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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients: A Matched Cohort Study显示文摘 | Alan H. Gradman Hélène Parisé Patrick Lefebvre Heather Falvey Marie-Hélène Lafeuille Mei Sheng Duh | 2013 | Hypertension2013，，2： | 2 |
| 3 | Applications of solid-phase microextraction in food analysis显示文摘 | Hiroyuki Kataoka Heather L Lord Janusz Pawliszyn | 2000 | Journal of Chromatography A2000，，1： | 2 |
| 4 | Oxidative stress markers are associated with persistent atrial fibrillation显示文摘 | Robert B Heather L Irfan S | 2007 | Clin Chem2007，53，9： | 1 |
| 5 | The effect of operational parameters on the photocatalytic degradation of humic acid显示文摘 | Fiona L Palmer Brian R Eggins Heather M Coleman | 2002 | Journal of Photochemistry & Photobiology, A: Chemistry2002，，1： | 1 |
| 6 | Applications of solid-phase microextraction in food analysis显示文摘 | Hiroyuki Kataoka Heather L Janusz Pawliszyn | 2000 | Journal of Chromatography A2000，880，： | 1 |
| 7 | Evaluation of CHROMagar Candida for Presumptive Identification of Clinically Important Candida Species显示文摘 | Heather L Powell Crystal A Sand Robert P Rennie | 1998 | Diagn Microbiol Infect Dis1998，32，4： | 1 |
| 8 | Studies on the microbial populations of the rhizosphere of big sagebrush (Artemisia tridentata)显示文摘 | Antony J B Janice L S Heather M K | 2004 | Journal Indian Microbiology and Biotechnology2004，31，6： | 1 |
| 9 | Decreased immunoreactivity for p27 protein in patients with Her-2/neu overexpression and chemotherapy in patients with negative lymph node status显示文摘 | Vito JS Heather L Cluseppe V | 2003 | Cancer2003，97，7： | 1 |
| 10 | Applications of solidphase microextration in food analysis显示文摘 | HIROYUKI K HEATHER L L JANUSZ P | 2000 | J Chromatography A2000，880，： | 1 |
| 11 | Proteomies and genomics of microgravity显示文摘 | Heather L Nichols Ning Zhang | 2006 | Physiol Genomices2006，26，： | 1 |
| 12 | Fatty acid transporterlevels and palmitate oxidation rate correlate with ejection fraction inthe infarcted rat heart显示文摘 | Heather L C Cole M A Lygate C A | 2006 | Cardiovasc Res2006，72，3： | 1 |
| 13 | Application of solid-phase mieroextraetion in fond analysis显示文摘 | HIROYUKI K HEATHER L TANUSZ P | 2000 | J Chromatography A2000，880，1： | 1 |
| 14 | Impact of health literacy on health outcomes in ambulatory care patients:a systematic review显示文摘 | Darcie L Julie W Heather A | 2008 | The Annals of Pharmacotherapy2008，42，9： | 1 |
| 15 | Formation and dissociation studies for optimizing the uptake of methane by methane hydrates 显示文摘 | LINK D D EDWARD P L HEATHER A E | 2003 | Fluid Phase Equilibria2003，，211： | 1 |
| 16 | Determination of carbendazim in blue berries by reversed phase high 2 perfomance liquid chromatography显示文摘 | Rodney J B Heather L H Jasotha K | 1991 | Journal of Chromatography1991，，587： | 1 |
| 17 | Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol - and obesity - induced fatty liver diseases 显示文摘 | Mantena Sudheer K King Adrienne L Andringa Kelly K Ec- cleston Heather B Bailey Shannon M | 2008 | Free radical biology & medi- cine2008，44，7： | 1 |
| 18 | Biosensor system for continuous monitoring of organophosphate aerosols 显示文摘 | Heather R L Roby G Mike H B | 2007 | Biosensors and Bioelectronics2007，23，： | 1 |
| 19 | Governing the Carbon Offset Market显示文摘 | Heather C L | 2010 | WIREs Climate Change2010，，1： | 1 |
| 20 | Genetic evidence for the convergent evolution of light skin in Europeans and east Asians显示文摘 | Norton Heather L Kittles | 2007 | Molecular Biology and Elolution2007，24，3： | 1 |
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