygenic health problems. SH2B3/LNK is known to repress the JAK2/ABL1 dependent proliferation of white blood cells. Its null mutations in human and mouse are triggers of autoimmune traits and leukemia(acute lymphoblastic leukemia or chronic myeloid leukemia-like), while missense mutations were found in erythrocytosis-1 patients. Ataxin-2 is known to act on RNA-processing and trophic receptor internalization. While its polyglutamine-expansion mediated gain-of-function causes neuronal atrophy in human and mouse, its deletion leads to obesity and insulin resistance in mice. Thus, it is conceivable that the polygenic pathogenesis of type 1 diabetes is enhanced by an SH2B3-dysregulation-mediated predisposition to autoimmune diseases that conspires with an ATXN2-deficiency-mediated predisposition to lipid and glucose metabolism pathology. | Georg Auburger Suzana Gispert Suna Lahut Ozgür Omür Ewa Damrath Melanie Heck Nazlι Basak | 2014 | World Journal of Diabetes2014，5，3： | 2 |
| 12 | Analysis of the time course of core breakdown in 'Conference' pears by means of MRI and X-ray CT显示文摘 | Lammertyn J Dresselaers T Van Hecke P | 2003 | Postharvest Biology and Technology2003，29，1： | 1 |
| 13 | Variation in CAS Pogene is associated with idiopathic talipes equlnovarus 显示文摘 | Heck AL Bray MS Scott A | 2005 | J Pediar Orthop2005，25，5： | 1 |
| 14 | Status epilepticus increase CSF levels of neuronspecific enolase and alters the blood-brain barrier 显示文摘 | Correle J Rabinowicz AL Heck CN Smith TD Loskota WJ Degiorgio CM | 1998 | Neurology1998，50，5： | 1 |
| 15 | Mathematical modeling of monolithic catalysts 显示文摘 | Heck R H Wei J and Katzer J R | 1976 | AIChE Journal1976，22，3： | 1 |
| 16 | MR spectroscopy quantitation: a review of time-domain methods显示文摘 | Vanhamme L Sundin T Hecke PV | 2001 | NMR Biomed2001，14，4： | 1 |
| 17 | Hepatitis B virus - specific cytotoxic T lymphocyte response in patients with acute and chronic hepatitis B virus infections显示文摘 | Van Hecke E Paradijs J Molitor C | 1994 | J Hepatol1994，20，4： | 1 |
| 18 | UVB light regulates expression ofantioxidants and inf]arl+rnatory mediators in human corneal epithelial cells显示文摘 | Black AT Gordon M K Heck DE el al | 2011 | Bioehem Pharmacol2011，81，： | 1 |
| 19 | Dialysate so- dium concentration and the association with interdialytic weight gain, hospitalization, and mortality显示文摘 | HECKING M KARABOYAS A SARAN R | 2012 | Clin J Am Soc Nephrol2012，7，1： | 1 |
| 20 | Analysis of cerebellar function inUbe3a-deficient mice reveals novel genotype-specific behaviors显示文摘 | HECK D H ZHAO Y ROY S | 2008 | HumMol Genet2008，17，14： | 1 |
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