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| 1 | Moxibustion Promotes Formation of Granulation in Wound Healing Process through Induction of Transforming Growth Factor-β in Rats显示文摘Objective:To examine the effect of moxibustion on the wound healing process and its mechanism using a rat wound model.Methods:Sixty male Sprague-Dawley rats were randomly divided into a sham-treated group(n=30,wound surgery only)and a moxibustion group(n=30,wound treated with moxibustion).Circular fullthick ness skin wounds were produced in rats.Moxibustion was applied to the edge of wound and was continued on alternating days till 14 days after surgery,followed by measurement of wound size.Expression of collagens,prolyl-4-hydroxylase(P4H)and transtorming growth factor-β(TGF-β)were evaluated by histochemical study and real-time polymerase chain reaction.Results:The size of the wound lesion was significantly reduced in rats treated with moxibustion as compared to that in sham-treated rats at 4-10 days after wounding(P<0.01).Moxibusti on stimulated mRNA expressi on of collage ns at 4 days(P<0.01),but not at 7 days,accompa nied by enhanced proliferation of P4H-positive fibroblasts.Of importanee,expression of TGF-β in tissue from the wound lesio n treated with moxibusti on was sign ifica ntly in creased as compared to that in sham-treated rats at 4 days(P<0.01 or P<0.05),but not at 7 days.Conclusions:The treatment with moxibustion promoted the wound healing process in the early phase through proliferation of fibroblasts and rapid formation of granulation,possibly mediated by induction of TGF-β which is a key molecule in the physiological process of wound healing.Moxibustion can be expected to be effective as complementary treatment for intractable ulcers. | Hiroshi Kawanami Hirohisa Kawahata Hiroko-Miyuki Mori Motokuni Aoki | 2020 | Chinese Journal of Integrative Medicine2020，26，1： | 3 |
| 2 | 医学生颈痛情况及相关因素分析显示文摘目的调查医学生颈痛的发生率和相关影响因素,以及颈痛的症状和对日常生活的影响。方法用自行设计的问卷调查2018年9月至2019年10月昆明医科大学的在校医学生,采用随机抽样调查法选取了850名医学生进行调查(有效问卷836份),包括一般情况、颈痛相关状况和对日常生活的影响,并对颈痛的相关因素进行统计分析。结果 836名医学生在12个月调查中曾发生过颈痛658人(占78.71%),未曾发生颈痛178人(占21.29%)。颈痛的发生与每天使用手机的时间,每天伏案阅读和写作时间、背包习惯、心理状况、是否进行日常颈部锻炼具有相关性(P <0.05)。多因素Logistics回归分析显示:每天使用手机时间每升高一个时间段,颈痛发生的可能增加1.392倍(OR=1.392),不进行日常颈部锻炼的人与进行日常颈部锻炼的人比,发生颈痛的可能性增加1.183倍(OR=1.943)。绝大部分颈痛的医学生颈椎功能障碍指数NDI评估为轻度功能障碍。结论医学生颈痛发生率高,导致颈痛的因素包括每日使用手机的时间、伏案阅读和写作时间、背包习惯、心理状况、日常颈部锻炼。日常颈部锻炼可降低颈痛的发生,建议医学生进行常规的颈部锻炼。大部分颈痛的医学生其日常生活受影响程度较轻。 | 孟繁媛 唐欣 陈茉弦 王洋 李锦秀 保文莉 | 2020 | 昆明医科大学学报2020，41，12： | 0 |
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