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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | 全球溺水负担:GBD 2017全球疾病负担死亡率的估计研究显示文摘世界卫生组织已将溺水确定为公共卫生优先事项。溺水指因淹没或者浸没于液体中而出现呼吸障碍的过程,其结果分为死亡、受伤和不受伤。致命性溺水是世界范围内导致非故意伤害相关死亡的主要原因,全球每年约有30万人溺水死亡。中低收入国家非故意溺水发生尤为严重。此外,男性和儿童是非故意溺水的高危人群。伤害预防工作者掌握准确和及时的数据将有助于合理分配公共卫生资源和评价干预措施的效果。 | 黄锦裕 佘宇航(摘译) 李丽萍(审校) Franklin R C Peden A E Hamilton E B | 2020 | 伤害医学(电子版)2020，9，4： | 6 |
| 3 | Reconstructing the Primordial Spectrum of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘 | Hamilton A J S Kumer P Lu E | 1991 | ApJ1991，374，： | 3 |
| 4 | Using individual tree growth projection models to estimate stand-level gains attributable to genetically improved stock显示文摘 | Hamilton D A Rehfeldt G E | 1994 | For Ecol Manage1994，68，： | 2 |
| 5 | Disrupted tonotopy of the auditory cortex in mice lacking M1 muscarinis acetycholine receptor显示文摘 | ZHANG Y DYCK R H HAMILTON S E | 2005 | Hear Res2005，201，： | 1 |
| 6 | Laparoscopic adrena lectomy: th e preferred choice? A comparison to open adrenalectomy显示文摘 | HAMILTON B D BRAVO E L | 1998 | J Urol1998，160，： | 1 |
| 7 | Renovascular hypertension in children显示文摘 | Tullus K Brennan E Hamilton G | | 0，，9622： | 1 |
| 8 | Incidence and reasons for reoperation after minimally invasive unicompartmental knee arthroplasty显示文摘 | Hamilton WG Collier MB Tarabee E | | 0，，2： | 1 |
| 9 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
| 10 | Finding deeply-buried deposits using geochemistry显示文摘 | Cameron E M Hamilton S M Leyboume M I | 2004 | Geochemistry: Exploration Environment Analysis2004，4，1： | 1 |
| 11 | The nitrogen budget of a pine forest under free air CO2 enrichment显示文摘 | Delucia E H Hamilton J G | 2002 | Oecologia2002，132，： | 1 |
| 12 | Differential effects of invasion by and phagocytosis of Salmonella typhimurium on apoptosis in human macrophages:potential role of Rho-GTPases and Akt显示文摘 | Forsberg M Blomgran R Lerm M Sarndahl E Sebti SM Hamilton A | 2003 | J Leukoc Biol2003，74，4： | 1 |
| 13 | Redox, pH and SP variation over mineralization in thick gla eial overburden显示文摘 | Hamilton S M Cameron E M McClenaghan M B | 2004 | Geochemistry: Exploration Environ ment AnaLysis2004，4，： | 1 |
| 14 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 15 | Prediction of in-situ acoustic and elastic properties of marine sediments显示文摘 | Hamilton E L | 1971 | Geophysics1971，36，2： | 1 |
| 16 | Down and out: estimating the relationship between mental health and unemployment 显示文摘 | HAMILTON VH MERRIGAN P DUFRESNE E | 1997 | Health Econ1997，，6： | 1 |
| 17 | Acousticand other physical properties of shallow-water sediments offSan Diego显示文摘 | HAMILTON E L MENARD H W SHIPEX C J 1956 | 1956 | The Journal of the Acoustical Society ofAmerica1956，28，： | 1 |
| 18 | A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia显示文摘 | Hamilton J Guthrie E Greed F | 2000 | Gastroenterology2000，119，3： | 1 |
| 19 | Use of a ramp velocity test to measure critical swimming speed in Rainbow trout (Oncorhynchus mykiss) 显示文摘 | Jain K E Hamilton J C Farrell A P | 1997 | Comparative Biochemistry Physiology1997，117，： | 1 |
| 20 | Sound velocity and related properties of marine sediments 显示文摘 | Hamilton E L Bachman T | 1982 | Journal of the A- coustical Society of America1982，72，： | 1 |
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