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| 1 | Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics(英文)显示文摘OBJECTIVE: Radiation-induced meningiomas are known to occur after high and low-dose cranial radiation therapy. The goal of this study was to discern the distinguishing findings and characteristics of radiation-induced meningiomas. METHODS: The records of 16 patients (seven men and nine women) who fulfilled the criteria for radiation-induced meningiomas were retrospectively reviewed.Clinical, histopathological, cytokinetic,and cytogenetic findings as well as the patients' outcome were analyzed. The mean age of the patients was 38.8 years and the mean tumor latency was 26. 5 years. Five patients had multiple meningiomas in the irradiated field. The recurrence rate was 100% after the initial resection; 62% of patients had a second recurrence and 17% had a third recurrence. Thirtyeight percent of patients had atypical or malignant histopathological findings. The presence of progesterone receptors and low | Al-Mefty O Topsakal C Pravdenkova S Sawyer JR Harrison MJ | 2004 | 中国神经肿瘤杂志2004，2，2： | 6 |
| 2 | Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: an open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2 study显示文摘 | Timothy Iveson Ross C Donehower Irina Davidenko Sergey Tjulandin Andrzej Deptala Mark Harrison Somanath Nirni Kuntegowdanahalli Lakshmaiah Anne Thomas Yizhou Jiang Min Zhu Rui Tang Abraham Anderson Sarita Dubey Kelly S Oliner Elwyn Loh | 2014 | Lancet Oncology2014，，9： | 3 |
| 3 | Walking a tightrope: creating value through interorganizational relationships显示文摘 | Bruce R Barringer Jeffrey S Harrison | 2000 | Journal of Management2000，，3： | 3 |
| 4 | 化学气体污染突发事件中的人群疏散:横断面调查显示文摘目的比较一个塑料工厂发生化学事故后躲藏和被疏散人群的健康结局。设计横断面调查。背景英格兰西南的市区。研究对象该地区1750位曾暴露于化学烟雾的居民,其中472人被疏散,剩下的1278人被建议躲藏在室内。主要结局测定不利于健康的症状数目。出现4个或以上症状者被确定为一个病例。主要的结果1096位居民(63%;299人被疏散,797人躲藏起来)为本分析提供了资料。被疏散人群的平均症状分值和病例的比例比躲藏人群的要高(疏散者:症状分值1.9,病例比例19.7%(n=59);躲藏者:症状分值1.0,病例比例9.5%(n=76),二者比较P<0.001)。在事故发生后两周末时二组间的差异明显变小。成为病例的两个主要可变更危险因子是疏散(比值比2.5,95%可信区间1.7~3.8)和在事故当天直接暴露于烟雾的时间超过2小时(比值比2.0,95%可信区间1.7~2.3)。住所距工厂的距离或是干预前(头6个小时)暴露的水平对于研究对象成为病例的作用不大。结论在此次化学事故中躲藏起来可能是优于疏散人群的保护措施。这与专家们普遍认为的观点一致。尽管本研究有一定的局限性,但它是基于一场真实的事件。疏散本身有一定的风险和资源上的限制,认识上的增加可能会有助于减少将来不必要的疏散。 | S Kinra G Lewendon R Nelder N Herriott R Mohan M Hort S Harrison V Murray 陈雷(译) | 2005 | 英国医学杂志中文版2005，8，5： | 3 |
| 5 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 6 | Chemical associations of lead, cadmium, copper and zinc in street dusts and roadside soils显示文摘 | Harrison R M Laxen D P H Wilson S J | 1981 | Environmental Science and Technology1981，15，11： | 2 |
| 7 | Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting显示文摘 | Quyen Dao Padma Krishnaswamy Radmila Kazanegra Alex Harrison Rambod Amirnovin Leslie Lenert Paul Clopton Joel Alberto Patricia Hlavin Alan S Maisel | 2001 | Journal of the American College of Cardiology2001，，2： | 2 |
| 8 | A randomized comparison of a fot pump and low-molecular-weight heparin in theprevention of deep-vein thrombosis after total knee replacement显示文摘 | Warwick D Harrison J Whitehouse S | 2002 | J Bone Joint Surg Br2002，84，406： | 1 |
| 9 | A randomised comparison of a foot pump and low-molecular-weight heparin in the prevention of deep-vein thrombosis after total knee replacement显示文摘 | Warwick D Harrison J Whitehouse S | 2002 | J Bone Joint Surg Br2002，84，3： | 1 |
| 10 | Propofol increasesagonist efficacy at the GABAA receptor显示文摘 | O′Shea S M Wong L C Harrison N L | 2000 | Brain Research2000，852，2： | 1 |
| 11 | Glacial-interglacial changes in dust deposition on the Chinese Loess Plateau 显示文摘 | Kohfeld K E Harrison S P | 2003 | Quaternary Science Reviews2003，22，： | 1 |
| 12 | Raising Tibet显示文摘 | Harrison T M Copeland P Kidd W S | 1992 | Science1992，255，： | 1 |
| 13 | Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care ( PAC-Man ) : a randomised controlled trial 显示文摘 | Harvey S Harrison DA Singer M | 2005 | Lancet2005，366，9484： | 1 |
| 14 | Motor evoked potential monitoring during spinal surgery: responses of distal limb muscles to transcranial cortical stimulation with pulse trains 显示文摘 | Jones S J Harrison R Koh K F | 1996 | Electroencephalogr Clin Neurophysiol1996，100，5： | 1 |
| 15 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 16 | Taehykinins in the re- spiratory tract显示文摘 | Groneberg DA Harrison S Dinh QT | 2006 | Curt Drug Targets2006，7，8： | 1 |
| 17 | Moving to greener pastures? Multinationals and thepollution haven hypothesis 显示文摘 | Eskeland G S Harrison A E | 2003 | Journal of Development Economics2003，，1： | 1 |
| 18 | DIRTMAP: the geological re- cord of dust 显示文摘 | Kohfeld K E Harrison S P | 2001 | Earth-Science Reviews2001，54，1： | 1 |
| 19 | The JAK/STAT Signaling Pathway显示文摘 | Rawlings J S Rosler K M Harrison D A | 2004 | J Cell Sci2004，17，： | 1 |
| 20 | The effect of changing land use on soil radiocarbon显示文摘 | Harrison K G Broecker W S Bonani G | 1993 | Science1993，262，： | 1 |
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