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| 1 | Reduction of the incidence and mortality of rectal cancer bypolypectomy:a prospective cohort study in Haining County显示文摘AIM: To reduce the incidence and morlality of rectal cancerand address the hypothesis that colorectal cancer often arisefrom precursor lesion (s), either adenomas or non-alenomatous polyps, by conducting a population-basedmass screening for colorectal cancer in Haining County,Zhejiang, PRCMETHODS: From 1977 to 1980, physicians screened thepopulation of Haining County using 15 cm rigid endoscopy.Of over 240 000 participants, 4076 of them were diagnoselwith Precursor Iesions, eitler alenomas or non-adenomatous polyps, which were then removedl surgically.All individuals with precursor lesionswere followed up andreexamined by endoscopy every two to five years upto 1998.RESULTS: After the initial screening, 953 metactronousadenomas and 417 non-adenomatous polyps ware detected andremoved from the members of this cohort. Further, 27 cases ofcolorectal cancer were detected and treated. Log-rank tuestsshowed that the survival time among those cancer patients whounderwent mass screening increased significantly comparedtothat of other colorectal cancer patients (P < 0.0001). Accordingto the population-based cancer registry in Haining County,age-adjusted incidence and mortality of rectal cancer decreasedby 41% and 29 % from 1977-1981 to 1992-1996, respectively.Observed cumulative 20-year rectal cancer incidence was 31%lower than the expected in the screened group; the mortalitydue to rectal cancer was 18 % lower thah the expected in thescreened group.CONCLUSION: Mass screening for rectal cancer andprecursor lesions with protocoscopy in the generalpopulation and periodical following-up with routineendoscopy for high-risk patients may decrease both theincidence and mortality of rectal cancer. | Shu Zheng Xi-Yong Liu Qi Dong,Cancer Institute,Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Ke-feng Ding Lin-Bo Wang Pei-Lin Qiu Su-Zhan Zhang,The 2~(nd)affiliated Hospital,Medical School of Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Xin-Feng Ding Yong-Zhou Shen Gao-Fei Shen Oi-Rong Sun Wei-Dong Li,Haining Cancer Institute,Haining 314400,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 37 |
| 2 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 3 | A review of chatter vibration research in milling显示文摘Chatter is a self-excited vibration of parts in machining systems. It is widely present across a range of cutting processes, and has an impact upon both efficiency and quality in production processing. A great deal of research has been dedicated to the development of technologies that are able to predict and detect chatter. The purpose of these technologies is to facilitate the avoidance of chatter during cutting processes, which leads to better surface precision, higher productivity,and longer tool life. This paper summarizes the current state of the art in research regarding the problems of how to arrive at stable chatter prediction, chatter identification, and chatter control/-suppression, with a focus on milling processes. Particular focus is placed on the theoretical relationship between cutting chatter and process damping, tool runout, and gyroscopic effect, as well as the importance of this for chatter prediction. The paper concludes with some reflections regarding possible directions for future research in this field. | Caixu YUE Haining GAO Xianli LIU Steven Y.LIANG Lihui WANG | 2019 | Chinese Journal of Aeronautics2019，32，2： | 12 |
| 4 | Enhanced removal of ethylbenzene from gas streams in biotrickling filters by Tween-20 and Zn(Ⅱ)显示文摘The effects of Tween-20 and Zn(II)on ethylbenzene removal were evaluated using two biotrickling filters(BTFs),BTF1 and BTF2.Only BTF1 was fed with Tween-20 and Zn(II).Results show that ethylbenzene removal decreased from 94%to 69%for BTF1 and from 74%to 54%for BTF2 with increased organic loading from 64.8 to 189.0 g ethylbenzene/(m3·hr)at EBRT of 40 sec.The effect of EBRT(60–15 sec)at a constant ethylbenzene inlet concentration was more significant than that of EBRT(30–10 sec)at a constant organic loading.Biomass accumulation rate within packing media was reduced significantly. | Lu Wang Chunping Yang Yan Cheng Jian Huang Haining Yang Guangming Zeng Li Lu Shanying He | 2014 | Journal of Environmental Sciences2014，26，12： | 8 |
| 5 | China’s WUB Community vs. America’s TOD Community显示文摘1. Critiques and reflections on WUB CommunityThe working unit system and the WUB Community, i.e., working-unit-based community, are two completely | YU Wenbo,Postdoctoral,Department of Architecture,Zhejiang University Associate Professor,Department of Architecture and Planning,Zhejiang University of Technology,Hangzhou,P. R. China. WANG Zhu,Professor,Chair of Department of Architecture,Zhejiang University,Hangzhou,P. R. China. MENG Haining,Associate Professor,Chair of Department of Architecture,Zhejiang University,Hangzhou,P. R. China. Editorial Department | 2007 | China City Planning Review2007，16，4： | 7 |
| 6 | An efficient bifunctional electrocatalyst derived from layer-by-layer self-assembly of a three-dimensional porous Co-N-C@graphene显示文摘Three-dimensional (3D) porous carbon-based materials with tunable composition and microstructure are of great interest for the development of oxygen involved electrocatalytic reactions. Here, we report the synthesis of 3D porous carbon-based electrocatalyst by self-assembling Co-metal organic frameworks (MOF) building blocks on graphene via a layer-by-layer technique. Precise control of the structure and morphology is achieved by varying the MOF layer to tune the electrocatalytic properties. The as-produced electrocatalyst exhibits an excellent catalytic activity for the oxygen reduction reaction in 0.1molL^-1 KOH, showing a high onset potential of 0.963V vs. reversible hydrogen electrode (RHE) and a low tafel slope of 54mVdec^-1, compared to Pt/C (0.934V and 52mVdec^-1, respectively). Additionally, it shows a slightly lower potential vs. RHE (1.72V) than RuO2 (1.75V) at 10mAcm^-2 in an alkaline electrolyte. A rechargeable Zn-air battery based on the as-produced 3D porous catalyst demonstrates a high peak power density of 119mWcm^-2 at a cell voltage of 0.578V while retaining an excellent stability over 250 charge-discharge cycles. | Shichang Cai Rui Wang William M. Yourey Junsheng Li Haining Zhang Haolin Tang | 2019 | Science Bulletin2019，64，14： | 6 |
| 7 | Redox regulation in tumor cell epithelial-mesenchymal transition:molecular basis and therapeutic strategy显示文摘Epithelial–mesenchymal transition(EMT)is recognized as a driving force of cancer cell metastasis and drug resistance,two leading causes of cancer recurrence and cancer-related death.It is,therefore,logical in cancer therapy to target the EMT switch to prevent such cancer metastasis and recurrence.Previous reports have indicated that growth factors(such as epidermal growth factor and fibroblast growth factor)and cytokines(such as the transforming growth factor beta(TGF-β)family)are major stimulators of EMT.However,the mechanisms underlying EMT initiation and progression remain unclear.Recently,emerging evidence has suggested that reactive oxygen species(ROS),important cellular secondary messengers involved in diverse biological events in cancer cells,play essential roles in the EMT process in cancer cells by regulating extracellular matrix(ECM)remodeling,cytoskeleton remodeling,cell–cell junctions,and cell mobility.Thus,targeting EMT by manipulating the intracellular redox status may hold promise for cancer therapy.Herein,we will address recent advances in redox biology involved in the EMT process in cancer cells,which will contribute to the development of novel therapeutic strategies by targeting redox-regulated EMT for cancer treatment. | Jingwen Jiang Kui Wang Yan Chen Haining Chen Edouard C Nice Canhua Huang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 5 |
| 8 | A regulated digital currency显示文摘The decentralized digital currency Bitcoin is an anonymous alternative to the centralized banking system and enjoys widespread and increasing adoption. Since Bitcoin created, many other electronic currencies have been developed. We propose a protocol for an electronic currency for making anonymous payments that can be supervised by an auditor, who has sole access to the transaction history. Other electronic currencies provide only anonymity, which is convenient for making illegal transactions without regulation. For users, miners, and banks, the transactions of our electronic currency are anonymous, and only auditors can see how it is used. We make use of POW(prove-of-work) technique that allows for distributed decisionmaking within a network, namely the Bitcoin blockchain protocol. We combine the POW and blockchain technology of Bitcoin to give better protection against double-spending attacks. | Yanbing WU Haining FAN Xiaoyun WANG Guangnan ZOU | 2019 | Science China(Information Sciences)2019，62，3： | 4 |
| 9 | Nocardiopsistins A-C:New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp.HB-J378显示文摘Marine natural products have become an increasingly important source of new drug leads during recent years.In an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria,three new angucyclines,nocardiopsistins A-C,were isolated from Nocardiopsis sp.strain HB-J378.Notably,the supplementation of the rare earth salt Lanthanum chloride(LaCl3)during fermentation of HB-J378 significantly increased the yield of these angucyclines.The structures of nocardiopsistins A-C were identified by 1D and 2D NMR and HR-MS data.Nocardiopsistins A-C have activity against MRSA(methicillin-resistant Staphylococcus aureus)with MICs of 3.12–12.5μg/mL;the potency of nocardiopsistin B is similar to that of the positive control,chloramphenicol.Bioinformatic analysis of the draft genome of HB-J378 identified a set of three core genes in a biosynthetic gene cluster that encode a typical aromatic or type II polyketide synthase(PKS)system,including ketoacyl:ACP synthaseα-subunit(KSα),β-subunit(KSβ)and acyl carrier protein(ACP).The production of nocardiopsistins A-C was abolished when the three genes were knocked out,indicating their indispensable role in the production of nocardiopsistins. | Dongbo Xu Keshav K.Nepal Jing Chen Dedra Harmody Haining Zhu Peter J.McCarthy Amy E.Wright Guojun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 3 |
| 10 | A Flexible Three Clouds 5G Mobile Network Architecture Based on NFV & SDN显示文摘Along with the completion of the development of 4G technologies, the global mobile community starts the study of the next generation technologies, i.e. 5G technologies. This paper proposes a new flexible architecture for 5G mobile networks based on Network Function Virtualization(NFV) and Software Defined Network(SDN) technologies, which is adaptable to use cases and scenarios. Then implementation reference architecture and some typical 5G network deployment cases are discussed. Besides, some key issues for further study are also indicated at the end. | YANG Fengyi WANG Haining MEI Chengli ZHANG Jianmin WANG Min | 2015 | China Communications2015，12，S1： | 3 |
| 11 | New algorithms for verifiable outsourcing of bilinear pairings显示文摘Dear editor,Outsourcing of computation has received widespread attention with the development of cloud computing and the proliferation of mobile devices[1].Despite the huge benefits that it provides,it also encounters some security concerns and other challenges.First,the | Yanli REN Ning DING Tianyin WANG Haining LU Dawu GU | 2016 | Science China(Information Sciences)2016，59，9： | 3 |
| 12 | Resistance to powdery mildew in the pea cultivar Xucai 1 is conferred by the gene er1显示文摘Powdery mildew, caused by Erysiphe pisi D.C., is a major constraint to pea production worldwide. The pea cultivar Xucai 1 has shown high resistance to E. pisi under greenhouse and field conditions. The objectives of this study were to identify and characterize genes conferring resistance to powdery mildew in Xucai 1. Three crosses, Qizhen 76 × Xucai 1,Bawan 6 × Xucai 1, and Xucai 1 × Bawan 6, were made to generate populations for genetic analysis. The resistance to E. pisi and segregation ratios in the F_1, F_2, and F_(2:3)populations suggested a single recessive gene conferring the resistance of Xucai 1. Bulked segregant analysis was used to map the resistance gene using two F2 populations. The resistance gene was close to markers AD60 and c5 DNAmet on linkage group VI with genetic distances of9.9 c M and 15.4 c M in the Xucai 1 × Bawan 6 F_2 population and 8.7 c M and 8.1 c M in the Qizhen 76 × Xucai 1 F_2 population, respectively, suggesting that the resistance gene was an er1 allele. This hypothesis was confirmed by comparison of the c DNA sequences of the Ps MLO1 gene between the parents and the Ps MLO1 wild type. Three distinct types of transcripts in Xucai 1, characterized by a 129-bp deletion and 155- and 220-bp insertions,were detected, consistent with the structure of the er1-2 allele. We concluded that resistance in Xucai 1 was conferred by er1-2 and that its linked markers will be useful in pea breeding programs. | Suli Sun Zhongyi Wang Haining Fu Canxing Duan Xiaoming Wang Zhendong Zhu | 2015 | The Crop Journal2015，3，6： | 2 |
| 13 | Construction of porous covalent organic polymer as photocatalysts for RhB degradation under visible light显示文摘In the present work,a novel porous,and chemically stable amine-based covalent organic polymer(POP-1) was designed and synthesized under solvothermal conditions.The porosity,crystallinity,chemical stability,electrochemical properties,and diffuse reflectance of POP-1 were investigated via N_2 sorption experiment,power X-ray diffraction,thermogravimetric analysis,cyclic voltammetry,and ultraviolet visible near infrared spectrometry,respectively.POP-1 exhibits good chemical stability in both acidic and alkaline aqueous solutions,as well as in organic solvents.Undoped POP-1 can be directly used as a photocatalyst for rhodamine B irradiation degradation under light-emitting diode and natural light.The E_a of POP-1 for RhB degradation is 82.37 kJ/mol.Furthermore,POP-1 can be reused as a catalyst in RhB degradation without degraded catalytic activity. | Pingxiao Liu Lingbao Xing Hongtao Lin Haining Wang Ziyan Zhou Zhongmin Su | 2017 | Science Bulletin2017，62，13： | 2 |
| 14 | Glycidyl methacrylate-compatibilized poly(lactic acid)/hemp hurd biocomposites: Processing, crystallization, and thermo-mechanical response显示文摘Poly(lactic acid)-based biocomposites were developed with hemp hurd(Cannabis sativa L.) with grafting-based interfacial compatibilization. Poly(lactic acid) was extruded with hemp hurd and glycidyl methacrylate as the polymer/hurd interfacial compatibilizer, and injection molded. Interfacial compatibility between poly(lactic acid) and hemp hurd increased with grafted glycidyl methacrylate in comparison to the non-compatibilized control, as corroborated by scanning electron microscopy fractography and mechanical analysis, which showed increases in the glycidyl methacrylate-grafted 20%(w/w)hemp hurd/poly(lactic acid) biocomposite, retaining 94% of the neat polymer strength, with increases in crystallinity, and showing a range of thermo-mechanical properties desirable for rigid biocomposite applications. | Belas Ahmed Khan Haining Na Venkata Chevali Philip Warner Jin Zhu Hao Wang | 2018 | Journal of Materials Science & Technology2018，34，2： | 2 |
| 15 | Research on beamforming method for dual-line array with space mismatch between the two line arrays显示文摘当在双线的数组的二个线数组之间的空格是延期和的 mismatched.The 择向性功能,延期减去 beamforming 被推出,延期和和延期减去 beamforming 的港口/右舷辨别也在理想的地位下面两个都被学习时,双线的数组的港口/右舷辨别的性能将严重被降级并且在双线的数组的二个线数组之间的空格在下面被错配的地位。分析结果证明延期减去 beamforming 有港口 / 右舷辨别的更好的性能。最后,海试用结果表明理论结果。 | WANG Huakui LI Qihu HUANG Haining YE Qinghua LI Shuqiu ZHANG Chunhua | 2008 | Chinese Journal of Acoustics2008，27，1： | 2 |
| 16 | Structure and Properties of PLA Composite Enhanced with Biomass Fillers from Herbaceous Plants显示文摘PLA composites containing biomass fillers from the three herbaceous plants such as reed,wheat stalk,and coco-nut fiber with length and diameter at the scale of several millimeters were prepared without using additives.The reinforcement effect on the properties of PLA/biomass filler composites is investigated.The research results show that the PLA/biomass filler composites exhibit good stiffness,flexural strength,and impact toughness.Among the three kinds of biomass fillers,reed reinforced PLA composites show optimal mechanical properties.When filled with 40%–50%reed,the flexural moduli of the composites are over 7000 MPa.Flexural strength retains at the same level of pure PLA.The notch impact strength reaches to 4.50±0.73 kJ/m^(2),which is 2.06 times higher than that of pure PLA.Furthermore,the introduction of biomass fillers increases the crystallization ability of PLA and does not increase the water absorption of the composites.This research demonstrated that PLA composites prepared with biomass fillers from the herbaceous plants(namely herb plastic composites,HPCs)is a material with good comprehensive mechanical properties while retaining the intrinsic particularity of biological sources. | Haining Na Juncheng Huang Hongguang Xu Fei Liu Liangke Xie Baoqing Zhu Jiuchen Wang Jin Zhu | 2023 | Journal of Renewable Materials2023，11，2： | 2 |
| 17 | Effect of electroacupuncture at Ximen(PC 4) and Hegu(LI 4) on expression of Akt in rats with myocardial ischemia-reperfusion injury显示文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) at acupoints on the pericardium meridian on the expression of phosphorylated Akt(p-Akt) protein in rat myocardium after ischemia and reperfusion.METHODS: Seventy Wistar rats were evenly randomized into seven groups: the sham operation group(group A), ischemia-reperfusion model Ⅰgroup(group B), ischemia-reperfusion model Ⅱgroup(group C), EA at Neiguan(PC 6) group(group D), EA at Ximen(PC 4) group(group E), EA at Hegu(LI 4) group(group F), and LY294002 + EA at Neiguan(PC 6) group(group G). All processes were monitored by electrocardiography. In group A, the left anterior descending coronary artery was only threaded without ligation for 100 min. In group B,the left anterior descending coronary artery was ligated for 40 min and reperfused for 60 min. The left anterior descending coronary artery in group C was ligated for 40 min and reperfused for 100 min.Groups D, E, and F received EA for 20 min before undergoing ischemia for 40 min, and then received EA for 20 min before undergoing reperfusion for 60 min. Before modeling, group G was injected with LY294002(0.3 mg/kg) into the tail vein, and then underwent the same intervention as the other EA groups. After reperfusion, myocardial tissue from the left cardiac ventricle was collected to enable Western blot analysis of the p-Akt level, and analysis of electrocardiographic changes.RESULTS: In groups B and C, electrocardiography showed obvious elevation of the ST-segment Ⅱlead(ECG-STⅡ), while the ECG-STⅡvalues were significantly lower in groups D, E, and G(P < 0.01). The p-Akt levels in groups D and E were significantly greater than those in groups B and C(P < 0.01).Compared with all other groups, group G showed a significantly different expression of p-Akt(P < 0.01).CONCLUSION: The expression of p-Akt protein in cardiomyocytes was significantly greater in rats that were injected with LY294002 and received EA at Ximen(PC 4) compared with all other groups.This suggests that EA at Ximen(PC 4) resulted in activation of the phosphoinositide 3-kinase/Akt signaling pathway and phosphorylation of Akt. | Tian Yuefeng Gao Haining Li Leiyong Wang Jun Zhai Chuntao | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 2 |
| 18 | Towards enriching and isolation of uncultivated archaea from marine sediments using a refined combination of conventional microbial cultivation methods显示文摘The archaea that can be readily cultivated in the laboratory are only a small fraction of the total diversity that exists in nature.Although molecular ecology methods,such as metagenomic sequencing,can provide valuable information independent of cell cultivation,it is only through cultivation-based experiments that they may be fully characterized,both for their physiological and ecological properties.Here,we report our efforts towards enriching and isolation of uncultivated archaea from marine sediments using a refined combination of conventional microbial cultivation methods.Initially,cells were retrieved from the sediment samples through a cell extraction procedure and the sediment-free mixed cells were then divided into different size-range fractions by successive filtration through 0.8µm,0.6µm and 0.2µm membranes.Archaeal 16S rRNA gene analyses indicated noticeable retention of different archaeal groups in different fractions.For each fraction,supplementation with a variety of defined substrates(e.g.,methane,sulfate,and lignin)and stepwise dilutions led to highly active enrichment cultures of several archaeal groups with Bathyarchaeota most prominently enriched.Finally,using a roll-bottle technique,three co-cultures consisting of Bathyarchaeota(subgroup-8)and a bacterial species affiliated with either Pseudomonas or Glutamicibacter were obtained.Our results demonstrate that a combination of cell extraction,size fractionation,and roll-bottle isolation methods could be a useful protocol for the successful enrichment and isolation of numerous slow-growing archaeal groups from marine sediments. | Haining Hu Vengadesh Perumal Natarajan Fengping Wang | 2021 | Marine Life Science & Technology2021，3，2： | 2 |
| 19 | Novel Cathelicidins with Potent Antimicrobial,Biofilm Inhibitory,and Anti-inflammatory Activities from the Frog Fejervarya multistriata显示文摘Antimicrobial peptides(AMPs),a class of gene-encoded peptides,are the first line of immune system to defense microbial invasions in multicellular organisms.Cathelicidins are an important family of AMPs that have been identified exclusively in vertebrates.However,up to now,cathelicidins from amphibians are poorly understood.In the present study,we reported the identification and characterization of two novel cathelicidins(FM-CATH1 and FMCATH2) from the frog Fejervarya multistriata.The c DNA sequences encoding FM-CATHs were successfully cloned from the constructed lung c DNA library of F.multistriata.Both of the c DNA sequences encoding FM-CATHs are 447 bp in length,and the deduced mature peptides of FM-CATHs are composed of 34 residues.Structural analysis indicated that FM-CATH1 and FM-CATH2 mainly assume amphipathic alpha-helical conformations.Antimicrobial and bacterial killing kinetic analysis indicated that both FM-CATH1 and FM-CATH2 possess potent,broad-spectrum and rapid antimicrobial potency.And cytoplasmic membrane permeabilization analysis indicated that FM-CATH1 and FMCATH2 kill bacteria by inducing the permeabilization of bacterial membrane.Besides direct antimicrobial activities,FM-CATHs also exhibited significant inhibitory effect on the formation of bacterial biofilms at low concentrations below 1×MIC.Furthermore,FM-CATH1 and FM-CATH2 exhibited potent anti-inflammatory activities by inhibiting LPS-induced transcription and production of pro-inflammatory cytokines TNF-α,IL-1β,and IL-6 in mouse peritoneal macrophages.Meanwhile,FM-CATHs showed relatively low cytotoxic activity against mammalian normal and tumor cell lines,and low hemolytic activity against human erythrocytes.In summary,the identification of FM-CATHs provides novel clues for our understanding of the roles of cathelicidins in amphibian immune systems.The potent antimicrobial,biofilm inhibitory,anti-inflammatory activities,and low cytotoxicity of FM-CATHs imply their great potential in novel antibiotics development. | Aili WANG Yan CHEN Haining YU Yipeng WANG | 2017 | Asian Herpetological Research2017，18，3： | 2 |
| 20 | Transarterial chemoembolization in combination with programmed death-1/programmed cell death-ligand 1 immunotherapy for hepatocellular显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies worldwide.With the development of systemic therapies,several studies are currently underway,especially those related to the use of programmed death-1/programmed cell death-ligand 1(PD-1/PD-L1)immunotherapy.Moreover,studies on transarterial che-moembolization(TACE)and PD-1/PD-L1 immunotherapy have demonstrated some interesting outcomes.This article reviewed the current clinical evidence on the combination of TACE and PD-1/PD-L1 immunotherapy.Overall,our review summarized that a favorable survival time could be achieved using this combination in most patients.However,complications such as hyperprogression should be taken seriously,and the underlying mechanisms need to be explored. | Jingxin Yan Manjun Deng Shunyu Kong Ting Li Zhenwu Lei Lushun Zhang Yutong Zhuang Xin He Huanwei Wang Haining Fan Yingxing Guo | 2022 | iLIVER2022，1，4： | 2 |
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