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| 1 | 三维超高场7T高分辨磁敏感加权像静脉造影(英文)显示文摘目的超高场磁共振具有高信噪比和独特的磁敏感对比,使其在无创性脑血管造影尤其是对小静脉的检测有明显优势。本文探讨如何在超高场磁共振7T优化和获取高质量的磁敏感加权像(SWI)静脉造影。方法选择10例正常志愿者作为研究对象,采集一系列7TSWI静脉造影数据并与3T结果作对比。选择参数TR=30~45ms,TE=13~26ms,带宽(BW)=80~140Hz/pixel,翻转角(FA)=10~25?;所有的数据用同样的图像后处理方式得到最小信号叠加投影(mIP)的SWI静脉造影像,并进行定量化分析。结果图像优化后,我们得到高分辨率的7T静脉造影图像。根据静脉血的T2*选择优化TE:16ms(7T),28ms(3T);FA:15?(3T和7T)。相对于3T,7TSWI图像有较高的信噪比和静脉与周围组织的对比度,并显示出更多的微小静脉。结论超高场SWI静脉造影对于显示微小静脉具有明显的优势。 | Yulin Ge Samuel Barnes Samantha Heller Daniel K.Sodickson Lin Tang E.Mark Haacke Jianping Dai Robert I.Grossman | 2010 | 磁共振成像2010，1，2： | 8 |
| 2 | Detecting prostate cancer and prostatic calcifications using advanced magnetic resonance imaging显示文摘前列腺癌症和 prostatic 石灰化在老人有高发生。我们试图在检测前列腺癌症和 prostatic 石灰化调查危险性加权的成像的诊断能力。156 个人的一个全部的数字,与前列腺癌症包括 34 并且 122 在这研究与良性的前列腺被注册。计算断层摄影术,常规磁性的回声成像,散开加权的成像,和危险性加权的成像在所有病人上被执行。112 prostatic 石灰化在 87 个病人被检测。常规磁性的回声成像,明显的散开系数,和在检测前列腺癌症和 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性是计算的。McNemars Chi 平方测试被用来在在这些技术之间的敏感和特性比较差别。结果证明在检测 prostatic 癌症的过滤危险性的阶段图象的敏感和特性比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。另外,在检测 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性比得上计算断层摄影术的并且比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。在前列腺癌症给危险性加权的成像(SWI ) 的高发生反常,我们断定危险性加权的成像在检测前列腺癌症比常规磁性的回声成像,散开加权的成像,和计算断层摄影术更敏感、特定。而且,危险性加权的成像能识别类似于计算断层摄影术的 prostatic 石灰化,并且它比常规磁性的回声成像和散开加权的成像好一些。 | Shewei Dou Yan Bai Ankit Shandil Degang Ding Dapeng Shi E Mark Haacke Meiyun Wang | 2017 | Asian Journal of Andrology2017，19，4： | 7 |
| 3 | Pathophysiology of cystic fibrosis and drugs used in associated digestive tract diseases显示文摘Cystic fibrosis(CF)causes chronic infections in the respiratory tract and alters the digestive tract.This paper reviews the most important aspects of drug treatment and changes in the digestive tract of patients with CF.This is a review of the literature,emphasizing the discoveries made within the last 15 years by analyzing scientific papers published in journals indexed in the Scientific Electronic Library Online,Sciences Information,United States National Library of Medicine and Medical Literature Analysis and Retrieval System Online databases,both in English and Portuguese,using the key words:cystic fibrosis,medication,therapeutic,absorption,digestion.Randomized,observational,experimental,and epidemiological clinical studies were selected,among others,with statistical significance of 5%.This review evaluates the changes found in the digestive tract of CF patients including pancreatic insufficiency,constipation and liver diseases.Changes in nutritional status are also described.Clinical treatment,nutritional supplementation and drug management were classified in this review as essential to the quality of life of CF patients,and became available through public policies for monitoring and treating CF.The information gathered on CF and a multi professional approach to the disease is essential in the treatment of these patients. | Adriana Haack Giselle Gonalves Arago Maria Rita Carvalho Garbi Novaes | 2013 | World Journal of Gastroenterology2013，19，46： | 7 |
| 4 | Pine wilt disease in Yunnan, China: Evidence of non-local pine sawyer Monochamus alternatus (Coleoptera: Cerambycidae) populations revealed by mitochondrial DNA显示文摘 | Da-Ying Fu Shao-Ji Hu Hui Ye Robert A. Haack Ping-Yang Zhou | 2010 | Insect Science2010，17，5： | 4 |
| 5 | Imaging iron stores in the brain using magnetic resonance imaging显示文摘 | E. Mark Haacke Norman Y.C. Cheng Michael J. House Qiang Liu Jaladhar Neelavalli Robert J. Ogg Asadullah Khan Muhammad Ayaz Wolff Kirsch Andre Obenaus | 2005 | Magnetic Resonance Imaging2005，，1： | 3 |
| 6 | 同行评议与发表:对法律工作者的启迪显示文摘在确定某理论或者技术是否属于科学知识,从而有助于事实审判者时,该理论或者技术是否通过了同行评议并发表是一个重要的考量因素。本文讨论了同行评议的起源、在科学和医学期刊建设中的现行角色、出版前同行评议的基本理论,以及同行评议作为质量控制机制的固有的局限性。 | Susan Haack 王进喜 | 2014 | 证据科学2014，22，1： | 3 |
| 7 | 大鼠中风模型的超小氧化铁粒子神经血管成像(英文)显示文摘现今诱导血管增生剂在中风后的治疗效应引起了人们的关注.这项工作的一个目的是用短时脑中动脉栓塞大鼠中风模型(MCAO)和磁化率加权成像(SWI)的核磁共振成像(MRI)方法,监测在中风后半月形损伤区新生成的旁侧血管.P904是法国格尔伯实验室生产的超小超顺磁氧化铁粒子弛豫试剂(USPIO).它在低剂量减少T1弛豫时间,适中剂量时减少T2*弛豫时间.实验动物被随机分为3组:中风Sildenafil治疗组(n=6)、中风无治疗对照组(n=5)和无中风无治疗对照组(n=1).在P904注入前后分别进行MRI成像.磁化率加权成像的时间点是:栓塞手术前、栓塞手术后24小时、栓塞手术后两周和四周.结果表明,术后两周,在治疗组中中风严重的动物的缺血区的周边显示了MRI可见的新生血管.结论:在短时脑中动脉栓塞大鼠中风模型中,使用超小超顺磁氧化铁粒子弛豫试剂和7 T高分辨磁化率加权成像能够监测半月形损伤区新生血管的形成. | 沈伊民 郑伟丽 CHENG Yu-Chung N 丁玉川 HIGASHIDA Tetsuhiro 李杰 叶永泉 RAYNAUD Jean-Sebastien HAACKE E Mark | 2014 | 波谱学杂志2014，31，1： | 2 |
| 8 | Ultrafast photonic PCR显示文摘Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental science.Ultrafast multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC testing.Here,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon coupling.We demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 min.Using this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 min.Using photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)amplification.Our simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications. | Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee Ori Hoxha Amanda J Haack Luke P Lee | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 9 | An All-Speed Asymptotic-Preserving Method for the Isentropic Euler and Navier-Stokes Equations显示文摘The computation of compressible flows becomesmore challengingwhen the Mach number has different orders of magnitude.When the Mach number is of order one,modern shock capturing methods are able to capture shocks and other complex structures with high numerical resolutions.However,if theMach number is small,the acoustic waves lead to stiffness in time and excessively large numerical viscosity,thus demanding much smaller time step and mesh size than normally needed for incompressible flow simulation.In this paper,we develop an all-speed asymptotic preserving(AP)numerical scheme for the compressible isentropic Euler and Navier-Stokes equations that is uniformly stable and accurate for all Mach numbers.Our idea is to split the system into two parts:one involves a slow,nonlinear and conservative hyperbolic system adequate for the use of modern shock capturing methods and the other a linear hyperbolic system which contains the stiff acoustic dynamics,to be solved implicitly.This implicit part is reformulated into a standard pressure Poisson projection system and thus possesses sufficient structure for efficient fast Fourier transform solution techniques.In the zero Mach number limit,the scheme automatically becomes a projection method-like incompressible solver.We present numerical results in one and two dimensions in both compressible and incompressible regimes. | Jeffrey Haack Shi Jin Jian-Guo Liu | 2012 | Communications in Computational Physics2012，12，9： | 2 |
| 10 | Ineffective oesophageal motility:Manometric subsets exhibit different symptom profiles显示文摘AIM:To compare the demographic and clinical features of different manometric subsets of ineffective oesophageal motility(IOM;defined as ≥ 30% wet swallows with distal contractile amplitude < 30 mmHg) ,and to determine whether the prevalence of gastro-oesophageal reflux differs between IOM subsets. METHODS:Clinical characteristics of manometric subsets were determined in 100 IOM patients(73 female,median age 58 years) and compared to those of 100 age-and gender-matched patient controls with oesophageal symptoms,but normal manometry. Supine oesophageal manometry was performed with an eight-channel DentSleeve water-perfused catheter,and an ambulatory pH study assessed gastro-oesophageal reflux. RESULTS:Patients in the IOM subset featuring a majority of low-amplitude simultaneous contractions(LASC) experienced less heartburn(prevalence 26%) ,but more dysphagia(57%) than those in the IOM subset featuring low-amplitude propagated contractions(LAP;heartburn 70%,dysphagia 24%;both P ≤ 0.01) . LASC patients also experienced less heartburn and more dysphagia than patient controls(heartburn 68%,dysphagia 11%;both P < 0.001) . The prevalence of heartburn and dysphagia in IOM patients featuring a majority of non-transmitted sequences(NT) was 54%(P = 0.04 vs LASC) and 36%(P < 0.01 vs controls) ,respectively. No differences inage and gender distribution,chest pain prevalence,acid exposure time(AET) and symptom/reflux association existed between IOM subsets,or between subsets and controls. CONCLUSION:IOM patients with LASC exhibit a different symptom profile to those with LAP,but do not differ in gastro-oesophageal reflux prevalence. These findings raise the possibility of different pathophysiological mechanisms in IOM subsets,which warrants further investigation. | Horst Gunter Haack Ross David Hansen Allison Malcolm John Edward Kellow | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 11 | In vivo measurement of tissue damage, oxygen saturation changes and blood flow changes after experimental traumatic brain injury in rats using susceptibility weighted imaging显示文摘 | Yimin Shen Zhifeng Kou Christian W. Kreipke Theodor Petrov Jiani Hu E. Mark Haacke | 2007 | Magnetic Resonance Imaging2007，，2： | 2 |
| 12 | The role of voxel aspect ratio in determining apparent vascular phase behavior in susceptibility weighted imaging显示文摘 | Xu Y Haacke EM | 2006 | Magn Reson lmaging2006，24，2： | 1 |
| 13 | Serine-derived oxazolidines as seeondary structure disrupting, solubilizing buildingbloeks in peptide-synthesis显示文摘 | Haack T Mutter M | 1992 | Tetrahedron Lett1992，33，： | 1 |
| 14 | Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma ceils reveals a significant decrease of intracellu- lar calcium levels by selected L-type calcium channel blockers 显示文摘 | An Haack K Narayan SB Li H | 2011 | Biochim Biophys Acta2011，1810，2： | 1 |
| 15 | Human interleukin-I beta and interleukin-I receptor antagonist secretion and velocity of tooth movement显示文摘 | lwasaki LR Haack JE Nickel JC | 2001 | Arch Oral Biol2001，46，2： | 1 |
| 16 | Susceptibaility weigh- ted imaging (SWI) 显示文摘 | Haacke EM Xu Y Cheng YC | 2004 | Magn Reson Mecl2004，52，： | 1 |
| 17 | Increased extracellular k + concentration reduces the efficacy of n- methyl-d-aspartate receptor antagonists to block sprea- ding depression-like depolarizations and spreading ische- mia显示文摘 | Petzold G C Windmuller O Haack S | 2005 | Stroke2005，36，： | 1 |
| 18 | Imaging cerebral microbleeds using susceptibility weighted imaging: one step toward detecting vascular dementia 显示文摘 | Ayaz M Boikov AS Haacke EM | 2010 | J Magn Reson Imaging2010，31，1： | 1 |
| 19 | Surface modification and characterization of thermoplastic polyurethane显示文摘 | ALVES P COELHO J F J HAACK J | | 0，，02： | 1 |
| 20 | susceptibility weighted ima-ging(SWl) 显示文摘 | Haacke EM Xu Y Chen YC ei al | 2004 | Magnetic Resonan cein Medicine2004，52，3： | 1 |
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