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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Assessment of diastolic function in endomyocardial fibrosis: value of flow propagation velocity显示文摘 | SALEMI V M C PICARD M H MADY C | 2004 | Artificial Organs2004，28，4： | 1 |
| 3 | Muhipte Step- stress Accelerated Life Test: The Tampered Failure Rate Model显示文摘 | MADI M T | 1993 | Communication In Statistics Theory And Methods1993，22，9： | 1 |
| 4 | Bayesian inference for partially accelerated life tests using gibbs sampling 显示文摘 | MADI M T | 1997 | Mieroelectron Reliability1997，37，8： | 1 |
| 5 | Rapid detection of foot - and - mouth disease virus using a field - portable nucleic acid extraction and real- time PCR amplification platform显示文摘 | MADI M HAMILTON A SQUIRRELL D | 2012 | Vet J2012，193，1： | 1 |
| 6 | Biophysical studies on chitosan-coated liposomes显示文摘 | Mohsen M Mady Mirhane M Darwish Safaa Khalil | 2009 | European Biophysics Journal2009，38，8： | 1 |
| 7 | Toxoplasma gondii seropositivity and co - infection with TORCH pathogens in high- risk patients from Qatar 显示文摘 | ABU - MADI M A BEHNKE J M DABRITZ H A | 2010 | The American Journal of Tropical Medicine and Hygiene2010，82，4： | 1 |
| 8 | A survey and a layered taxonomy of software-defined networking 显示文摘 | Jarraya Y Madi T Debbabi M | 2014 | IEEE Communications Surveys & Tutorials2014，16，1： | 1 |
| 9 | Multiple step-stress accelerated life test: the tampered failure rate model 显示文摘 | Madi M 1' | 1993 | Communication in statistics theory and methods1993，22，9： | 1 |
| 10 | An inactivated vaccine based on a glycoprotein E-negative strain of bovine herpesvirus 1 induees protective immunity and allows serological differentiation 显示文摘 | Kaashoek M J Moerman A Madie J A | 1995 | Vaccine1995，13，4： | 1 |
| 11 | Performance characteristics correlation for round tube and plate finned heat exchangers: Equations relatives aux per- formances d'6changeurs de chaleur constitu6s de tubes ronds et de plaques a ailettes显示文摘 | Abu Madi M Johns R A Heikal M R | 1998 | International journal of refrigeration1998，21，7： | 1 |
| 12 | An inactivated vaccine based on a glyeoprotein E-negative strain of bovine herpesvirus 1 induces protective immunity and allows serological differentiation显示文摘 | KAASHOEK M J MOERMAN A MADIE J A | 1995 | Vaccine1995，13，4： | 1 |
| 13 | Multiple step -stress accelerated life test:the tampered failure rate model显示文摘 | MADI M T | 1993 | Communication in Statistics Theory and Methods1993，22，9： | 1 |
| 14 | Rapid detection of foot- and-mouth disease virus using a field-portable nucleic acid extraction and real-time PCR amplification platform显示文摘 | MADI M HAMILTON A SQUIRRELL D | 2012 | The Veterinary Journal2012，193，1： | 1 |
| 15 | Benznidazole and Cha-gas disease: can an old drug be the answer to an old problem显示文摘 | Mady C Ianni B M de Souza J L Jr | 2008 | Expert Opin Investig Drug2008，17，： | 1 |
| 16 | Homocysteine and hy- droxyproline levels in patients with primary open-angle glaucoma 显示文摘 | Ghanem A A Mady S M E1 A H | 2012 | Curt Eye Res2012，37，8： | 1 |
| 17 | Bayesian inference for the generalized exponential distribution 显示文摘 | RAQAB M Z MADI M T | 2005 | Statistical Computation and Simulation2005，75，10： | 1 |
| 18 | Closed-form expressions for the approximation of arc length parameterization for Bezier curves 显示文摘 | Madi M | 2004 | International Journal of Applied Mathematics and Computer Sciences2004，14，1： | 1 |
| 19 | Synthesis of two distinct exopolysaccharide fractions by cultures of the polymorphic fungus显示文摘 | Madi N S Harvey L M Mehlert A | 1997 | Carbohydrate Polymers1997，32，： | 1 |
| 20 | Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non- small cell lung cancer patients显示文摘 | Gao W Mady H H Melhem M F | 2009 | Molecular Carcinogenesis2009，48，7： | 1 |
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