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| 1 | Effect of power ultrasound on microstructural characteristics and mechanical properties of Al_(81.3)Sn_(12.3)Cu_(6.4) monotectic alloy显示文摘The liquid phase separation process and solidification process of ternary Al_(81.3)Sn_(12.3)Cu_(6.4) monotectic alloy was accomplished with a 20 kHz ultrasonic field in the power range up to 500 W.As ultrasound power rised,the coarse primary(Al) dendrites turned into fine equiaxed grains,whose size decreased by one order of magnitude as that during static solidification.Meanwhile,rather than pronounced segregation of large secondary(Sn) blocks in the alloy sample solidified under static condition,tiny secondary(Sn) droplets dispersed homogenously within the(Al)matrix in the presence of ultrasound.Under the highest ultrasound power of 500 W,the spherical ternary(Al + Sn + θ(Al_2Cu)) monotectic cells formed.The refinement of primary(Al) dendrites and uniform distribution of secondary(Sn) droplets induced by power ultrasound result in the improvement of microhardness,wear resistance,compressive and yield strength of ternary Al_(81.3)Sn_(12.3)Cu_(6.4) monotectic alloy. | Wei Zhai Hanman Liu Pengfei Zuo Xiannian Zhu Bingbo Wei | 2015 | Progress in Natural Science:Materials International2015，25，5： | 2 |
| 2 | High-fat, low-carbohydrate diet and etiology of non-insulin-dependent diabetes mellitus: the San Luis Valley Diabetes Study显示文摘 | Marshall JA Hanman RF Baxter J | 1991 | Am J Epidemiol1991，134，6： | 1 |
| 3 | High-fat , Low-carbohy- drate diet and etiology of non-insulin-dependent diabetes mellitus : the San Luis Valley diabetes Study 显示文摘 | Marshall JA Hanman RF Baxter J | 1991 | Am J Epidemiol1991，134，6： | 1 |
| 4 | Multisource Effects on the Satisfaction Formation Process 显示文摘 | Halstead D Hanman D Schmidt S L | 1994 | Journal of the Academy of Marketing Science1994，22，2： | 1 |
| 5 | Effeets of weight and body mass index on bone mineral density in men and women:The Framingham study显示文摘 | Felson DT Yuqing Zlaang Hanman MT | 1992 | Bone Mineral Res1992，7，： | 1 |
| 6 | High-fat,low-carbohydrate diet and etiology of non-insulin-dependent diabetes mellitus:the San Luis Valley Diabetes Study显示文摘 | Marshall JA Hanman RF Baxter J | | 0，，06： | 1 |
| 7 | Aging: a theory based on free redical and radiation chemistry 显示文摘 | HANMAN D | 1956 | J Gerontol1956，11，： | 1 |
| 8 | High - Fat, Low - carbohydrate diet and the etiology of non - insulin - dependent diabetes mellitus:The Sam Luis Valley diabetes Study显示文摘 | Marshall JA Hanman RF Baxter J | 1991 | Am J Epidernial1991，134，6： | 1 |
| 9 | Chemical behavior of Cd in rice rhizosphere显示文摘 | LIN Qin CHEN Yingxu CHEN Hanman | 2003 | Chemosphere2003，50，： | 1 |
| 10 | The use of generic medication in epilepsy: a review of potential issues and challenges显示文摘 | Paesschen WV Hanman H Lagae L | 2009 | European Journal of Paediatric neurology2009，3，： | 1 |
| 11 | Recursive estimation of mixed autogressivemoving显示文摘 | Hanman E.J | | 0，，01： | 1 |
| 12 | Adrenergic agents,but not triiodo-L-thyronine induce c-fos and c-myc expression in the rat heart显示文摘 | West A K | 1991 | Basic Res Cardiol1991，86，2： | 1 |
| 13 | Targeting proprotein convertase subtilisin/kexin type 9(PCSK9):from bench to bedside显示文摘Proprotein convertase subtilisin/kexin type 9(PCSK9)has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its related cardiovascular diseases(CVD).This comprehensive review delineates the intricate roles and wide-ranging implications of PCSK9,extending beyond CVD to emphasize its significance in diverse physiological and pathological states,including liver diseases,infectious diseases,autoimmune disorders,and notably,cancer.Our exploration offers insights into the interaction between PCSK9 and low-density lipoprotein receptors(LDLRs),elucidating its substantial impact on cholesterol homeostasis and cardiovascular health.It also details the evolution of PCSK9-targeted therapies,translating foundational bench discoveries into bedside applications for optimized patient care.The advent and clinical approval of innovative PCSK9 inhibitory therapies(PCSK9-iTs),including three monoclonal antibodies(Evolocumab,Alirocumab,and Tafolecimab)and one small interfering RNA(siRNA,Inclisiran),have marked a significant breakthrough in cardiovascular medicine.These therapies have demonstrated unparalleled efficacy in mitigating hypercholesterolemia,reducing cardiovascular risks,and have showcased profound value in clinical applications,offering novel therapeutic avenues and a promising future in personalized medicine for cardiovascular disorders.Furthermore,emerging research,inclusive of our findings,unveils PCSK9’s potential role as a pivotal indicator for cancer prognosis and its prospective application as a transformative target for cancer treatment.This review also highlights PCSK9’s aberrant expression in various cancer forms,its association with cancer prognosis,and its crucial roles in carcinogenesis and cancer immunity.In conclusion,this synthesized review integrates existing knowledge and novel insights on PCSK9,providing a holistic perspective on its transformative impact in reshaping therapeutic paradigms across various disorders.It emphasizes the clinical value and effect of PCSK9-iT,underscoring its potential in advancing the landscape of biomedical research and its capabilities in heralding new eras in personalized medicine. | Xuhui Bao Yongjun Liang Hanman Chang Tianji Cai Baijie Feng Konstantin Gordon Yuekun Zhu Hailian Shi Yundong He Liyi Xie | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
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