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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Risk-based evaluation of different postmortem inspection procedures for pigs in Australia显示文摘 | Hamilton D R Gallas P Lyall L | 2002 | The Veterinary Record2002，151，4： | 1 |
| 3 | Laparoscopic adrena lectomy: th e preferred choice? A comparison to open adrenalectomy显示文摘 | HAMILTON B D BRAVO E L | 1998 | J Urol1998，160，： | 1 |
| 4 | Chemical characteristics of fluid phase from a subducted lithosphere and origin of arc magmas: Evidence from high-pressure experiments and natural rocks 显示文摘 | Tatsumi Y Hamilton D L Nesbitt R W | 1986 | Journal of Velcanology and Geothermal Research1986，29，： | 1 |
| 5 | Ritual-enema-induced colitis显示文摘 | Segal I Tim L O Hamilton D G | 1979 | Dis Colon Rectum1979，22，3： | 1 |
| 6 | Optical propertiesof cubic SiC:luminescence of nitrogen-exciton complexes,and interband absorption显示文摘 | Choyke W J Hamilton D R Patrick L | 1964 | Physical Review1964，133，4： | 1 |
| 7 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 8 | Attribution difficulty and memory for attribution -relevant information 显示文摘 | Hamilton D L ETC | 1990 | Journal of Personal and Social Psychology1990，，59： | 1 |
| 9 | Characterization of a pollen-specific cDNA clone from Zea mays and its expression 显示文摘 | Hanson D D Hamilton D A Travis J L | 1989 | Plant Cell1989，1，2： | 1 |
| 10 | Breast cancer stage at diagnosis and survival among patients with prior breast implants 显示文摘 | Deapen D Hamilton A Bernstein L | 2000 | Plast Re- constr Surg2000，105，2： | 1 |
| 11 | Multi-model integration in decision support system:a technical user interface approach for watershed and lake management scenarios显示文摘 | LAM D LEON L HAMILTON S | | 0，，03： | 1 |
| 12 | Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes: studies in a new experimental model显示文摘 | Hamilton A Huang S L Warnick D | 2002 | Circulation2002，105，23： | 1 |
| 13 | Left ventricular thrombus enhancement following intravenous injection of eehogenic immunoliposomes: studies in a new experimental model显示文摘 | Hamilton A Huang S L Wamick D | 2002 | Circulation2002，105，： | 1 |
| 14 | Modelling the impact of zooplankton grazing on phytoplankton biomass during a dinoflagellate bloom in the Swan River Estuary, Western Australia 显示文摘 | Griffm S L Herzfeld M Hamilton D P | 2001 | Ecological Engineering2001，162，： | 1 |
| 15 | Olanzapine versus placebo and haloperidol:Quality of life and efficacy results of the north American double-blind trial显示文摘 | Hamilton S H Revicki D A Genduso L A | 1998 | Neuropsychopharmacology1998，18，1： | 1 |
| 16 | Evaluation of the effect of culture configuration on morphology,survival time,antioxidant status and metabolic capacities of cultured rat hepatocytes显示文摘 | Richert L Binda D Hamilton G | 2002 | Toxicol In Vitro2002，16，1： | 1 |
| 17 | Phage lambda cDNA cloning vectors for subtractive hybridization,fusion-protein synthesis and Cre-loxP automatic plasmid subcloning显示文摘 | Palazzolo M J Hamilton B A Ding D L | 1990 | Gene1990，1，： | 1 |
| 18 | A Numerical Simulation of the Role of Zooplankton in C, N and P Cycling in Lake Kinneret, Israel 显示文摘 | BRUCE L C HAMILTON D IMBERGER J | 2006 | Ecological Modelling2006，193，34： | 1 |
| 19 | mVps34 is activated following high-resistance contractions显示文摘 | MACKENZIE M G HAMILTON D L MURRAY J T | 2009 | J Physiol2009，587，1： | 1 |
| 20 | Oxygen in the Cupola: A Comparison of Enrichment versus Direct Injection 显示文摘 | Trammell P G and Hamilton J A | 1981 | AFS Transactions1981，81，： | 1 |
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