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| 1 | 胆汁纳米细菌的培养与鉴定显示文摘目的 探讨纳米细菌在胆汁中的分布情况及微生物学特性 ,并对其鉴定方法进行评价。方法 对 75例胆囊胆汁标本进行纳米细菌培养 ,观察其生长情况 ,并采用免疫组化染色、透射电镜扫描和钙染色进行纳米细菌鉴定。结果 胆汁中纳米细菌感染率为 6 1 3% ,其中出现完全或部分黏附于管底壁的白色沉淀者 ,纳米细菌阳性率为 75 7% ,而沉淀完全呈絮状或无沉淀者 ,阳性率为4 7 4 % ,两者间存在显著性差异。免疫组化染色阳性的胆汁标本经透射电镜扫描均发现纳米细菌。钙染色的阳性率为 38 7% ,与免疫组化染色相比较 ,其灵敏度为 5 8 7% ,特异度为 93 1% ,假阳性率6 9% ,假阴性率 4 1 3%。结论 纳米细菌单克隆抗体联合透射电镜扫描可鉴定纳米细菌 ;钙染色对纳米细菌的鉴定有着重要的参考价值 ;紧密黏附于管底的白色沉淀是纳米细菌培养过程中的一个重要微生物学特性。 | 李永国 文宇 杨竹林 魏红 刘威 谭爱玲 吴晓瑛 王群伟 黄生福 Kajander EO Ciftcioglu N | 2002 | 中华医学杂志2002，82，22： | 17 |
| 2 | Comparison of selected inflammation-based prognostic markers in relapsed or refractory metastatic colorectal cancer patients显示文摘AIM: To investigate the impact of systemic inflammationbased prognostic markers on overall survival in relapsed/refractory metastatic colorectal cancer(m CRC) patients. METHODS: To investigate prognostic markers in m CRC patients,this study was performed with patients who have experienced relapsed/refractory m CRC with standard chemotherapy or were inapplicable to conventional treatment modality because of poor performance status,age,or comorbidity. We reviewed the medical records of 177 m CRC patients managed with Korean Medicine(KM) treatment modality using an anticancer agent of Rhus verniciflua Stokes extract from June 2006 to April 2013. The clinicopathologic characteristics,laboratory test,the systemic inflammation markers including the modified Glasgow prognostic score(m GPS),neutrophil lymphocyte ratio(NLR),platelet lymphocyte ratio(PLR),lymphocyte monocyte ratio(LMR),and prognostic nutritional index(PNI) were analyzed. The overall survival of patients was calculated with the Kaplan-Meier method and the statistical significance was compared using with the log-rank test. To compare the impact of systemic inflammation based markers,the hazard ratio(HR) of m GPS,NLR,PLR,LMR,and PNI for overall survival were evaluated with the Cox proportional hazards regression.RESULTS: The majority of m CRC patients had relapsed/refractory to standard chemotherapy; 128 patients(72.3%) had undergone more than second line chemotherapy,and the median time from diagnosis of m CRC to initiation of KM was 9.4 mo. The median overall survival of enrolled patients was 8.3 mo. On univariate analyses,the inflammation markers of higher m GPS(P < 0.001),NLR ≥ 5(P < 0.001),PLR > 300(P = 0.004),LMR ≤ 3.4(P < 0.001),and PNI ≤ 45.3(P = 0.001) were significantly associated with decreased survival time. On stepwise multivariate proportional hazards model,m GPS at 2 vs 0(HR = 3.212,95%CI: 1.437-7.716,P = 0.004),and LMR ≤ 3.4(HR = 1.658,95%CI: 1.092-2.518,P = 0.018) as independent predictors associated with poor overall survival along with carbohydrate antigen 19-9(HR = 1.482,95%CI: 1.007-2.182,P = 0.046),AST ≥ 40(HR = 2.377,95%CI: 1.359-4.155,P = 0.002),and the treatment duration for KM less than 2.9 mo(HR = 1.718,95%CI: 1.160-2.543,P = 0.007).CONCLUSION: These results indicate that the inflammatory markers,m GPS and LMR are independent prognostic factors for predicting overall survival in relapsed/refractory m CRC patients. | Anna Song Wankyu Eo Sookyung Lee | 2015 | World Journal of Gastroenterology2015，21，43： | 8 |
| 3 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 4 | Nuclear imaging for functional evaluation and theragnosis in liver malignancy and transplantation显示文摘Currently,nuclear imaging such as positron emission tomography(PET)and single photon emission computed tomography(SPECT)is increasingly used in the management of liver malignancy.18F-fluorodeoxyglucose(FDG)-PET is the most widely used nuclear imaging in liver malignancy as in other cancers,and has been reported to be effective in diagnosis,response monitoring,recurrence evaluation,and prognosis prediction.Other PET imaging such as 11C-acetate PET is also used complementarily to FDG-PET in diagnosis of liver malignancy.Additionally,image-based evaluation of regional hepatic function can be performed using nuclear imaging.Those imaging modalities are also effective for candidate selection,treatment planning,and perioperative evaluation in liver surgery and transplantation.Recently,nuclear imaging has been actively adopted in the transarterial radioembolization therapy of liver malignancy,according to the concept of theragnosis.With the development of new hybrid imaging technologies such as PET/magnetic resonance imaging and SPECT/CT,nuclear imaging is expected to be more useful in the management of liver malignancy,particularly regarding liver surgery and transplantation.In this review,the efficacy and roles of nuclear imaging methods in diagnosis,transplantation and theragnosis are discussed. | Jae Seon Eo Jin Chul Paeng Dong Soo Lee | 2014 | World Journal of Gastroenterology2014，20，18： | 3 |
| 5 | 体质量状态变化与高血压发生的相关性显示文摘在美国近1/3的儿童和青少年是肥胖或超重的。虽然最近该比值保持稳定,但在过去40年中则呈快速上升的趋势。儿童肥胖与高血压显著相关。主要在初中和高中学生中进行的流行病学调查研究报道,高血压的发病率在0.8%~3.2%,而在肥胖学生中高血压发病率则〉10%。在大型的医疗保健系统门诊和小学儿童中进行的一项研究报道显示,正常体质量的儿童高血压总发病率为0.3%~0.9%,肥胖儿童为1.0%~9.2%。 | Parker ED Sinaiko AR Kharbanda EO Margolis KL Daley MF Trower NK Sherwood NE Greenspan LC Lo JC Magid DJ o'connor pj | 2016 | 中华高血压杂志2016，24，6： | 3 |
| 6 | A case of intrahepatic clear cell cholangiocarcinoma显示文摘Intrahepatic clear cell cholangiocarcinoma is very rareonly 8 cases have been reported.A 56-year-old Japanese man with chronic hepatitis B infection was diagnosed with a 2.2 cm hepatocellular carcinoma on imaging,and hepatic segmentectomy was performed.Histopathologically,the tumor cells had copious clear cytoplasm and formed glandular structures or solid nests.These pathological findings suggested the tumor was a clear cell variant of intrahepatic cholangiocarcinoma.Particular stains and radiological images suggested that the cause of the clear cell change had been glycogen,not mucin nor lipid.On immunohistochemical staining,cytokeratin(CK)7 and CK19 were positive,whereas CK20 was negative.Vimentin was detected on the cell membranes,and CD56 was focally positive.The patient was given adjuvant chemotherapy and is currently free from the tumor 7 mo postoperatively.Careful follow-up with adequate postoperative supplementary chemotherapy is necessary because the characteristics of this type of tumor are unknown. | Eo Toriyama Atsushi Nanashima Hideyuki Hayashi Kuniko Abe Naoe Kinoshita Shunsuke Yuge Takeshi Nagayasu Masataka Uetani Tomayoshi Hayashi | 2010 | World Journal of Gastroenterology2010，16，20： | 2 |
| 7 | 生理过度觉醒相关失眠增加高血压风险显示文摘先前的研究显示,失眠和客观睡眠时间过短与高血压风险增加相关,并推测其潜在的机制是生理过度觉醒。在该研究中,研究者通过多次睡眠潜伏期试验(multiplesleeplatencytest,MSLT)——一种睡眠/觉醒的标准测试,探讨与生理过度觉醒相关的失眠是否与高血压风险增加相关。 | Li Y Vgontzas AN Fernandez-Mendoza J Bixler EO Sun Y Zhou J Ren R Li T Tang X 戴伦 练桂丽 | 2015 | 中华高血压杂志2015，23，2： | 2 |
| 8 | Perioperative complications and risk factors of percutaneous nephrolithotomy显示文摘 | Vorrakitpokatorn P Permtongchuchai K Raksamani EO | 2006 | Journal of the Medical Association of Thailand2006，，06： | 2 |
| 9 | Hepatitis B virus infection and risk of non-Hodgkin lymphoma in South Korea: a cohort study显示文摘 | Eric A Engels Eo Rin Cho Sun Ha Jee | 2010 | Lancet Oncology2010，，9： | 2 |
| 10 | Vascular anatomy and microcirculation of skeletal zones vulnerable to osteonecrosis : vascularization of the femoral head 显示文摘 | Johnson EO Souhanis K Soucacos PN | 2004 | Orthop Clin North Am2004，35，： | 1 |
| 11 | Antiherpetic activities of acidic protein bound polysaccharide isolated from Ganoderma lucidumalone and in combinations with mterferons 显示文摘 | Kim Y S Eo S K Oh K W etal | 2000 | J Ethnopharmacol2000，72，3： | 1 |
| 12 | Substance P and beta endorphin mediate electroacupuncture induced analgesic activity in mouse cancer pain model显示文摘 | Lee HJ Lee JH Lee EO | 2009 | Acupunct Electrother Res2009，34，12： | 1 |
| 13 | Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness:role of insulin resistance显示文摘 | Vgontzas AN Legro vs Bixler EO | 2001 | Clin Endo Metab2001，86，2： | 1 |
| 14 | Prevalence of sleep -disordered breathing in women:effects of gender显示文摘 | Bixler EO Vgontzas AN Lin HM | 2001 | Am J Respir Crit Care Med2001，163，4： | 1 |
| 15 | Sexual identity, sex of sexual con- tacts,and health - risk behaviors among students in grades 9 - 12 - - youth risk behavior surveillance, selected sites, United States, 2001 - - 2009显示文摘 | Kann L Olsen EO McManus T | 2011 | MMWR Surveill Suture2011，60，7： | 1 |
| 16 | The results of transplantation of intercalary allografts after resection of tumors 显示文摘 | Cruz EO Gebhardt MC Jennings C | 1997 | J Bone Joint Surg(Am)1997，79，： | 1 |
| 17 | GP120:Biologic aspects of structural features显示文摘 | Poignard P Saphire EO Parren PW | 2001 | Annu Rev Immunol2001，19，： | 1 |
| 18 | Haematuria and clot retention after transurethral resection of the prostate: a pilot study显示文摘 | Olapade-Olaopa EO Solomon LZ Carter CJM | 1998 | Br J Urol1998，82，： | 1 |
| 19 | Evidence for a dose-response relationship between occupational noise and blood pressure显示文摘 | Talbott EO Gibson LB Burks A | 1999 | Arch Environ Health1999，54，： | 1 |
| 20 | Photorecepter desity of the domestic pig retina显示文摘 | Chandler MJ Smith PJ Samuelson DA Mackay EO | 1999 | Vet Ophthalmol1999，2，3： | 1 |
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