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| 1 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 2 | Performance of biotrickling filters packed with structured or cubic polyurethane sponges for VOC removal显示文摘Two identical bench-scale biotrickling filters (BTFs),BTF 1 and BTF 2,were evaluated for toluene removal at various gas empty bed contact times (EBCTs) and organic loadings.BTF 1 and BTF 2 were packed with structured and cubic synthetic polyurethane sponges,respectively.At a constant toluene loading of 16 g/(m 3 ·hr),toluene removal efficiencies decreased from 98.8% to 64.3% for BTF 1 and from 98.4% to 74.1% for BTF 2 as gas EBCT decreased from 30 to 5 sec.When the toluene loading increased from 35 to 140 g/(m 3 ·hr) at a gas EBCT of 30 sec,the removal efficiencies decreased from 99.1% to 77.4% for BTF 1 and from 99.0% to 81.5% for BTF 2.The pressure drop for both BTFs increased with increased air flow rate,and did not significantly vary while the toluene loading was increased under similar operation conditions.BTF 1 and BTF 2 could start up successfully within 19 and 27 days,respectively,when packed with fresh sponge media,and the performances could be restored in 3-7 days after biomass was removed and wasted from the media.BTF 2 displayed higher removal efficiency even under shorter EBCT or higher loading rate than BTF1 when other operation conditions were similar,while it showed lower pressure drop than BTF 1 during the whole period of operation.These results demonstrated that both BTFs could treat waste gas containing toluene effectively. | Chunping Yang Guanlong Yu Guangming Zeng Haining Yang Fayuan Chen Congying Jin | 2011 | Journal of Environmental Sciences2011，23，8： | 10 |
| 3 | Current progress in developing metal oxide nanoarrays-based photoanodes for photoelectrochemical water splitting显示文摘Solar energy driven photoelectrochemical(PEC) water splitting is a clean and powerful approach for renewable hydrogen production. The design and construction of metal oxide based nanoarray photoanodes is one of the promising strategies to make the continuous breakthroughs in solar to hydrogen conversion efficiency of PEC cells owing to their owned several advantages including enhanced reactive surface at the electrode/electrolyte interface, improved light absorption capability, increased charge separation efficiency and direct electron transport pathways. In this Review, we first introduce the structure,work principle and their relevant efficiency calculations of a PEC cell. We then give a summary of the state-of the-art research in the preparation strategies and growth mechanism for the metal oxide based nanoarrays, and some details about the performances of metal oxide based nanoarray photoanodes for PEC water splitting. Finally, we discuss key aspects which should be addressed in continued work on realizing high-efficiency metal oxide based nanoarray photoanodes for PEC solar water splitting systems. | Yongcai Qiu Zhenghui Pan Haining Chen Daiqi Ye Lin Guo Zhiyong Fan Shihe Yang | 2019 | Science Bulletin2019，64，18： | 7 |
| 4 | Emissions of automobiles fueled with alternative fuels based on engine technology:A review显示文摘Diversi?cation of alternative fuels for automobiles is not only an actual situation,but also a development trend.Whether the alternative fuels are clean is an important issue.Emissions of automobiles fueled with natural gas(NG),methanol,ethanol,biodiesel,dimethyl ether(DME)and polyoxymethylene dimethyl ethersare investigated and reviewed based on engine technology and fuel properties.Compared to gasoline,NG/gasoline bi-fuel and NG automobiles have higher brake thermal ef?ciencies(BTE)and produce less HC,CO and PM emissions,while moreCompared to diesel,NG/diesel dual fuel automobiles have lower BTE and emit lower soot andbut higher HC and CO emissions.Methanol and ethanol blending in gasoline can obviously reduce the HC,CO and PM emissions of spark ignition(SI)automobiles.Methanol or ethanol blending in diesel may prolong the ignition delay,shorten the combustion duration and improve the BTE,resulting in lower soot emissions.However,the HC,CO andof methanol or ethanol diesel blend fuels are uncertain due to low cetane number,high latent heat of vaporization.Most biodiesel has higher viscosity,distillation temperature,cetane number and oxygen content than diesel.Soot emission of biodiesel is lower than that of diesel,whileis higher.Both DME andnot contain Ce C bonds and their blend with diesel can prohibit the formation of soot.high cetane number and low viscosity,resulting in better ignitability and spray quality respectively.shortens both the ignition delay and the combustion duration,improves the BTE,and increases the temperature in the diffusion combustion phase,leading to a higher NOx emission. | Yisong Chen Jinqiu Ma Bin Han Peng Zhang Haining Hua Hao Chen Xin Su | 2018 | Journal of Traffic and Transportation Engineering(English Edition)2018，5，4： | 5 |
| 5 | Redox regulation in tumor cell epithelial-mesenchymal transition:molecular basis and therapeutic strategy显示文摘Epithelial–mesenchymal transition(EMT)is recognized as a driving force of cancer cell metastasis and drug resistance,two leading causes of cancer recurrence and cancer-related death.It is,therefore,logical in cancer therapy to target the EMT switch to prevent such cancer metastasis and recurrence.Previous reports have indicated that growth factors(such as epidermal growth factor and fibroblast growth factor)and cytokines(such as the transforming growth factor beta(TGF-β)family)are major stimulators of EMT.However,the mechanisms underlying EMT initiation and progression remain unclear.Recently,emerging evidence has suggested that reactive oxygen species(ROS),important cellular secondary messengers involved in diverse biological events in cancer cells,play essential roles in the EMT process in cancer cells by regulating extracellular matrix(ECM)remodeling,cytoskeleton remodeling,cell–cell junctions,and cell mobility.Thus,targeting EMT by manipulating the intracellular redox status may hold promise for cancer therapy.Herein,we will address recent advances in redox biology involved in the EMT process in cancer cells,which will contribute to the development of novel therapeutic strategies by targeting redox-regulated EMT for cancer treatment. | Jingwen Jiang Kui Wang Yan Chen Haining Chen Edouard C Nice Canhua Huang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 5 |
| 6 | High-quality perovskite in thick scaffold: a core issue for hole transport material-free perovskite solar cells显示文摘器官无机的 perovskite 太阳能电池(PSC ) 由于力量变换效率(PCE ) 的非凡的增加在最后几年里吸引了强烈注意,但是他们的低稳定性极大地妨碍了他们的实际申请。由移开不稳定的洞运输材料(HTM ) , HTM 免费的 PSC 的设备稳定性极大地被改进了。然而, PCE 大部分基于 HTM 的 PSC 落后于那些。我们主张进厚脚手架的高质量的 perovskite 的那免职是完成高效的、 HTM 免费的 PSC 的关键。确实,一些免职方法被用来成功地扔高质量的 perovskite 层进相对厚的 TiO 2 脚手架,因此与相对高的 PCE 生产 PSC。在这评论,我们将介绍 HTM 免费的 PSC 的基本工作原则并且分析厚 TiO 2 支架的重要角色。最重要地,在厚 TiO 2 支架的常规 perovskite 免职方法的问题将被检验,一些最近的成功的免职方法将被调查。最后,我们将得出结论并且加亮为 HTM 免费的 PSC 答应研究方向的一些。 | Haining Chen Shihe Yang | 2016 | Science Bulletin2016，61，21： | 3 |
| 7 | Nocardiopsistins A-C:New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp.HB-J378显示文摘Marine natural products have become an increasingly important source of new drug leads during recent years.In an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria,three new angucyclines,nocardiopsistins A-C,were isolated from Nocardiopsis sp.strain HB-J378.Notably,the supplementation of the rare earth salt Lanthanum chloride(LaCl3)during fermentation of HB-J378 significantly increased the yield of these angucyclines.The structures of nocardiopsistins A-C were identified by 1D and 2D NMR and HR-MS data.Nocardiopsistins A-C have activity against MRSA(methicillin-resistant Staphylococcus aureus)with MICs of 3.12–12.5μg/mL;the potency of nocardiopsistin B is similar to that of the positive control,chloramphenicol.Bioinformatic analysis of the draft genome of HB-J378 identified a set of three core genes in a biosynthetic gene cluster that encode a typical aromatic or type II polyketide synthase(PKS)system,including ketoacyl:ACP synthaseα-subunit(KSα),β-subunit(KSβ)and acyl carrier protein(ACP).The production of nocardiopsistins A-C was abolished when the three genes were knocked out,indicating their indispensable role in the production of nocardiopsistins. | Dongbo Xu Keshav K.Nepal Jing Chen Dedra Harmody Haining Zhu Peter J.McCarthy Amy E.Wright Guojun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 3 |
| 8 | In-situ fabrication of dual porous titanium dioxide films as anode for carbon cathode based perovskite solar cell显示文摘We develop a dual porous(DP) TiO_2 film for the electron transporting layer(ETL) in carbon cathode based perovskite solar cells(C-PSCs). The DP TiO_2 film was synthesized via a facile PS-templated method with the thickness being controlled by the spin-coating speed. It was found that there is an optimum DP TiO_2 film thickness for achieving an effective ETL, a suitable perovskite/TiO_2 interface, an efficient light harvester and thus a high performance C-PSC. In particular, such a DP TiO_2 film can act as a scaffold for complete-filling of the pores with perovskite and for forming high-quality perovskite crystals that are seamlessly interfaced with Ti_O2 to enhance interfacial charge injection. Leveraging the unique advantages of DPTiO2 ETL, together with a dense-packed and pinhole-free TiO_2 compact layer, PCE of the C-PSCs has reached 9.81% with good stability. | Xiaoli Zheng Zhanhua Wei Haining Chen Yang Bai Shuang Xiao Teng Zhang Shihe Yang | 2015 | Journal of Energy Chemistry2015，24，6： | 3 |
| 9 | Effect of Adsorption of ZrO2 in Catalysts on the Efficiency of Hydrolysis of Cellulose to Sugar in Aqueous System under Microwave Radiation显示文摘Summary of main observation and conclusion Five types of ZrO2 are used to simply establish an effective aqueous catalytic system with sulfuric acid for the hydrolysis of cellulose to sugar,respectively.By adjusting surface roughness and particle size of ZrO2 dfferent adsorption is produced.Accordingy,following the thought to inhibit the self-aggregation nature of cellulose,after the introduction of ZrO2 with adsorption in catalysts,the efficiency of the hydrolysis of cellulose to sugar is improved.The results show different ZrO2 can produce different effects during the hydrolysis of the cellulose with rela-tively low crystallinity.Under the optimal conditions,the conversion of cellulose and TRS yield reaches 95.5%and 93.6%,respectively.Through this re-search,it reveals the critical point to organize a feasible and useful way for the hydrolysis of cellulose to sugar with high efficiency in an aqueous system.An important theoretical and technical support is also provided for the conversion and utiliation of cellulose in the future. | Ying Qiao Lixin Feng Zhongqiu Li Zhenyu Zhang Jing Chen Haining Na Jin Zhu Lai Chen | 2020 | Chinese Journal of Chemistry2020，38，4： | 3 |
| 10 | Cep57, a NEDDl-binding pericentriolar material component, is essential for spindle pole integrity显示文摘 | Qixi Wu Runsheng He Haining Zhou Albert CH Yu Bo Zhang Junlin Teng Jianguo Chen | 2012 | Cell Research2012，22，9： | 2 |
| 11 | Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A显示文摘Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown. | Wenjing Zhang Haining Ou Borui Zhang Meifeng Zheng Lan Yan Yang Chen Kwok-Fai So Li Zhang | 2021 | Neuroscience Bulletin2021，37，10： | 2 |
| 12 | Novel Cathelicidins with Potent Antimicrobial,Biofilm Inhibitory,and Anti-inflammatory Activities from the Frog Fejervarya multistriata显示文摘Antimicrobial peptides(AMPs),a class of gene-encoded peptides,are the first line of immune system to defense microbial invasions in multicellular organisms.Cathelicidins are an important family of AMPs that have been identified exclusively in vertebrates.However,up to now,cathelicidins from amphibians are poorly understood.In the present study,we reported the identification and characterization of two novel cathelicidins(FM-CATH1 and FMCATH2) from the frog Fejervarya multistriata.The c DNA sequences encoding FM-CATHs were successfully cloned from the constructed lung c DNA library of F.multistriata.Both of the c DNA sequences encoding FM-CATHs are 447 bp in length,and the deduced mature peptides of FM-CATHs are composed of 34 residues.Structural analysis indicated that FM-CATH1 and FM-CATH2 mainly assume amphipathic alpha-helical conformations.Antimicrobial and bacterial killing kinetic analysis indicated that both FM-CATH1 and FM-CATH2 possess potent,broad-spectrum and rapid antimicrobial potency.And cytoplasmic membrane permeabilization analysis indicated that FM-CATH1 and FMCATH2 kill bacteria by inducing the permeabilization of bacterial membrane.Besides direct antimicrobial activities,FM-CATHs also exhibited significant inhibitory effect on the formation of bacterial biofilms at low concentrations below 1×MIC.Furthermore,FM-CATH1 and FM-CATH2 exhibited potent anti-inflammatory activities by inhibiting LPS-induced transcription and production of pro-inflammatory cytokines TNF-α,IL-1β,and IL-6 in mouse peritoneal macrophages.Meanwhile,FM-CATHs showed relatively low cytotoxic activity against mammalian normal and tumor cell lines,and low hemolytic activity against human erythrocytes.In summary,the identification of FM-CATHs provides novel clues for our understanding of the roles of cathelicidins in amphibian immune systems.The potent antimicrobial,biofilm inhibitory,anti-inflammatory activities,and low cytotoxicity of FM-CATHs imply their great potential in novel antibiotics development. | Aili WANG Yan CHEN Haining YU Yipeng WANG | 2017 | Asian Herpetological Research2017，18，3： | 2 |
| 13 | A Preliminary Study on the Datong Fault Belt显示文摘The Datong fault belt is a NE trending fault in the northern Qinghai-Xizang (Tibet) Plateau and controls the boundary of the Xining Basin and Datong Basin. It consists of the Maziying-Miaogou (F_1) fault and the Laoye Mountain-Nanmenxia fault (F_2). There is obvious displacement in vertical direction along the belt. The field investigation results show that this belt has long-term activity. There are several meters long crushed zones and veins along the fault side in the basement rock. On the fault section,the Cambria system thrusts over the red-brick-colored Quaternary Period gravel,and there is a fault gouge of several centimeters thick developed on the fault plane. The fault gouge date (ESR) on the fault plane is 610±61ka. The covering deluvial loess is not dislocated,and the OSL result is 14.6±1.5ka. So it can be concluded that the fault belt was active in the middle Pleistocene,but inactive in the late Pleistocene according to the age data and geomorphologic features. Interior formations of the Datong basin features fold with the major axis orienting northwest. According to the relation of fault and fold deformation,Datong fault is a transversal tear,which is due to uneven compression of the folds in different parts and NNE trending regional compressive stress. It is common among the NE trending faults in the northeast of Qinghai-Xizang (Tibet) Plateau. These NE trending faults aren't large,and most are located in the active plate. They are all nearly vertical to the axis of the folds and compressive basins. | Li Zhimin Tian Qinjian Yao Shenghai Li Wenqiao Chen Youshun Zou Haining Gao Zhanwu | 2008 | Earthquake Research in China2008，22，3： | 2 |
| 14 | High-performance, stable and low-cost mesoscopic perovskite (CH3NH3PbI3) solar cells based on poly(3-hexylthiophene)- modified carbon nanotube cathodes显示文摘这个工作探索使用(3-hexylthiophene )(P3HT ) poly 修改了碳 nanotubes (CNTs@P3HT ) 因为洞 transporter 的阴极释放, mesoscopic perovskite (CH 3 NH 3 PbI 3) 太阳能电池(PSC ) ,同时完成高效的、高稳定性和便宜 PSC。这里,薄 P3HT 修饰词充当电子 blocker 禁止电子转移进 CNT 和一个恐水病的聚合物文件夹到紧交叉结合 CNT 一起压缩碳电极电影并且极大地稳定太阳能电池。在另一方面, CNT 的存在极大地改进 P3HT 的传导性。由优化 P3HT 修饰词( 2 mg/mL )的集中,我们改进了 CNTs@P3HT 的力量变换效率( PCE )有12.54%的平均效率的基于的 PSC 直到13.43%,它比纯 CNT 基于 PSC (最好的PCE 10.59%),三明治类型 P3HT/CNTs 基于 PSC (最好的PCE 9.50%)的高得多。另外, CNTs@P3HT 的磁滞现象基于 PSC 显著地由于在 perovskite 和 CNTs@P3HT 电极之间的亲密接口被减少。CNT 的降级@基于的 PSC 也是的 P3HT 强烈作为与当暴露了到 20%40% 湿度的周围的条件时,采用纯 CNT 电极的房间相比延迟了。 | Xiaoli ZHENG Haining CHEN Zhanhua WEI Yinglong YANG He LIN Shihe YANG | 2016 | Frontiers of Optoelectronics2016，9，1： | 1 |
| 15 | Urban structure and the risk of influenza A(H1N1) outbreaks in municipal districts显示文摘Changsha was one of the most affected areas during the 2009 A(H1N1)influenza pandemic in China.Here,we analyze the spatial–temporal dynamics of the 2009 pandemic across Changsha municipal districts,evaluate the relationship between case incidence and the local urban spatial structure and predict high-risk areas of influenza A(H1N1).We obtained epidemiological data on all cases of influenza A(H1N1)reported across municipal districts in Changsha during period May 2009–December 2010 and data on population density and basic geographic characteristics for 239 primary schools,97 middle schools,347 universities,96 malls and markets,674 business districts and 121 hospitals.Spatial–temporal K functions,proximity models and logistic regression were used to analyze the spatial distribution pattern of influenza A(H1N1)incidence and the association between influenza A(H1N1)cases and spatial risk factors and predict the infection risks.We found that the 2009 influenza A(H1N1)was driven by a transmission wave from the center of the study area to surrounding areas and reported cases increased significantly after September 2009.We also found that the distribution of influenza A(H1N1)cases was associated with population density and the presence of nearest public places,especially universities(OR=10.166).The final predictive risk map based on the multivariate logistic analysis showed high-risk areas concentrated in the center areas of the study area associated with high population density.Our findings support the identification of spatial risk factors and highrisk areas to guide the prioritization of preventive and mitigation efforts against future influenza pandemics. | Hong Xiao Xiaoling Lin Gerardo Chowell Cunrui Huang Lidong Gao Biyun Chen Zheng Wang Liang Zhou Xinguang He Haining Liu Xixing Zhang Huisuo Yang | 2014 | Chinese Science Bulletin2014，59，5： | 1 |
| 16 | Fox P3(+)regulatory T cells promote T helper 17 cell development in vivothrough regulation of interleukin-2显示文摘 | Chen Y Haines CJ Gutcher I | 2011 | Immunity2011，34，3： | 1 |
| 17 | 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design显示文摘 | Hugh Calkins Karl Heinz Kuck Riccardo Cappato Josep Brugada A. John Camm Shih-Ann Chen Harry J.G. Crijns Ralph J. Damiano D. Wyn Davies John DiMarco James Edgerton Kenneth Ellenbogen Michael D. Ezekowitz David E. Haines Michel Haissaguerre Gerhard Hindric | 2012 | Heart Rhythm2012，，： | 1 |
| 18 | The effect of peryiene diimide aggregation on the light collection efficiency of luminescent concentrators 显示文摘 | HAINES C CHEN M GHIGGINO K P | 2012 | Solar Energy Materials and Solar Cells2012，10，： | 1 |
| 19 | SDF-1α upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines显示文摘 | Feng Pan Shijie Ma Weike Cao Haining Liu Fengli Chen Xiaofei Chen Ruihua Shi | 2013 | Molecular Biology Reports2013，，7： | 1 |
| 20 | Foxp3(+)regula-tory T cells promote T helper 17 cell development in vivothrough regulation of interleukin-2显示文摘 | Chen Y Haines C J Gutcher I | 2011 | Immunity2011，34，3： | 1 |
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