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| 1 | Oxidative stress and antioxidants in hepatic pathogenesis显示文摘Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases,including hepatocellular carcinoma (HCC). The HBV encod-ed proteins,hepatitis B virus X protein and preS,appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress,which can damage cellular molecules like lipids,proteins,and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants,such as curcumin,silymarin,green tea,and vitamins C and E,can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis,focusing upon HBV and alcohol,and suggests antioxidant therapeutic approaches. | Hye-Lin Ha Hye-Jun Shin Mark A Feitelson Dae-Yeul Yu | 2010 | World Journal of Gastroenterology2010，16，48： | 18 |
| 2 | 托瑞米芬的安全性评估显示文摘托瑞米芬临床用于进展期激素依赖性乳腺癌的治疗和早期乳腺癌的辅助治疗已有8年之久。累积超过350 000名患者数年的治疗足以评估托瑞米芬与他莫昔芬,还有雷洛昔芬和芳香化酶抑制剂的长期安全性。复习1978-2004年间所有的临床前和临床安全性资料,以及1995年10月到2004年底的临床对比安全性资料。托瑞米芬引起的继发性子宫内膜癌发生率低于他莫昔芬,与雷洛昔芬相似。推测托瑞米芬可能暴露了原已存在的子宫内膜肿瘤而不是诱发新生肿瘤。托瑞米芬引起脑卒中、肺栓塞和白内障的风险低于他莫昔芬,并且肺栓塞和深静脉血栓的风险低于雷洛昔芬。对骨密度有益的类雌激素作用等同于他莫昔芬,而脂质代谢方面优于他莫昔芬。 | Harvey HA Kimura M Hajba A 李文萍(译) 王颀(审校) | 2007 | 中华乳腺病杂志(电子版)2007，1，1： | 8 |
| 3 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 4 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 5 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 6 | 心电图左心室肥厚电压标准与心血管病死亡率的关系显示文摘目前已提出多种使用心电图来诊断左心室肥厚的方法。它们识别病理性肥厚的灵敏度有限,至少部分是由于它们不能区分病理性和生理性肥厚。为此,Ha等使用心血管病死亡作为病理性肥厚的替代指标,比较主要的心电图左心室肥厚标准的预测能力。 | 刘莉 叶鹏 Ha LD Elbadawi A Froelicher VF | 2017 | 中华高血压杂志2017，25，12： | 3 |
| 7 | Gastric per-oral endoscopic myotomy: Current status and future directions显示文摘Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field. | Alexander Podboy Joo Ha Hwang Linda A Nguyen Patricia Garcia Thomas A Zikos Afrin Kamal George Triadafilopoulos John O Clarke | 2019 | World Journal of Gastroenterology2019，25，21： | 3 |
| 8 | Multicenter evaluation of recurrence in endoscopic submucosal dissection and endoscopic mucosal resection in the colon:A Western perspective显示文摘BACKGROUND While colon endoscopic mucosal resection(EMR)is an effective technique,removal of larger polyps often requires piecemeal resection,which can increase recurrence rates.Endoscopic submucosal dissection(ESD)in the colon offers the ability for en bloc resection and is well-described in Asia,but there are limited studies comparing ESD vs EMR in the West.AIM To evaluate different techniques in endoscopic resection of large polyps in the colon and to identify factors for recurrence.METHODS The study is a retrospective comparison of ESD,EMR and knife-assisted endoscopic resection performed at Stanford University Medical Center and Veterans Affairs Palo Alto Health Care System between 2016 and 2020.Knife-assisted endoscopic resection was defined as use of electrosurgical knife to facilitate snare resection,such as for circumferential incision.Patients≥18 years of age undergoing colonoscopy with removal of polyp(s)≥20 mm were included.The primary outcome was recurrence on follow-up.RESULTS A total of 376 patients and 428 polyps were included.Mean polyp size was greatest in the ESD group(35.8 mm),followed by knife-assisted endoscopic resection(33.3 mm)and EMR(30.5 mm)(P<0.001).ESD achieved highest en bloc resection(90.4%)followed by knife-assisted endoscopic resection(31.1%)and EMR(20.2%)(P<0.001).A total of 287 polyps had follow-up(67.1%).On follow-up analysis,recurrence rate was lowest in knife-assisted endoscopic resection(0.0%)and ESD(1.3%)and highest in EMR(12.9%)(P=0.0017).En bloc polyp resection had significantly lower rate of recurrence(1.9%)compared to non-en bloc(12.0%,P=0.003).On multivariate analysis,ESD(in comparison to EMR)adjusted for polyp size was found to significantly reduce risk of recurrence[adjusted hazard ratio 0.06(95%CI:0.01-0.57,P=0.014)].CONCLUSION In our study,EMR had significantly higher recurrence compared to ESD and knife-assisted endoscopic resection.We found factors including resection by ESD,en bloc removal,and use of circumferential incision were associated with significantly decreased recurrence.While further studies are needed,we have demonstrated the efficacy of ESD in a Western population. | Mike T Wei Margaret J Zhou Andrew A Li Andrew Ofosu Joo Ha Hwang Shai Friedland | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，6： | 2 |
| 9 | C (-260)-T Polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction显示文摘 | Hubacek J A Pit'ha J Skodova Z | 1999 | Circulation1999，99，： | 2 |
| 10 | Hepatitis B virus infection and risk of non-Hodgkin lymphoma in South Korea: a cohort study显示文摘 | Eric A Engels Eo Rin Cho Sun Ha Jee | 2010 | Lancet Oncology2010，，9： | 2 |
| 11 | Intraocular pressure changes during laparoscopy in patients anesthetized with propofol total intravenous anesthesia versus isoflurane inhaled anesthesia 显示文摘 | Mowafi HA Al-Ghamdi A Rushood A | 2003 | Anesth Analg2003，97，2： | 1 |
| 12 | Contracting and information sharing under supply chain competition显示文摘 | Ha A Tong S | 2008 | Management Science2008，54，： | 1 |
| 13 | Cholangiocarcinoma: a spectrum of intrahepatic, perihilar, and distal tumors 显示文摘 | Nakeeb A Pitt HA Sohn TA | 1996 | Ann Surg1996，224，46： | 1 |
| 14 | Evaluation of diagnnstic criteria for ankylosing spondylitis: A proposal for modification of the New York criteria显示文摘 | Van der Linden S Valkenburg HA Cats A | 1984 | Arthritis Rheum1984，27，4： | 1 |
| 15 | Time to pregnancy as a function of male and female serum concentrations of 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (P,p'-DDE)显示文摘 | Thulstrup AM Rignell HA | 2006 | Hum Repred2006，21，： | 1 |
| 16 | Prevalence and Impact of Diabetes Mellitus in Patients With Acute Myocardial Infarction:A 10-year Experience显示文摘 | El-Menyar AA Albinali HA Bener A | 2009 | Angiology2009，60，6： | 1 |
| 17 | Endovenous treatment of the greater saphenous vein with a 940 nm diode laser:Thrombotic occlusion after endoluminal thermal damage by laser-generated steam bubbles显示文摘 | Proebstle TM Lehr HA Kargl A | 2002 | J Vasc Surg2002，35，4： | 1 |
| 18 | Roles of DNA frag- mentation factor and poly (ADP-ribose) polymerase in an amplifi-cation phase of tumor necrosis factor-induced apoptosis显示文摘 | Boularc HA Zoltoski AJ Yakovlev A | 2001 | J Bio Chemi2001，276，28： | 1 |
| 19 | Phytochelatin synthase genes from Arabidopsis and the yeast Schiz- osaccharomyces pombe显示文摘 | Ha S B Smith A P Howden R | 1999 | Plant Cell1999，11，6： | 1 |
| 20 | Synthesis of biologically active steroid derivativesby the utility of Lawesson's reagent显示文摘 | MOHAMED N R ELMEGEED G A ABD-ELMALEK HA | 2005 | Steroids2005，70，3： | 1 |
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