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| 1 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 2 | Occurrence, Fate, and Removal of Pharmaceutical Residues in the Aquatic Environ- ment:a Review of Recent Research Data 显示文摘 | Thomas Heberer | 2002 | Toxi- cology Letters2002，131，12： | 1 |
| 3 | Occurrence of residues of the veterinary drug malachite green in eels caught downstream from municipal sewage treatment plants显示文摘 | Schuetze Andrea Heberer Thomas Juergensen Susanne | 2008 | Chemosphere2008，72，11： | 1 |
| 4 | County and Township Cadres as a Strategic Group. A New Approach to Political Agency in China’s Local State显示文摘 | Thomas Heberer Gunter Schubert | 2012 | Journal of Chinese Political Science2012，，3： | 1 |
| 5 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data显示文摘 | Thomas Heberer | 2002 | Toxicology Letters2002，，1： | 1 |
| 6 | Preterm premature rupture of membranes: Risks of recurrent complications in the next pregnancy among a population-based sample of gravid women显示文摘 | Thomas Lee Marshall W. Carpenter Walter W. Heber Helayne M. Silver | 2003 | American Journal of Obstetrics and Gynecology2003，，1： | 1 |
| 7 | Tracking Persistent Pharmceutical residues from municipal sewage to drinking water 显示文摘 | Thomas Heberer | 2002 | Journal of Hydrology2002，266，： | 1 |
| 8 | Tracking persistent pharmaceutical residues from municipal sewage to drinking water显示文摘 | Thomas Heberer | 2002 | Journal of Hydrology2002，，3： | 1 |
| 9 | Occurrence, fate and removal of pharmaceutical residues in the aquatic environment: a review of recent research data显示文摘 | Thomas Heberer | 2002 | Toxicology Letters2002，131，： | 1 |
| 10 | Occurrence, fate and assessment of polar metamizole (dipyrone) residues in hospital and municipal wastewater 显示文摘 | Dirk F Feldmann Sebastian Zuehlke Thomas Heberer | 2008 | Chemosphere2008，71，9： | 1 |
| 11 | Pre- term premature rupture of membranes:risks of recurrent compli-cations in the next pregnancy among a population - based sam- ple of gravid women 显示文摘 | Lee Thomas Carpenter Marshall W Heber Walter W | 2003 | American Journal of Obstetrics & Gy- necology2003，1881，： | 1 |
| 12 | Evolvement of Citizenship in Urban China or Authoritarian Communitarianism? Neighborhood development, community participation, and autonomy显示文摘 | Thomas Heberer | 2009 | Journal of Contemporary China2009，，61： | 1 |
| 13 | Behaviour and redox sensitivity of pharmaceutical residues during bank filtration-Investigation of residues of phenazone-type analgesics 显示文摘 | Gudrun Massmann Uwe Dunnbier Thomas Heberer | 2008 | Chemosphere2008，，71： | 1 |
| 14 | 中国农村的巨变显示文摘只有打击地方政府的腐败,只有地方干部的所思所行能以农民的需求为准则,政府的执政才有合法性。 | Thomas Heberer 辛琦 | 2009 | 中国报道2009，，12： | 0 |
| 15 | Three new late-type hypervelocity star candidates from Gaia DR2 with refined selection criteria显示文摘Several dozen hypervelocity star(HVS)candidates have been reported based on the second data release of Gaia(Gaia DR2).However,it has been proven that the radial velocities of some Gaia HVS candidates are not reliable.In this paper,we employ refined astrometric criteria to re-examine Gaia DR2,arriving at a more reliable sample of HVS and high velocity star candidates than those found by previous authors.We develop a method called Binary Escape Probability Analysis to identify some HVS candidates.This method allows us to work with stars having only two epochs of measured radial velocity.These stars were usually discarded in previous similar studies.A scrutiny of our final results sheds light on selection effects present in our studies,which we propose to be the focus of future studies.In total,we find three late-type(2 G-type and 1 K-type)HVS and 21 high velocity star candidates,3 and 11 of which are new,respectively.Judging by their historical trajectories,which we calculate,all three HVS candidates could not have had Galactic center origins.Further monitoring is required to confirm their status. | Jiao Li Shi Jia Yan Gao Deng-Kai Jiang Thomas Kupfer Ulrich Heber Chao Liu Xue-Fei Chen Zhan-Wen Han | 2020 | Research in Astronomy and Astrophysics2020，20，3： | 0 |
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