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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 3 | Pheochromocytom a in pregnancy: when is operative intervention indicated 显示文摘 | Junglee N Harries SE Davies N | 2007 | J Womens Health (Larchmt)2007，16，9： | 1 |
| 4 | Pheochromocytoma inPregnancy: When is Operative Intervention Indicated 显示文摘 | Junglee N Harries SE Davies N | 2007 | JWomens Health (Larchmt)2007，16，9： | 1 |
| 5 | Abnormal mitral valve anatomy in d-transposition of the great arteries : anatomic characterization and surgical outcomes显示文摘 | Camarda JA Harris SE Hambrook J | 2013 | Pediatr Cardiol2013，34，1： | 1 |
| 6 | Identification of carcinoma cells in peripheral blood samples of patients with advanced breast carcinoma using RT-PCR amplification of CK7 and MUC1显示文摘 | Felton T Harris GC Pinder SE | 2004 | Breast2004，1，3： | 1 |
| 7 | New approaches to lymphoma diagnosis显示文摘 | Harris NL Stein H Coupland SE | 2001 | Hematology2001，1，： | 1 |
| 8 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 9 | Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression显示文摘 | Zhang W Feng JQ Harris SE | 2002 | Transgenic Res2002，10，5： | 1 |
| 10 | Identification of novel mutations in FOXL2 associated with premature ovarian failure显示文摘 | Harris SE Chand1 AL Winship IM | 2002 | Molecular Human Reprod2002，8，8： | 1 |
| 11 | Pheochromocytoma in preganancy: when is operative intervention indicated? 显示文摘 | Junglee N Harries SE Davies N | 2007 | J Womens Health2007，16，9： | 1 |
| 12 | Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure显示文摘 | Ponnampalam AP Harris SE | 2006 | Fertil Steril2006，86，4： | 1 |
| 13 | 20-year experience with cemented primary and conversion total hip arthroplasty using so-called second-generation cementing techniques in patients aged 50 years or younger显示文摘 | Estok DM 2nd Harris WH | 2000 | J Arthroplasty2000，15，3： | 1 |
| 14 | Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of DLX2 and DLX5 transcription factors显示文摘 | Harris SE Guo DY Harris MA | 2003 | Front Biosci2003，8，4： | 1 |
| 15 | Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation 显示文摘 | Zhao M Harris SE Horn D | 2002 | J Cell Biol2002，157，6： | 1 |
| 16 | Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis:role of DIx2 and Dlx5 transcription factors显示文摘 | Hams SE Guo D Harris MA | 2003 | Front Biosci2003，8，： | 1 |
| 17 | Von kossa staining alone is not sucient to conform that mineralization in vitro represents bone formation显示文摘 | Bonewald LF Harris SE Rosser J | 2003 | Calcif Tissue Int2003，72，5： | 1 |
| 18 | Wnt/beta-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts显示文摘 | Zhang R Oyajobi BO Harris SE | 2013 | Bone2013，52，1： | 1 |
| 19 | Signal transduction and biological functions of bone morphogenetic proteins 显示文摘 | Chen D Zhao M Harris SE | 2004 | Front Biosci2004，1，9： | 1 |
| 20 | Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts 显示文摘 | Zhang R Oyajobi BO Harris SE | 2013 | Bone2013，52，1： | 1 |
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