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917篇 您的检索式:作者名="Hamilton W"
    题名 作者 年代 出处 被引量
1Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD.Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele 2009World Journal of Gastroenterology2009,15,10:20
2Antisense gene that inhibits synthesis of the hormone ethylene in transgenic plant 显示文摘Hamilton A J Yycett G W Grierson D 1990Nature1990,346,:2
3Chemical characteristics of fluid phase from a subducted lithosphere and origin of arc magmas: Evidence from high-pressure experiments and natural rocks 显示文摘Tatsumi Y Hamilton D L Nesbitt R W 1986Journal of Velcanology and Geothermal Research1986,29,:1
4Maglignancy and deep vein thrombosis 显示文摘Barett J Hamilton W 2006Br J Gen Pract2006,56,530:1
5Antisense gene that inhibit synthesis of hormone ethylene in transgenic plants 显示文摘Hamilton A J Lyett G W Grierson D 1990Nature1990,346,6281:1
6Simulation of flexible-link manipulators applying sequential integration method 显示文摘Chang L W Hamilton J F 1991Journal of dynamic systems measurement and control1991,113,:1
7Evidence for a male-produced sex pheromone in the western flower thrips Frankliniella occidentals显示文摘Kirk W D J Hamilton J G C 0,,01:1
8Mierofibrillated cellulose : morphology and accessibility 显示文摘Herrick F W Casebier R L Hamilton J K 1983Journal of Applied Poly- mer Science1983,37,2:1
9Natural occurrences of ochratoxicosis in poultry显示文摘Hamilton P A T B Huff W E Harris J R A Y 1982Poultry Science1982,61,9:1
10Optical propertiesof cubic SiC:luminescence of nitrogen-exciton complexes,and interband absorption显示文摘Choyke W J Hamilton D R Patrick L 1964Physical Review1964,133,4:1
11Wasteful commuting 显示文摘Hamilton B W 1982Journal of Political Eco-nomics1982,90,05:1
12REACH:Clinicalfeasibility of a rural telestroke network显示文摘Hess DC Wang S Hamilton W 2005Stroke2005,36,:1
13Bending strength of steel beams with corrugated webs显示文摘Elgaaly M Seshadri A Hamilton R W 1997Journal of Structural Engineering1997,123,6:1
14Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R 2009Journal of Bacteriology2009,191,16:1
15The evolution of cooperation显示文摘Axelrod R Hamilton W 1981Science1981,211,:1
16Acousticand other physical properties of shallow-water sediments offSan Diego显示文摘HAMILTON E L MENARD H W SHIPEX C J 1956 1956The Journal of the Acoustical Society ofAmerica1956,28,:1
17Changes in tibiotalar area of eontct caused by later talar shift 显示文摘Ramsery PL Hamilton W 1976J Bone Joint Surg (Am)1976,58,3:1
18Sulphate-reducing Bacteria and Anaerobic Corrosion 显示文摘Hamilton W A 1985Annual Review of Microbiology1985,39,10:1
19Non- attendance at general practices and outpatienl clinics显示文摘Sharps DJ Hamilton W 2001BMJ2001,323,7321:1
20Metabolism and biliary excretion of the novel anticancer agent 10-hydroxycamptothecin in the isolated perfused rat liver显示文摘Platzer P Thalhammer T Reznicek G Hamilton G Zhang R Jager W 2001Int J Oncol2001,19,:1
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