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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Antisense gene that inhibits synthesis of the hormone ethylene in transgenic plant 显示文摘 | Hamilton A J Yycett G W Grierson D | 1990 | Nature1990，346，： | 2 |
| 3 | Chemical characteristics of fluid phase from a subducted lithosphere and origin of arc magmas: Evidence from high-pressure experiments and natural rocks 显示文摘 | Tatsumi Y Hamilton D L Nesbitt R W | 1986 | Journal of Velcanology and Geothermal Research1986，29，： | 1 |
| 4 | Antisense gene that inhibit synthesis of hormone ethylene in transgenic plants 显示文摘 | Hamilton A J Lyett G W Grierson D | 1990 | Nature1990，346，6281： | 1 |
| 5 | Evidence for a male-produced sex pheromone in the western flower thrips Frankliniella occidentals显示文摘 | Kirk W D J Hamilton J G C | | 0，，01： | 1 |
| 6 | Optical propertiesof cubic SiC:luminescence of nitrogen-exciton complexes,and interband absorption显示文摘 | Choyke W J Hamilton D R Patrick L | 1964 | Physical Review1964，133，4： | 1 |
| 7 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 8 | Feature fatigue: When product capabilities become too much of a good thing 显示文摘 | Thompson D V Hamilton R W Rust R T | 2005 | Journal of Marketing Research2005，42，4： | 1 |
| 9 | Antisense gene that inhibits synthesis of the hormone ethylene in transgenic plant 显示文摘 | Hamilton A J Lycett G W Grierson D | 1990 | Nature1990，346，： | 1 |
| 10 | The evolution of cooperation显示文摘 | Axelrod R Hamilton W D | 1981 | Science1981，211，： | 1 |
| 11 | The evolution of altruistic behavior显示文摘 | Hamilton W D | 1963 | American Naturalist1963，97，896： | 1 |
| 12 | Brillouin scattering measurement on optical glasses显示文摘 | Heiman D Hamilton D S Hellwarth R W | 1979 | Phy Rev B1979，19，12： | 1 |
| 13 | The Genetical Evolution of Social Behavior, I and II显示文摘 | Hamilton W D | 1964 | Journal of Theoretieal Biology1964，7，1： | 1 |
| 14 | The evolution of cooperation显示文摘 | Hamilton W D | 1981 | Science1981，211，4489： | 1 |
| 15 | Nitrogen fixation in Canadian precarnbrian shield lakes显示文摘 | FLETT R J SCHINDER D W HAMILTON R D | 1980 | Canadian Journal of Fisheries and Aquatic Sciences1980，37，3： | 1 |
| 16 | Patient, hospital, and general praetition-er characteristics associated with non-attend- ance:a cohort study显示文摘 | Hamilton W Round A Sharp D | 2002 | Bri-J - Gen- Praet2002，52，7： | 1 |
| 17 | Measuring sustainable development: Progress on indicators 显示文摘 | Pearce D W Hamilton K Atkinson G | 1996 | Environment and Development Economics1996，，1： | 1 |
| 18 | The evolution of social behavior显示文摘 | Hamilton W D | 1964 | J Theor Biol1964，7，： | 1 |
| 19 | Comparison of thalamotomy and pallidotomy for treatment of dystonia 显示文摘 | Hamilton WJ Ondo W | 2001 | Neurosurgery2001，48，4： | 1 |
| 20 | The risk of colorectal cancer with symptoms at different ages and between the sexes:a case-control study显示文摘 | Hamilton W Lancashire R Sharp D | 2009 | BMC Med2009，7，： | 1 |
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