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| 1 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 2 | Thiol-stabilized atomically precise, superatomic silver nanoparticles for catalysing cycloisomerization of alkynyl amines显示文摘Both the electronic and surface structures of metal nanomaterials play critical roles in determining their chemical properties. However, the non-molecular nature of conventional nanoparticles makes it extremely challenging to understand the molecular mechanism behind many of their unique electronic and surface properties. In this work, we report the synthesis, molecular and electronic structures of an atomically precise nanoparticle, [Ag206 L72]~q(L = thiolate, halide; q = charge). With a four-shell Ag7@Ag32@Ag77@Ag90 Ino-decahedral structure having a nearly perfect D_(5h) symmetry, the metal core of the nanoparticle is co-stabilized by 68 thiolate and 4 halide ligands. Both electrochemistry and plasmonic absorption reveal the metallic nature of the nanoparticles, which is explained by density functional theory calculations.Electronically, the nanoparticle can be considered as a superatom, just short of a major electron shell closing of 138 electrons(q = –4). More importantly, many of ligands capping on the nanoparticle are labile due to their low-coordination modes, leading to high surface reactivity for catalysing the synthesis of indoles from 2-ethynylaniline derivatives. The results exemplify the power of the atomic-precision nanocluster approach to catalysis in probing reaction mechanisms and in revealing the interplay of heterogeneous reactivities,electronic and surface structural dynamics, thereby providing ways for optimization. | Juanzhu Yan Jun Zhang Xumao Chen Sami Malola Bo Zhou Elli Selenius Xiaomin Zhang Peng Yuan Guocheng Deng Kunlong Liu Haifeng Su Boon K.Teo Hannu Hakkinen Lansun Zheng Nanfeng Zheng | 2018 | National Science Review2018，5，5： | 3 |
| 3 | Carbon combustion synthesis of lithium cobalt oxide as cathode material for lithium ion battery显示文摘Lithium cobalt oxide(LiCoO2) was synthesized by carbon combustion synthesis(CCS) using carbon as fuel.X-ray diffraction(XRD) and scanning electron microscope(SEM) measurements showed that carbon combustion led to the formation of layered structure of LiCoO2 and the particle size could be controlled by carbon content.For the LiCoO2 sample prepared at 800℃ for 2 h,at molar ratio of C/Co=0.5,the particle-size distribution fell in the narrow range of 3-5 m.Electrochemical tests indicated this LiCoO2 sample delivered an initial discharge capacity of 148 mAh/g with capacity retention rate higher than 97% after 10 cycles. | Yongle Gan Li Zhang Yanxuan Wen Fan Wang Haifeng Su | 2008 | Particuology2008，6，2： | 3 |
| 4 | Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP显示文摘 | Juyi Gao Jianli Tao Weili Liang Meng Zhao Xiaoxia Du Shan Cui Haifeng Duan Biao Kan Xiaodong Su Zhengfan Jiang | 2015 | Cell Research2015，25，5： | 2 |
| 5 | Aberrant expression of BDNF might serve as a candidate target for cocaine- induced psychosis: insights from bioinformatics analysis and microarray validation显示文摘Background Cocaine use disorder(CUD)and associated psychosis are major public health issues worldwide,along with high relapse outcome and limited treatment options.Exploring the molecular mechanisms underlying cocaine-induced psychosis(CIP)could supply integrated insights for understanding the pathogenic mechanism and potential novel therapeutic targets.Aims The aim of the study was to explore common alterations of CUD-schizophrenia target genes and identify core risk genes contributing to CIP through data mining and network pharmacology approach.Methods Target genes of CUD were obtained from GeneCards,Comparative Toxicogenomics Database,Swiss Target Prediction platform and PubChem.Schizophrenia-related target genes were derived from DisGeNET,GeneCards,MalaCards and Online Mendelian Inheritance in Man databases.Then,the overlap genes of these two sets were regarded as risk genes contributing to CIP.Based on these CUD-schizophrenia target genes,functional annotation and pathway analysis were performed using the clusterProfiler package in R.Protein-protein interaction network construction and module detection were performed based on the Search Tool for the Retrieval of Interacting Genes(STRING)database and Cytoscape software.Gene expression datasets GSE54839 and GSE93577 were applied for data validation and diagnostic capacity evaluation of interested hub genes.Results A total of 165 CUD-schizophrenia target genes were obtained.These genes were mainly contributing to chemical synaptic transmission,neuropeptide hormone activity,postsynaptic membrane and neuroactive ligand-receptor interaction pathway.Network analysis and validation analysis indicated that BDNF might serve as an important risk gene in mediating CIP.Conclusions This study generates a holistic view of CIP and provides a basis for the identification of potential CUD-schizophrenia target genes involved in the development of CIP.The abnormal expression of BDNF would be a candidate therapeutic target underlying the pathogenesis of CUD and associated CIP. | Youwei Zhu Yan Zhao Xiaomin Xu Hang Su Xiaotong Li Na Zhong Haifeng Jiang Jiang Du Min Zhao | 2021 | General Psychiatry2021，34，5： | 2 |
| 6 | The energy method to predict disc cutter wear extent for hard rock TBMs显示文摘 | Lihui Wang Yilan Kang Zongxi Cai Qian Zhang Yu Zhao Haifeng Zhao Pengcheng Su | 2011 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2011，，： | 2 |
| 7 | Atomically precise metal-chalcogenide semiconductor molecular nanoclusters with high dispersibility:Designed synthesis and intracluster photocarrier dynamics显示文摘A comprehensive understanding of excited-state dynamics of semiconductor quantum dots or nanomaterials at the atomic or molecular level is of scientific importance.Pure inorganic(or non-covalently protected)seimiconductor molecular nanoclusters with atomically precise structure are contributive to establish accurate correlation of excited-state dynamics with their composition/structure,however,the related studies are almost blank because of unresolved solvent dispersion issue.Herein,we designedly created the largest discrete chalcogenide seimiconductor molecular nanoclusters(denoted P2-CuMSnS,M=In or/and Ga)with great dispersibility,and revealed an interesting intracluster“core–shell”charge transfer relaxation dynamics.A systematic red shift in absorption spectra with the gradual substitution of In by Ga was experimentally and computationally investigated,and femtosecond transient absorption measurements further manifested there were three ultrafast processes in excited-state dynamics of P2 nanoclusters with the corresponding amplitudes directed by composition variation.Current results hold the great promise of the solution-processible applications of semiconductor-NC-based quantum dots and facilitate the development of atomically precise nano-chemistry. | Jiaxu Zhang Chaochao Qin Yeshuang Zhong Xiang Wang Wei Wang Dandan Hu Xiaoshuang Liu Chaozhuang Xue Rui Zhou Lei Shen Yinglin Song Dingguo Xu Zhien Lin Jun Guo Haifeng Su Dong-Sheng Li Tao Wu | 2020 | Nano Research2020，13，10： | 2 |
| 8 | Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia显示文摘Patients with chronic kidney disease are at high risk of hyperkalemia that is associated with various lifethreatening complications.Treatments primarily rely on orally administered potassium binding agents,along with low curative effects and various side effects.Herein,direct serum potassium uptake was realized via zeolite–heparin-mimicking-polymer hybrid microbeads.The preparation process involved the synthesis of the heparin-mimicking polymer via the in situ cross-linking polymerization of acrylic acid and N-vinylpyrrolidone in polyethersulfone solution,the fabrication of microbeads via zeolite-mixing,electro-spraying and phase-inversion,and the subsequent aqueous-phase modifications based on ion-exchange and metal-leaching.An ultra-high(about 88%)amount of zeolite could be incorporated and well locked inside the polymer matrix.Potassium uptake capability was verified in water,normal saline and human serum,showing high selectivity and fast adsorption.The microbeads exhibited satisfying blood compatibility,negligible hemolysis ratio,prolonged clotting time,inhibited contact activation,and enhanced antifouling property toward serum proteins and cells.The proposed approach toward zeolite–heparin-mimicking-polymer hybrid microbeads provided a cheap,efficient and safe treatment protocol of hyperkalemia for the high-risk patients. | Zhoujun Wang Wei Sun Zhiwei Wei Jianxu Bao Xin Song Yupei Li Haifeng Ji Jue Zhang Chao He Baihai Su Weifeng Zhao Changsheng Zhao | 2021 | Bioactive Materials2021，6，2： | 2 |
| 9 | Development of RTV silicone coatings in China: overview and bibliography显示文摘 | Zhidong Jia Su Fang Haifeng Gao | 2008 | IEEE Electrical Insulation Magazine2008，24，2： | 1 |
| 10 | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha , and Boswellia carterii显示文摘 | Shulan Su Yongqing Hua Yanyan Wang Wei Gu Wei Zhou Jin-ao Duan Haifeng Jiang Ting Chen Yuping Tang | 2011 | Journal of Ethnopharmacology2011，，2： | 1 |
| 11 | Development of RTV silicone coatings in China: overview and bibliography显示文摘 | Jia Zhidong Fang Su Gao Haifeng | 2008 | IEEE Electrical Insulation Magazine2008，24，2： | 1 |
| 12 | The cytotoxicity of cadmium-based quantum dots显示文摘 | Nan Chen Yao He Yuanyuan Su Xiaoming Li Qing Huang Haifeng Wang Xiangzhi Zhang Renzhong Tai Chunhai Fan | 2011 | Biomaterials2011，，5： | 1 |
| 13 | Characterisation of aroma profiles of commercial soy sauce by odour activity value and omission test 显示文摘 | Yunzi Feng Guowan Su Haifeng Zhao | 2015 | Food Chemistry2015，167，： | 1 |
| 14 | Reductive leaching of manganese from low-grade manganese ore in H2S04 using cane mo- lasses as reductant 显示文摘 | Su Haifeng Wen Yanxuan Wang Fan | 2008 | Hydrometallurgy2008，93，34： | 1 |
| 15 | The energy method to predict disc cutter wear extent for hard rock TBMs显示文摘 | Lihui Wang Yilan Kang Zongxi Cai Qian Zhang Yu Zhao Haifeng Zhao Pengcheng Su | 2011 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2011，，： | 1 |
| 16 | An in vivo Transient Expression System Can Be Applied for Rapid and Effective Selection of Artificial MicroRNA Constructs for Plant Stable Genetic Transformation显示文摘The utility of artificial microRNAs(amiRNAs) to induce loss of gene function has been reported for many plant species,but expression efficiency of the different amiRNA constructs in different transgenic plants was less predictable,In this study,expressions of amiRNAs through the gene backbone of Arabidopsis miR168a were examined by both Agrobacterium-mediated transient expression and stable plant genetic transformation.A corresponding trend in expression of amiRNAs by the same amiRNA constructs between the transient and the stable expression systems was observed in the experiments.Plant genetic transformation of the constructs that were highly expressible in amiRNAs in the transient agro-infiltration assays resulted in generation of transgenic lines with high level of amiRNAs.This provides a simple method for rapid and effective selection of amiRNA constructs used for a time-consuming genetic transformation in plants. | Basdeo Bhagwat Ming Chi Li Su Haifeng Tang Guiliang Tang Yu Xiang | 2013 | Journal of Genetics and Genomics2013，40，5： | 1 |
| 17 | Development of RTV Silicone Coatings in China: Overview and Bibliography显示文摘 | Zhidong Jia Su Fang Haifeng Gao | 2008 | IEEE Electrical Insulation Magazine2008，24，2： | 1 |
| 18 | Fabrication of Photo-crosslinked Chitosan- Gelatin Scaffold in Sodium Alginate Hydrogel for Chondrocyte Culture显示文摘 | Feng Liu Ali Goodarzi Haifeng Wang Joanna Stasiak Jianbo Sun Yu Zhou Peng Zhao Cuijun Deng Hongzhen Xu Xing Tang Hailong He Chao Lin Jiansheng Su | 2014 | Bio-Medical Materials and Engineering2014，，1： | 1 |
| 19 | Reductive leaching of manganese from low-grade manganese ore in H 2 SO 4 using cane molasses as reductant显示文摘 | Su Haifeng WenYanxuan WangFan | 2009 | Hydromet-allurgy20092009，102，： | 1 |
| 20 | Reductive leaching of manganese from low-grade manganese ore in H2 SO4 using cane molasses as reduetant显示文摘 | Haifeng Su Yanxuan Wen Fan Wang | 2008 | Hydromet- allurgy2008，93，34： | 1 |
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