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| 1 | Bowel cleansing before colonoscopy:Balancing efficacy,safety,cost and patient tolerance显示文摘Effective colorectal cancer screening relies on reliable colonoscopy findings which are themselves dependent on adequate bowel cleansing. Research has consistently demonstrated that inadequate bowel preparation adversely affects the adenoma detection rate and leads gastroenterologists to recommend earlier follow up than is consistent with published guidelines. Poor preparation affects as many as 30% of colonoscopies and contributes to an increased cost of colonoscopies. Patient tolerability is strongly affected by the preparation chosen and manner in which it is administered. Poor tolerability is,in turn,associated with lower quality bowel preparations. Recently,several new developments in both agents being used for bowel preparation and in the timing of administration have brought endoscopists closer to achieving the goal of effective,reliable,safe,and tolerable regimens. Historically,large volume preparations given in a single dose were administered to patients in order to achieve adequate bowel cleansing. These were poorly tolerated,and the unpleasant taste of and significant side effects produced by these large volume regimens contributed significantly to patients' inability to reliably complete the preparation and to a reluctance to repeat the procedure. Smaller volumes,including preparations that are administered as tablets to be consumed with water,given as split doses have significantly improved both the patient experience and efficacy,and an appreciation of the importance of the preparation to colonoscopy interval have produced additional cleansing. | Nicole M Harrison Michael C Hjelkrem | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，1： | 19 |
| 2 | 环形扩散管和滤膜联用采集和测定大气中气固相物质显示文摘建立了环形扩散管(annular diffusion denuder)和滤膜连用的采样装器。采用涂渍1%碳酸钠甲醇水溶液和5%亚磷酸甲醇溶液的两段环形扩散管串联分别收集气态HNO_3,HCl,SO_2和NH_3、空气经扩散管后,继而抽入滤膜采样头,用Teflon滤膜采集颗粒物,Nylon滤膜收集由Teflon滤膜上颗粒物挥发产生的气态HNO_3和HCl。样品提取后,用离子色谱法测定SO_4^(2-),NO_3^-和Cl^-;采用流动注射荧光法测定NH_4^+。当采样流速为10L/min,采样24h,环形扩散管对气态硝酸、氯化氢和二氧化硫的检出限(3σ)为0.04—0.09μg/m^3,对氨的检出限为0.12μg/m^3。实验结果表明本法适用于大气和室内空气的采样和测定。 | 黎源倩 Harrison R M | 1992 | 环境化学1992，11，1： | 5 |
| 3 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 4 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 5 | 爱尔兰海岸夏季空气颗粒物水溶性离子粒径分布研究显示文摘研究了爱尔兰西海岸国际海洋大气研究站夏季(2002年8月12~22日)大西洋气团颗粒物中水溶性无机离子的含量与其粒径关系.海盐成分(Cl-、SO42-、Na+、Ca2+、Mg2+、K+)含量在粗颗粒物中随粒径呈双峰分布(0.8~30 μm),但Ca2+和K+受陆域源影响,在亚微米颗粒区间出现另一分布峰(0.1~0.8 μm).二次颗粒物成分在所有颗粒物中均有检出;NO3-呈广域宽带分布,其中大部分出现在海盐主峰区(0.8~8 μm,存在Dp 1.4 μm和Dp 4.4 μm两种模态);nss-SO42-(非海盐硫酸根)和NH4+呈相关三峰分布(Dp 0.44 μm、Dp 1.4 μm和Dp 4.4 μm),CH3SO3-也呈相似三峰分布(Dp 0.44 μm、Dp 1.4 μm和Dp 8 μm),三者在亚微米颗粒区间同位出现主峰.二次颗粒物成分Dp 1.4 μm模态在海岸空气颗粒物研究文献中尚少见报道.讨论了亚微米区间二次颗粒物盐类的化学形态.TSP中nss-SO42-、NO3-、NH4+和CH3SO3-的日均浓度分别为0.279、0.171、0.158和0.041 μg/m3. | 黄卓尔 Roy M Harrison 殷建新 | 2005 | 海洋环境科学2005，24，4： | 3 |
| 6 | 化学气体污染突发事件中的人群疏散:横断面调查显示文摘目的比较一个塑料工厂发生化学事故后躲藏和被疏散人群的健康结局。设计横断面调查。背景英格兰西南的市区。研究对象该地区1750位曾暴露于化学烟雾的居民,其中472人被疏散,剩下的1278人被建议躲藏在室内。主要结局测定不利于健康的症状数目。出现4个或以上症状者被确定为一个病例。主要的结果1096位居民(63%;299人被疏散,797人躲藏起来)为本分析提供了资料。被疏散人群的平均症状分值和病例的比例比躲藏人群的要高(疏散者:症状分值1.9,病例比例19.7%(n=59);躲藏者:症状分值1.0,病例比例9.5%(n=76),二者比较P<0.001)。在事故发生后两周末时二组间的差异明显变小。成为病例的两个主要可变更危险因子是疏散(比值比2.5,95%可信区间1.7~3.8)和在事故当天直接暴露于烟雾的时间超过2小时(比值比2.0,95%可信区间1.7~2.3)。住所距工厂的距离或是干预前(头6个小时)暴露的水平对于研究对象成为病例的作用不大。结论在此次化学事故中躲藏起来可能是优于疏散人群的保护措施。这与专家们普遍认为的观点一致。尽管本研究有一定的局限性,但它是基于一场真实的事件。疏散本身有一定的风险和资源上的限制,认识上的增加可能会有助于减少将来不必要的疏散。 | S Kinra G Lewendon R Nelder N Herriott R Mohan M Hort S Harrison V Murray 陈雷(译) | 2005 | 英国医学杂志中文版2005，8，5： | 3 |
| 7 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 8 | Chemical associations of lead, cadmium, copper and zinc in street dusts and roadside soils显示文摘 | Harrison R M Laxen D P H Wilson S J | 1981 | Environmental Science and Technology1981，15，11： | 2 |
| 9 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 10 | Planar chips technology for miniaturization and integration of separation techniques into monitoring systems:capillary electrophoresis on a chip 显示文摘 | MANZ A HARRISON D J VERPOORTE E M J | 1992 | Chromatography1992，593，： | 2 |
| 11 | Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia显示文摘ObjectiveTo 在在检验生活和资源使用的质量的 17 所澳大利亚的疗养院的代表性的研究的 Australia.MethodsAs 部分住在疗养院的更老的成年人与认知功能和痴呆的诊断检验在心血管的系统药使用之间的协会,我们检验了在认知缺陷和心血管的药使用之间的协会(使用解剖治疗学的分类系统识别)用一般线性回归和逻辑 regressio 正在收到生活照顾的结束的人是包括的 excluded.ResultsParticipants 有一个平均数的 541 个居民 85.5 | Enwu Liu Suzanne M Dyer Lisa Kouladjian O'Donnell Rachel Milte Clare Bradley Stephanie L Harrison Emmanuel Gnanamanickam Craig Whitehead Maria Crotty | 2017 | Journal of Geriatric Cardiology2017，14，6： | 2 |
| 12 | Hepatitis delta virus显示文摘 | Sarah A Hughes Heiner Wedemeyer Phillip M Harrison | 2011 | The Lancet2011，，9785： | 2 |
| 13 | Effect of Aspirin in Amaurosis Fugax显示文摘 | Harrison M J Marshall J Meadows J C | 1971 | Lancet1971，2，7727： | 1 |
| 14 | People,parks and the urban green:a study of popular meanings and value for open space in the city显示文摘 | Burgess J Harrison C M Limb M | 1988 | Urban Studies1988，25，： | 1 |
| 15 | Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin dependent diabetes显示文摘 | DEMPSEY C M KRAMER D R | 1996 | J Exp Med1996，184，6： | 1 |
| 16 | Prognostic significance of immunohistochemical micrometastasis in node negative gastric cancer patients显示文摘 | Choe JK Goldstein M | 2000 | J Surg Oncol2000，73，3： | 1 |
| 17 | Risk and predictors for pregnancy-related complications in women with heart disease显示文摘 | Siu SC Sermer M Harrison DA | 1997 | Circulation1997，96，： | 1 |
| 18 | Ethi cal Leadership: A Social Learning Perspective for Construct Development& Testing显示文摘 | BROWN M E TREVIN L K HARRISON D | 2005 | Organizational Behavior & Human Decision Processes2005，97，2： | 1 |
| 19 | Propofol increasesagonist efficacy at the GABAA receptor显示文摘 | O′Shea S M Wong L C Harrison N L | 2000 | Brain Research2000，852，2： | 1 |
| 20 | Uptake of urea C and urea N by the coastal marine diatom 显示文摘 | Price N M Harrison P J | 1988 | Limnol Oceanogr1988，33，： | 1 |
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