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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Relationships between longissimus glycolytic potential and swine growth performance,carcass traits,and pork quality显示文摘 | Hamilton D N Miller K D Ellis M | 2003 | J Anim Sci2003，81，： | 1 |
| 3 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 4 | An EWMA for monitoring a process standard deviation显示文摘 | CROWDER S V HAMILTON M D | | 0，，01： | 1 |
| 5 | Feline ilial fractures:assessment of screw loosening and pelvic canal narrowingafter lateral plating显示文摘 | Hamilton M H Evans D A Langley-Hobbs S J | 2009 | Vet Surg2009，38，： | 1 |
| 6 | A theory of lubrication by micro-irregularities显示文摘 | Hamilton D B Walawit J A Allen C M | 1966 | ASME Journal of Basie Engineering1966，88，1： | 1 |
| 7 | Rapid detection of foot - and - mouth disease virus using a field - portable nucleic acid extraction and real- time PCR amplification platform显示文摘 | MADI M HAMILTON A SQUIRRELL D | 2012 | Vet J2012，193，1： | 1 |
| 8 | Predicting tourism flows under climate change显示文摘 | Bigano A M Hamilton M J Maddison J D | 2006 | Climatic Change2006，79，3： | 1 |
| 9 | Optical sampling and demultiplexing applied to A/D conversion显示文摘 | Hamilton M C Leep D A | 1991 | Proc SPIE1991，1562，： | 1 |
| 10 | Patron-initiatedcollection development: progress of a paradigmshift显示文摘 | Hodges D Preston C Hamilton M J | 2010 | Collection Management2010，35，34： | 1 |
| 11 | Simulation of vertical position of buoyancy regulating Microcystis aeruginosa in a shallow eutrophic lake 显示文摘 | Wallace B B Bailey M C Hamilton D P | 2000 | Aquatic Science2000，62，： | 1 |
| 12 | Convention- al in-vitro fertilisation versus intracytoplasmic sperm in- jection for the treatment of non-malefactor infertility:a ran- domised controlled trial显示文摘 | Bhattacharya S Hamilton MP Shaaban M et d | 2001 | Lancet2001，357，9274： | 1 |
| 13 | A spatially resolved model of seasonal variations in phytoplankton and clam (Tapes philippinarum) biomass in Barbamarco Lagoon,Italy显示文摘 | Spillman C M Hamilton D P Hipsey M R | 2008 | Estuarine Coastal and Shelf Science2008，79，2： | 1 |
| 14 | Effects of gibberellic acid on endogenous indole-3-acetic acid and indoleacetyl as partic acid levels in a dwarf pea显示文摘 | Law D M Hamilton R H | 1984 | Plant Physiol1984，75，： | 1 |
| 15 | Modelling the impact of zooplankton grazing on phytoplankton biomass during a dinoflagellate bloom in the Swan River Estuary, Western Australia 显示文摘 | Griffm S L Herzfeld M Hamilton D P | 2001 | Ecological Engineering2001，162，： | 1 |
| 16 | P-ultimate for undrainedanalysis of laterally loaded piles 显示文摘 | Murff J D Hamilton J M | 1993 | ASCE Journal ofGeotechnical Engineering1993，119，1： | 1 |
| 17 | Patron-initiated collection development: Progress of a paradigm shift显示文摘 | Hodges D Preston C Hamilton M J | 2010 | Collection Management2010，35，34： | 1 |
| 18 | Climate change and international tourism: A simulation study 显示文摘 | Hamilton J M Maddison D J Richard S J | 2005 | Global Environmental Change2005，15，3： | 1 |
| 19 | Phage lambda cDNA cloning vectors for subtractive hybridization,fusion-protein synthesis and Cre-loxP automatic plasmid subcloning显示文摘 | Palazzolo M J Hamilton B A Ding D L | 1990 | Gene1990，1，： | 1 |
| 20 | 显示文摘 | Grynpas M D Hamilton E Cheung R | 1996 | Bone1996，18，3： | 1 |
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