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| 1 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 2 | Roles of DNA frag- mentation factor and poly (ADP-ribose) polymerase in an amplifi-cation phase of tumor necrosis factor-induced apoptosis显示文摘 | Boularc HA Zoltoski AJ Yakovlev A | 2001 | J Bio Chemi2001，276，28： | 1 |
| 3 | Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury显示文摘 | Yakovlev A G Knoblach SM Fan I | 1997 | Neurosci1997，17，74： | 1 |
| 4 | High-level modeling and design of asynchronous interface logic显示文摘 | A V Yakovlev A M Koelmans L Lavagno | 1995 | IEEE Design and Test of Computers1995，1995，： | 1 |
| 5 | Clockless circuits and system synthesis显示文摘 | Sokolov D Yakovlev A | 2005 | Computers and Digital Techniques2005，152，3： | 1 |
| 6 | Development of new catalytic systems for upgraded bio-fuels production from bio-crude-oil and biodiesel显示文摘 | Yakovlev V A Khromova S A Sherstyuk O V | 2009 | Catalysis Today2009，144，： | 1 |
| 7 | Use of thermally expanded graphite in waterpurification and water-treat ment systems 显示文摘 | Yakovlev A V | 2004 | Environmental Problems of Chemistry and Technology2004，，11： | 1 |
| 8 | In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury显示文摘 | Di Giovanni S De Biase A Yakovlev A | 2005 | J Biol Chem2005，280，3： | 1 |
| 9 | Outcomes of percutaneous disc decompression utilizing nucleoplasty for the treatment of chronic discogenic pain 显示文摘 | Yakovlev A Tamimi MA Liang H | 2007 | Pain Physician2007，10，2： | 1 |
| 10 | SETT-subcutaneousendoscopic transaxillary tcnotomy for congenital muscular torticollis显示文摘 | Kozlov Y Yakovlev A Novogilov V | 2009 | J Laparoendosc Adv Surg Tech A2009，191，： | 1 |
| 11 | In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury显示文摘 | Di Giovanni S De Biase A Yakovlev A | 2005 | J Biol Chem2005，280，3： | 1 |
| 12 | Mode locking of electron spin coherences in singly charged quantum dots显示文摘 | Greilich A Yakovlev DR Shabaev A etal | 2006 | Science2006，313，5785： | 1 |
| 13 | Transmission through stacked 2D periodic distributions of square conduc- ting patches显示文摘 | Kaipa C S R Yakovlev A B Medina F | 2012 | J Appl Phys2012，112，03： | 1 |
| 14 | Neuronal plasticity after spinal cord injury; identification of agene cluster driving neurite outgrowth 显示文摘 | Di Giovanni S Faden AI Yakovlev A | 2005 | FASEB J2005，19，1： | 1 |
| 15 | Circuit mo- deling of multiband high-impedanee surface absorbers in the microwave regime显示文摘 | Padooru Y R Yakovlev A B Kaipa C S R | 2011 | Phys Rev B2011，84，03： | 1 |
| 16 | Set subcutaneous en- doscopic transaxillary tenotomy for congenital muscular torticollis 显示文摘 | Kozlov Y Yakovlev A Novogilov V | 2009 | J Laparoendosc Adv Surg Tech A2009，19，1： | 1 |
| 17 | BOK and NOXA are essential mediators of p532dependent apoptosis 显示文摘 | Yakovlev A G Di Giovanni S Wang G | 2004 | J Biol Chem2004，279，28： | 1 |
| 18 | Hydrogen effects in III-nitride MOVPE显示文摘 | Yakovlev E V Talalaev R A Segal A S | 2008 | J Cryst Growth2008，310，23： | 1 |
| 19 | Early detection and treatment of postoperative pharyngocutaneous fistula 显示文摘 | Friedman M Venkatesan TK Yakovlev A | 1999 | Otolaryn- gology Head and Neck Surgery1999，121，4： | 1 |
| 20 | Outcomes of percutaneouszlisc decompression utilizing nucleoplasty for the treatment of chronic discogenic pain显示文摘 | Yakovlev A Tamimi MA Liang H | 2007 | Pain Physician(S1533-3159)2007，10，2： | 1 |
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