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| 1 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 2 | Assessment of the Progress of the Back-Pain Patient显示文摘 | R MILLION W HALL K HAAVIK NILSEN R D BAKER M I V JAYSON | 1982 | Spine1982，，3： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Three dimensional transonic aeroelasticity using proper orthogonal decompo- sition-based reduced order models显示文摘 | Thomas J P Dowell E H Hall K C | 2003 | Journal of Aircraft2003，40，3： | 1 |
| 5 | Carburization behavior of HK40 steel in furnaces used for ethylene production 显示文摘 | D J Hall M K Hossain and R F Atkinson | 1982 | High Temperature High Pressure1982，14，： | 1 |
| 6 | Smote: Synthetic Minority Over-sampling Technique显示文摘 | Chawla N V Bower K W Hall L O | 2002 | Journal of Artificial Intelligence Research2002，16，3： | 1 |
| 7 | Disposition and metabolism of 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur)in humans 显示文摘 | Benvenuto J A Lu K Hall S W | 1978 | Cancer Res1978，38，111： | 1 |
| 8 | Evaluation of four different methods to measure endothelium-dependent vasodilation in the human peripheral circulation显示文摘 | Lind L Hall J Johansson K | 2002 | Clin Sci2002，102，： | 1 |
| 9 | Parametric studies of interaction strengths in polymer/CO2 systems: Discontinuous molecular dynamics Simulations显示文摘 | Li Z M Hall C K | 2005 | Langmuir2005，21，16： | 1 |
| 10 | The burden of respiratory syncytial virus infection in young children 显示文摘 | Hall C B Weinberg G A Iwane M K | 2009 | New England Journal of Medicine2009，360，6： | 1 |
| 11 | Computation of un- steady nonlinear flows in cascades using a harmonic balance teehnique显示文摘 | HALL K C THOMAS J P CLARK W S | 2002 | AIAA Journal2002，40，5： | 1 |
| 12 | Azithromycin and the risk of cardiovascular death显示文摘 | Ray WA Murray KT Hall K | 2012 | N Engl J Med2012，366，20： | 1 |
| 13 | Fingerprints of globalwarming on wild animals and plants显示文摘 | ROOTT L PRICE J T’HALL K R | 2003 | Nats2003，421，： | 1 |
| 14 | Imagery use in sport:A literature review and applied model 显示文摘 | Martin K A Moritz S E Hall C R | 1999 | The Sport Psychologist1999，13，24： | 1 |
| 15 | Consideration of the errors inherent in mapping historical glacier positions in Austria from ground and space ( 1893 -2001 ) 显示文摘 | Hall D K Bayr K Schfner W | 2003 | Remote Sensing of Environment2003，86，： | 1 |
| 16 | New mobile gene cassettes containing an aminogly coside resistance gene,aaeA 7,and a chloramphenico resistance gene, catB, in an integron in pBWH301 显示文摘 | Bunny K L Hall R M Stokes H W | 1995 | Antimicrob A gents Chem other1995，39，： | 1 |
| 17 | Acute and chronic toxicity of veterinary antibiotics to Daphnia magna 显示文摘 | Wollenberger L Halling Sensen B Kusk K O | 2000 | Chemosphere2000，40，7： | 1 |
| 18 | Protection from oxidative stress induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia inducible factor1 and ATF 1/CREB and increased expression of glycolytic enzymes,p2 (waf1/cip1),and erythropoietin显示文摘 | Ryu H Hall D | 1999 | Neurosci1999，19，： | 1 |
| 19 | Fingerprints of global warming on wild animals and plants显示文摘 | Root T L Price J T Hall R K | 2003 | Nature2003，421，： | 1 |
| 20 | CT features of intraductal intrahepatie cholangioearcinoma显示文摘 | Lee J W Hall J K Kim T K | 2000 | Am J Roentgenol2000，175，3： | 1 |
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