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    题名 作者 年代 出处 被引量
1Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He 2017Cell Research2017,27,9:96
2Wnt/β-catenin signalling:function,biological mechanisms,and therapeutic opportunities显示文摘The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis.The deregulation of Wnt/β-catenin signalling often leads to various serious diseases,including cancer and non-cancer diseases.Although many articles have reviewed Wnt/β-catenin from various aspects,a systematic review encompassing the origin,composition,function,and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking.In this article,we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research.Finally,we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.Jiaqi Liu Qing Xiao Jiani Xiao Chenxi Niu Yuanyuan Li Xiaojun Zhang Zhengwei Zhou Guang Shu Gang Yin 2022Signal Transduction and Targeted Therapy2022,7,2:28
3Variations of organic carbon isotopic composition and its environmental significance during the last glacial on western Chinese Loess Plateau显示文摘A high-resolution loess section in the western Chinese Loess Plateau, Yuanbao Section, was sampled for organic carbon isotopic analyses. The soil organic carbon isotope (δ13Corg) varied be- tween ?22.6‰ and ?27.5‰ during the last glacial at the section. During the last interstadial, the δ 13Corg values were more negative than those in both early and late periods of the last glacial by 4‰. The iso- topic composition indicates a coupled response of the pure C3 plants to the temperature, precipitation and the concentration of atmospheric CO2. Decrease in temperature and the atmospheric CO2 concentration from the last interstadial to Last Glaicial Maximum (LGM) caused the organic carbon isotopes to be- come positive by 1.5‰―2.0‰. The amplitude of 4‰ in the δ 13Corg variation during the last glacial should be mainly caused by the precipitation change. Therefore, the δ 13Corg variations of the Yuanbao Section during the last glacial period documented the large-amplitude fluctuation of the monsoon precipita- tion, which is estimated to be 250―310 mm more during the last interstadial than that in the LGM, and 100 mm more than that during early last glacial. The rapid changes of the monsoon precipitation on mil-lennial scale during the last glacial have also been recorded in the isotopic variations in Yuanbao loess section. As the isotopic composition varies compli- catedly as shown in the loess-paleosol sequence, it cannot be simply attributed to the abundances of C3 and C4 plants or be used as an indicator of the summer monsoon variations.CHEN Fahu RAO Zhiguo ZHANG Jiawu JIN Ming MA Jianying 2006Chinese Science Bulletin2006,51,13:25
4Diagnostic Study on the Structural Characteristics of a Typical Mei-yu Front System and Its Maintenance Mechanism显示文摘In this paper, a typical mei-yu front process with heavy rainfall from June 12 to 15 in 1998 is analyzed. The results show that the mei-yu front is a front system which consists of an iso-θe dense area with strong horizontal gradient, a deep-convective cloud tower band, a passageway transporting warm and moist air ?ow from the summer monsoon surge in the mid and low levels to the south of the mei-yu front, and a migrating synoptic scale trough to the north of the mei-yu front, which transports cold and dry air southward in the mid and upper levels. The maintenance of the mei-yu front is realized by: (1) is a positive feedback between the moist physical process enhancing frontogenesis and the development of the strong convective system in front of the mei-yu front; (2) the sustaining system to the north of the mei-yu front which is a migrating synoptic scale trough transporting cold and dry air to the mei-yu front and positive vorticity to the mesoscale system in front of the mei-yu front.JIANG Jianying(蒋建莹) NI Yunqi(倪允琪) 2004Advances in Atmospheric Sciences2004,21,5:22
5Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction显示文摘To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction,23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction.The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days.The diffusion coefficient remained unchanged.Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction.Ruiman Xie Min Fang Linjiang Zhou Shanghua Fan Jianying Liu Hongbo Quan Man Luo Dongying Qiu 2012Neural Regeneration Research2012,7,12:20
6A heat-driven thermoacoustic cryocooler capable of reaching below liquid hydrogen temperature显示文摘A 'double-gas acoustic amplifier' is introduced to couple a thermoacoustic heat engine and a two-stage pulse tube cooler in this paper. Compared with previous acoustic amplifiers, this new acoustic amplifier maintains the function of amplification for pressure amplitude. In particular, the novel acoustic amplifier with a reservoir makes it possible to install an acoustic transparent but gas blocking elastic membrane between the engine and the cooler. Thus, the engine can use nitrogen as the working gas to work at low frequency; and meanwhile, the cooler can still use helium as the working gas to maintain its high performance. With this new amplifier, the cooling temperature of a two-stage pulse tube cooler driven by an energy-focused thermoacoustic engine reached 18.7 K.HU JianYing LUO ErCang DAI Wei Zhou Yuan 2007Chinese Science Bulletin2007,52,4:18
7Comparisons between centrifuge and numerical modeling results for slope toppling failure显示文摘This paper presents series studies on the toppling mechanism by centrifuge tests and numerical simulations. Two different discrete element methods, i.e., the continuum-based discrete element method(CDEM) and the discontinuous deformation analysis(DDA), are adopted. The modeling results show that both the methods can accurately capture the failure modes of the centrifuge tests, including three distinct zones and two failure surfaces. Comparisons are made between the physical test and numerical simulation results. The critical inclination angle of the tilting table where the slope models are fixed on can be moderately predicted by the two methods, with different degrees of precision. The error between the test results and the simulated results is within 1% for the slope models without rock-bridges by both CDEM and DDA. However, it is amplified for the staggered-joint models that simulate the rock-bridges. With DDA, the average error is about 5%, and the maximum error is up to 17%. While with CDEM, the errors for the aligned-joint models are ranged from 1% to 6%, and it is from 10% to 29% for the staggered-joint models. The two numerical methods show the capability in simulating toppling failure of blocky rock mass with and without rock-bridges. The model with rock-bridges which provides a certain bending resistance is more stable than the one without any rock-bridge. In addition, the two failure surfaces were observed, which is different from the common understanding that only one failure surface appears.CHEN ZuYu GONG WenJun MA GuoWei WANG Jie HE Lei XING YiChuan XING JianYing 2015Science China(Technological Sciences)2015,58,9:18
8Comparison of Transformation Efficiency of piggyBac Transposon among Three Different Silkworm Bombyx mori Strains显示文摘在由编码 transposase 定序的小猪用绳子拖的平底渡船向量和助手 plasmidcontaining 的混合物的微注射编码基因进蚕鸡蛋的提高的绿荧光蛋白质(EGFP ) 的介绍以后比较的蚕 Bombyx moriwas 的三不同紧张的转变率。尽管在在在微注射鸡蛋(P=0.1258 ) 的肥沃的蛾的百分比的三紧张之中没有重要差别, G0 的百分比转变了在肥沃的蛾和注射鸡蛋的蛾两个都是显著地不同的(P=0.01368 和 P=0.02398,分别地) 。Nistari 紧张(印度紧张) 的转变率比另外的二紧张, Golden-yellow-cocoon (Vietnamesestrain ) 和 Jiaqiu (中国紧张) 的显著地高,它有类似的率。这些结果显示基于 piggyBac 的系统的转变效率可能与不同基因背景与蚕紧张变化。内长的象 piggyBac 一样元素的存在可能是影响介绍 piggyBac-derivedvectors,和多样的数量的转变效率的一个重要因素,在不同的蚕紧张的激活可能说明重要差别。Boxiong ZHONG~1 Jianying LI~1 Jin’e CHEN~(1,2) Jian YE~1 and Songdong YU~1 ~1College of Animal Sciences,Zhejiang University,Hangzhou 310029,China ~2Institute of Sericultural Research,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,China 2007Acta Biochimica et Biophysica Sinica2007,39,2:17
9An HBV-encoded miRNA activates innate immunity to restrict HBV replication显示文摘We previously identified that hepatitis B virus(HBV)encodes a microRNA(HBV-miR-3)that restrains HBV replication by targeting the HBV transcript.However,whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear.Here,we examined the vital functions of HBV-miR-3 in the innate immune response after HBV infection.We found that HBV-miR-3 expression gradually increased in a dose-and time-dependent manner in HBV-infected HepG2-NTCP cells.HBV-miR-3 activated the JAK/STAT signaling pathway by downregulating SOCS5 in hepatocytes,thereby enhancing the IFN-induced anti-HBV effect.In addition,HBVmiR-3 in exosomes facilitated the Ml polarization of macrophages.Furthermore,exosomes containing HBV-miR-3 enhanced the secretion of IL-6 via inhibiting the SOCS5-mediated ubiquitination of EGFR.In short,these results demonstrate that HBV-miR-3 activates the innate immune response to restrain HBV replication by multiple pathways,which may suppress HBV-induced acute liver cell injury and affect the progression of persistent HBV infection.Xiaoqing Zhao Lu Sun Ting Mu Jianying Yi Chaoqun Ma Hong Xie Min Liu Hua Tang 2020Journal of Molecular Cell Biology2020,12,4:17
10Determination of N-nitrosodimethylamine in drinking water by UPLC-MS/MS显示文摘The method for detecting N-nitrosodimethylamine(NDMA) in drinking water using ultra performance liquid chromatography(UPLC) coupled with tandem mass spectrometry(MS/MS) was improved by optimizing the clean-up procedure to remove the matrix interference in pretreatment process,and was then applied to a survey of NDMA in both raw and finished water samples from five water treatment plants in South China.The NDMA concentrations ranged from 4.7 to 15.1 ng/L in raw water samples,and from 4.68 to 46.9 ng/L in finished water.The NDMA concentration in raw water was found to be related with nitrite concentration,and during the treatment,the NDMA concentration increased following ozonation but decreased after subsequent activated carbon treatment.Wanfeng Wang Jianying Hu Jianwei Yu Min Yang 2010Journal of Environmental Sciences2010,22,10:16
11Occurrence of sulfonamide antibiotics in sewage treatment plants显示文摘The occurrence of sulfonamide antibiotics(SAs) was investigated in the six sewage treatment plants(STPs) of Beijing,China.Of the 13 objective antibiotics,sulfamethoxazole,sulfapyridine,sulfamerazine,sulfadiazine and sulfamethizol were detected in the influents with the average concentrations of 1.2 ± 0.45,0.29 ± 0.25,0.048 ± 0.012,0.35 ± 0.52 and 0.33 ± 0.21 μg·L-1,respectively,and those in the effluents were 1.4 ± 0.74,0.22 ± 0.19,0.021 ± 0.008,0.22 ± 0.21and 0.01± 0 μg·L-1,respectively.Sulfamethoxazole was the predominant compound detected,and was found in all wastewater samples with the other two compounds sulfapyridine and sulfamerazine.It should be noted that sulfadiazine was first reported in wastewaters,and the concentration levels of all detected compounds except for sulfamethizol(detected once in the effluent samples) in the influents were observed to be similar to those in the effluents.From the data in this study,it can be found that sulfamethoxazole,sulfapyridine,sulfamerazine and sulfadiazine could be partly removed in anoxic and aerobic treatment unit and vice versa in anaerobic process,which led to their low or even negative removal rates in the effluents.The increase on the concentrations of sulfamethoxazole and sulfapyridine in the effluents was found probably due to the biotransformation of their acetylated forms in anaerobic treatment unit.In addition,it was observed that the biodegradation of sulfamethoxazole and sulfapyridine could partly occur during the anoxic and aerobic process,while sulfamerazine was partly eliminated in the anaerobic and anoxic units.CHANG Hong HU JianYing WANG LeZheng SHAO Bing 2008Chinese Science Bulletin2008,53,4:15
12A novel method for singularity analysis of the 6-SPS parallel mechanisms显示文摘Singularity analysis is a basic problem of parallel mechanism, and this problem cannot be avoided in both workspace and motion planning. How to express the singularity locus in an analytical form is the research emphasis for many researchers for a long time. This paper presents a new method for the singularity analysis of the 6-SPS parallel mechanism. The rotation matrix is described by quaternion, and both the rotation matrix and the coordinate vectors have been expanded to four-dimensional forms. Through analyzing the coupling relationship between the position variables and the orientation variables, utilizing properties of the quaternion, eight equivalent equations can be obtained. A new kind of Jacobian matrix is derived from those equations, and the analytical expression of the singularity locus is obtained by calculating the determinant of the new Jacobian matrix. The singularity analysis of parallel mechanisms, whose moving platform actuated by 6 links and the vertices of both the base and the moving platforms has been placed on a circle respectively, can be solved by this analytical expression.CHENG ShiLi WU HongTao WANG ChaoQun YAO Yu ZHU JianYing 2011Science China(Technological Sciences)2011,54,5:15
13Geochemical Characteristics of the Upper Triassic Xujiahe Formation in Sichuan Basin, China and its Significance for Hydrocarbon Accumulation显示文摘The alternative development of coal-bearing hydrocarbon source rocks and low-porosity and low-permeability tight sandstone reservoirs of the Triassic Xujiahe Formation in the Sichuan Basin is favorable for near-source hydrocarbon accumulation. The natural gas composition of the Xujiahe Formation in the Sichuan Basin is dominated by hydrocarbon gases, of which the methane content is80.16%-98.67%. Typically, the C_2^+ content is larger than 5% in main wet gas. The dry gas is mainly distributed in the western and northern regions of the basin. The non-hydrocarbon gases mainly contain nitrogen, carbon dioxide, hydrogen, and helium, with a total content of <2%. The carbon isotope ranges of methane and its homologues in natural gas are: δ^(13)C_1 of-43.8‰ to-29.6‰, δ^(13)C_2 of-35.4‰ to-21.5‰, δ^(13)C_3 of-27.6‰ to-19.8‰,and δ^(13)C_4 of-27.7‰ to-18.8‰. δ^(13)C_3>δ^(13)C_4 occurs in some natural gas with a low evolution degree; such gas is mainly coal-related gas from humic-type source rocks of the Xujiahe Formation. As for the natural gas, δ~2 H_(CH4) values ranged from-195‰ to-161‰,δ~2 H_(C2H6) values ranged from-154‰ to-120‰, and δ~2 H_(C3H8) values ranged from-151‰ to-108‰. The dry coefficient,δ^(13)C and δ~2 H_(CH4) are all positively correlated with the maturity of source rocks. The higher the maturity of source rocks is, the larger the natural gas dry coefficient is and the larger the δ^(13)C and δ~2 H_(CH_4) values are, indicative of the characteristic of near-source accumulation. The δ~2 H_(C2H6) value of natural gas is influenced by paleosalinity to a relatively large extent; the higher the paleosalinity is, the larger the δ~2 H_(C2H6) value is. The Pr/Ph value of the condensate oil ranged from 1.60 to 3.43, illustrating light oxidization-light reduction and partial-oxidization characteristics of the depositional environment of coal-bearing source rocks of the Xujiahe Formation. The natural gas light hydrocarbon(C_5-C_7) from the Xujiahe Formation presented two characteristics: the first was the relatively high aromatic hydrocarbon content(19%-32.1%), which reveals the characteristic of natural gas with humic substances of high-maturity; the second was the low content of aromatic hydrocarbon(0.4%-9.3%),reflecting water-washing during the accumulation of the natural gas. The reported research outcomes indicate a potential mechanism for natural gas accumulation in the Xujiahe Formation, which will further guide natural gas exploration in this region.XIE Zengye LI Jian LI Zhisheng GUO Jianying LI Jin ZHANG Lu DONG Caiyuan 2017Acta Geologica Sinica(English Edition)2017,91,5:14
14High-Speed EMUs:Characteristics of Technological Development and Trends显示文摘1.A worldwide history of high-speed trains High-speed railway(HSR)is defined by the International Union of Railways(UIC)as new lines with design speeds above 250 kmh1 and upgraded existing lines with speeds of up to 200 kmh1[1].In China,HSR is defined as new passenger-dedicated lines designed for electric multiple unit(EMU)trains running at a speed of 250 kmh1 or above(actual or reserved),with an initial operation speed not lower than 200 kmh1[2].The worldwide development of HSRs and high-speed EMUs can be roughly divided into three stages:initial operation,line platform expansion,and rapid development.Hongwei Zhao Jianying Liang Changqing Liu 2020Engineering2020,6,3:14
15A novel coupling configuration for thermoacoustically-driven pulse tube coolers: Acoustic amplifier显示文摘Thermoacoustically-driven pulse tube cooler can provide cryogenic cooling power with no moving com-ponents. Up to now, pulse tube cooler is directly coupled with the thermoacoustic engine and obtainable pressure ratio for the pulse tube cooler is limited by the capability of the ther-moacoustic engine. The authors propose here the concept of acoustic amplifier, which is actually a long tube connecting the engine with the pulse tube cooler. Theoretical calculation shows that suitable length and diameter of the tube can lead to a pressure wave amplification effect which means that pressure wave amplitude coming from the thermoacoustic engine can be much amplified to drive the pulse tube cooler. Based on this, a 2.8 m long copper tube with 8 mm inner diameter is used as the acoustic amplifier in experiments. The experimental results show that due to the amplification effect, pressure wave amplitude at the inlet of the pulse tube cooler is over 2.5 times of that at the engine outlet. Typically, with 1.67 kW heating power, the pressure ratio provided by the engine is 1.11 while at the inlet of the pulse tube cooler the pressure ratio is 1.32, which leads to a lowest no-load temperature of 65.7 K.DAI Wei LUO Ercang HU Jianying CHEN Yanyan 2005Chinese Science Bulletin2005,50,18:14
16Quantitative prediction of mining subsidence and its impact on the environment显示文摘This study is focused on the prediction of mining subsidence and its impact on the environment in the Hongqi mining area. The study was carried out by means of a probability integral model based, in first instance based on field surveys and the analysis of data collected from this area. Isolines of mining subsidence were then drawn and the impact caused by mining subsidence on the environment was analyzed quantitatively by spatial analysis with Geographic Information System (GIS). The results indicate that the subsidence area of the first working-mine can be as large as 2.54 km 2 , the maximum subsidence is 3440 mm which will cause 1524 houses to be relocated. The entire subsidence area of the mine can reach 8.09 km 2 , with a maximum subsidence of 3590 mm. Under these circumstances the value of the loss of ecosystem services will reach 5.371 million Yuan and the cost of relocating buildings will increase to 6.858 million Yuan.Jianjun Song Chunjian Han Ping Li Junwei Zhang Deyuan Liu Minde Jiang Lin Zheng Jingkai Zhang Jianying Song 2012International Journal of Mining Science and Technology2012,22,1:13
17Allowance and allocation of industrial volatile organic compounds emission in China for year 2020 and 2030显示文摘As an effective pollution control method, emission allowance and allocation just implemented in volatile organic compounds(VOCs) control strategy of China in 2016. This article presents a possible way to set the emission allowance targets and establishes an allowance allocation model for the object year, 2020 and 2030, using 2010 as the reference year. On the basis of regression and scenario analysis method, the emission allowance targets were designed,which were 17.902 Tg and 18.224 Tg for 2020 and 2030, with an increasing rate of 28.75% and31.06% compared to 2010. From the perspective of industries, processes using VOCscontaining products, like machinery and equipment manufacturing, would continue to be the most significant industrial VOCs emission sources in the future of China. Four allocation indicators were selected, which are per capita GDP of each province, per capita industrial VOCs emission of each province, the economic contribution of industrial sector to regional economy of each province, and the emission intensity per land area of each province, respectively.Based on information entropy, the weights of the indicators were calculated and an emission allocation model was established, and the results showed that provinces like Shandong,Jiangsu, Guangdong, Zhejiang and Fujian were calculated to obtain more emission allowance while burden more reduction responsibility. Meanwhile, provinces like Guizhou, Ningxia,Hainan, Qinghai and Xizang were on the contrary. This paper suggests governments to enhance or ease to industrial VOCs reduction burden of each province in order to stimulate its economy or change its way of economy development.Jiani Zhang Jingfang Xiao Xiaofang Chen Xiaoming Liang Liya Fan Daiqi Ye 2018Journal of Environmental Sciences2018,30,7:13
18大数据资源规划研究框架的构建显示文摘大数据资源规划是组织和国家管理大数据资源初期解决'如何开始,从哪里开始'的关键环节。基于对国内外大数据资源规划研究进展的系统梳理,本文从实践视角和理论视角对大数据资源规划研究进行了科学定位,并结合战略规划理论与信息资源规划理论,从宏观、中观和微观三个层面构建了大数据资源规划的研究框架。通过研究,得出如下结论:(1)大数据应用尚处在起步阶段,在此阶段研究大数据资源规划具有现实意义;(2)国内外学者已经着手研究大数据资源管理与规划,但研究视角有所差异,研究内容尚未系统化;(3)大数据资源、大数据资源管理需要从广义和狭义明晰地界定;(4)战略规划与信息资源规划理论都经历一个从微观到宏观的发展历程,为大数据资源规划研究提供了理论参考;(5)需要从国家、领域、组织三个视角构建大数据资源规划的研究框架,探索其研究的共性与个性问题。周耀林 赵跃 Zhou Jiani 2017图书情报知识2017,34,4:12
19Optimal guidance against active defense ballistic missiles via differential game strategies显示文摘The optimal guidance problem for an interceptor against a ballistic missile with active defense is investigated in this paper.A class of optimal guidance schemes are proposed based on linear quadratic differential game method and numerical solution of Riccati differential equation.By choosing proper parameters, the proposed guidance schemes are able to drive the interceptor to the target and away from the defender simultaneously.Additionally, fuel cost, control saturation,chattering phenomenon and parameters selection were taken into account.Satisfaction of the proposed guidance schemes of the saddle point condition is proven theoretically.Finally, nonlinear numerical examples are included to demonstrate the effectiveness and performance of the developed guidance approaches.Comparison of control performance between different guidance schemes are presented and analysis.Haizhao LIANG Jianying WANG Yonghai WANG Linlin WANG Peng LIU 2020Chinese Journal of Aeronautics2020,33,3:12
20Hybrid hierarchy storage system in MilkyWay-2 supercomputer显示文摘Weixia XU Yutong LU Qiong LI Enqiang ZHOU Zhenlong SONG Yong DONG Wei ZHANG Dengping WEI Xiaoming ZHANG Haitao CHEN Jianying XING Yuan YUAN 2014Frontiers of Computer Science2014,8,3:11
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