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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Progress of mesenchymal stem cell therapy for neural and retinal diseases显示文摘Complex circuitry and limited regenerative power make central nervous system(CNS)disorders the most challenging and difficult for functional repair.With elusive disease mechanisms,traditional surgical and medical interventions merely slow down the progression of the neurodegenerative diseases.However,the number of neurons still diminishes in many patients.Recently,stem cell therapy has been proposed as a viable option.Mesenchymal stem cells(MSCs),a widely-studied human adult stem cell population,have been discovered for more than 20 years.MSCs have been found all over the body and can be conveniently obtained from different accessible tissues:bone marrow,blood,and adipose and dental tissue.MSCs have high proliferative and differentiation abilities,providing an inexhaustible source of neurons and glia for cell replacement therapy.Moreover,MSCs also show neuroprotective effects without any genetic modification or reprogramming.In addition,the extraordinary immunomodulatory properties of MSCs enable autologous and heterologous transplantation.These qualities heighten the clinical applicability of MSCs when dealing with the pathologies of CNS disorders.Here,we summarize the latest progress of MSC experimental research as well as human clinical trials for neural and retinal diseases.This review article will focus on multiple sclerosis,spinal cord injury,autism,glaucoma,retinitis pigmentosa and age-related macular degeneration. | Tsz Kin Ng Veronica R Fortino Daniel Pelaez Herman S Cheung | 2014 | World Journal of Stem Cells2014，6，2： | 13 |
| 3 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 4 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 5 | Microcellular polymeric materials from microemulsions:Control of microstructure and morphology显示文摘 | W R P Raj M Sasthav H M Cheung | 1993 | Journal of Applied Polymer Science1993，47，3： | 2 |
| 6 | Pollutants in Hong Kong soils: Potycyclic aromatic hydrocarbons显示文摘 | CHUNG M K HU R CHEUNG K C | 2007 | Chemosphere2007，67，3： | 1 |
| 7 | Visualization of ischaemic penumbra using a computed tomography pefusion method 显示文摘 | Cheung R T Cheng P W Lui W M | 2003 | Cerebrovasc Dis2003，15，： | 1 |
| 8 | Tunneling,propping and expropriation:evidence from connected party transactions in Hong Kong显示文摘 | Cheung Y L Raghavendra R P Stouraitis A | 2006 | Journal of Financial Economics2006，82，： | 1 |
| 9 | Immunological aspects ofnutritional diabetes prevention in NOD mice: a pilot study for the cow's milk-based IDDMprevention trial显示文摘 | Karges W Hammond-McKibben D Cheung R K | 1997 | Diabetes1997，46，： | 1 |
| 10 | Ecotoxicological as-sessment of persistent organic and heavy metal contamination in HongKong coastal sediment显示文摘 | WONG C K C YEUNG H Y CHEUNG R Y H | 2000 | Archives of Environmental Contamination andToxicology2000，38，4： | 1 |
| 11 | Tunneling,propping,and expropriation:Evidence from connected party transactions in Hong Kong 显示文摘 | CHEUNG Y L RAU P R STOURAITIS A | 2006 | Journal of Financial Economics2006，82，： | 1 |
| 12 | Pre- dicting the Whole-Life Cost of a product at the con- ceptual design stage 显示文摘 | Newnes L ]3 Mileham A R Cheung W M | 2008 | Journal of Engineering De- sign2008，19，2： | 1 |
| 13 | Breast cancer and osteoporosis 显示文摘 | Cheung AM Heisey R Srighanthan J | 2013 | Curt Opin Endocrinol Diabetes Obes2013，20，6： | 1 |
| 14 | Model-based probabilistic frequent itemset mining显示文摘 | BERNECKER T CHENG R CHEUNG D W | 2013 | Knowledge and Informa- tion System2013，37，1： | 1 |
| 15 | A Two Stage Stochastic Network Model and Solution Methods for the Dynamic Empty Container Allocation Problem显示文摘 | Cheung R K and Chen C | 1998 | Transportation Science1998，32，2： | 1 |
| 16 | pH-sensitive polymers that enhance intracellular drug delivery in vivo显示文摘 | Kyriakides T R Cheung C Y Murthy N | 2002 | J Control Release2002，78，13： | 1 |
| 17 | Composition of extracellular polymeric substances in the activated sludge floc matrix 显示文摘 | Bura R Cheung M Liao B | 1998 | Water Science and Technology1998，37，45： | 1 |
| 18 | Microcellular polymeric materials from microemulsions:control of microstmcture and morphology显示文摘 | Palani Raj W R Sasthav M Cheung H M | 1993 | J Appl Polym Sci1993，47，3： | 1 |
| 19 | What is the relationship between the Glasgov coma scale and airway protective reflexes in the Chinese population? 显示文摘 | Rotheray K R Cheung P S Cheung C S | 2012 | Resus- citation2012，83，1： | 1 |
| 20 | Tunneling, Propping, and Expropriation: Evidence from Connected' Party Transactions in Hong Kong显示文摘 | Cheung Y P R Rau A Stouraitis | 2006 | Journal of Financial Economics2006，82，： | 1 |
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