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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Machine learning models compared to existing criteria for noninvasive prediction of endoscopic retrograde cholangiopancreatography-confirmed choledocholithiasis显示文摘Background and aims:Noninvasive predictors of choledocholithiasis have generally exhibited marginal performance characteristics.We aimed to identify noninvasive independent predictors of endoscopic retrograde cholangiopancreatography(ERCP)-confirmed choledocholithiasis and accordingly developed predictive machine learning models(MLMs).Methods:Clinical data of consecutive patients undergoing first-ever ERCP for suspected chol-edocholithiasis from 2015 to 2019 were abstracted from a prospectively-maintained database.Multiple logistic regression was used to identify predictors of ERCP-confirmed choledocholithiasis.MLMs were then trained to predict ERCP-confirmed choledocholithiasis using pre-ERCP ultrasound(US)imaging only as well as using all available noninvasive imaging(US,computed tomography,and/or magnetic reso-nance cholangiopancreatography).The diagnostic performance of American Society for Gastrointestinal Endoscopy(ASGE)“high-likelihood”criteria was compared to MLMs.Results:We identified 270 patients(mean age 46 years,62.2%female,73.7%Hispanic/Latino,59%with noninvasive imaging positive for choledocholithiasis)with native papilla who underwent ERCP for suspected choledocholithiasis,of whom 230(85.2%)were found to have ERCP-confirmed chol-edocholithiasis.Logistic regression identified choledocholithiasis on noninvasive imaging(odds ratio(OR)¼3.045,P¼0.004)and common bile duct(CBD)diameter on noninvasive imaging(OR¼1.157,P¼0.011)as predictors of ERCP-confirmed choledocholithiasis.Among the various MLMs trained,the random forest-based MLM performed best;sensitivity was 61.4%and 77.3%and specificity was 100%and 75.0%,using US-only and using all available imaging,respectively.ASGE high-likelihood criteria demonstrated sensitivity of 90.9%and specificity of 25.0%;using cut-points achieving this specificity,MLMs achieved sensitivity up to 97.7%.Conclusions:MLMs using age,sex,race/ethnicity,presence of diabetes,fever,body mass index(BMI),total bilirubin,maximum CBD diameter,and choledocholithiasis on pre-ERCP noninvasive imaging predict ERCP-confirmed choledocholithiasis with good sensitivity and specificity and outperform the ASGE criteria for patients with suspected choledocholithiasis. | Camellia Dalai John M Azizian Harry Trieu Anand Rajan Formosa C Chen Tien Dong Simon W Beaven James H.Tabibian | 2021 | Liver Research2021，5，4： | 3 |
| 3 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 4 | 腹腔镜、开腹和机器人手术切除直肠癌的肿瘤学和围手术期结果:一项多中心、倾向评分加权队列研究显示文摘目的:尽管进行了多个随机对照试验,但微创和传统开腹直肠癌手术的短期和长期结果仍不清楚。本研究的目的是比较腹腔镜、开腹和机器人直肠癌切除术的成功率和术后结果。方法:这是一项使用倾向评分加权的多中心、准实验队列研究。数据源于2016年'美国外科医生学院国家外科手术质量改善计划(NSQIP)'中所有年龄在18~89岁的接受开腹、腹腔镜或机器人直肠癌切除术的成年患者。主要结果是代表肿瘤切除术成功的复合指标,包括远端切缘阴性、环周切缘阴性、至少评估12枚淋巴结。次要结果是全身和手术部位的并发症,以及再入院、再手术、手术时间和住院时间。 | 孙凌宇 KETHMAN W C HARRIS A H S MORRIS A M | 2020 | 结直肠肛门外科2020，26，1： | 2 |
| 5 | 继发性腹膜炎:诊断和干预原则显示文摘继发性腹膜炎的患者占急诊入院患者总数的1%。在全球范围内,继发性腹膜炎是重症监护病房(ICU)发生脓毒症的第二大原因。继发性腹膜炎的总体病死率是6%,但是当患者发展成为严重脓毒症时,其病死率上升为35%O尽管影像学和实验室检查日益普及,但是对于急诊、外科和ICU医生来说,如何快速诊断和早期处理腹膜炎仍然是一个难题。本文将综述腹膜炎的病理生理学机制以及发展为脓毒症的过程,我们还讨论了物理检查、实验室检查和影像学检查在诊断继发性腹膜炎中的有效性和局限性,并且提出一个治疗继发性腹膜炎的思路。 | James T Ross Michael A Matthay Hobart W Harris 陈国榕(译) 吴东(校) | 2019 | 英国医学杂志中文版2019，22，7： | 2 |
| 6 | Foreword显示文摘The contributions to this Special Issue were called on the occasion of the upcoming birthday anniversary of one of the outstanding scientists in field of mantle rheology and rock deformation, Prof. Zhenmin Jin, China University of Geosciences, to celebrate | Harry W Green II 章军锋 Larissa F Dobrzhinetskaya Tetsuo Irifune | 2010 | Journal of Earth Science2010，21，5： | 2 |
| 7 | A comparison of several vector quantization codebook generation approaches显示文摘 | Huang C M Harris R W | 1993 | IEEE Transactions on Image Processing1993，2，1： | 1 |
| 8 | Work - life Benefits and Positive Organizational Behavior:Is There A Connection 显示文摘 | Muse L Harris S G Giles W F Feild H S | 2008 | Journal of Or- ganizational Behavior2008，29，2： | 1 |
| 9 | Chloroplast transformation in Chlamydomonas with high velocity microprojectiles显示文摘 | BOYNTON J E GILLHAN N W HARRIS E H | 1988 | Science1988，240，： | 1 |
| 10 | Failure of acetabular autogenous grafts in total hip arthroplasty,Increasing incidence;A follow up note显示文摘 | MULROY Jr R D HARRIS W H | 1990 | J Bone Joint Surg(Am)1990，72，： | 1 |
| 11 | Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth ractor in HaCaT keratinocytes 显示文摘 | Harris I R Hoppner H Siefken W | 2000 | J Invest Dermatol2000，114，1： | 1 |
| 12 | The World Health Organization (WHO) classification of the myeloid neoplasms显示文摘 | Vardiman J W Harris N L Brunning R D | 2002 | Blood2002，100，7： | 1 |
| 13 | In vitro techniques for the assessment of neurotoxicity 显示文摘 | Harry GJ Billingsley M Bruinink A Campbell IL Classen W Dorman DC | 1998 | Environ Health Perspect1998，106，1： | 1 |
| 14 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 15 | Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘 | Haupt Y Bath M L Harris A W | 1993 | Oncogene1993，8，11： | 1 |
| 16 | Ef/ects of low-temperature pyrolysis conditions on biochar for agricultural use显示文摘 | Gaskin J W Steincr C Harris K | 2008 | Transactions of the ASABE2008，51，6： | 1 |
| 17 | Carbonate and magnesium interactiye effect on calcium phosphate precipitation显示文摘 | Cao X Harris W | 2007 | Environmental Science dr Technology2007，42，2： | 1 |
| 18 | Variance decompositions of nonlinear dynamic stochastic systems 显示文摘 | Harris T J Yu W | 2010 | Journal of Process Control2010，20，2： | 1 |
| 19 | Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance 显示文摘 | Park Y Harris W S | 2003 | The Journal of Lipid Research2003，44，3： | 1 |
| 20 | Physical properties of near Earth asteroids from thermal infrared observations and thermal modeling显示文摘 | Delbo M Harris A W | 2002 | Meteoritics & Planetary Science2002，37，12： | 1 |
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