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| 1 | Recognition of Ophiolite Belt and Granulite in Northern Area of Mian-Lue, Southern Qinling, China and Their Implication显示文摘RecognitionofOphioliteBeltandGranuliteinNorthernAreaofMian-Lue,SouthernQinling,ChinaandTheirImplication￥XuJifeng(Departmentof... | Xu Jifeng(Department of Geology, China University of Geosciences, Wuhan 430074)Zhang Benren Han Yinwen(Department of Geochehastry, China University of Geosciences, Wuhan 430074) | 1994 | Journal of Earth Science1994，13，1： | 9 |
| 2 | Discovery of the highly depleted N-MORB-type volcanic rocks: new evidence for the Mianlue paleo-ocean显示文摘The highly depleted N-MORB-type volcanic rocks have been discovered in Mianlue mélange of Qinling orogenic belt, central China. These mafic rocks are associated with the meta-peridotites, showing LREE-depleted pattern, similar to N-MORB and typical ophiolites. It is indicated that an ancient ocean existed in the Mianlue area of Qinling orogenic belt during the late Paleozoic. | Jifeng Xu Xueyuan Yu Xianhua Li Yinwen Han Jihu Shen Benren Zhang | 1998 | Chinese Science Bulletin1998，43，6： | 7 |
| 3 | Phase 1 studies comparing safety, tolerability, pharmacokinetics and pharmacodynamics of HLX01(a rituximab biosimilar) to reference rituximab in Chinese patients with CD20-positive B-cell lymphoma显示文摘Objective: This study aimed to compare the pharmacokinetic, pharmacodynamic and safety profiles of HLX01(a rituximab biosimilar) and reference rituximab sourced from China(Mab Thera?;rituximab-CN).Methods: Here we report the results of two phase 1 studies. In the phase 1 a, open-label, dose-escalation study(NCT03218072, CTR20140400), eligible patients received 250, 375 and 500 mg/m^(2) HLX01 sequentially at 7-day intervals, after confirming no dose-limiting toxicity(DLT). In the phase 1 b, double-blind study(NCT02584920,CTR20140764), eligible patients were given a single dose of 375 mg/m^(2) HLX01 or rituximab-CN. The primary endpoints included safety and tolerability parameters for the phase 1 a and the area under the plasma concentrationtime curve from time zero to day 91(AUC0-91 d) for the phase 1 b study. Equivalence was concluded if 90%confidence interval(90% CI) for the geometric least squares mean ratio(GLSMR) fell in the pre-specified equivalence criteria(80%-125%).Results: Between June 20, 2014 and January 5, 2015, 12 patients were enrolled in the phase 1 a study. The pharmacokinetics of HLX01 showed dose proportionality and accumulation to steady state. HLX01 was well tolerated, with no serious adverse events(AEs), discontinuations or DLTs. Between November 8, 2014 and August13, 2015, 87 eligible patients were enrolled in the phase 1 b study, including 43 who received HLX01 and 44 who were treated with rituximab-CN. The equivalence endpoint was met with GLSMR for AUC0-91 d being 89.6%(90% CI: 80.4%-99.8%). AEs, anti-drug antibodies, and CD19+ and CD20+ B lymphocyte counts were similar between the HLX01 and rituximab-CN treatment groups.Conclusions: Treatment with HLX01 was safe and well tolerated in Chinese patients with B-cell lymphoma.HLX01 and rituximab-CN have similar pharmacokinetic, pharmacodynamic and safety profiles. | Yuankai Shi Qingyuan Zhang Xiaohong Han Yan Qin Xiaoyan Ke Hang Su Li Liu Jinxiang Fu Jie Jin Jifeng Feng Xiaonan Hong Xiaohong Zhang Depei Wu Bin Jiang Xiaodong Dong | 2021 | Chinese Journal of Cancer Research2021，33，3： | 5 |
| 4 | PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis显示文摘In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease(PD).However,difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1.Here we report that PINK1 kinase form is selectively expressed in the human and monkey brains.CRISPR/Cas9-mediated deficiency of PINK1 causes similar neurodegeneration in the brains of fetal and adult monkeys as well as cultured monkey neurons without affecting mitochondrial protein expression and morphology.Importantly,PINK1 mutations in the primate brain and human cells reduce protein phosphorylation that is important for neuronal function and survival.Our findings suggest that PINK1 kinase activity rather than its mitochondrial function is essential for the neuronal survival in the primate brains and that its kinase dysfunction could be involved in the pathogenesis of PD. | Weili Yang Xiangyu Guo Zhuchi Tu Xiusheng Chen Rui Han Yanting Liu Sen Yan Qi Wang Zhifu Wang Xianxian Zhao Yunpeng Zhang Xin Xiong Huiming Yang Peng Yin Huida Wan Xingxing Chen Jifeng Guo Xiao-Xin Yan Lujian Liao Shihua Li Xiao-Jiang Li | 2022 | Protein & Cell2022，13，1： | 3 |
| 5 | UV-enhanced bioactivity and cell response of micro-arc oxidized titania coatings显示文摘 | Yong Han Donghui Chen Jifeng Sun Yumei Zhang Kewei Xu | 2008 | Acta Biomaterialia2008，，5： | 2 |
| 6 | Microstruc ture and bioactivity of Ca,P and Sr doped TiO2 coating formed on porous titanium by micro-arc oxidation显示文摘 | Yan Yuanyuan Sun Jifeng Han Yong | 2010 | Surface & Coatings Technology2010，205，： | 1 |
| 7 | UV-enhanced bioactivity and cell response of micro-arc oxidized titania coatings显示文摘 | Han Yong Chen Donghui Sun Jifeng | 2008 | Acta Biomaterialia2008，4，： | 1 |
| 8 | 显示文摘 | Sun Jifeng Han Yong Huang Xin | | Surface & Coatings Technology0，201，： | 1 |
| 9 | Explicit solvent model for spectral shift of acrolein and simulation with molecular dynamics显示文摘By introducing the concept of spring energy of permanent dipole and taking the conforma-tions of solvent molecules into account,the formulas of electrostatic solvation energy in equilibrium and nonequilibrium are derived from the explicit solvent scheme,with the spatial distribution of the discrete permanent charges and induced dipoles of the sol-vent molecules involved. The energy change of sol-ute due to the variation of wave function from the case of vacuum to that in solution is estimated by treating the solvent effect as external field in the it-eration cycles of the self-consistent field. The ex-pression for spectral shift is deduced and applied to the processes of light absorption and emission in solution. According to the new formulations,the av-eraged solvent electrostatic potential/molecular dy-namics program is modified and adopted to investi-gate the equilibrium solvation energy of water mole-cule and spectral shift of acrolein. | ZHU Quan LIU Jifeng FU Kexiang HAN Keli LI Xiangyuan | 2006 | Chinese Science Bulletin2006，51，24： | 1 |
| 10 | Microstructure and bioactivity of Ca, P and Sr doped TiO 2 coating formed on porous titanium by micro-arc oxidation显示文摘 | Yuanyuan Yan Jifeng Sun Yong Han Dichen Li Kai Cui | 2010 | Surface & Coatings Technology2010，，6： | 1 |
| 11 | The effectiveness of online shopping characteristics and well-designed websites on satisfaction 显示文摘 | Luo Jifeng Ba Sulin Zhang Han | 2012 | MIs Quarterly2012，36，4： | 1 |
| 12 | Microstructure and apatite- forming ability of the MAO-treated porous titanium显示文摘 | Sun Jifeng Han Yong Cui Kai | 2008 | Surface & Coatings Technology2008，202，： | 1 |
| 13 | Microstructure and bioactivity of Ca,P and Sr doped TiO2 coating formed on porous titanium by microarc oxidation显示文摘 | Yan Yuanyuan Sun Jifeng Han Yong | | 0，，： | 1 |
| 14 | UV-enhanced bioactivity and cell response of microarc oxidized titania coatings显示文摘 | Han Yong Chen Donghui Sun Jifeng | | 0，，： | 1 |
| 15 | Residue and Safety Use of 45% Prochloraz EW in Ginger显示文摘[Objective]The paper was to evaluate the safety of 45%prochloraz EW in ginger,and to study the residue and degradation of 45%prochloraz EW in ginger.[Method]45%Prochloraz EW was sprayed once at the dose of 455.625 g a.i./ha in dynamic degradation test,and ginger plants were collected at 2 h,1,3,5,7,14,21,28,35 and 42 d post spraying,respectively.45%Prochloraz EW was sprayed at the doses of 303.75 and 455.625 g a.i./ha for 2-3 times with an interval of 7 d in final residue test,and ginger plants were collected at 7,14 and 21 d post spraying,respectively.The content of prochloraz was quantitatively analyzed by gas chromatography.[Result]Dynamic degradation test demonstrated that prochloraz degraded quickly in plants,and the half-life in Shandong and Anhui were 5.8 and 7.9 d,respectively.The final residue of prochloraz in ginger samples was<0.01-0.145 mg/kg,lower than the maximum residue limit of prochloraz in ginger formulated by European Union(0.2 mg/kg).[Conclusion]Prochloraz should be sprayed at the recommended dose of 202.5-303.75 g a.i./ha for prevention and control of anthracnose on ginger.The agent should be sprayed twice in the early stage of incidence,with an interval of 7 d,and the safety interval of 14 d was safe. | Feng Yizhi Han Jifeng Qi Xiaoxue Wang Xiaoyu Pan Jinju Jin Jie Liang Lin Zuo Bojun | 2019 | Plant Diseases and Pests2019，10，5： | 1 |
| 16 | The Effectiveness Of On- line Shopping Characteristics And Well - Designed Web- sites On Satisfaction显示文摘 | Jifeng Luo Sulin Ba Han Zhang | 2012 | MIS Quarterly2012，36，4： | 1 |
| 17 | Overview of the LAMOST survey in the first decade显示文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST),also known as the Guoshoujing Telescope,is a major national scientific facility for astronomical research located in Xinglong,China.Beginning with a pilot survey in 2011,LAMOST has been surveying the night sky for more than 10 years.The LAMOST survey covers various objects in the Universe,from normal stars to peculiar ones. | Hongliang Yan Haining Li Song Wang Weikai Zong Haibo Yuan Maosheng Xiang Yang Huang Jiwei Xie Subo Dong Hailong Yuan Shaolan Bi Yaoquan Chu Xiangqun Cui Licai Deng Jianning Fu Zhanwen Han Jinliang Hou Guoping Li Chao Liu Jifeng Liu Xiaowei Liu Ali Luo Jianrong Shi Xuebing Wu Haotong Zhang Gang Zhao Yongheng Zhao | 2022 | The Innovation2022，3，2： | 0 |
| 18 | Elite sd1 alleles in japonica rice and their breeding applications in northeast China显示文摘The Green Revolution gene sd1 has been used extensively in modern rice breeding,especially in indica cultivars.However,elite sd1 alleles and related germplasm resources used for japonica rice breeding have not been identified,and extensive efforts are needed for japonica rice breeding to obtain new dwarfing sources.Data from MBKbase-Rice revealed seven sd1 haplotypes in indica and four in japonica rice.Two new sd1 alleles were identified in indica rice.In 295 japonica accessions from northeast Asia,except for the weak functional allele SD1-EQ,sd1-r was the major allele,reducing plant height in comparison with SD1-EQ.Japonica germplasm resources carrying reported sd1 alleles were identified by genotype searching and further verified by literature search,genealogical analysis,and d Caps markers.Pedigrees and geographic distribution showed that sd1-r is an excellent allele widely used in northern China and Tohoku in Japan,and sd1-j is commonly used in east China and Kyushu in Japan.Dongnong-and Xiushui-series cultivars carrying sd1-r and sd1-j,respectively,are essential branches of the backbone parents of Chinese japonica rice,Akihikari and Ce21,with the largest number of descendants and derived generations.In semi-dwarf japonica rice breeding,sd1-d was introgressed into Daohuaxiang 2(DHX2).Dwarf and semi-dwarf lines carrying sd1-d were selected and designated as 1279 and 1280,respectively,after withstanding typhoon-induced strong winds and heavy rains in 2020,and are anticipated to become useful intermediate materials for future genetic research and breeding.This work will facilitate the introduction,parental selection,and marker-assisted breeding,and provide a material basis for the next step in identifying favorable genes that selected together with the sd1 alleles in japonica backbone parents. | Hanjing Sha Hualong Liu Guangxin Zhao Zhongmin Han Huilin Chang Jingguo Wang Hongliang Zheng Jifeng Zhang Yang Yu Yuqiang Liu Detang Zou Shoujun Nie Jun Fang | 2022 | The Crop Journal2022，10，1： | 0 |
| 19 | Exploration of the “Four-Three-Four” Internship and Training Mode in Higher Vocational Colleges Under the Modern Vocational Education System显示文摘This article mainly introduces the innovative internship and training model of vocational colleges,including five aspects such as“four-party collaboration,three-stage progression,four-way integration,value-added evaluation,and double selection and promotion.”The model aims to improve students’practical skills and professional quality to better adapt to market demand and social development.The article also presents the prospects of the future internship and training model,including strengthening cooperation and communication with industry enterprises,focusing on students’personalized development and practical skill cultivation,and establishing a scientific and objective evaluation and feedback mechanism. | Jifeng Liu Na Han Xiaojiao Li Jing Wang Xuezhen Feng | 2024 | Journal of Contemporary Educational Research2024，8，3： | 0 |
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