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347篇 您的检索式:作者名="Hamilton M C"
    题名 作者 年代 出处 被引量
1Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD.Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele 2009World Journal of Gastroenterology2009,15,10:20
2Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus 2010The Lancet2010,,9739:2
3An integrated anal ytical approach for determining the origin of solid bitumens in the McArthur Basin,Northern Australia显示文摘George S C Llorca S M Hamilton P J 1994Org Geochem1994,21,:1
4Phytoremediation of soil contaminated with low concentrations of radionuclides显示文摘Entry J A Vance N C Hamilton M A 1996Water Air Soil Pollution1996,88,:1
5A sampling method for measurement of large root systems with scanner based image analysis显示文摘Costa C Dwyer L M Hamilton R I 2000Agronomy Journal2000,92,:1
6Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R 2009Journal of Bacteriology2009,191,16:1
7Organic polymer thin-film transistor photosensors 显示文摘Hamilton M C Kanicki J 2004IEEE J Sel Top Quantum Electron2004,10,4:1
8The assessment of anxiety states by rating显示文摘Hamilton M C 1959British Journal of Medical Psychology1959,,:1
9Excess of nonparental bands in offspring from known pedigrees assayed using RAPD PCR显示文摘Reidy M F Hamilton W J Aquadro C F 1992Nucleic Acids Res1992,20,:1
10Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass 显示文摘Fu C Mielenz JR Xiao X Ge Y hamilton CY Rodriguez M Chen F Foston M Ragauskas A Bouton J Dixon RA Wang ZY 2011Proc Natl Acad Sci USA2011,108,9:1
11Angiographic as- sessment of microvascular perfusion-myocardial blush in clinical practice显示文摘Porto I Hamilton Craig C Brancati M 2010Am Heart J2010,160,6:1
12Stable transfer of intact high molecular weight DNA into plant chromosomes显示文摘Hamilton C M Frary A Lewis C 1996Proceedings of the National Academy of Sciences of the USA1996,93,18:1
13A comparison of complications associated with colostomy revered versus ileostomy reversal显示文摘Bell C Asolati M Hamilton E 2005J Am Coll Surg2005,190,:1
14A theory of lubrication by micro-irregularities显示文摘Hamilton D B Walawit J A Allen C M 1966ASME Journal of Basie Engineering1966,88,1:1
15Thyroid cancer in childhood: a retrospective review of childhood course 显示文摘O'GORNIAN C S HAMILTON J RACHMIEL M 2010Thyroid2010,20,4:1
16Optical sampling and demultiplexing applied to A/D conversion显示文摘 Hamilton M C Leep D A 1991Proc SPIE1991,1562,:1
17Patron-initiatedcollection development: progress of a paradigmshift显示文摘Hodges D Preston C Hamilton M J 2010Collection Management2010,35,34:1
18Efficiency and stability of high molecular weight DNA transformation: an analysis in tomato显示文摘Frary A Hamilton C M 2001Transgenic Research2001,10,2:1
19Effects of eapsaiein on liver microsomal metabolism of the tobacco-specific nitrnsamine NNK显示文摘 Z Zhang S M Hamilton 1993Cancer Letters1993,,75:1
20Simulation of vertical position of buoyancy regulating Microcystis aeruginosa in a shallow eutrophic lake 显示文摘Wallace B B Bailey M C Hamilton D P 2000Aquatic Science2000,62,:1
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